ライフサイエンスコーパス: mature

1 et there is scant information about how they mature.

2 ient population years before PFS results are mature.

3 nd the vesicle transport system develops and matures.

4 ch clamp recordings from auditory neurons in mature (2-4 months) and aged (20-26 months) mice.

5 A synthetic version of the mature 68-aa peptide potently blocks biofilm development

6 re transcriptionally down-regulated as seeds mature: 99% of them during early maturation were down-re

7 l physical environment eventually leads to a mature adaptive response whereby feedforward changes in

8 pocyte precursor cells generate lipid-filled mature adipocytes in multiple tissues during a high-fat

9 ogram establishes the properties that define mature adipocytes, but the contribution of posttranscrip

10 ene expression and blocks differentiation to mature adipocytes.

11 n-binding protein 1 (LDB1) serve to maintain mature adult beta cell identity, revealing clues as to h

12 he homotypic interactions that would lead to mature amyloid fibrils.

13 st efficiently invade host cells in order to mature and be transmitted.

14 Definitive erythroblasts mature and enucleate extravascularly and form a unique m

15 hiPSCs can be differentiated into mature and functional dopaminergic (DA) neurons.

16 Furthermore, we identified populations of mature and immature megakaryocytes along with haematopoi

17 nts develop from the seedling to juvenile to mature and senescent stages.

18 ferent from those in which full-term infants mature and thus likely impact the development of functio

19 show that early AnkG-deficient nodes fail to mature and undergo rapid destabilization.

20 herin tension that occur as the dorsal aorta matures and upon genetic and chemical perturbations duri

21 ecision nodes (eg, how fast to grow, when to mature, and how long to live).

22 he in vivo kinetics and proteomes of banded, mature, and hypersegmented neutrophils to determine whet

23 l progenitors from peripheral blood survive, mature, and proliferate without SCF and KIT signaling in

24 lity) over calendar time and as ART services matured, and identified factors associated with attritio

25 n progenitor cell population differentiated, matured, and integrated into the rodent spinal cords ove

26 stabilizing mechanisms in neural networks of mature animals remain elusive.

27 ic transmission, indicating that synapses in mature animals require MAGUKs for anchoring glutamate re

28 t, these novel compounds are also present in mature Argan fruits.

29 during early arteriogenesis but was down in mature arteries.

30 Systems biology has matured as a discipline, and its methods are commonplace

31 Mature astrocyte markers first appeared after 6 months,

32 Finally, mature autophagosomes detach from the ER membrane by an

33 Local protein synthesis in mature axons may play a role in synaptic plasticity, axo

34 and partial deletion at the transitional to mature B cell stage, but become Env(-) upon receptor edi

35 Mature B cells coexpress both IgM and IgD B-cell antigen

36 etion of Spi1 and Spib resulted in a lack of mature B cells in the spleen and a block in B cell devel

37 previously described, a 2-fold reduction in mature B cells.

38 ytic leukaemia (CLL) is a clonal disorder of mature B cells.

39 Hairy cell leukemia (HCL) is a chronic mature B-cell neoplasm with unique clinicopathologic fea

40 Inducible ablation of LDB1 in mature beta cells impaired insulin secretion and glucose

41 t islets are thought to contain functionally mature beta cells, recent analyses of transgenic rodent

42 when placed in the V3 polypeptide context, a mature bi-antennary complex-type N-glycan also could be

43 The released pro-IL-1beta was cleavable to mature bioactive IL-1beta in the extracellular space by

44 Mature biocrusts in black grama grassland suffered sever

45 isolates would also have the ability to form mature biofilms and the bpsABCD locus would serve a key

46 serve a critical role in the development of mature biofilms formed by the sequenced laboratory strai

47 early biofilm events and reduce biomass from mature biofilms in the presence of neutrophils.

48 (CH) arises when a substantial proportion of mature blood cells is derived from a single dominant hem

49 ng deduced precursor V(D)J rearrangements of mature bnAbs or unrearranged germline V, D, J segments (

50 Despite strong expression in the mature brain, the role of Sema7A in the adult remains po

51 Es are functionally distinct from their more mature but still naive T cell counterparts, because they

52 cally ablated in skin, sweat glands appeared mature, but the mice were severely hypohidrotic.

