ライフサイエンスコーパス: matrix metalloproteinase 1

1 , which is resistant to degradation by human matrix metalloproteinase 1.

2 cell migration through the up-regulation of matrix metalloproteinase 1.

3 tissue growth factor and tissue inhibitor of matrix metalloproteinase 1.

4 n-6, monocyte chemoattractant protein 1, and matrix metalloproteinase 1.

5 that obtained via direct immunodepletion of matrix metalloproteinase-1.

6 ), cyclooxygenase-2, and tissue inhibitor of matrix metalloproteinase-1.

7 lammation-responsive genes including SAA and matrix metalloproteinase-1.

8 was further characterized by upregulation of matrix metalloproteinases 1, 10, and 13, cathepsin L2, c

9 signaling pathway, and induces expression of matrix metalloproteinases 1, 2, and 3.

10 raised reactive oxygen species production or matrix metalloproteinase-1, -2 and -9 activity nor decre

11 sion across an ECM layer was quantitated and matrix metalloproteinase-1, -2, -3, -9, and -11 gene and

12 The up-regulated production of matrix metalloproteinases 1, 3, and 13 and cytokines IL-

13 ecan mRNA levels and increased the levels of matrix metalloproteinases 1, 3, and 13 mRNA, as well as

14 dorferi infection revealed colocalization of matrix metalloproteinase-1, a degradative enzyme that de

15 al encoding angiogenic regulators, including matrix metalloproteinase-1, an interstitial collagenase,

16 in basic calcium phosphate crystal-mediated matrix metalloproteinase 1 and 3 expression in human fib

17 with elevated levels of tissue inhibitor of matrix metalloproteinase 1 and elastin in the infarct (P

18 se, in both groups there was upregulation of matrix metalloproteinase 1 and laminin 5 in the tumors.

19 280-320 nm) causes these changes by inducing matrix metalloproteinase 1 and suppressing type I collag

20 Certain Ets-1-associated genes, namely matrix metalloproteinase 1 and vascular endothelial grow

21 helin-1 inhibited both protein expression of matrix metalloproteinase 1 and zymographic activity excl

22 Matrix metalloproteinase-1 and -9 mRNA increased 5- (P=0

23 ed a peptide with micromolar K(i) values for matrix metalloproteinase-1 and -9 that are selective inh

24 gle treatment, as shown by lower IL-6, IL-8, matrix metalloproteinase-1 and matrix metalloproteinase-

25 two biologically relevant polymorphic genes, matrix metalloproteinase-1 and myeloperoxidase.

26 emonstrated the presence of higher levels of matrix metalloproteinase-1 and SAF-1 in the inflamed joi

27 Downregulated transcripts included matrix metalloproteinase-1 and thrombomodulin.

28 kin 1 to reduce production of collagenolytic matrix metalloproteinases 1 and 13 in tenosynovial tissu

29 ation of antimetastatic tissue inhibitors of matrix metalloproteinases 1 and 2 and plasminogen activa

30 epiregulin, the cyclooxygenase COX2, and the matrix metalloproteinases 1 and 2, when expressed in hum

31 ion, relaxin decreases endometrial levels of matrix metalloproteinases 1 and 3 and increases levels o

32 cellular matrix remodeling, and they include matrix metalloproteinases 1 and 3, IL-8, human beta-defe

33 f a number of chondrocyte proteins including matrix metalloproteinases 1 and 3, tissue inhibitor of m

34 g in adhesive signaling and up-regulation of matrix metalloproteinases 1 and 3.

35 n of inducible nitric oxide synthase (iNOS), matrix metalloproteinases 1 and 8 (MMP-1 and -8), bone m

36 ects were also associated with a decrease of matrix metalloproteinases 1 and 8, inducible nitric oxid

37 ors alpha and beta, and tissue inhibitors of matrix metalloproteinases-1 and -2, increased by 4 weeks

38 Membrane-type matrix metalloproteinases-1 and -3 (MT1- and MT3-MMPs) a

39 giogenesis, and reduction of blood levels of matrix metalloproteinases-1 and -3.

