ライフサイエンスコーパス: matur(e|es|ed|ing) (into|to)

1 d the lowest dead cell ratio (p < 0.001) and matured into 0.5 mm diameter myofiber bundles with great

2 on ( 40% tyrosine hydroxylase (TH) positive, maturing into 25% cells exhibiting mDA neuron-like spiki

3 y neurula (stages 13-14), will independently mature into a floor plate as assayed three criteria: (1)

4 sociate with a partner sGCalpha1 subunit and mature into a nitric oxide (NO)-responsive active form.

5 matic domains form via phase separation, and mature into a structure that includes liquid and stable

6 Simultaneously, the central TVN begins to mature into a tubular network, and ultimately into a pla

7 altered; high-affinity DNA-reactive B cells mature to a marginal zone phenotype, and the mice are in

8 that normally are deleted and causes them to mature to a marginal zone phenotype.

9 of the heart has left the research realm and matured into a clinical application that is about to ful

10 Canopy science has matured into a cutting-edge subset of forest research, a

11 JSBML has matured into a major, active open-source project with co

12 same time fragment-based drug discovery has matured into a powerful and widely applied technique.

13 kazaki fragments, which must subsequently be matured into a single covalent DNA strand.

14 the loose collection of bacteria in the IBC matured into a slower growing, highly organized biofilm-

15 l Raman microspectroscopic (CRM) imaging has matured into a useful analytical tool to obtain spatiall

16 hroughput next-generation RNA sequencing has matured into a viable and powerful method for detecting

17 s to gas sensors to protective coatings, has matured to a degree that patterns with multinanometre un

18 r the last decades, theoretical modeling has matured to a level that model guided design has become w

19 n that present computational techniques have matured to a level where accurate enthalpy barriers and

20 p to 14 days, when they are believed to have matured to a near adult state.

21 It has now matured to a point that as long as good-quality crystals

22 Single molecule spectroscopy (SMS) has matured to a point where it can be used as a convenient

23 T-conditioned DCs in the B6 background stock matured to a state that actually supported rather than i

24 At the same time, neuromorphic hardware has matured to a state where fast silicon implementations of

25 Proteomics has matured to a technology platform way beyond two-dimensio

26 The wide tubular network matures into a convoluted fenestrated sheet in a process

27 ent conformational and assembly states as it matures into a functional helicase.

28 s physiologically relevant and is capable of maturing into a complete 50S particle.

29 (a) values suggests that the CPHMD method is maturing into a practical tool for the quantitative pred

30 riteria, it also suggested the potential for maturing into a predictive algorithm if provided with a

31 consuming quantitative PCR strategies and is maturing into a routine tool to quantify gene expression

32 Sporulation involves an inner cell maturing into a spore and an outer cell nurturing the de

33 rvival after solid organ transplantation has matured to acceptable levels.

34 ed autologous neutralization, then gradually matured to achieve breadth.

35 y arresting the normal process of phagosomes maturing into acidified phagolysosomes.

36 them, as well as defined how such antibodies mature to acquire breadth.

37 access of dying tumor cells to DCs that are maturing to activated NKT cells efficiently induces long

38 ons in a stereotypical temporal order before maturing to actively fire action potentials, undergo syn

39 Moreover, on TSC2 correction, AML cells mature into adult lymphatic endothelial cells and have f

40 develop into either reproductive larvae that mature into adult wasps or soldier larvae whose function

41 As HIV-infected children mature into adulthood, close monitoring of ART, adherenc

42 nt and undergo a substantial loss as animals mature into adulthood.

43 across a 16-day period, and then allowed to mature into adulthood.

44 ely lost from alpha-cells as endocrine cells mature into adulthood.

45 aily from postnatal days 2-9 were allowed to mature to adulthood at which time they were chronically

46 were completed, the animals were allowed to mature into adults and then tested for differences in et

47 As juvenile zebrafish mature into adults, this structure becomes fully envelop

48 clone develop into reproductive larvae that mature into adults, whereas others develop into sterile

49 GOX3 is predominantly present in roots and mature to aging leaves but is largely absent from young

50 lection, producing activated thymocytes that matured into agonist-responsive T cells in reaggregates

51 nt bone marrow stromal cells were allowed to mature into alkaline phosphatase-positive colony-forming

52 ryonic development but declines as the brain matures to almost undetectable levels by postnatal day (

53 rive in the lungs during a late fetal stage, maturing to alveolar macrophages through a prealveolar m

54 uding trimers and pentamers, that ultimately matures into amorphous aggregates.