53 Using the mature calyx of Held (P16-20), we report that tissue-spe

54 C protease to cleave the P1 polyprotein into mature capsid proteins, but the FMDV 3C protease is toxi

55 exposure also time-dependently increased the mature caspase-1 and IL-1beta levels and enhanced the IL

56 (+) hematopoietic precursor to the CD45RA(+) mature CD4(+) and CD8(+) single-positive (SP) T cells.

57 lin heavy chain VDJ rearrangements of naive, mature CD5(+), IgM(+) memory, and class-switched memory

58 have been functionally shown to generate all mature cell types for the lifetime of the organism.

59 K3 kinase inhibition can greatly enhance the mature character of NK cells most desired for effective

60 rain-hormone-behavior constellations for the mature, child-orientated coparental bond; and demonstrat

61 erweight/obese children (RR = 0.81), earlier maturing children (RR = 0.93), and those who spent more

62 iolar protein known to remain at the base of mature cilia and is required for intraflagellar transpor

63 ning self-assembled InAs/GaAs quantum dots-a mature class of solid-state quantum emitter-with low-los

64 s (CPs) expressing early biliary markers and mature CLCs displaying cholangiocyte functionality.

65 However, the role of local translation in mature CNS axons is unknown.

66 und to be localized at the outer boundary of mature colonies in contrast to a uniform distribution in

67 h p-type activation of GaN by Mg underpins a mature commercial technology, the nature of the Mg accep

68 f-reactive specificities into the follicular mature compartment and thereby likely increasing the ris

69 -whether the transformation of immature into mature contact calls by infants is influenced by conting

70 on with higher delta(13)C and are located in mature continental arcs that have accreted carbonate pla

71 ures include hyperplastic bone consisting of mature cortical and trabecular bone.

72 into computational models of developing and mature cortical pyramidal cells that express NaV1.2.

73 As they progress in culture, the FLI-matured cumulus-oocyte complexes display distinctly diff

74 al trafficking genes are up-regulated in the mature cyst, potentially preserved as mRNA in preparatio

75 Patients in MMR and MR(4.5) had a more mature, cytolytic CD57(+)CD62L(-) NK cell phenotype, con

76 Previously, we have shown that mature cytoplasmic tRNAs are cleaved during stress respo

77 There were also fewer and less mature dendritic spines on OGT knockout neurons.

78 we found that Bax deletion in developing and mature dentate neurons increased EPSCs and prevented neu

79 mmune phenotype that developed toward a more mature differentiated status.

80 to a convoluted luminal structure, permitted matured differentiation to a FTE lineage.

81 p of monomeric unprocessed proMPO versus the mature dimeric MPO and the functional role of the propep

82 females significantly differed from that of mature diploid fish.

83 Specifically, mature diploids had higher percentage of EPA and DHA in

84 bor their own independent targeting signals (mature domain targeting signals [MTSs]).

85 We now reveal that mature domains harbor their own independent targeting si

86 Evidently, mature domains have their own previously unsuspected dis

87 The role of mature domains in targeting and secretion is unclear.

88 embrane, signal peptides are cleaved off and mature domains reach their destinations and fold.

89 l frontal cortex, an associative region that matures during the pubertal transition and is implicated

90 ity of its differentiation intermediates and mature effector cells to expand upon demand, thereby pro

91 on by the pathogen and the N terminus of the mature effector was found likely to be acetylated.

92 not occur in response to DNA damage in fully mature eggs during meiosis II, despite the divisions bei

93 epidermis and digestive tract epithelia have matured, ensuring that both organs can withstand the mec

94 has been suggested that FD is secreted as a mature enzyme that does not require subsequent activatio

95 Transcriptome profiling of E2F-2-null, mature erythroblasts demonstrated widespread changes in

96 parasites modify their human host cell, the mature erythrocyte.

97 re expressed in all cell types tested except mature erythrocytes, but do not reach the plasma membran

98 rlying the high-level expression of GATA1 in maturing erythroid cells have been studied extensively,

99 ompared the transcriptomes of pre-HSCs, HSCs matured ex vivo, and fetal liver HSCs.

