ライフサイエンスコーパス: maturation

1 mmatory cell recruitment, and dendritic cell maturation.

2 also in later fetal/early neonatal stages of maturation.

3 tion and, at a late stage, by modulating OPC maturation.

4 elB, the key regulators involved in conidial maturation.

5 sphingomyelinase but not clathrin-coated pit maturation.

6 ch with a delay, suggesting a role in branch maturation.

7 activation affect many aspects of phagosome maturation.

8 ut partially redundant roles in growth plate maturation.

9 evident that MASP-3 is implicated in pro-FD maturation.

10 y cluster during the vesicular transport and maturation.

11 differentiation and cytotoxic effector cell maturation.

12 uropeptide biogenesis, and connective tissue maturation.

13 quired to maintain stability during affinity maturation.

14 ich triggers NKT cell lineage commitment and maturation.

15 H became highly active during oocyte meiotic maturation.

16 l or subcortical neuronal synaptogenesis and maturation.

17 ulfur bonds during the final stages of sperm maturation.

18 tions that could enhance dendritic cell (DC) maturation.

19 optimized to induce cell differentiation and maturation.

20 CR signal transduction and subsequent T cell maturation.

21 ing protein PSD95, promoting dendritic spine maturation.

22 ion went through dynamic changes during seed maturation.

23 spontaneous activity and may further refine maturation.

24 ovince, Sardinia (Italy), at three stages of maturation.

25 cells, and beta cells that were incapable of maturation.

26 hanging antibody sequences to drive affinity maturation.

27 , intercellular aggregation and architecture maturation.

28 timing of both vascular pruning and barrier maturation.

29 ssociated impairment of B cell signaling and maturation.

30 eract fibronectin-mediated inhibition of OPC maturation.

31 t microtubules and fail to undergo centriole maturation.

32 th STAT1 GOF mutations had impaired terminal maturation.

33 ficant utility for studying viral fusion and maturation.

34 tor involved in neuronal differentiation and maturation.

35 iations and defects in the timing of vesicle maturation.

36 he excitatory/inhibitory balance and circuit maturation.

37 ferentiating the process of aggregation from maturation.

38 insights into the role of Unc-104 in synapse maturation.

39 ity around cell cycle genes during postnatal maturation.

40 theless functions atypically to support bone maturation.

41 YY1, a transcription factor required for OL maturation.

42 migration that are associated with terminal maturation.

43 ly, but may accelerate or coordinate midbody maturation.

44 the level of PAPhy_a expression during grain maturation.

45 PR143 to function as a monitor of melanosome maturation.

46 sential for postnatal tendon development and maturation.

47 otypes associated with impaired Fe-S protein maturation.

48 ucocorticoid hormones are critical for heart maturation.

49 Glucocorticoids are vital for lung maturation.

50 phorylation, and is essential for neutrophil maturation.

51 om human PSCs with a high degree of synaptic maturation.

52 s in human hUTP23 are essential for 18S rRNA maturation.

53 m the kinetics of microtubule growth and cap maturation.

54 ic cells (moDC) and lower moDC costimulatory maturation.

55 e a blood meal and use the nutrients for egg maturation.

56 An open and unresolved question is how STRF maturation affects stimulus-evoked correlated activity b

57 Pre-maturation aging of immature oocytes may adversely affec

58 s an intrinsic negative regulator of NK-cell maturation and antitumor immune responses.

59 stem demonstrate normal somatic growth, lung maturation and brain growth and myelination.

60 ate by ensuring their proper development and maturation and by suppressing aberrant proliferation med

61 Moreover, Cu- and Zn-AMSs enhanced maturation and cytokine release of bone marrow dendritic

62 erved that GUWE dose-dependently promoted DC maturation and cytokine secretion through TLR4 signaling

63 se diverse cell types at different stages of maturation and differentiation coexist in the emerging t

64 t roles for non-Cas nuclease(s) during crRNA maturation and establish a link between Type III-A CRISP

65 humans, in which the contribution of neural maturation and experience cannot be experimentally manip

66 ontributions of the Cas10-Csm complex toward maturation and explore roles of non-Cas nucleases in thi

67 clude transcription, translation and protein maturation and folding.

