ライフサイエンスコーパス: mature form

1 vel of the 130-kDa form of beta(1) integrin (mature form).

2 nally (accelerating primiR processing to the mature form).

3 ilitates processing of precursor GILT to the mature form.

4 retion signal sequence that is absent in the mature form.

5 essing of precursor cytochrome b mRNA to the mature form.

6 a precursor form and 189 amino acids in the mature form.

7 site and the 3' terminal stem-loop into the mature form.

8 ctA) and posttranslationally modified to its mature form.

9 ro, resulting in a rapid conversion into the mature form.

10 of MT6-MMP converts proMMP-2 into mostly the mature form.

11 s responsible for cleaving pro-sigmaK to its mature form.

12 opeptides are cleaved to generate the 30-kDa mature form.

13 SREBP-1 is proteolytically processed to the mature form.

14 utation of Cys-200, which is retained in the mature form.

15 mal processing into the enzymatically active mature form.

16 as an integral membrane protein to yield its mature form.

17 the conversion of the IL-18 precursor to the mature form.

18 sis of pro-ICA512 and the degradation of its mature form.

19 necessary for the biosynthesis of the final mature form.

20 t is C-terminally processed into a 64-66-kDa mature form.

21 nverted the intermediate form of Yfh1 to the mature form.

22 e of IL-1alpha by calpain to the more active mature form.

23 lyhedral capsids but can be converted to the mature form.

24 d autocatalytic processing of zymogen to the mature form.

25 whereas bFGF-Short induced only the 17.8 kDa mature form.

26 of pro-a-factor, a mating pheromone, to its mature form.

27 he trans-Golgi network to yield a 35-residue mature form.

28 to process the 40-kDa molecule to the 28-kDa mature form.

29 d, purified, and cleaved by ICE into a 18-kD mature form.

30 tracellular matrix (ECM) proteins into their mature form.

31 and impairs conversion of precursors to the mature form.

32 he Cas system to process CRISPR RNA into its mature form.

33 n stems from their resistance to taking on a mature form.

34 F, that is cleaved to release its C-terminal mature form.

35 n post-Golgi compartments to yield a 3.7-kDa mature form.

36 rm that is distinct from the function of its mature form.

37 mitochondria faster than their corresponding mature forms.

38 zymogen activation and inhibits activity of mature forms.

39 tivating prochymase and protryptase to their mature forms.

40 L-33 through the generation of highly active mature forms.

41 e that processes microRNAs (miRNAs) to their mature forms.

42 a-glutamyl carboxylated, propeptide-cleaved (mature) form.

43 Smac-DIABLO in its mature form (20.8 kDa) binds to baculoviral IAP repeat (

44 otein (66 kDa) and an N-terminally truncated mature form (55 kDa) have been described in human brain.

45 s, GEC1 expression enhanced the level of the mature form (55-kDa band) of FLAG-hKOR at 4, 8, and 22 h

46 The protein (mature form: 87 amino acids) is an atypical member of th

47 cessed the 40-kDa mutant zymogen to a 28-kDa mature form, a result suggesting that the derivative pro

48 whereas gp120 preferentially recognized the mature form, a result that underscores a role for posttr

49 syncytial virus (RSV) is synthesized as two mature forms: a membrane-anchored form and a smaller sec

50 syncytial virus (RSV) is synthesized as two mature forms: a membrane-anchored form and a smaller sec

51 y activating p75NTR to mediate apoptosis and mature forms activating Trk receptors to promote surviva

52 kedly elevated active ( approximately 60 kDa mature form) ADAM10 protein.

53 t these basal body proteins are FliP (in its mature form after signal peptide cleavage) and FliR resp

54 riations and processing of pre-miRNAs to the mature form also may account for various differences in

55 d tumor cell migration via its intracellular mature form (amino acids 46-218).