100 will be necessary to refine markers of HSCs matured ex vivo.

101 ocols would promote T-tubule development and mature excitation-contraction coupling of hiPSC-CM when

102 range of experiences can promote the proper mature expression of direction selectivity in primary vi

103 f intermediate states to generate particular mature fates.

104 allowing for the establishment of relatively mature features, including the formation of dendritic sp

105 Eggs produced by the mature female parasite are responsible for the pathogene

106 pically doing so in the presence of sexually mature females, although social groups predominantly con

107 rpin binder) to detect soluble oligomers and mature fibrils formed from recombinant alpha-syn protein

108 t of the junction to the microtubules in the mature flagellum.

109 s before ovulation activates EcR.B2 to prime mature follicles to be responsive to neuronal ovulatory

110 1 (a gene-expression pattern associated with mature follicular B cells) and also attained increased c

111 y should have reduced performance outside of mature forest conditions.

112 matory conditions, clearly distinguishes the mature from the immature ones.

113 y to the commonly used drug piperaquine, and mature gametocytes reappear in the bloodstream 10 days a

114 i) based on the presence of individuals with mature gonads and conducted statistical analysis of the

115 henotypic characterisation of developing and mature grains from the NILs was performed.

116 Mature granule cells also contributed to functional moss

117 G-MDSCs, made of immature and mature granulocytes expressing high levels of degranulat

118 anscriptionally regulated by ethylene during mature green (MG) fruit transition into ripening.

119 one to tumor cell dissemination contain less-mature HA (i.e., smaller, less-perfect, and less-oriente

120 still fall short of recapitulating the full mature hepatocellular phenotype.

121 cutely promote the production of Ephexin5 in mature hippocampal neurons and in mice expressing human

122 A receptor (GABAAR)-mediated transmission in mature hippocampal neurons.

123 eptors during NMDA-receptor-dependent LTP at mature hippocampal synapses.

124 Unexpectedly, expression of mature HMR failed to rescue not only the plastidial but

125 ptide and additional proteolytic processing, mature HMR, which begins from Lys-58, retains its bioche

126 Mature human B cells infected by Epstein-Barr virus (EBV

127 in all the meals were comparable to those in mature human breast milk.

128 NA sequence abrogates immune activation, and mature human circRNA is associated with diverse RNA bind

129 ation of defined populations of functionally mature human GABAergic neurons represents an important s

130 re we cloned and characterized rare affinity-matured human NANP-reactive memory B cell antibodies eli

131 1, which cleaves pro-inflammatory IL-1beta o mature IL-1beta causing inflammation and cell death by p

132 The release of mature IL-1beta depends on 2 regulated events: the de no

133 PGE2 did not inhibit ATP-induced mature IL-1beta production in monocytes.

134 We found that pro-IL-1beta and mature IL-1beta release from human monocytes is stimulat

135 d inflammasome activation (ASC oligomers and mature IL-1beta).

136 Our research identifies intracellular mature IL-37 as a novel endogenous inhibitor of Rac1.

137 Mechanistically, intracellular mature IL-37 directly bound to the CAAX motif in the C-t

138 the virus hijacks the autophagic vacuoles to mature in an acidic environment and release progeny viri

139 these findings, viral glycoproteins fail to mature in SPCA1-deficient cells preventing viral spread,

140 sual experience determines when interneurons mature in the visual cortex.

141 precedented spatial transcriptome map of the mature in vitro Pseudomonas aeruginosa biofilm model, re

142 n tertiary structure prediction methods have matured in recent years.

143 For reasons not fully clear, oocytes matured in vitro tend to be much less competent to becom

144 More mature individuals with superior inhibition evidenced on

145 HEK293T cells, we show that FLIL33, but not mature interleukin-33, physically interacts with IPO5 an

146 During infection, dendritic cells (DC) mature into antigen-presenting cells that activate T cel

147 showed that neonatal Nkx2.5+ cardiomyoblasts mature into cardiomyocytes in vivo.

148 same time fragment-based drug discovery has matured into a powerful and widely applied technique.

149 hat 13% of spheroids were pre-organoids that matured into intestinal organoids.