40 Matrix metalloproteinases-1 and -9 and tissue inhibitor

41 JAG2 also induced matrix-metalloproteinases 1 and 12, which are highly exp

42 inases 7, 9, 10, and 12, tissue inhibitor of matrix metalloproteinase 1, and secreted protein acidic

43 mural and luminal flow induced expression of matrix metalloproteinase 1, and this up-regulation was r

44 vated levels of the matrix degrading protein matrix metalloproteinase-1, and a promigratory phenotype

45 protein A8, IL-6, IL-8, and tissue inhibitor matrix metalloproteinase-1 are up-regulated by these NOS

46 nd its inhibitor TIMP-1 (tissue inhibitor of matrix metalloproteinase 1) are regulated in a manner th

47 cells depend on up-regulation of Drosophila matrix metalloproteinase-1 as assessed by promoter activ

48 21SNFT in HepG2 cells leads to repression of matrix metalloproteinase-1 by 70-80%.

49 indicate that the mechanism of repression of matrix metalloproteinase-1 by p21SNFT may be exploited i

50 es that may be involved in the repression of matrix metalloproteinase-1 by p21SNFT.

51 decreases the expression of the collagenase, matrix metalloproteinase 1, by IL-34-Mphi and M-CSF-Mphi

52 In mice, transgenic expression of human matrix metalloproteinase 1 causes caseous necrosis, the

53 al telopeptide of collagen type I (CITP) and matrix metalloproteinase-1 (CITP:MMP-1) was determined i

54 e designed to include cell-adhesion ligands, matrix metalloproteinase-1 cleavage sites, and full-leng

55 inase-9 (gelatinase B; pro-MMP-9) and active matrix metalloproteinase-1 (collagenase-1; MMP-1).

56 e plasminogen activator, tissue inhibitor of matrix metalloproteinase-1, cyclooxygenase-2, and VEGF r

57 or collagens, laminins, decorin, E-cadherin, matrix metalloproteinase-1, endorepellin, and several vi

58 GBP1 was required for EGFR-mediated MMP1 (matrix metalloproteinase 1) expression and glioma cell i

59 SLFN5 negatively controls expression of the matrix metalloproteinase 1 gene (MMP-1), MMP-13, and sev

60 dose UV-A1 irradiation significantly induced matrix metalloproteinase 1 gene expression, which increa

61 metalloproteinase 2 and tissue inhibitor of matrix metalloproteinase 1 gene expression.

62 mulatory effect of insulin on collagenase-1 (matrix metalloproteinase-1) gene transcription a series

63 cular endothelial growth factor, KDR, Ang-2, matrix metalloproteinase 1, GRO-alpha, and CD31).

64 growth factor receptor, estrogen signaling, matrix metalloproteinase-1, histone deacetylase, methylt

65 degeneration through the regulation of human matrix metalloproteinase-1 (hMMP-1, collagenase-1) gene

66 , IL-20, chemokine C-X-C motif ligand 8, and matrix metalloproteinase 1, IL-19 had no clear influence

67 ype 1 collagen genes and tissue inhibitor of matrix metalloproteinase 1 in both wild-type and egr-1(-

68 RANTES stimulated the release of matrix metalloproteinase 1 in normal and OA chondrocytes

69 The expression of collagenase (matrix metalloproteinase 1) in human fibroblasts increas

70 coprotein transporter protein gene and MMP1 (Matrix Metalloproteinase 1), indicative of the invasive

71 a occludens-1, laminin), tissue inhibitor of matrix metalloproteinase-1, inflammation (interleukin-1b

72 of type I collagen were exposed in vitro to matrix metalloproteinase-1 (interstitial collagenase), a

73 Increased synthesis of SAA and matrix metalloproteinase-1 is associated with pathogenes

74 rix metalloproteinase-2, tissue inhibitor of matrix metalloproteinase 1, left atrial volume), myocard

75 le to regression mediated by factors such as matrix metalloproteinase-1, matrix metalloproteinase-10,

76 eutralizing reagents blocked hypoxia-induced matrix metalloproteinase-1, matrix metalloproteinase-9 e

77 in humans suggest that PTX3, P-selectin, and matrix metalloproteinase-1 may be novel biomarkers that

78 fibroblasts in response to stimulation were matrix metalloproteinase 1, MCP-1, IL-1beta, IL-6, IL-8,

79 The 1G/2G polymorphism of matrix metalloproteinase 1 (MMP-1) affects activity of t

80 Presently, matrix metalloproteinase 1 (MMP-1) and collagen triple-h

81 a1 (TGFbeta1) resulted in down-regulation of matrix metalloproteinase 1 (MMP-1) and MMP-13 concomitan