56 y: (1) processing of full-length SUMO to its mature form and (2) deconjugation of SUMO from targeted

57 o a reproducible ratio of two sequences, the mature form and a form starting at Ala3, by adjustment o

58 NGF exists in both a mature form and a pro-form (proNGF).

59 ity converting the proNEDD8 precursor to its mature form and an isopeptidase activity deconjugating N

60 fic protease NEDP1 processes preNEDD8 to its mature form and deconjugates NEDD8 from substrates such

61 cifically cleaves precursor TNF-alpha to its mature form and is involved in the ectodomain shedding o

62 less stable in the matrix space than is the mature form and provides an explanation for why the lead

63 in flexibility between the germ line and the mature form and the differences in structure between TSA

64 d in Escherichia coli BL21(DE3) cells in its mature form and with the R. sphaeroides or E. coli N-ter

65 n endonuclease that trims pre-rRNAs to their mature forms and a sentinel that partners with RnaseR to

66 utant hKOR-N25/39Q was resolved as a 43-kDa (mature form) and a 38-kDa (intermediate form) band.

67 ions of IL-1 alpha, IL-1 beta (precursor and mature forms), and IL-1 receptor antagonist (IL-1Ra) wer

68 ng the proteolytic processing of SUMO to its mature form, and negatively, by catalyzing SUMO deconjug

69 ignal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1

70 targeted first to plastids, processed to the mature form, and then relocated to the nucleus.

71 ired for efficient processing of AtlA to its mature form, and treatment of the thmA mutant strain wit

72 nslational disulfide bonding, attained their mature form, and were subsequently secreted.

73 e by mitochondrial processing peptidase to a mature form approximately 54 kDa in size.

74 ent processing of the miRNA precursor to its mature form as well as diminished capacity to regulate t

75 Rescue of the defect, i.e., increase in the mature form at the bile canaliculi, was obtained by cell

76 l, IL-1 induces expression of MMP-13 and its matured form at 50 and 25 kDa, respectively.

77 -fibers in early prometaphase to their fully matured form at metaphase, just before anaphase onset.

78 Pichia pastoris, was processed to its active mature form autocatalytically or by incubation with peps

79 ing along the axon and the expression of the mature form (BFA insensitive, P/Q type Ca2+ channel medi

80 ses, subtilisin is kinetically stable in the mature form but unable to fold without assistance from i

81 milar specific activity as the corresponding mature form but was much less stable.

82 ecause pro-IL-16 is cleaved to its bioactive mature form by caspase-3, and caspase-3 is also the pivo

83 imported by mitochondria and processed to a mature form by cleavage of the NH2-terminal mitochondria

84 pro-IL-1beta, and following cleavage to its mature form by IFN-gamma-activated ICE, IL-1 then initia

85 olecule and proteolytically processed to the mature form by members of the family of the proprotein c

86 ce the isomerization of the Cdk into a fully mature form by promoting the exposure of the T-loop for

87 e endoplasmic reticulum and processed to the mature form by proteolytic cleavage.

88 f prointerleukin-1beta (pro-IL-1beta) to its mature form by the cysteine protease caspase-1 are not w

89 ong to Type II LTP characterized under their mature forms by a molecular weight of around 7.3 kDa, a

90 ociates with their precursors as well as the mature forms by binding to regions in addition to the IA

91 uration of the zymogen, procaspase-3, to its mature form, caspase-3.

92 ismatch) lead to increased expression of the mature form compared to the unedited version in cell cul

93 s a progression from initial attachment to a mature form composed of pillar-like multicellular struct

94 led by precursor Gag (PrGag) proteins; and a mature form, composed of proteins processed from PrGag.

95 Their mature form contains a passenger domain and a C-terminal

96 umor suppressor gene that, by utilizing both mature forms, coordinately controls the key cancer hallm

97 stine, ex vivo, as did Zot and its processed mature form, DeltaG.

98 inflammatory responses were higher with the mature form, demonstrating that the cysteine protease ac

99 interfering RNA precursors into their short mature forms, enabling them to regulate gene expression.

100 ), which is proteolytically processed to the mature form, F(1) + F(2).

101 h an NH(2) terminus identical to that of the mature form found in tissues.

102 inal propeptide that is cleaved to yield the mature form found in vertebrate tissues.

103 the cleavage of the precursor gp160 into its mature form, gp120.