150 servable engraftment potential, but directly matures into megakaryocytes when placed in culture.

151 Both matrix degradation and the number of mature invadopodia were significantly decreased with APO

152 rt the cryo-electron microscopy structure of mature Japanese encephalitis virus at near-atomic resolu

153 Wang et al. report the cryo-EM structure of mature JEV at near-atomic resolution and identify struct

154 vels in eggs, 1(st) and 2(nd) instar larvae, mature larvae, pupae, male and female adults.

155 e examined the hydraulic architecture of the mature leaves of the model species Populus tremula x alb

156 se compounds stimulate cAMP levels and raise mature let-7 levels to suppress let-7 target genes in mu

157 ment of CMML and JMML disease-initiating and mature leukemic cells in vivo, allowing creation of gene

158 Disparity selectivity has already reached a matured level before the monocular deprivation.

159 NCgl2760 gene resulted in a complete loss of mature LM/LAM and the appearance of a truncated LM (t-LM

160 wed samples comprised 36,920 newly diagnosed mature lymphomas, 321 precursor lymphoid neoplasms, 314

161 retrograde direction toward the soma, where mature lysosomes are mainly located.

162 Vs) from distal axons toward the soma, where mature lysosomes are mainly located.

163 phagocytosed apoptotic cells as functionally matured macrophages, adhered to the newly formed subvent

164 have leveraged to express reporter genes in mature male and female gametocytes.

165 t seal Mirounga angustirostris, the calls of mature males comprise a rhythmic series of pulses, with

166 We previously identified two mature members of the miR-142 family, miR-142-5p and miR

167 Loss of neurogenic capacity in mature MG is accompanied by reduced chromatin accessibil

168 ge from immature MHC class II (MHCII)(lo) to mature MHCII(hi) mTECs has recently been extended to inc

169 he dynamic yet discrete self-organization of mature microglia in the healthy and diseased CNS.

170 Finally, we find that mature microglia rapidly lose signature gene expression

171 addition to proteins, the virus encodes >40 mature microRNAs for which the functions remain largely

172 Finally, we demonstrate that OA induces mature miR-7 production in HeLa cells.

173 isms (SNPs) in the primary miRNA outside the mature miRNA sequences.

174 Here, we demonstrate that mature miRNA-22 is more abundant in muscle from male mic

175 y described to result in increased levels of mature miRNA.

176 (Fe/S) cluster assembly machinery resides to mature mitochondrial Fe/S cluster-containing proteins.

177 Functional ABA receptors exist in mature Mks because ABA induces an intracellular Ca(2+) i

178 Both fusion proteins matured monocyte-derived dendritic cells through TLR5.

179 Mature moral judgments rely on the consideration of a pe

180 nstrate the timed generation of neurons with mature morphologies, as well as the subsequent generatio

181 oding, noncoding, and intergenic RNAs in the mature mouse brain with RNA-Seq and validation with inde

182 avily expressed in AII amacrine cells in the mature mouse retina, and which conjointly identify this

183 epithelial cell types in the developing and mature mouse ureter.

184 e production of the non-transposase-encoding mature mRNA isoform in Drosophila germ cells.

185 mitochondrion-targeted PPR78 protein in nad5 mature mRNA stability and maize (Zea mays) seed developm

186 pping, short deletions, or insertions in the mature mRNA, underlying one common molecular mechanism o

187 tsm)-treated animals involves an increase in mature mutant SOD1 protein in the disease-affected spina

188 rase (FUT8) to directly fucosylate full-size mature N-glycans in a chemoenzymatic approach.

189 Our data imply the assembly of mature nad5 mRNA precedes the protection of PPR78.

190 However, it is the instability of mature nad5 rather than nad5T1 causing loss of the full-

191 ical NF-kappaB signaling was impaired in all mature naive CVID-derived B cells.

192 f T cells in the maintenance/survival of the mature naive peripheral B cell population.

193 hey undergo an additional maturation step to mature naive T cells that circulate through secondary ly

194 ney, an interesting time in development when mature nephrons are present yet nephrogenesis remains ex

195 n allowing axon regeneration to occur in the mature nervous system following axonal injury.