82 or retinoid X receptor, on the expression of matrix metalloproteinase 1 (MMP-1) and MMP-13 induced by

83 Elevations in matrix metalloproteinase 1 (MMP-1) and MMP-3 have been f

84 infection and elevated expression of tissue matrix metalloproteinase 1 (MMP-1) are both associated w

85 Matrix metalloproteinase 1 (MMP-1) cleaves types I, II,

86 Matrix metalloproteinase 1 (MMP-1) expression in cell cu

87 Catalysis of collagen degradation by matrix metalloproteinase 1 (MMP-1) has been proposed to

88 in inhibitor, Dec-RVKR-CH(2)Cl, or selective matrix metalloproteinase 1 (MMP-1) inhibitors.

89 Matrix metalloproteinase 1 (MMP-1) plays a pivotal role

90 east in part, by interstitial collagenase 1 (matrix metalloproteinase 1 (MMP-1)).

91 duction of mRNA for CXCL8/IL-8, CCL5/RANTES, matrix metalloproteinase 1 (MMP-1), and MMP-3 after TNFa

92 aspase 8, Fas, Fas ligand, p53, aggrecanase, matrix metalloproteinase 1 (MMP-1), and MMP-3.

93 Levels of messenger RNA (mRNA) for matrix metalloproteinase 1 (MMP-1), MMP-13, and ADAMTS-4

94 cytokine combination synergistically induced matrix metalloproteinase 1 (MMP-1), MMP-3, and MMP-13 mR

95 ative levels of mRNA for aggrecan, tenascin, matrix metalloproteinase 1 (MMP-1), MMP-3, and tissue in

96 Matrix metalloproteinase 1 (MMP-1), one of the Ets-1 dow

97 ermal fibroblasts revealed overexpression of matrix metalloproteinase 1 (MMP-1), the gene encoding th

98 agen and phospho-Smad3 and reduced levels of matrix metalloproteinase 1 (MMP-1).

99 ulcerations of any form is the expression of matrix metalloproteinase 1 (MMP-1; collagenase-1) by lea

100 association occurred only in carriers of the matrix metalloproteinase-1 (MMP-1) 2G (rs1799750) or the

101 ric collagen I by both the human collagenase matrix metalloproteinase-1 (MMP-1) and collagenase from

102 RATIONALE: Matrix metalloproteinase-1 (MMP-1) and mast cells are pr

103 d NF-kappaB can transactivate genes encoding matrix metalloproteinase-1 (MMP-1) and MMP-9.

104 rin by type I collagen induces expression of matrix metalloproteinase-1 (MMP-1) and that MMP-1 activi

105 of endoglin in modulating Ang II effects on matrix metalloproteinase-1 (MMP-1) and type I collagen e

106 We used matrix metalloproteinase-1 (MMP-1) as a model protease a

107 Importantly, we identify matrix metalloproteinase-1 (MMP-1) as a novel downstream

108 ainst interleukin-8 (IL-8) and inhibition of matrix metalloproteinase-1 (MMP-1) expression before and

109 Increased matrix metalloproteinase-1 (MMP-1) expression is associa

110 terleukin-8 (IL-8) and for the inhibition of matrix metalloproteinase-1 (MMP-1) expression, an inflam

111 uent downstream transcriptional increases in matrix metalloproteinase-1 (MMP-1) expression, which wer

112 e that Met controls the transcription of the matrix metalloproteinase-1 (MMP-1) gene in carcinoma cel

113 reeclampsia involves increased expression of matrix metalloproteinase-1 (MMP-1) in endothelial cells,

114 Iris and CB were the major source of matrix metalloproteinase-1 (MMP-1) in the naive eye, and

115 Matrix metalloproteinase-1 (MMP-1) is a collagenase that

116 Our previous studies demonstrated that matrix metalloproteinase-1 (MMP-1) is able to digest fib

117 Matrix metalloproteinase-1 (MMP-1) is highly expressed b

118 cted to determine the following: (1) whether matrix metalloproteinase-1 (MMP-1) is increased in syste

119 Extracellular matrix-degrading matrix metalloproteinase-1 (MMP-1) is one of the interst

120 A polymorphism at -1607 in the matrix metalloproteinase-1 (MMP-1) promoter (an insertio

121 amined the hypothesis that H. pylori induces matrix metalloproteinase-1 (MMP-1) secretion, with poten