68 lts reveal a novel role for Erk5 during bone maturation and homeostasis in vivo.

69 ovides a strategy to promote human beta-cell maturation and identifies an unexpected role for the ROC

70 e programming unique to this period of brain maturation and its interaction with the hormonal changes

71 ially restricted trajectories of radial glia maturation and neurogenesis in developing human telencep

72 idues and has been shown to disrupt neuronal maturation and OR expression in the developing embryonic

73 quently, contributes to the differentiation, maturation and plasticity of neurons.

74 oid cell-deficient mice impeded myeloid cell maturation and promoted immune repressor function.

75 ron responses, suppression of dendritic cell maturation and promotion of inflammatory responses.

76 e assembly of the NLRP3 inflammasome and the maturation and release of IL-1beta, a response that is a

77 ing glia, in cochlea undergoing development, maturation and repair in response to damage.

78 ly of the conical viral capsid during virion maturation and results in perturbations at a specific pr

79 LRC3 indeed decreases NALP3-induced IL-1beta maturation and secretion, pro-caspase-1 cleavage, and sp

80 ribonuclease activities that catalyze crRNA maturation and ssRNA degradation.

81 egulator of the Th17/Treg axis and Th17 cell maturation and suggest that CK2 could be targeted for th

82 nist of H3 receptors, on AHN (proliferation, maturation and survival) in 3-month-old and in aged 16-m

83 require IRF8 for development and functional maturation and that dysregulation of this function resul

84 at controls myeloid cell differentiation and maturation and that malfunction of this switch during se

85 of CA and SP1 are critical for orderly HIV-1 maturation and that small molecules can inhibit maturati

86 ent, whereas STAT5 tetramers mediate NK cell maturation and the expression of maturation-associated g

87 ry processes that link TLR stimulation to DC maturation and the subsequent development of effector T

88 other hand, B cells can directly promote DC maturation and thereby enhance T-cell stimulation.

89 to coordinate the expression, Fe-S cofactor maturation, and activity of the respiratory complexes.

90 es the mechanism behind Aap-mediated biofilm maturation, and also demonstrates a novel role for a sec

91 ymphatic drainage, defective lymphatic valve maturation, and complete lethality.

92 ployed by viruses to ensure efficient entry, maturation, and egress as well as the avoidance of antiv

93 modified astrocytes to improve the survival, maturation, and integration of engrafted NSC/NPCs as a r

94 ue in EGFP that is essential for chromophore maturation, and is also an efficient deacetylation subst

95 source, we analyzed cDC subset distribution, maturation, and migration in mucosal tissues (lungs, int

96 subunit complex that catalyzes RNA turnover, maturation, and quality control processes.

97 s, we assayed perineurial glial development, maturation, and response to injury.

98 tored polyprotein processing, virus particle maturation, and significant levels of replication capaci

99 e regulation of megakaryocyte specification, maturation, and thrombopoiesis.

100 ify rate-limiting SHM positions for VRC-PG04 maturation, as well as SHM hotspots and intrinsically fr

101 ate NK cell maturation and the expression of maturation-associated genes.

102 probe allows digitized reporting of dynamic maturation at single-organelle resolution over time.

103 After stacking of tissue layers and tissue maturation at the air-liquid interface (stage 4), the 3D

104 tially inhibited DNM2 activity during muscle maturation, BIN1 had no effect on the isoform of DNM2 fo

105 CMTM6 is not required for PD-L1 maturation but co-localizes with PD-L1 at the plasma mem

106 residues in Csm5 are required for efficient maturation, but recombinant Csm5 fails to cleave crRNAs

107 egrase (IN) plays a key role during particle maturation by binding to the viral RNA genome.

108 uration and that small molecules can inhibit maturation by perturbing molecular motions.

109 Maturation by proteolytic cleavage is known to activate

110 ccurs in domain mobility, prFMN binding, and maturation by the UbiD enzyme family.