196 is robustly expressed in the developing and mature nervous system, but its contributions to neural c

197 c transmission throughout the developing and mature nervous system.

198 sion, the accumulation of gamma-tubulin-2 in mature neurons and neuroblastoma cells during oxidative

199 ntracellular chloride concentration found in mature neurons and thereby establishes the driving force

200 dual human neural precursor cells (NPC) into mature neurons are currently not fully understood.

201 ignaling, which is in sharp contrast to most mature neurons hyperpolarized by GABA.

202 ases (Cdks) are inappropriately activated in mature neurons under ischemic stress conditions.

203 We further show that AICD increase in mature neurons, as reported in AD, alters synaptic NMDAR

204 fraction of dendritic regions in relatively mature neurons, but this structure develops slower and f

205 es of immature interneurons to those of more mature neurons, we identified genes important for human

206 late transcription during the development of mature neurons.

207 with subcellular localization indicative of mature neurons.

208 oride-permeable ionotropic GABAA receptor in mature neurons.

209 ocampal neural progenitors into functionally mature neurons.

210 , spanning nearly the entire axonal shaft of mature neurons.

211 e into robust typological distinctions among maturing neurons.

212 Mature neutrophils from Hbb(th3/+) mice displayed a sign

213 56(bright) NK cells and is confined to fully mature NK cells characterized by the NKG2A(-)KIR(+)CD57(

214 Notably, A2AR-deficient, terminally mature NK cells retained proliferative capacity and exhi

215 After ablation of mature NK cells, starting from day 15 after HSCT and fav

216 expressed primarily in the invasion zone of mature nodules.

217 sts but prevented their differentiation into mature odontoblasts.

218 rs first appeared after 6 months, while more mature oligodendrocyte markers were not present until 1

219 on of 2-AG hydrolysis augments the number of mature oligodendrocytes and increases MBP, leading to re

220 esterol homeostasis and differentiation into mature OLs.

221 Isolated maturing oocytes autonomously synthesized betaine in vit

222 stress during intrauterine development of a maturing organism.

223 ndependent lineages work coordinately within mature organs to ensure proper ratios of cell types.

224 regulate differentiation of osteocytes from mature osteoblasts are poorly understood.

225 ursors and drives their differentiation into mature osteoblasts.

226 The Ca(2+) transients matured over several hours into regular low-frequency (0

227 , but crucially, also blocks transmission of mature P. falciparum gametocytes to Anopheles stephensi

228 pplied this protocol to the 3.3-A map of the mature P22 bacteriophage capsid, a large and complex mac

229 view that newly generated ASCs can acquire a mature PC phenotype that is accompanied by loss of CD19

230 McpM has four cysteines within the mature peptide and site-directed mutagenesis experiments

231 Mature peripheral double negative T (DNT) cells expressi

232 e click chemistry to fluorescently label the mature PG in whole bacterial cells of Bacillus subtilis.

233 the most rapid transition from colostrum to mature phase lactation yet observed.

234 planted cells are able to differentiate into mature photoreceptors expressing various opsins and can

235 nd extension, leading to severe reduction of mature piwi-interacting RNAs in the testis.

236 The production of mature piwi-interacting RNAs requires a critical step of

237 remarkably similar to profiles obtained from mature post-mortem DaNs.

238 The results support the hypothesis that a mature prefrontal cortex competes with implicit learning

239 We used in situ-matured primary human MCs and matched CD4(+) T cells to

240 early nephron derivatives, but disappears in mature proximal tubules.

241 ssembly, is followed by N-methylation of the mature (pseudo)pilin N terminus.

242 conserved Glu residue at position 5 (E5) of mature (pseudo)pilins is essential for assembly.

243 nditions of nutrient starvation and that the mature Red Blood Cells of some RTT patients retain mitoc

244 oRNA (miRNA)-processing enzyme DICER1 in the mature retinal pigmented epithelium (RPE).

245 f miRNAs in RPE cells, we used two different mature RPE cell-specific Cre recombinase drivers to inac

246 d secretion of extracellular proteins, while mature RRCs express genes implicated in innate immunity.

247 ator of multiple pre-rRNA cleavages, driving mature rRNA formation and discarded rRNA decay.