104 om their initial unstructured state to their mature form has long been known to be promoted by other

105 full-length human IL-33(1-270) and generate mature forms IL-33(95-270), IL-33(99-270), and IL-33(109

106 The Y212C precursor was activated to its mature form in a manner similar to that of the wild-type

107 ediate form was only slowly processed to the mature form in Deltassq1 mitochondria.

108 icient processing of the intermediate to the mature form in isolated mitochondria.

109 A portion of the IL-1beta is shed in its mature form in membrane microvesicles, and induces adhes

110 ial SPase I converted Toc75 precursor to its mature form in vitro.

111 the RNAs, and these can be converted to the mature forms in vitro by the purified RNases.

112 likely to be used both in its precursor and mature forms in vivo.

113 Defective processing of let-7a precursors to mature forms, in part, explained the discrepancies obser

114 The mature form is retro-translocated from the ER into the c

115 S.cerevisiae, the mitochondrially generated mature form is separated by gel filtration into monomer

116 Cleavage of pro-IL-1beta to a mature form is stimulated by damage-associated molecular

117 process from the pro-silicatein state to the mature form is the crucial step during which silicatein

118 eltaF508 has substantial accumulation in its mature form, leading to higher level of processing at th

119 lated in both heterologous systems is in its mature form, localizes in the chloroplast thylakoid memb

120 orted into chloroplasts and processed to the mature form located in the thylakoid lumen, as shown by

121 Failure of SREBP-1 to be processed to the mature form <18 days postpartum correlates with low hepa

122 econd unknown peptidase, which generates its mature form (mAtTic40).

123 recursors that are poorly converted to their mature forms may be polyadenylated and subsequently degr

124 n normal samples (P = 3.52E-05), whereas the mature form modified for secretion (sCLU) was not signif

125 ng protein 1 (SREBP1), when presented in its mature form (mSREBP1), enhances lipogenesis by increasin

126 The genes encoding the mature form of 29 of these proteins were cloned, and 16

127 approximately 68-kDa band identified as the mature form of ADAM 12.

128 The extracellular domain of the mature form of ADAM12 consists of the metalloprotease, d

129 genesis and cancer, but the structure of the mature form of ADAM12 is not known, and its localization

130 UDCA reduced the level of the mature form of ADAM17.

131 rsican at the Glu(441)-Ala(442) bond and the mature form of ADAMTS-4 was detected by Western analysis

132 k regulatory mechanism that functions on the mature form of ALAS-1 protein through the activity of a

133 he heterodimeric, more enzymatically active, mature form of AOAH.

134 However, only the mature form of BDNF and CREB were increased in the vehic

135 The mature form of BDNF is minimally expressed in preparatio

136 The mature form of BDNF is required for synaptic delivery of

137 analyses showed that exercise increased the mature form of BDNF, synapsin I and cyclic-AMP response-

138 Here, we found that the functional mature form of BMP-15 is barely detectable in the mouse

139 temporal variations in the production of the mature form of BMP-15.

140 9 amino acid propeptide produces the active, mature form of cathepsin K.

141 The predicted mature form of cBD-1, expressed as a recombinant peptide

142 hat involves the extracellular region of the mature form of cell surface ADAM17 and not its intracell

143 (His27DeltactpAPSII) and a second one with a mature form of D1 (His27PSII).

144 Here, we report the crystal structure of the mature form of Der f 1, which was isolated from its natu

145 ed glycoprotein, indicating that this is the mature form of Ebo-GP.

146 33 kDa protease showed 100% identity to the mature form of elastase.

147 sequence and the first 27 amino acids of the mature form of gD.

148 Once delivered to the lysosome, the mature form of GILT-tagged GAA was indistinguishable fro

149 Here we show that the purified mature form of gp175 is active and cleaves purified IB s

150 The mature form of green fluorescent protein (GFP) is genera

151 lational processing from the immature to the mature form of HERG.

152 The active, mature form of HlyA is produced by posttranslational mod

153 he extracellular domain of TVA linked to the mature form of human EGF.