55 Once ISTAPs mature into amyloid deposits comprising >10(6) molecules

56 , only peptides with Q(N) of eight or longer mature into amyloid-like aggregates, doing so by a slow

57 , the secreted protease does not efficiently mature into an enzymatically active form, suggesting tha

58 as secreted normally, it did not efficiently mature to an active form.

59 ment-based lead discovery has over the years matured into an attractive alternative to high-throughpu

60 consensus emerged that hepatic fibrosis has matured into an integrated discipline that promises to s

61 When E. chaffeensis matures into an infectious form, morulae become loose to

62 a multisubunit portal but lacking DNA, which matures into an infectious virion.

63 The cystoblast then divides and matures into an oocyte, a process in which centrosomes e

64 nts, into a cone of overlapping bundles that matures into an oval base by the asymmetric addition of

65 f the affected oocytes, however, could still mature to and arrest at metaphase II, and be ovulated.

66 dase, produced ROS, associated with LC3, and matured into antibacterial lysosomes.

67 ic B cells require an additional stimulus to mature into antibody-secreting plasma cells.

68 During infection, dendritic cells (DC) mature into antigen-presenting cells that activate T cel

69 agic induction, these autophagosomes fail to mature into autolysosomes and degrade LC3.

70 lopmental cues, and these autophagosomes can mature into autolysosomes; however the autophagosomes ar

71 into the fetal liver, where they develop and mature to B cells in a transient wave, which preferentia

72 ther text mining techniques are sufficiently mature to be useful.

73 hievement and disappointment, and ultimately matured to be accepted by a community.

74 er enrichment, and these proliferating cells mature to become new neurons and glia.

75 ss spectrometric (MS) detection has recently matured to become a potent biophysical tool capable of p

76 ulation of nascent murine reticulocytes that mature into biconcave erythrocytes in vitro should be us

77 e discovered that the intracellular bacteria matured into biofilms, creating pod-like bulges on the b

78 these clusters undergo apoptosis and fail to mature into blood lineages in vivo and in vitro.

79 ly complete development in reticulocytes and mature into both schizonts and gametocytes.

80 o their infecting virus, which in some cases mature into broadly neutralizing antibodies.

81 on studies show that WT but not MT nicastrin matures into buoyant membrane fractions enriched in gamm

82 ulatory molecule expression, allowing DCs to mature into capable APCs.

83 showed that neonatal Nkx2.5+ cardiomyoblasts mature into cardiomyocytes in vivo.

84 )Foxp3(+) cells that are highly efficient at maturing to CD25(+)Foxp3(+) cells in response to IL-2.

85 Immature double-positive (DP) thymocytes mature into CD4(+)CD8(-) cells in response to coengageme

86 ons diminishes as double-positive thymocytes mature into CD8(+) T cells.

87 mDC2 could be matured into CD83+ DC cells in the presence of anti-CD40

88 lting pancreatic progenitor-like cells could mature into cells of all three pancreatic lineages in vi

89 rs induce androgen-independent PC-3 cells to mature into cells with a phenotype that resembles normal

90 Single-molecule methods have matured into central tools for studies in biology.

91 Centroblasts then mature into centrocytes to undergo clonal selection.

92 On arrival, they have matured into chemokine-producing DCs that express co-sti

93 yields interhomolog crossovers (COs), which mature into chiasmata that temporarily connect the homol

94 Crossovers mature into chiasmata, which hold and orient the homolog

95 y of foveal cones, develop by 24 months, and mature into childhood.

96 days after birth in mice and then gradually matured to connect supporting cells before the onset of

97 in the absence of retinal waves, but quickly mature to control levels by the end of the second week,

98 s at a subset of CO-designated sites fail to mature into COs and chiasmata, indicating a pro-CO role

99 enorhabditis elegans spermatids activate and mature into crawling spermatozoa without synthesizing ne

100 imately 25% of the intermediates that should mature into crossover products actually fail to do so.

101 , and localizes to those DSB sites that will mature into crossovers.

