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1 The elevated production of CCL22 by PGE(2)-matured DC persists after the removal of PGE(2) and is f
2 erent Treg-recruiting abilities, with PGE(2)-matured DC, but not type 1-polarized DC, generated in th
3 not LTB(4) or LTD(4), are superior to PGE(2)-matured DCs in stimulating CD4(+) T-cell responses and i
4 at high surface expression of CCR7 on PGE(2)-matured DCs is associated with their suppressed producti
5 In accordance with these findings, PGE(2)-matured DCs show significantly higher in vitro migratory
14 -DR) by flow cytometry was consistent with a mature DC phenotype, indicating that pulsing with CPD-MA
16 HC-II is significantly greater in activated (mature) DCs than in resting (immature) DCs, but the mole
17 mmatory cytokines produced by TLR-activated, mature DCs are required for reversal of Treg anergy, but
20 ecific CD8+ CTL when compared with TNF-alpha-matured DCs pulsed with an HLA-A*0201-restricted FMP pep
23 d by unexpectedly high levels of T cells and mature (DC-lysosome-associated membrane glycoprotein pos
24 The combination of follicular B cell and mature DC densities allowed the identification of patien
25 d HLA-DP, DQ, DR) markers in immature DC and mature DC and was associated with down-regulation of bot
26 ptidomes of MUTZ3-derived human immature and mature DC lines and THP1-derived macrophages by liquid c
27 ations were expanded, including immature and mature DC, myeloid (CD11c(+)CD11b(+)CD8a(-)), lymphoid (
31 al venules (HEV) and clusters of T cells and mature DCs, in 7 of 29 cutaneous metastases from melanom
35 of HIV-1 mediated by immature DCs (iDCs) and mature DCs (mDCs), using replication-competent and singl
38 s of ICAMs and their ligands on immature and mature DCs and various types of HIV-1 target cells were
41 ially found in mature DCs, both immature and mature DCs contained similar amounts of viral RNA, sugge
43 slational isoforms expressed in immature and mature DCs probably contribute to the DC maturational st
44 ions, promoted the migration of immature and mature DCs to CCL19 and CCL21, which was associated with
54 -1 cells is enhanced upon DC maturation, and mature DCs are superior to monocytes for the expansion o
55 sampling for antigen and danger signals, and mature DCs (mDCs), which exhibit enhanced antigen-presen
58 At the level of glycolysis, tolerogenic and mature DCs showed similar glycolytic rates, but glycolyt
62 how how tumors infiltrated by TLS-associated mature DC generate a specific immune contexture characte
63 grate to lymphoid tissues, where they become mature DCs (mDCs) for effective antigen presentation.
64 ted dying cells promoted monocytes to become mature DCs and cross-present cell-associated Ags for the
65 rather, the bioactivity of IL-12 produced by mature DC depends on IL12p70, IL12p40, and IL12(p40)2 pr
68 LR-induced cross-presentation is mediated by mature DCs, is independent of endosomal acidification, a
70 vivo DC maturation step could be replaced by maturing DC in situ by injecting immature DC into sites
71 uppresses the generation of key cytokines by maturing DCs through the activation of ERK-dependent pat
74 h1 cells but augmented the capacity of CD40L-matured DCs to polarize naive T cells into Th1 cells.
78 an immunization strategy with peptide-coated mature DC that, in the absence of inflammatory cytokines
79 suggest that under inflammatory conditions, mature DCs may contribute to T cell stimulation without
85 ceived intranodal vaccinations with cytokine-matured DCs loaded with keyhole limpet hemocyanin and MH
88 ed intravenous injection of monocyte-derived mature DCs that were loaded with a synthetic NKT cell li
93 In contrast, exposure to IFN-beta during mature DC-mediated primary stimulation of naive Th cells
95 glioblastoma to pre-conditioning with either mature DCs or Td unilaterally before bilateral vaccinati
96 zed transcriptional determinants that enable mature DCs to direct these opposing T cell outcomes.