111 n-mediated endocytosis (CME), endocytic-site maturation can be divided into two stages corresponding

112 These results show how progress in the maturation cascade is linked to a test for a key functio

113 parasite control, (iv) may promote granuloma maturation (CCL2, CCL5), (v) may exert a granuloma-indep

114 cluding Rhodobacter capsulatus, cytochrome c maturation (Ccm) is carried out by a membrane-integral m

115 n were studied longitudinally for markers of maturation (CCR7, CD45RA, CD57, PD1), recent thymic emig

116 its self-assembly and dictate the extent of maturation cleavage.

117 ltracentrifugation analysis reveals that the maturation complex is composed of four protomers and one

118 al and functional features of a viral genome maturation complex, an essential intermediate in the dev

119 tors have been described in some detail, the maturation complexes remain ill characterized.

120 resenting a wide range of kerogen origin and maturation conditions.

121 The resulting kidneys showed maturation defects associated with early postnatal death

122 pecific to Deltalsr2; it does not rescue the maturation-deficient biofilms of a DeltagroEL1 mutant, t

123 vasopressin is not dependent on the level of maturation (depolarizing vs. hyperpolarizing) of postsyn

124 human NSCs retain an intrinsic human rate of maturation, despite implantation into the injured rodent

125 n and is an essential Ca(2+) channel for OPC maturation during the remyelination of the adult brain.S

126 ll development, but essential for alpha cell maturation during the transition from a milk-based diet

127 hese findings illustrate how glycan-specific maturation enables a human Ab to cope with pathogen esca

128 olism, fatty acid metabolism, and intestinal maturation, events that are controlled predominantly by

129 lts, we conclude that RH50 is a plastid rRNA maturation factor.

130 of THAP1 function disrupts a core set of OL maturation genes and reduces the DNA occupancy of YY1, a

131 of EVs in vascular development, growth, and maturation has been widely documented and their potentia

132 utational changes that occur during affinity maturation, however, requires accurate partitioning of s

133 ed stress fiber formation and focal adhesion maturation in a dynamin-dependent manner.

134 e first time that M. bovis arrests phagosome maturation in a process that depends on P27.

135 expected and substantial slowing of parasite maturation in acutely infected mice, extending the life

136 e BCR activation precluded functional B-cell maturation in cGVHD.

137 ls to examine the role of NAc silent synapse maturation in cocaine-conditioned place preference (CPP)

138 h rAAV.Tbeta4 enhanced capillary density and maturation in db hearts less efficiently than in wt hear

139 e of repopulation recapitulated the order of maturation in healthy homeostasis.

140 v2 to activate Rac3 and promote invadopodial maturation in invasive breast cancer cells.

141 derived paracrine signals promote hepatocyte maturation in liver organoids, but organoid self-organiz

142 also characterized sequential stages of TLS maturation in LSCC culminating in the formation of germi

143 during task performance is related to brain maturation in old age as well as individual differences

144 position of ER phospholipids affect SREBP-1c maturation in physiology and disease.

145 of Kv1.1 was sufficient to enable dendritic maturation in the absence of sensory input.

146 cate that VGCCs can modulate oligodendrocyte maturation in the demyelinated brain and suggest that vo

147 ngs highlight a role for PSPC1-dependent RNA maturation in the posttranscriptional control of adipose

148 l migration as a feature of NK cell terminal maturation in this system.

149 Further oxidative maturation in vitro occurs only at alkaline pH, suggesti

150 We found that HSC maturation in vivo or ex vivo is accompanied by the down

151 sents an important mechanism during antibody maturation in vivo.

152 th lysosomes, in a process termed "phagosome maturation." In this issue, Yin et al. identify GOP-1 as

153 al steps of mitochondrial RNA processing and maturation, including RNA post-transcriptional modificat

154 Here we investigate brain maturation, indexed by age-related decreases in cortical

155 combinant S100A9 proteins increased AML cell maturation, induced growth arrest, and prolonged surviva

156 en new responses are needed to support brain maturation, intense social engagement, and emotional con

157 y acid-containing medium promotes their fast maturation into adult-like CMs with higher oxidative met

158 can act to specifically facilitate ZEITLUPE maturation into an active form in vitro and in planta.