102 cells surrounding a matrix-filled lumen that mature into cup-shaped cells through the formation and f

103 lt1p and several kinases appear early in G2, mature into cytokinetic nodes by adding anillin Mid1p, m

104 g proliferation in lymphopenic hosts did not mature to cytotoxic effectors and displayed a partially

105 gated whether influenza A-infected monocytes matured to DCs with a high capacity to stimulate T cells

106 is required for acidification once endosomes mature into degradative compartments.

107 Stabilized filopodia mature into dendritic branches, and successive iteration

108 epidermal myeloid cells that can migrate and mature into dendritic cells.

109 iron signaling and iron redistribution from mature to developing tissues.

110 , but not veins, contain pre-HSCs capable of maturing into dHSCs in the presence of exogenous interle

111 otent blood cell progenitors proliferate and mature into differentiated haemocytes.

112 cells to be precursors that are committed to mature into differentiated secretory cells of the Paneth

113 We hypothesized that fetal lung macrophages mature into distinct subpopulations during mouse develop

114 Strand invasion events mature into double Holliday junctions that can be resolv

115 (EGFR) occurs from APPL early endosomes that mature into early EEA1 endosomes.

116 These EVCs can mature into ECs and pericytes, and can self-organize to

117 rates that the same DNA-reactive B cells can mature to either subset, depending on the hormonal envir

118 ed in BMMs, phagosomes containing Legionella matured into endoplasmic reticulum (ER)-derived organell

119 nd another one where cisternae biochemically mature to ensure anterograde transport.

120 lates that transient cisternae biochemically mature to ensure anterograde transport.

121 r traversing the nuclear envelope and do not mature into enveloped virus.

122 AQP9 levels rise as reticulocytes mature into erythrocytes and as neonatal pups develop in

123 generate lineage-committed progenitors that mature into erythrocytes, is regulated by numerous chrom

124 s of the process whereby human reticulocytes mature to erythrocytes have been hampered by the difficu

125 In the presence of doxycycline, HD10.6 cells mature to exhibit neuronal morphology and express sensor

126 B-lymphocyte culture conditions these cells matured to express CXCR4 and other surface antigens char

127 )Rip3(-/-) double mutant mice are viable and mature into fertile adults with a full immune complement

128 iking gradient in VH gene use as pre-B cells mature into follicular and then into marginal zone B cel

129 s IgD is coexpressed with IgM when the cells mature into follicular or marginal zone B cells, but the

130 We show that pre-amyloid oligomers (PAO) mature to form linear and circular protofibrils, and amy

131 oderm defects are apparent later, when cells mature to form muscle fibers.

132 n culture, neonatal rat ventricular myocytes mature to form striated myocytes and electrically uncoup

133 D1, CD69+ thymocytes remained in the cortex, maturing to form ectopic single positive (SP) thymocyte

134 he emergence of allergic asthma, the time is mature to foster the research field of biomarkers in AD

135 not clear why some of the initial aggregates mature into fruiting bodies, whereas others disperse, me

136 ective mucus barrier is poorly developed but matures to full thickness over P2-P9, coincident with th

137 is related to the failure of these cells to mature into fully differentiated effector cells.

138 laboratories and the cells do not appear to mature into fully functional adult motor neurons.

139 nsition to a Rab7-positive stage, but do not mature to fully acidified phagolysosomes.

140 s are highly enriched and activated and have matured into fully differentiated cells producing the ch

141 us path, with woven bone matrix subsequently maturing into fully mineralized compact bone exhibiting

142 e been specified from mesoderm, they have to mature into functional HSCs and undergo self-renewing di

143 l-1-deficient endocrine precursors failed to mature into functional islet cells.

144 at extrude from autolysosomes and ultimately mature into functional lysosomes, thereby restoring the

145 dings demonstrate that newly generated cells mature into functional neurons in the adult mammalian br

146 y are incorporated into neural circuitry and mature into functional neurons.

147 ther fuse with preexisting peroxisomes or to mature into functional peroxisomes by uptake of peroxiso

148 The hESC-derived TEPs further mature into functional TECs that support T cell developm

149 9-expressing motoneurons at the 5th week and mature to functional motor neurons thereafter.

150 Wild-type hemopoietic stem cells rapidly matured into functional T cell progenitors in the marrow

151 These autophagosomes mature to fuse with lysosomes and deliver the enclosed c

152 nsit amplifying cells, and by 30 d all cells matured into GABAergic interneurons.