97 ditions, when FRCs are unlikely to encounter mature DCs expressing the PDPN receptor CLEC-2, PDPN end
99 We demonstrate that beta2-AR agonist-exposed mature DC display a reduced ability to cross-present pro
102 actic activity toward CCL19 (a chemokine for mature DCs) in vitro, and in vivo, Langerhans cells show
103 r alpha (TNF-alpha) are effective agents for maturing DCs; however, they have potential in vivo toxic
104 n, they decreased the density of HLA-DR from mature DCs, the expression of CD80 and CD86 coactivation
105 stered Treg-DC as a discrete population from mature-DC and immature-DC, with 51 and 93 genes that wer
106 Suppression of IL-12p70 production from maturing DCs was not observed in the presence of nicotin
107 capable of differentiating into functional, mature DCs, which can now be reproducibly prepared for i
109 l studies, we evaluated whether functionally mature DCs could be generated in chimpanzee plasma by go
110 material derived from sonicates of IFN-gamma-matured DC is enriched in small membrane vesicles that c
112 yeloid DC precursors) and in vitro generated mature DCs are not cytotoxic or are less cytotoxic, resp
116 ort the gene expression profiling of hypoxic mature DCs and identify TREM-1 as a novel hypoxia-induci
117 ochemical analysis was performed to identify mature DCs, myeloid DCs (MDCs), and plasmacytoid DCs (PD
121 in entry routes (FcgammaRIIa or DC-SIGN) in mature DC broadens target options and suggests additiona
128 f whole viruses were preferentially found in mature DCs, both immature and mature DCs contained simil
129 megalovirus promoter (hIE-CMVp) is higher in mature DCs than in immature DCs and is further increased
136 cgammaRIIb expression is patently reduced in mature DCs, an effect that is modulated by treatment wit
138 the 3 inducible immunoproteasome subunits in mature DCs, we found that such DCs expressed increased i
142 n the impact of PGE(2) on CCR7 expression in maturing DCs and demonstrate a novel mechanism of regula
145 o induced cyclooxygenase-2 protein levels in maturing DCs and significantly augmented endogenous PGE2
148 osure to COX-2-overexpressing glioma induced mature DCs to overexpress IL-10 and decreased IL-12p70 p
149 THD-modulated MSCs from ITP patients induced mature DCs to become tolerogenic DCs, whereas unmodulate
151 ciated with a higher density of infiltrating mature DC and effector memory T-cell subsets, suggesting
152 l(-/-) DC maturation results in insufficient mature DCs that require microbial activation to restore
153 he life cycle of LC is their activation into mature DC in response to various stimuli, including epic
154 t, unlike immature DCs, did not develop into mature DCs expressing CCR7 and high levels of MHC II, ev
156 recursors readily able to differentiate into mature DCs once the Notch signal is stopped (eg, after c
158 5 (RANTES), where their differentiation into mature DCs is impaired by tumor-derived interleukin-10.
162 persistent differentiation of monocytes into mature DCs that expressed IL-12 and stimulated T cell pr
163 DCs) and intratumoral injection of Ag-loaded mature DCs delayed the tolerization of tumor-infiltratin
166 the rolling or capturing of immature and LPS-matured DCs to the CNS microvascular endothelium, inhibi
167 aptors allowed maximal T cell priming by LPS-matured DCs, with MyD88 playing a larger role than TRIF.
184 ne marrow (BM)-derived immature DCs, but not mature DCs, can inhibit BCR-induced proliferation of B c
187 In this work we examined the ability of mature DC presenting a high vs low level of peptide to g
188 he current data, showing that the ability of mature DC to interact with Treg cells is predetermined a
191 h iDC was associated with the development of mature DC that were morphologically, phenotypically, and
193 reveal significantly enhanced expression of mature DC-specific marker CD83, secondary lymphoid tissu
195 is widely assumed to restrict the ability of mature DCs to capture and present antigens encountered a
197 ly, there was a preferential accumulation of mature DCs in the PLNs of alpha-GalCer-treated NOD mice,
199 These data suggest that the availability of mature DCs at the site of inoculation is a critical rate
200 ibited morphologic changes characteristic of mature DCs and expressed increased levels of CD40, CD80,
201 nduced phenotypic changes, characteristic of mature DCs and the production of interleukin-12p70 (IL-1
203 o CD11c(+) cells with the characteristics of mature DCs (CD80(+), I-A/I-E(+)) but also enhanced innat
207 ponse to IFN-alpha/beta, whereas exposure of mature DCs to IFN-alpha/beta results in signaling via ST
209 as an instructive tool for the generation of mature DCs with enhanced immunogenicity from pluripotent
210 ursors (pre-cDCs) changed the homeostasis of mature DCs or pre-DCs in the lung, dermis, and spleen.
214 ivate naive T cells, whereas the majority of mature DCs produced IL-12 and activated naive T cells.