154 When expressed in E.coli, the mature form of human frataxin assembles into a stable ho

155 The mature form of human mtMetRS has been cloned and express

156 Overexpression of the mature form of hyaluronan-binding protein 1 (HABP1/gC1qR

157 IK(IR) and the development of IK(Ca) and the mature form of ICa are all prevented by transcription bl

158 The mature form of IF3(mt) has short extensions on the N and

159 The mature form of IF3(mt) is predicted to be 247 residues.

160 The cDNA for the predicted mature form of IF3(mt) was cloned, and the protein was e

161 moting initiation complex formation than the mature form of IF3(mt).

162 in response to IL-1 stimulation secreted the mature form of IL-18.

163 irus strain (FMLV-IL-1beta) that encodes the mature form of IL-1beta.

164 as enhanced and there was an increase in the mature form of IL-1beta.

165 Intracellular mature form of IL-37, but not its extracellular form, ma

166 HP1 monocytes and horizontally transferred a mature form of liver-specific miRNA-122.

167 These studies demonstrate that the mature form of lysyl oxidase retains many of its functio

168 The mature form of mTim44 could be recovered in the supernat

169 d were preferentially bound to the processed mature form of neurexophilin.

170 S-CTF, respectively), a highly glycosylated, mature form of nicastrin (NCT), Aph-1, and Pen-2.

171 Thus, the mature form of NS5, when not expressed as a precursor, w

172 asts (MEFs) produce primarily the processed, mature form of OGN, MEFs homozygous null for genes encod

173 The precursor and the mature form of one HSV-1 miRNA candidate, which is encod

174 w PAP accesses ribosomes and showed that the mature form of PAP is targeted to the cytosol from the e

175 s 64 kDa PC3-TM, and differs from the 64 kDa mature form of PC3.

176 The mature form of PDPr was expressed in Escherichia coli as

177 rometry analysis, we show that the in planta mature form of proGrCLE1, a multidomain CLE effector sec

178 oss of enzymatic activity and absence of the mature form of protease IV.

179 The proteolytically processed, mature form of pVI, protein VI, also bound to DNA; its K

180 Interestingly, the fully glycosylated mature form of SI was decreased in C2GnT-2 knock-out mic

181 The mature form of SREBP-1 generated by TNF-alpha, sphingomy

182 g protein 1c), nor the nuclear levels of the mature form of SREBP-1 protein were elevated in apoB/BAT

183 The mature form of SREBP-2 was in very low abundance and dif

184 In pull-down experiments, the mature form of sterol regulatory element-binding protein

185 shows that inordinately slow folding of the mature form of subtilisin results from the accrued effec

186 er, the addition of Cat B generated a 25-kDa mature form of TGF-beta1 in Cat B siRNA-pretreated lysat

187 Although the mature form of the BCR requires ligand-induced aggregati

188 The mature form of the chloroplast translational initiation

189 e various complexes that they form, only the mature form of the complex was detectable at the infecte

190 The fully mature form of the elongation complex may not appear unt

191 The N terminus of the mature form of the enzyme was identified by in vitro mit

192 583 amino acid residues corresponding to the mature form of the enzyme, whereas the monomer consists

193 goes a series of phosphorylation to render a mature form of the enzyme.

194 ell signalling precedes the formation of the mature form of the immunological synapse, but that full

195 ned for proteins differentially bound to the mature form of the miR-1 or miR-133 miRNA families.

196 Unlike caspases, the active and mature form of the paracaspase domain remains a single u

197 NLRP3 inflammasome-mediated secretion of the mature form of the proinflammatory cytokine IL-1beta.

198 The mature form of the protein is predicted to contain three

199 the unprocessed, predominant form and in the mature form of the protein.

200 suggests that this treatment stabilized the mature form of the protein.

201 ern blot conditions that likely represents a mature form of the protein.

202 cleavage of TLR9 in endosomes to generate a mature form of the receptor (TLR9(471-1032)).

203 The mature form of the SDP toxin contains a disulfide bond.

204 form of hKOR-N25/39Q was 6 times that of the mature form of the wild type.

205 Although the mature form of this enzyme is highly stable and resistan

206 hose with activated alphavbeta3 produced the mature form of this metalloproteinase.