153 iptional regulators RORalpha and Gata3, they mature to give rise to IL-5, IL-9 and IL-13 producing IL

154 to neurons or endothelial cells, while a few matured into glial cells.

155 expression, although a majority of the cells matured to granule neurons, a few cells remained as imma

156 and induce the malignant cells to terminally mature into granulocytes resulting in complete albeit tr

157 om cardiogenic and hemogenic mesoderm can be matured into >90% CD31(+)/VE-cadherin(+) definitive ECs.

158 Importantly, precursors mature into HB9/ChAT-expressing functional MNs.

159 nd proliferate in injured livers in vivo and mature into hepatocytes expressing dipeptidyl peptidase

160 ess proliferation while hepatoblasts fail to mature into hepatocytes, defects that result in perinata

161 osporium surface protein BclA, ExsK fails to mature into high-molecular-mass species observed in wild

162 rmally in Hox6 mutant pancreata, but fail to mature into hormone-producing cells.

163 ontain pre-HSCs (or HSC precursors) that can mature into HSCs in vivo (as shown by the successful lon

164 hondral ossification holds that chondrocytes mature to hypertrophy, undergo apoptosis and new bone fo

165 LSO excitatory and inhibitory synaptic drive matures to identical time-courses, that AT changes synap

166 These data suggest that newly formed B cells mature into IgD(hi) B cells simultaneously in the spleen

167 the site at which newly formed B lymphocytes mature into IgD(hi) naive recirculating B cells, but the

168 nates, the majority subset at this age, also mature to IgM+ cells (without passing through a CD138+ s

169 ion, electrochemical gradients, and ratio of mature to immature cells.

170 ature granulocytes and an increased ratio of mature to immature neutrophils in the bone marrow, perip

171 at the high-affinity DNA-reactive cells that mature to immunocompetence out-compete the low-affinity

172 st, agonists targeting TLR1/2 cause mMDSC to mature into immunosuppressive M2-like macrophages.

173 Biomarker development is maturing to include a wide array of molecular measuremen

174 uble, nonfibrillar aggregates, which did not mature into insoluble aggregates.

175 ates, i.e., protofibrils, which elongate and mature into insoluble fibrillar aggregates.

176 extended differences in their competence to mature into insulin/c-peptide-expressing cells in vivo.

177 hat 13% of spheroids were pre-organoids that matured into intestinal organoids.

178 ed to be posterior subcapsular and gradually matured to involve the entire lens.

179 This protein is able to mature into its active form in the presence of PDK-1 and

180 ty of the promoter, the time it takes GFP to mature into its fluorescent form, the susceptibility of

181 that inhibiting FTase would prevent Ras from maturing into its biologically active form, and FTase is

182 stripes of a two-segment periodicity before maturing into its segmental pattern.

183 the early-endosomal compartment and rapidly matured into LAMP-1(+), cathepsin D(+), and acidic phago

184 s into closed shells; then, these precursors mature into larger, stabler particles.

185 that form late in embryogenesis, as tailbuds mature into larvae.

186 d from the limiting membrane, and eventually mature to late endosomes.

187 transdifferentiating into myofibroblasts or maturing into lens fiber cells.

188 tes) undergo a hypertrophic response as they mature into lipid-laden adipocytes.

189 2B-containing NMDA receptors (NMDARs), which mature into low-Pr, GluN2B-deficient synapses.

190 dult Dorsett sheep (n=8) and were allowed to mature into LVAs for 10 weeks.

191 Thus, Arp2/3 is required as junctions mature to maintain apical proteins associated with the c

192 rough in vitro studies that these constructs mature to match native disc composition, structure, and

193 Transition from partially mature to mature Tg occurs as a discrete "jump" in mobil

194 servable engraftment potential, but directly matures into megakaryocytes when placed in culture.

195 Moreover, they could mature into memory cells after peptide stimulation.

196 ghest affinity B cell clones are selected to mature into memory or plasma cells while lower affinity

197 s induced self-reactive T cells in vivo that matured into memory T cells able to respond to secondary

198 ponse to a viral infection as it evolves and matures into memory.

199 phase I are stimulated to resume meiosis and mature to metaphase II, a sequence of events that prepar

200 These injected oocytes matured to metaphase II, and there was no effect on the

201 ing them into phagosomes, which subsequently mature into microbicidal phagolysosomes.