218 ripheral sites and controls the migration of mature DCs from sites of inflammation to lymph nodes.
219 at fascin1 positively regulates migration of mature DCs into lymph nodes, most likely by increasing d
220 rovides an essential signal for migration of mature DCs toward CCL19/macrophage inflammatory protein
221 allografts results from a reduced number of mature DCs in draining lymph nodes, leading to impaired
223 niae infection leads to increased numbers of mature DCs in the lung and draining lymph nodes during t
227 se DC1s exhibited surface marker profiles of mature DCs and produced high levels of IL-12 and CXCL10.
228 to the pronounced proinflammatory program of mature DCs, tolerogenic DCs displayed a markedly augment
229 of mature, immunogenic DCs and the ratio of mature DCs to CD4+ T cells were nearly identical in corn
232 there was a pronounced genomic signature of mature DCs in SCC, they showed different T-cell stimulat
234 appearance of cells with markers typical of mature DCs (CD83(+), CD86(+), CD11c(+), and CD14(-)) was
236 IL-15 that emerges onto the cell surface of matured DCs does not bind to neighboring cells expressin
237 Based on a large-scale proteome analysis of maturing DCs, we identified the GPI-anchored protein sem
240 DDR1b-overexpressing THP-1 cells or DDR1 on mature DCs induced the formation of TNFR associated fact
241 ase in surface expression of MHC class II on mature DCs, the surface expression of CD1 molecules was
242 e captured by CD169-expressing HeLa cells or mature DCs, and are sequestered within non-lysosomal tet
243 nic DCs, but not unpulsed tolerogenic DCs or mature DCs, significantly inhibited disease severity and
245 Falpha/IL-1beta/IL-6/prostaglandin E2 (PGE2)-matured DCs (sDC), the current "gold standard" in DC-bas
246 assumed that the presence of phenotypically mature DCs should promote protective antitumor immunity,
248 his synapse, where they are known to protect mature DCs from NK cell lysis, the NK cell also received
251 ity of C albicans- and P brasiliensis-pulsed mature DCs to induce autologous T-cell proliferation, ge
252 with a homogenous subpopulation of LPS/R848-matured DCs that were CD83(Hi)/CD80+/CD86+ reduced this
255 rticoids may spare immature DCs and suppress mature DCs and inflammation via differential expression
256 nt-pretreated sites were more effective than mature DC in stimulating antitumor immunity in mice.
259 lymicrobial septic challenge, we report that mature DC numbers were markedly increased in the lung du
260 However, we have previously reported that mature DC (mDC) prevented the onset of autoimmune diabet
261 le DC subsets mature in the gingiva and that mature DCs engage in antigen presentation with T-cells i
263 ptor significantly reduced expression of the mature DC marker CD83, decreased the production of the i
264 kinase inhibitor, only partially rescued the mature DC phenotype in the presence of VEGF, suggesting
267 b4(-/-) mice had significantly more of these mature DCs after challenge with OVA, which was accompani
268 this receptor attenuates the number of these mature DCs and attendant IL-4-producing lymphocytes in t
269 We demonstrated that the density of these mature DCs was associated with favorable clinical outcom
271 ligation also suppressed the ability of TLR-matured DCs to induce IFN-gamma-secreting Th1 cells but
272 in which the transfer of self-Ag-pulsed, TLR-matured DCs can induce a functional CD8 T cell response
273 beta, TNF-alpha, and IL-6 expression, and to mature DC into APC that cross-presented exogenous Ags to
275 Cantell has a particularly strong ability to mature DCs independently of type I IFNs and TLR signalin
279 correlated with monocyte differentiation to mature DCs and their ability to stimulate proliferation
288 nostimulatory capacity was not enhanced when mature DC were injected into adjuvant-pretreated sites a
289 nce to NK cell-mediated elimination, whereas mature DCs exhibited increased susceptibility to NKG2D-d
290 eshly isolated DCs are myeloid-type, whereas mature DCs induced by overnight culture are both "lympho
294 ional APC, CTL generated by stimulation with mature DC were of high avidity regardless of the amount
296 -2 commitment, and prolonged engagement with mature DCs is necessary, but not sufficient, for IL-2 ge
297 ith metastatic melanoma were vaccinated with mature DCs transfected with RNAs encoding melanoma antig
300 n large vesicular compartments deeper within mature DCs (in which macropinocytosis is down-regulated)
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