248 t, we show that sexually committed, AP2-G(+) mature schizonts specifically upregulate additional regu

249 ch the readiness level to compete with other mature sensor technologies, hence to find commercial app

250 ose that IHC functional differentiation into mature sensory receptors is initiated in the prehearing

251 acterize OM heterogeneity in an artificially matured series of New Albany Shales.

252 ultaneous morphogenetic events to obtain its mature shape.

253 type capable of differentiating in vivo into mature SMCs, resident macrophages, and endothelial-like

254 loping male gametes and histone retention in mature spermatozoa, potentially priming certain regions

255 a correlation between memory performance and mature spine density was found.

256 As the islet approaches its mature state, heterogeneity diminishes and beta-cells sy

257 syringyl units and reduced lignin content of mature stems, and led to improved saccharification of th

258 ng is largely driven by the loss of large or mature synapses.

259 stem and progenitor cells (HSPCs) through to mature T cells.

260 h positive and negative selections to become mature T cells.

261 The preimmune repertoire consists of mature T lymphocytes that have not yet been stimulated i

262 gue as a marker, we identified CD4-enriched, mature T lymphocytes with properties of T reg cells.

263 characterized events is the acquisition of a mature T-cell gene expression program characterized by t

264 erminus of iRhom2 alter its interaction with mature TACE, thereby licensing its proteolytic activity.

265 e (AD) are characterized by the formation of mature tangles in the entorhinal cortex and disorientati

266 Notably, mature taste cells have life spans of only 5-20 days and

267 evaluation, and methods are still needed to mature this field.

268 e thus propose a model in which kinetochores mature through Ska complex recruitment and that this is

269 Mature thymocytes with a Galphai2 mutation that disables

270 n, leading to an intrathymic accumulation of mature thymocytes within medullary perivascular spaces a

271 them, as well as defined how such antibodies mature to acquire breadth.

272 lates that transient cisternae biochemically mature to ensure anterograde transport.

273 In the presence of doxycycline, HD10.6 cells mature to exhibit neuronal morphology and express sensor

274 rough in vitro studies that these constructs mature to match native disc composition, structure, and

275 Single molecule spectroscopy (SMS) has matured to a point where it can be used as a convenient

276 Here, we demonstrate that the emergence of mature topography among motor nuclei involves a novel in

277 red for downregulation of ERBB2 signaling in maturing trabeculae.

278 Armagh numbering ca. 140 mature trees.

279 480 cells, which led to the detection of two mature TrkC-miR2 isomiRs, and their endogenous forms wer

280 YAMAT-seq has high specificity for mature tRNAs and high sensitivity to detect most isoacce

281 /100g FW during tuber growth; however, fully matured tubers contained only 10-39mg anthocyanidins/100

282 We showed that ASM continued to mature until approximately 3 wk after birth.

283 for selection of B cells into the follicular mature versus marginal zone B cell compartment.

284 ied based upon their maturity (peripheral or mature versus precursor) and lineage (B cell, T cell, an

285 ng HIV-1 maturation to prevent assembly of a mature viral capsid.

286 spherical particles instead of brick-shaped mature virions with well-defined core structures.

287 ith a major membrane protein of immature and mature virions.

288 technical difficulty of separating VLVs from mature virions.

289 ll culture due to a reduction in assembly of mature virions.

290 mall capsid protein and is unable to produce mature virions.

291 rger radius and are less compact than in the mature virus.

292 The secretion of mature VLDL particles occurs through the Golgi secretory

293 We find that mature VRC-PG04 has low SHM capability due to hotspot sa

294 In contrast, Adrb3 activation stimulates mature white adipocytes to convert into beige adipocytes

295 heterogeneous cell population consisting of mature white adipocytes, multipotent mesenchymal stem ce

296 restricted to a subset of preadipocytes and mature white adipocytes.

297 pal memory engram cells, became functionally mature with time.

298 Milk protein profiles matured within 24 hours or less, indicating the most rap

299 Functionally, mature WNT-5A attenuated canonical WNT-driven alveolar e

300 DC-RAs displayed a mature yet tolerogenic phenotype, expressing IL-10, TGF-