ライフサイエンスコーパス: maturing

1 the underlying neural circuits are actively maturing.

2 uctures by X-ray crystallography and NMR are maturing.

3 and executive cognitive functions are still maturing.

4 aracterize HIV-1 particles that are actively maturing.

5 adipocytes and reduced lipid accumulation in maturing 3T3-L1 preadipocytes, demonstrating an inhibito

6 er, it is unclear how AFs are displaced from maturing 40S ribosomes, if or how maturing subunits are

7 lasm ensures the structural integrity of the maturing 40S subunit.

8 e, we show that En1 and En2 are expressed in maturing 5-HT neurons that will form the dorsal raphe nu

9 is the predominant functional En paralog in maturing 5-HT neurons, although a small contribution fro

10 reveal complex intrinsic functions for En in maturing 5-HT neurons, hence necessitating a reinterpret

11 abundance of two multiprotein modules within maturing adhesions, one regulated by Rap1 and one by ten

12 normal or ablated neurogenesis, we find that maturing adult-born neurons are crucial only when memory

13 These findings indicate that maturing adult-born neurons regulate both functional net

14 Excitability is enhanced in maturing adult-born neurons, spurring the hypothesis tha

15 After a decade or more, maturing adults migrate back to the Sargasso Sea, spawn,

16 influenced by the proportions of naive cells maturing along regulatory T cell, Th1, Th2, or Th17 phen

17 This pattern is unique to the maturing and adult nervous system, as it requires the in

18 stems, beginning of integration between late maturing and early maturing brain structures, and develo

19 es, we compared functional responses of both maturing and established granule cells.

20 iding in phagosomes, which they prevent from maturing and fusing with lysosomes.

21 Biofabrication is maturing and growing, and scientists with different back

22 lls that have exited the bone marrow without maturing and have been shown to suppress CD4(+) and CD8(

23 ng chondrocytes in its upper zones (UGP) and maturing and hypertrophic chondrocytes in its lower zone

24 y, the analysis of IgM and IgD expression by maturing and mature naive B cells demonstrated an elevat

25 However, such studies are maturing and may foster clinical research, with opportun

26 We provide evidence of a maturing and more competitive stem cell workforce and di

27 The open access movement is maturing and must be embraced in some format.

28 sults should aid in the development of early-maturing and productive Upland cultivars with superior f

29 production process that allowed the skins of maturing animals of several species to be rendered into

30 During maturing antibody responses the increase in affinity for

31 initiation and becomes more dense with time, maturing as early as 14 days after wounding.

32 Although genetic therapies are maturing as the rules of bioenergetic genetics are clari

33 lterations, that preferentially impact later-maturing associative cortices important for higher cogni

34 The elevated susceptibility of early maturing axons to ischemic injury described here may sig

35 chpilot and Rim-binding protein complexes at maturing AZs.

36 tion and mutation process takes place in the maturing B cell and is responsible for the diversity of

37 erarchy, from stem cells, B-cell precursors, maturing B cells in the germinal center, and circulating

38 tion Tshz1 in the transcriptional network of maturing beta-cells and suggest that its dysregulation c

39 lic heterogeneity and proliferation within a maturing biofilm population, rather than a subtractive p

40 pendent effects in HSC and distinct roles in maturing blood cells.

41 the formation of a smooth muscle layer in a maturing blood vessel.

42 is study aimed to assess their impact on the maturing brain 20 to 30 years after diagnosis, providing

43 integration between late maturing and early maturing brain structures, and development of effective

44 ation factors and is highly expressed in the maturing brain.

45 RF-7 isoforms also occurred in the brains of maturing C57BL/6J mice.

46 the aorta at stem sites where they surround maturing CAs in both mouse and human hearts.

47 ocess of heme a biosynthesis and transfer to maturing CcO.

48 role of endocytic membrane remodeling in the maturing cell plate while the plate is stabilized by cal

49 In wild-type sepals, ROS accumulate in maturing cells and limit organ growth, suggesting that R

50 it the renin phenotype expressed Akr1b7, and maturing cells expressed angiogenic factors necessary fo

51 These maturing cells transition from a proliferative state to

52 n a delayed manner during dendritogenesis in maturing cerebellar granule neurons (CGNs).

53 As maturing CGNs become more hyperpolarized, NFATc4 binding

54 erweight/obese children (RR = 0.81), earlier maturing children (RR = 0.93), and those who spent more

55 J is the major ribonuclease responsible for maturing chloroplast mRNA 5' termini, with RNA-binding p

56 quired to control FGFR1-Ras-ERK signaling in maturing chondrocytes in vivo.

57 expressed in condylar chondroprogenitors and maturing chondrocytes that also expressed the Indian hed

58 everal hours after p107 dephosphorylation in maturing chondrocytes.

59 HIF-2 is a potent regulator of autophagy in maturing chondrocytes.

60 late neurons (SPNs) form one of the earliest maturing circuits in the cerebral cortex and are crucial

61 ng across stable cisternae and the other on "maturing" cisternae that carry cargo forward while progr

62 rnalized cargos are known to accumulate into maturing clathrin-coated pits (CCPs), whether and how ca

63 diator in augmenting metabolic energetics in maturing CMs.

64 or lacking from mature CNS axons by studying maturing CNS neurons in vitro.

65 capacity, which declines developmentally in maturing CNS neurons.

66 ended on factors having strong expression in maturing cone precursors and crucial roles in retinoblas

67 e life science trajectory, in the context of maturing conventional small-molecule product pipelines a

68 t for heme a biosynthesis and/or transfer to maturing cytochrome c oxidase.