122 hat smoke exposure leads to the induction of matrix metalloproteinase-1 (MMP-1) through the activatio

123 tokine release and the induction of mRNA for matrix metalloproteinase-1 (MMP-1) were also studied usi

124 In injured skin, collagenase-1 (matrix metalloproteinase-1 (MMP-1)) is induced in migrat

125 ll forms of cutaneous wounds, collagenase-1 (matrix metalloproteinase-1 (MMP-1)) is invariably expres

126 roblasts, and the production of collagenase (matrix metalloproteinase-1 (MMP-1)), the major enzyme in

127 The expression of cyclooxygenase-2 (COX-2), matrix metalloproteinase-1 (MMP-1), and the production o

128 howing that it transcriptionally upregulates matrix metalloproteinase-1 (MMP-1), and using rescue app

129 or collagens, laminins, decorin, E-cadherin, matrix metalloproteinase-1 (MMP-1), endorepellin, and se

130 One factor, matrix metalloproteinase-1 (MMP-1), is induced in Drosop

131 Matrix metalloproteinase-1 (MMP-1), or interstitial coll

132 A levels of six senescence-associated genes, matrix metalloproteinase-1 (MMP-1), was decreased, while

133 ype I procollagen and concurrently increases matrix metalloproteinase-1 (MMP-1), which initiates fibr

134 e production of the interstitial collagenase matrix metalloproteinase-1 (MMP-1), which is expressed s

135 ary tube regression in these cocultures in a matrix metalloproteinase-1 (MMP-1)-, MMP-10-, and ADAM-1

136 ed after 24 h of stretch with an increase in matrix metalloproteinase-1 (MMP-1).

137 Many tumor types express matrix metalloproteinase-1 (MMP-1); its collagenase acti

138 Enhanced production of matrix metalloproteinase-1 (MMP-1, collagenase-1) is imp

139 Matrix metalloproteinase-1 (MMP-1, collagenase-1), which

140 ns retinoic acid (atRA) on the expression of matrix metalloproteinase-1 (MMP-1, interstitial collagen

141 ture and human skin organ culture, levels of matrix metalloproteinase-1 (MMP-1; interstitial collagen

142 .000), IL-8/CXCL8 (P=0.006), IL-6 (P=0.002), matrix metalloproteinase-1 (MMP-1; P=0.002), and MMP-3 (

143 press increased levels of collagen-degrading matrix metalloproteinases-1 (MMP-1) in aged (>80 years o

144 Gene expression and protein production of matrix metalloproteinases-1 (MMP-1), -2, -3, -13, and -1

145 loid protein A [SAA]), inflammatory markers (matrix metalloproteinase 1 [MMP-1] and heme oxygenase 1

146 The levels of collagenase (matrix metalloproteinase 1 [MMP-1]) and tissue inhibitor

147 a induced significant levels of collagenase (matrix metalloproteinase 1 [MMP-1]) within 4 hours, and

148 Levels of fibroblast collagenase (matrix metalloproteinase 1 [MMP-1]), neutrophil collagen

149 Levels of matrix metalloproteinases (matrix metalloproteinase 1 [MMP-1], MMP-13, and MMP-3),

150 e upregulated genes (lactotransferrin [LTF], matrix metalloproteinase-1 [MMP-1], MMP-3, interferon in

151 e accumulation and interstitial collagenase (matrix metalloproteinase-1, MMP-1) expression in the les

152 and degradation by interstitial collagenase (matrix metalloproteinase-1, MMP-1) may determine whether

153 of SphK1 in the regulation of expression of matrix metalloproteinase 1 (MMP1) in dermal fibroblasts,

154 sed by preincubating HCECs with capsazepine, matrix metalloproteinase 1 (MMP1) inhibitor TIMP-1, broa

155 hermore, inhibition of Akt upregulated basal matrix metalloproteinase 1 (MMP1) production and reverse

156 upregulation of the interstitial collagenase/matrix metalloproteinase 1 (MMP1) promoter.

157 R-cad also suppressed the matrix metalloproteinase 1 (MMP1), MMP2, and cyclooxygen

158 ess that may be mediated by the DKK effector matrix metalloproteinase 1 (MMP1).