202 Rgs2-siRNA-injected oocytes matured to MII; however, they had increased sensitivity

203 Although Myo10 knockdown cells eventually mature into monolayers with normal TER, these monolayers

204 nsient adhesions, some of which subsequently mature into more stable FAs.

205 Over time, the droplets mature to more stable states, as assessed by slowed fluo

206 s the capsid of bovine papillomavirus type 1 matures into more extensively cross-linked forms.

207 r55Gag still forms particles that proceed to mature into morphologically wild-type virions, suggestin

208 properly but then persists as daughter cells mature into mother cells.

209 the assembly of another daughter until they mature into mothers during the next cell cycle [2-5].

210 lly, is essential for daughter centrioles to mature into mothers that can support centriole duplicati

211 ultured to confluence and then stimulated to mature into multilayered epithelia with addition of seru

212 oreover, placental macrophages spontaneously matured into multinucleated giant cells (MGCs), a proper

213 s into the vacuolar lumen, sorting endosomes mature into multivesicular bodies (MVBs) through the act

214 OPCs accrue and do not mature into myelin-forming cells in demyelinating lesion

215 ells (OPCs) can initiate differentiation and mature into myelin-forming cells.

216 endrocyte progenitors (OPCs), which normally mature into myelin-forming oligodendrocytes, are typical

217 recognized by O1 antibodies and subsequently mature to myelin basic protein (MBP)-positive cells prio

218 ls (OPCs) can repair demyelinated lesions by maturing into myelin-producing oligodendrocytes.

219 emyelinated areas or OPCs in lesions may not mature into myelinating oligodendrocytes.

220 but the regenerated preOLs fail to normally mature to myelinating cells required for white matter gr

221 transformed into migratory progenitors that matured into neural stem cells (neuroblasts) in a second

222 rs by epithelial-mesenchymal transition that mature into neuroblasts in a second proliferative zone.

223 ing remain in the hippocampus for months and mature into neurons (Leuner et al., 2004a; Shors, 2014).

224 However, these neuroblasts did not mature into neurons and most were lost between 1 and 2 w

225 nt of a VH1-46-derived antibody lineage that matured to neutralize 90% of HIV-1 isolates.

226 ) other recombination intermediates reliably mature into noncrossovers in a timely manner.

227 in pex3 cells, after which these structures mature into normal peroxisomes.

228 However, OPCs fail to mature into oligodendrocytes (OLs) even in regions of de

229 uited to demyelinating lesions often fail to mature into oligodendrocytes (OLs) that remyelinate spar

230 ression progressively decreased as the cells matured into oligodendrocytes (OLs).

231 inent in NG2-immunoreactive progenitors that matured into oligodendrocytes, and in a transient popula

232 within degenerate retinas of adult mice and mature into outer segment-bearing photoreceptors.

233 high molecular weight polypeptides and then mature into peptide-loaded complexes.

234 re capable of binding antigenic peptides and maturing into peptide-filled molecules.

235 Phagosomes mature into phagolysosomes by sequential fusion with ear

236 tol 3-monophosphate-positive phagosomes that mature into phagolysosomes using a pathway similar to th

237 Phagosomes then fuse with lysosomes to mature into phagolysosomes, acquiring an acidic and hydr

238 detected on model phagosomes, which normally mature into phagolysosomes, the existence of cyclical wa

239 accumulates in macrophage phagosomes as they mature into phagolysosomes.

240 es that fuse with early endosomes but do not mature to phagolysosomes.

241 ogenitors emigrates from the circulation and matures into phenotypically distinct MCs in different ti

242 nipulation of model organisms and cells, and mature into powerful new tools for molecular biology and

243 Consistently, the ratios of mature to precursor let-7a were progressively reduced in

244 oncentration (r(2) = 0.17, P < 0.02) and the mature-to-precursor IL-1 beta ratio (r(2) = 0.46, P < 0.

245 dependent process in which activated B cells mature to produce high-affinity Abs and differentiate in

246 B cells maturing to produce autoantibodies in systemic autoimmun

247 ctor (TE) differentiation states and fail to mature into protective memory T cells that contain self-

248 ABA synthesis (such as viviparous-5) do not mature to quiescent, desiccation-tolerant seeds, but ger

249 appear and remain as the uncoating vesicles mature into Rab5-positive endocytic intermediates.