159 Affinity maturation is a Darwinian process in which B lymphocytes

160 Seed maturation is an important developmental process to soyb

161 Oocyte maturation is associated with a wave of maternal RNA deg

162 nature of drug-context association, but this maturation is not required for establishing or retaining

163 roduction by OCs, and that P2X5-deficient OC maturation is rescued in vitro by addition of exogenous

164 NALE: The mechanistic foundation of vascular maturation is still largely unknown.

165 syndecan-1), which is upregulated during ASC maturation, is required in a cell-intrinsic manner to mo

166 on time-lapse microscopy to characterize the maturation kinetics of 50 FPs that span the visible spec

167 se for ash and protein contents by increased maturation level.

168 R in early differentiating osteocytes delays maturation, maintaining active bone synthesis.

169 the ligand, by measuring cell proliferation, maturation markers and cytokine production.

170 cated in oligodendrocyte differentiation and maturation may induce positive signals for myelin recove

171 Here we show that a chemically defined maturation medium supplemented with three cytokines (FGF

172 bi-directional vesicles, while the cisternal maturation model postulates that transient cisternae bio

173 s) reportedly tied to central nervous system maturation, myelin stability, and the pathobiology of va

174 und that during its mitochondrial import and maturation NDUFB10 transiently interacts with CHCHD4 and

175 on, as exemplified by the observation of the maturation of a second flagellar basal body in late G1 p

176 t, orofacial stereotypies are crucial to the maturation of aerodigestion in the neonatal period but a

177 (A) polymerase (PAP) is important for 3' end maturation of almost all eukaryotic mRNAs.

178 ed during this transition for the functional maturation of alpha- and beta-cells in order to maintain

179 t of epithelial cell polarity and functional maturation of alveolar cells.

180 e protrusions in 2D, and this in turn blocks maturation of anterior focal adhesions.

181 hape with 200 to 300nm diameter, and induced maturation of antigen presenting cells in vitro.

182 or the ROCKII pathway in the development and maturation of beta-like cells.Our incomplete understandi

183 a specific developmental window resulting in maturation of binocular cortical cells and depth percept

184 lation signatures during differentiation and maturation of cardiac myocytes.

185 xamined CXCR4-CXCL12 interactions during the maturation of CD4(+)CD8(+) thymocytes, including downstr

186 We assessed the maturation of ChCs and BCs in different layers of the mo

187 hromatin assembly, dissociating prior to the maturation of chromatin structure.

188 ally improved the development and functional maturation of circulating and tissue-resident human NK a

189 available cognitive processes underlies the maturation of cognition during adolescence.

190 The maturation of cortical parvalbumin-positive (PV) interne

191 igosaccharides lacked the capacity to induce maturation of DCs but significantly blocked alpha-(1,3)-

192 that is involved in the differentiation and maturation of DCs.

193 esults show that NBP35 has a function in the maturation of FeS proteins that is conserved in plants,

194 The enzyme is therefore essential for maturation of functional tRNAs and mRNA translation.

195 bition of ROCKII promotes the generation and maturation of glucose-responding cells.

196 esearchers take advantage of the proteolytic maturation of HIV, type 1 (HIV-1), which can generate fr

197 Maturation of human natural killer (NK) cells as defined

198 as been demonstrated that PGE2 can block the maturation of IL-1beta by inhibiting the NLRP3 inflammas

199 gonadal hormones do significantly alter the maturation of inhibitory neurotransmission in the cingul

200 in nonsensory cells prevented the functional maturation of inner hair cells.

201 These associations may reflect impaired maturation of intestinal immunity and integrity in boys

202 lters splicing of cell mRNAs involved in the maturation of many other cell mRNAs.

203 IRE1alpha attenuated maturation of miR-466 and miR-200 family members at prec

204 Maturation of most elements fell within the expected ran

205 (A2AR) acts as a checkpoint that limits the maturation of natural killer (NK) cells.