159 nase (JNK)/AP-1 signaling, and expression of matrix metalloproteinase-1 (Mmp1) are activated downstre

160 ), augmenter of liver regeneration (alr) and Matrix metalloproteinase-1 (Mmp1) expressed specifically

161 actor-alpha (TNF), interleukin-1beta (IL1B), matrix metalloproteinase-1 (MMP1), MMP-2, MMP-9, tissue

162 ase with thrombospondin motifs (ADAMTS1) and matrix metalloproteinase-1 (MMP1), orchestrate a paracri

163 lpha caused a rapid synergistic induction of matrix metalloproteinase 1 mRNA, which was sustained ove

164 Membrane type matrix metalloproteinase 1 (MT-MMP1), a novel 63-kDa mem

165 Membrane-type matrix metalloproteinase-1 (MT-MMP-1) has been proposed

166 Membrane-type matrix metalloproteinase 1 (MT1-MMP) is a key enzyme in

167 tion by binding to activated membrane type 1-matrix metalloproteinase 1 (MT1-MMP) on the plasma membr

168 Membrane-type matrix metalloproteinase 1 (MT1-MMP) plays a critical ro

169 Membrane-type matrix metalloproteinase-1 (MT1-MMP) plays a key role in

170 ion darkened skin slightly and did not alter matrix metalloproteinase 1 or type I procollagen gene ex

171 expression of the interstitial collagenase (matrix metalloproteinase-1 or MMP-1) gene.

172 The expression of matrix metalloproteinase-1, or procollagenase, was stimu

173 blunted nitric oxide production through the matrix metalloproteinase-1 pathway.

174 n the endothelial layer through a P-selectin/matrix metalloproteinase-1 pathway.

175 ession and suppress transcription of a human matrix metalloproteinase 1 promoter reporter construct i

176 p21SNFT interacted with Jun at the matrix metalloproteinase-1 promoter -88 Ets/AP-1 enhance

177 Notably, matrix metalloproteinase-1 promoter region, tissue inhib

178 eceptor mRNA expression also correlated with matrix metalloproteinase-1 promoter region, tissue inhib

179 y activating both an E74 site-driven and the matrix metalloproteinase-1 promoter.

180 ry products (ie, matrix metalloproteinase 12/matrix metalloproteinase 1/S100A9) were upregulated in b

181 collagen deposition and tissue inhibitor of matrix metalloproteinase-1 secretion induced by hepatic

182 els of PTX3 and its mediators P-selectin and matrix metalloproteinase-1 than normotensive subjects (n

183 f type III collagen, and tissue inhibitor of matrix metalloproteinase 1 that was subsequently evaluat

184 F-kappaB, promote induction of membrane-type matrix metalloproteinase-1 that then activates pro-MMP-2

185 ammation-responsive genes, including SAA and matrix metalloproteinase-1, that are implicated in the p

186 tion, the maintenance of tissue inhibitor of matrix metalloproteinase-1, the consequent preservation

187 d selective induction of tissue inhibitor of matrix metalloproteinase-1; this extracellular matrix re

188 -1 (MMP1), MMP-2, MMP-9, tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), TIMP-2, and hypoxan

189 or are increased whereas tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) expression in the ir

190 To examine whether tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) is changed to regula

191 or-alpha (TNF-alpha) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) while up-regulating

192 Serum tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), amino-terminal pept

193 hage markers arginase-1, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), and macrophage gala

194 mRNAs as well as that of tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) compared to subleth

195 nic role of the cytokine tissue inhibitor of matrix metalloproteinases 1 (TIMP1) in primary pancreati

196 (Col1a2) promoter, but in contrast to reduce matrix metalloproteinase 1 transcript expression and sup

197 ndothelial growth factor, interleukin-1beta, matrix metalloproteinase-1, versican, and fibronectin.

198 down-regulated, and genes encoding IL-10 and matrix metalloproteinase 1 were up-regulated.

199 proteinases-1 and -9 and tissue inhibitor of matrix metalloproteinase-1 were strongly upregulated by

200 irradiation also induced tissue inhibitor of matrix metalloproteinases-1, which regulates the enzyme.

201 uding serum amyloid A, gamma-fibrinogen, and matrix metalloproteinase 1, whose abnormal expression is

202 increased expression of tissue inhibitor of matrix metalloproteinase-1 with decreased activity of ma