207 The mature form of TweakR has only one hundred and two amino

208 aled that inhibition of DGK reduced only the mature form of tyrosinase, and the decrease of tyrosinas

209 The capacity of an adenovirus encoding the mature form of vascular endothelial growth factor (VEGF)

210 The mature form of VEGF-D, lacking both propeptides, can als

211 more sensitive to trypsin digestion than the mature form of wild type hERG.

212 The mature form of yeast frataxin (mYfh1p) assembles stepwis

213 We have expressed the mature form of Yfh1p (mYfh1p) in Escherichia coli and ha

214 o incomplete germ-line genes to generate the mature forms of antigen receptor genes.

215 risingly, the stability of both immature and mature forms of APP is dramatically elevated in cells ex

216 The N-terminal amino acid sequences of the mature forms of both UspA1 and UspA2 from strain O35E we

217 monstrated increased levels of precursor and mature forms of cathepsin S in agLDL-VSMC.

218 ed, pulse-chase analysis suggests that these mature forms of CatL are degraded by endocytic proteases

219 The 2D7 antibody recognized immature and mature forms of CCR5 equally, whereas gp120 preferential

220 Intriguingly, the mature forms of dme-miR-263a and -263b are very similar

221 of the developing nervous system to exhibit mature forms of electrical activity.

222 n to the previously identified precursor and mature forms of ExoR (designated ExoR(p) and ExoR(m), re

223 These data demonstrate that the mature forms of GAA characterized by polypeptides of 76

224 mutants 277, 291, and 348 bound gI, produced mature forms of gE that reached the cell surface, and we

225 rminal sequencing revealed that the cellular mature forms of hADAM19 started at (204)EDLNSMK, demonst

226 ileostomy fluid contained both precursor and mature forms of HD-5, with the majority present in a com

227 The mature forms of His-tagged wild-type and D37A Schizosacc

228 ly active form of MIF co-immunopurified with mature forms of HLA DP2/15, and a peptide derived from t

229 tein amounts of IL-1alpha, the precursor and mature forms of IL-1beta, IL-1 receptor antagonist (IL-1

230 d mast cells (chymase and tryptase) generate mature forms of IL-33 with potent activity on ILC2s.

231 provide concrete evidence that there are two mature forms of mammalian MRPL12 that are generated by a

232 wn reduced the expression of the primary and mature forms of miR-205 and the miR-205 "host" gene (miR

233 , we were able to identify both immature and mature forms of N-type VDCC.

234 Furthermore, the mature forms of nsp4 to nsp10 are thought to serve as co

235 Here, we show that both precursor and mature forms of PAP are localized in the endoplasmic ret

236 py demonstrated cell surface exposure of the mature forms of PrtP, PrcA1, PrcB, and Msp.

237 ng confirmed that the predicted immature and mature forms of Psd2(C2Delta)p, Psd2(GRDelta)p, and wild

238 Both precursor and mature forms of recombinant AIF were cleaved near the am

239 Both pro and mature forms of recombinant PAHX were produced in Escher

240 s leading to five mature forms of S6 and two mature forms of S10, C-terminal and/or internal modifica

241 f S9, N-terminal processings leading to five mature forms of S6 and two mature forms of S10, C-termin

242 f BRUCE to antagonize both the precursor and mature forms of Smac and caspase-9 is an important mecha

243 gnificantly alter the amount of precursor or mature forms of SREBP-1.

244 We found that TAK1 binds to and inhibits mature forms of SREBPs.

245 However, physiological quantities of mature forms of Tha4 and Hcf106 were integrated into iso

246 rgies of hapten binding to the germ line and mature forms of the 48G7 antibody Fab fragments by apply

247 The striking thermodynamic stability of mature forms of the ALS mutant SOD1 (Tm>70 degrees C) is

248 dependent signaling through intermediate and mature forms of the BCR has been postulated to regulate

249 Baculoviruses encoding full-length and mature forms of the catalytic and accessory subunits wer

250 -III and processes precursors to produce the mature forms of the cross-linking enzyme prolysyl oxidas

251 ently pointing out from the side of the more mature forms of the Env, was absent.

252 ired for activity of CatL by stabilizing the mature forms of the enzyme.