206 ication and is required for the function and maturation of OLs to promote myelination.Axon-glial comm

207 on, so-called "FLI medium," improves nuclear maturation of oocytes in cumulus-oocyte complexes derive

208 he RANKL/OPG Axis in vivo, and RANKL-induced maturation of osteoclast-precursors in vitro, indicate t

209 n et al. identify GOP-1 as essential for the maturation of phagosomes containing apoptotic cells, thr

210 Incomplete maturation of photoreceptors is followed shortly afterwa

211 Tiggrin mutants exhibit precocious maturation of plasmatocytes, whereas Tiggrin overexpress

212 as a potential novel molecular tool to boost maturation of resident OPCs to overcome remyelination fa

213 m cell survival and quiescence, and terminal maturation of select blood lineages.

214 Maturation of sensory receptor precursors is delayed, an

215 our results indicate that CP-AMPAR-mediated maturation of silent synapses in the NAc is a signature

216 various complexes that mediate the dedicated maturation of specific Fe/S recipient proteins.

217 Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a

218 renewal and differentiation and followed the maturation of stem cell-derived clones using sparse line

219 ided important mechanistic insights into the maturation of sunflower proalbumins into an albumin and

220 (iDCpp65) exhibited a faster development and maturation of T cells.

221 own to control the ER-to-Golgi transport and maturation of TACE.

222 onstrate that CX-4945 treatment inhibits the maturation of Th17 cells into inflammatory IFN-gamma-cop

223 ged exposure of the bNAb epitope enabled the maturation of the bNAb lineage.

224 patterning goes hand-in-hand with functional maturation of the entire heart.

225 MCH in late gestation promotes molecular maturation of the fetal lung, which may be an adaptive r

226 P1), which represents an intermediate during maturation of the HIV-1 virus.

227 he gut microbiota in infancy is important in maturation of the immune system.

228 ays a major role in repressing developmental maturation of the intestines.

229 Throughout postnatal maturation of the mouse inner ear, cochlear hair cells d

230 is dramatically regulated during functional maturation of the mouse visual cortex with miR-132/212 f

231 In adult mosquitoes, it is essential for maturation of the ovary and normal male reproductive beh

232 The slowest step is the final structural maturation of the PRD.

233 complex responsible for caspase-1-dependent maturation of the proinflammatory cytokines IL-1beta and

234 Here we demonstrate a delay in the maturation of the properties and synaptic connectivity o

235 established through the coordinated terminal maturation of the retinal pigment epithelium (RPE), fene

236 F) drugs can cause phenotypic alteration and maturation of the tumor's vasculature.

237 C) and appear to arise during the protracted maturation of this circuitry across childhood and adoles

238 RNase P is primarily responsible for the 5 maturation of transfer RNAs (tRNAs) in all domains of li

239 onal IAV, but not with pandemic IAV, enhance maturation of uninfected DC and T cell proliferation.

240 The in situ maturation of UQCRFS1 produces N-terminal polypeptides,

241 ependent of effects on esophageal eosinophil maturation or activation.

242 with diverse SHM-mediated antibody affinity maturation pathways and divergent epitope targeting.

243 of these scaffold proteins exhibit distinct maturation patterns of silent synapses and thus provided

244 P2X5 that is highly expressed during the OC maturation phase, and which we show here plays no appare

245 to Pdx1 gene regulation and islet beta-cell maturation postnatally.

246 n process, which is progressively removed as maturation proceeds.

247 peptide (SP) at its C-terminus early in the maturation process, which is progressively removed as ma

248 c materials in order to simulate the thermal maturation processes that occur during diagenesis.

249 cell death, BCG induced a robust adult-like maturation profile of neonatal DCs.