250 able to generate action potentials and many matured to receive synaptic contacts when co-cultured wi

251 x assembly until the complex is sufficiently mature to remain stably associated with the polymerase o

252 e other main component of the CHT niche, and mature into reticular cells lining and interconnecting s

253 evidence indicating that soluble aggregates mature into sedimentable aggregates.

254 d during albumin maturation, its sequence is matured into SFTI-1, a protease-inhibiting cyclic peptid

255 avity in a CCR2-dependent manner, where they mature into short-lived F4/80(lo)MHCII(+) cells that act

256 eeds are overtly identical to the wild type, maturing to similar size and weight, and in developmenta

257 However, complex primordia may mature into simple leaves.

258 ters, producing multi-tipped aggregates that mature into small fruiting bodies.

259 Most TP were fully fusiogenic and matured to spacious phagolysosomes containing degraded b

260 rm cells are still present but are unable to mature into spermatocytes and spermatids.

261 grows by sprouting filopodia, some of which mature into stable dendrite branches that bear synapses

262 ry intermediate PawS-Like1 (PawL1), which is matured into storage albumin, but makes no stable peptid

263 idge bundles recruit nonmuscle myosin II and mature into stress fibers.

264 uroblasts toward the damaged area where they mature to striatal neurons.

265 iques for protein structure predictions have matured to such a level to provide reliable structural c

266 after the developing embryo is sufficiently mature to survive outside the womb.

267 As fish mature to swimming stages, IC cells switch to a sustaine

268 Importantly, these induced neuroblasts can mature into synapse-forming neurons in vivo.

269 he central area of developing muscle fibers, mature into synapses by the combined action of neural fa

270 n, the phenomenon that selects thymocytes to mature into T cells only if the TCRs they bear react wit

271 cus and downregulate IL-4 expression as they mature into T cells.

272 he absence of Ikaros, thymocytes are able to mature into the CD4 lineage with reduced TCR signaling p

273 which normally acquire EEA1 and subsequently mature into the phagolysosome.

274 the plasma membrane that merge together and mature into the precursors of the cytokinetic contractil

275 nter the white pulp of the spleen until they mature into the T1 and T2 stages, and that this entry in

276 ng gene 2(-/-) double-negative thymocytes to mature to the double-positive stage.

277 nite rate with which the GFP-tagged proteins mature to the fluorescent state.

278 CD69(+)Qa2(-) CD4 single-positive thymocytes mature to the late CD69(-)Qa2(+) stage in the absence of

279 rane-integrated HA(++) molecules are able to mature to the plasma membrane with a conformation indist

280 Neurons that arise after transplantation mature to the point of expressing odorant receptors and

281 hat it binds to capsids only after they have matured into the polyhedral form.

282 lowed by progressive loss as the GC reaction matured into the second and third week.

283 eome, its data standardization has still not matured to the level of microarray genomics data or mass

284 s show great promise, the technology has not matured to the point of consistently generating robust a

285 above advances, the zebrafish model has now matured to the point that it can address more important

286 MRM has matured to the point that we can generate high contrast,

287 xican axolotl, a classic model organism, has matured to the point where it is now possible to identif

288 g the 81 putative mutants that recovered and matured to the reproductive adult, 63 retested as thermo

289 of the two P-clusters of the MoFe protein is matured to the ultimate [8Fe-7S] structure.

290 -shaped structure called the phagophore that matures into the autophagosome.

291 se to form the intermediate compartment that matures into the Golgi apparatus.

292 a four membrane-spanning intermediate, which matures into the six membrane-spanning topology at a lat

293 roins+ cells that uniquely differentiate and mature into thymic-like PAE-DC.

294 d progenitors derived from mouse PSCs can be matured into thyroid follicular organoids that provide f

295 traffic to various sites, and may or may not mature into tissue-directed granulated phenotypes and qu

296 The cells mature into transplantable HSCs in culture.

297 ry and naive T cells or as the immune system matures to understand the differences in cytokine respon

298 Nutritional metabolomics is rapidly maturing to use small-molecule chemical profiling to sup

299 human genome copy number variation (CNV) are maturing into useful resources for complex disease genet

300 cytes to take up iron excessively after they mature into villus cells in the duodenum of hereditary h