253 uctural biology of both the immature and the mature forms of the HIV capsid have made it possible to

254 y, stenotic lesions, but not AAAs, contained mature forms of the interferon-gamma-inducing cytokines

255 The deduced mature forms of the lipoproteins share no detectable hom

256 ength zymogen and a truncated zymogen, three mature forms of the SprE proteinase, Leu1-Ala237, Ser-1-

257 depletion of the cells or by coexpression of mature forms of the SRE-binding proteins (SREBP) 1a and

258 The mature forms of these proteins are translocated to the o

259 The mature forms of these proteins contain 9 and 12 fewer am

260 hile type XII collagen has been found in the mature forms of these tissues.

261 found that TACI interacts with the cleaved, mature forms of TLR7 and TLR9 and plays an important rol

262 e step in 3' end formation of one of the two mature forms of U5 snRNA but not the other.

263 cript, including the failure to generate the mature forms of viral mRNA encoding LANA.

264 he conversion of an iron-only precursor to a matured form of the M cluster before delivering the latt

265 Incompletely matured forms of SKI-1/S1P further process cellular and

266 ssays showed that the precursor, but not the mature form, of AtFKBP13 interacted with Rieske protein,

267 he MET oncogene as well as expression of its mature form on the cell surface.

268 ecursors in the cytoplasm and processed into mature forms on the cytoplasmic membrane.

269 rol ileostomy fluid, HD-5 was present in the mature form only.

270 g of the NFkappaB2 precursor (p100) into the mature form (p52).

271 zyme that processes PACAP's precursor to the mature form, peptidylglycine alpha-amidating monooxygena

272 In this report we show that, like its mature form, precursor GILT reduces disulfide bonds with

273 lated and then slowly processed to a smaller mature form, probably by endoproteolytic cleavage.

274 f growth factors and ECM proteins into their mature forms, resulting in TM stiffness and resistance t

275 are reduced 35-65% by cleavages making their mature form similar (26-31 kDa), while their precursors

276 : an abundant TMG-capped 124-nucleotide (nt) mature form (snR13F) and two less abundant RNAs, includi

277 in precursor to the intermediate but not the mature form, suggesting that a different peptidase might

278 d the conversion of TPP I proenzyme into the mature form, suggesting that this process takes place in

279 erived by alternative splicing of RNA into a mature form that either includes or excludes exon 4.

280 hing the Golgi complex for processing to the mature forms that activate cholesterol synthesis.

281 N-methyl-D-aspartate receptors (NMDARs) with mature forms that differ in subunit composition, electro

282 esults in initiation of fibrillation of more mature forms that have an intact Cys-57-Cys-146 disulfid

283 ein of 27 amino acids (rather than 81 in its mature form) that lacks bioactivity.

284 in polypeptides, not corresponding to pro or mature forms, that increased in accumulation in betaVPE

285 ess than 7 months of age, including the more mature forms; the visual status of these patients may be

286 Defining the constituent elements of its mature form, their organization within the particle, and

287 proMMP-9 can be irreversibly converted to a mature form through cleavage of the N-terminal propeptid

288 re in perinatal mice and do not attain their mature form until 3-6 weeks of age.

289 ized as inactive zymogens and convert to the mature form upon activation by specific enzymes, often a

290 suggest that the complex is processed to the mature form via the Golgi network prior to secretion.

291 leavage of intracellular pro-IL-1beta to the mature form was found to occur independently of NLRP3, i

292 g of human host cell factor 1 (HCF-1) to its mature form was recently shown, unexpectedly, to occur i

293 wed that SpeB expression and processing to a mature form was unaffected by either deletion mutation.

294 Yfh1p precursor protein from intermediate to mature forms was delayed.

295 n L (CatL) and CatB into their fully active, mature forms was reduced in pancreatitis, as were their

296 ells, whereas only TACE zymogen, but not its mature form, was detectable in M2 cells.

297 rate constants (ke) of the intermediate and mature forms were approximately 3 times those of the wil

298 Those mature forms were catalytically active.

299 the endoplasmic reticulum (ER), whereas the mature forms were present in non-ER fractions in culture

300 pol gammaB proteins were expressed in their mature forms, without their apparent mitochondrial local