250 like stable RNAs that require processing for maturation, prokaryotic cellular mRNAs generally follow

251 B-lymphocyte-induced maturation protein 1 (Blimp1) is a transcriptional repre

252 The maturation protein is responsible for attaching the viru

253 For the canonical Allolevivirus Qbeta the maturation protein, A2, has an additional role as the ly

254 of the genome interacts extensively with the maturation protein, which, with just a six-helix bundle

255 r of PC differentiation B lymphocyte-induced maturation protein-1 (BLIMP-1), and the cell surface ant

256 Further, we found that with maturation receptive field (RF) center sizes decrease, s

257 of human neuron specification and functional maturation remains a key challenge that hampers the rout

258 Thus, impairment of parasite maturation represents a host-mediated, immune system-dep

259 We found that adipocyte differentiation and maturation required a pulse of 25 mm glucose only during

260 y glomeruli elicit a pro-differentiation and maturation response in podocytes better than substrates

261 l processes such as antibody diversification/maturation, restriction of viral infection, and generati

262 tional Lyst leads to dysregulated phagosomal maturation, resulting in a failure to form an activation

263 An affinity maturation selection based on RasIn1 resulted in RasIn2,

264 g normative trajectories of functional brain maturation.SIGNIFICANCE STATEMENT Although brain signal

265 tivation occurring during the initiation and maturation stage of reprogramming in partially and fully

266 f nucleotides across substrates representing maturation stages of human VRC-PG04.

267 We compared availability, sizes and maturation stages of shellfish between two adjacent isla

268 ) mice, transition of thymocytes through the maturation stages was unaffected, with no overt signs of

269 exhibit heterogeneous neuronal subtypes and maturation stages.

270 apy are influenced in part by his/her T cell maturation state.

271 ffects of Act-A-iTreg cells on DC phenotype, maturation status, and TH2 cell priming potential.

272 hoid organs where they undergo an additional maturation step to mature naive T cells that circulate t

273 ng developing thymocytes to traverse through maturation steps and in regulating the expression of mos

274 ions, unparalleled structural and functional maturations, substantial individual variability, and hig

275 and autonomous regulators of focal adhesion maturation suggests a molecular mechanism that underlies

276 at, along with mutations at the level of the maturation system, are associated with specific diseases

277 Following thymic maturation, T cells egress as recent thymic emigrants to

278 While postsynaptic maturation, terminal branching and neurotransmission was

279 clude unique issues related to the extent of maturation that can be achieved in vitro or through chim

280 2 and Pno1 collectively preclude their final maturation, thereby preventing untimely tRNA and mRNA bi

281 s as an assembly factor that facilitates PIC maturation through its various stages.

282 egulates oligodendrocyte differentiation and maturation through the cytoplasmic gelsolin signaling pa

283 and subjected to multiple rounds of affinity maturation through the screening of macrocyclic peptide

284 Actin cytoskeleton-mediated FA growth and maturation thus culminate with FA traction oscillation t

285 The slow maturation time of fluorescent proteins (FPs) limits the

286 o banded cells despite a 2-day difference in maturation time.

287 ite initiation but still had defects in site-maturation timing, indicating separation of Ede1 functio

288 p, we present an in silico model of affinity maturation to examine two realistic new aspects pertinen

289 FMN (prFMN) cofactor, and requires oxidative maturation to form the catalytically competent prFMN(imi

290 on into mice, HCOs undergo morphogenesis and maturation to form tissue that exhibits molecular, cellu

291 We show that C1 acts during HIV-1 maturation to prevent assembly of a mature viral capsid.

292 in a physiological range, allowing dendritic maturation to proceed.

293 IF signaling events, thus linking phagosomal maturation to specific TLR signaling pathways.

294 liver progenitor cells and their subsequent maturation to the adult phenotype.

295 in resting-state variability exhibit unique maturation trajectories in specific brain regions and sy

296 To identify novel secreted regulators of HSC maturation, we performed RNA sequencing over these spati

297 sportation into axons becomes selective with maturation; we hypothesized that selective exclusion of

298 ed as seeds mature: 99% of them during early maturation were down-regulated, and preferentially assoc

299 Gene expression patterns specific for maturation were mimicked in PRP treated cartilage, with

300 lence factor, stimulates dendritic cell (DC) maturation which is dependent on TANK-binding kinase 1 (