69 Culture with a DC-maturing cytokine cocktail (IL-1beta, IL-6, TNF-alpha, a

70 n the impact of PGE(2) on CCR7 expression in maturing DCs and demonstrate a novel mechanism of regula

71 Based on a large-scale proteome analysis of maturing DCs, we identified the GPI-anchored protein sem

72 Second, DD blocked Stat3 phosphorylation in maturing DCs.

73 ell activation by dasatinib, pretreatment of maturing dendritic cells (DCs) with dasatinib strongly e

74 is improved by targeting vaccine proteins to maturing dendritic cells (DCs) within mAbs to DC recepto

75 this hurdle, proteins are being targeted to maturing dendritic cells (DCs) within monoclonal antibod

76 tic relationships that reflects a strong and maturing discipline.

77 s to the middle temporal (MT) area, an early maturing dorsal stream cortical field, and which bypass

78 tlantic bluefin tuna are managed as an early-maturing eastern stock, which spawns in the Mediterranea

79 yocyte markers were ectopically expressed by maturing Eklf-null EryP.

80 cell fate of early endocrine precursors and maturing endocrine-restricted cells, respectively.

81 Some maturing endocrine-restricted NeuroD1(+) cells in the pa

82 esis of BMP on the inner luminal membrane of maturing endosomes may possibly produce budded vesicles

83 siRNA release occurred invariably from maturing endosomes within ~5-15 min of endocytosis.

84 MYB118 is transcriptionally induced in the maturing endosperm, and seeds of myb118 mutants exhibit

85 DSTYK is highly expressed in the maturing epithelia of all major organs, localizing to ce

86 nd CH235.12 (week 323, 90%) demonstrated the maturing epitope to focus on the conformationally invari

87 ce died by E16.5, with profound reduction of maturing erythroblast populations within the fetal liver

88 In particular, maturing erythroblasts required Spi2A for cytoprotection

89 e via an EPOR-Spi2A serpin-cathepsin axis in maturing erythroblasts, with lysosomal cathepsins as nov

90 ear condensation, a morphological feature of maturing erythroblasts.

91 erythropoietin (EPO) to favor iron supply to maturing erythroblasts.

92 specialized roles supporting enucleation of maturing erythroblasts.

93 rlying the high-level expression of GATA1 in maturing erythroid cells have been studied extensively,

94 h PGC-1 proteins are abundantly expressed in maturing erythroid cells.

95 tors is associated temporally with a wave of maturing erythroid precursors in marrow and with emergen

96 er these trophic factors strengthen juvenile maturing extraocular muscles and gain insight into mecha

97 Vinculin slowed F-actin flow in maturing FA to establish a lamellipodium-lamellum border

98 l subset assembled in or was captured within maturing FA, and this behavior was promoted by active Ra

99 Within maturing fibres of host zebrafish embryos, our analysis

100 t describes the mechanical properties of the maturing fibrin network based on it structural quantitie

101 A constitutive model for the maturing fibrin network is developed that captures the e

102 lourished from almost nothing into a rapidly maturing field of research.

103 vasive, light delivery probes leveraging the maturing field of silicon photonics, enabling massively

104 Computational enzymology is a rapidly maturing field that is increasingly integral to understa

105 perspective on the future directions of this maturing field, including the prospects for advanced thi

106 evolution favoring faster-growing or earlier-maturing fish, or a combination of these processes.

107 s, we determined gene expression patterns in maturing flow-sorted 5-HT neurons and the temporal requi

108 atushka2S produced the brightest and fastest maturing fluorescence in all experimental setups.

109 motor response control regions provide early-maturing foundational capacities and suggest that some e

110 We identified fast-maturing FPs from this set that yielded the highest sign

111 h CD8 T cells are known to acquire KIRs when maturing from naive to terminally differentiated cells,

112 The study of de novo protein-coding genes is maturing from the ad hoc reporting of individual cases t

113 mponents of behavior mediated in part by the maturing frontal lobe.

114 this study, we demonstrate that hPSC-derived maturing GABAergic interneurons (mGINs) migrate extensiv

115 ally isolated inhibitory inputs develop onto maturing GCs.

116 In adolescence, early-maturing girls displayed higher levels of self-reported

117 Nevertheless, early-maturing girls, particularly those with a history of ado

118 Recombinant wild-type SEMA3E protected maturing GnRH neurons from cell death by triggering a pl

119 mpare here tFTs composed of different faster-maturing green fluorescent proteins (greenFPs) while kee

120 ding osteal macrophages, predominated in the maturing hard callus.

121 ardial organ migrate, adhere and envelop the maturing heart, forming the epicardium.

122 rine progenitor cells and next maintained in maturing hormone-expressing cells during pancreas develo

123 reported to be continuously up-regulated in maturing human primary erythroblasts.

124 rases assist in assembling the H-cluster and maturing hydrogenases into their catalytically active fo

125 ecular mimicry, mAb 2D10 was isolated from a maturing immune response elicited against methyl alpha-d

126 of innate immunity and the implications of a maturing immune system for trauma-related interventions

127 CD8(+) T cells maturing in CD4-sufficient hepatocyte recipients develop

128 However, CD8(+) T cells, maturing in the absence of CD4(+) T cells, mediate cytot

129 CD4 thymocytes maturing in the altered thymic epithelial environment of

130 Dendritic cells maturing in the presence of sCD200 serum could induce po

131 y of a cohort of NFI-dependent genes in CGNs maturing in vivo.

132 hifts towards young, small, and more quickly maturing individuals.

133 esearch has focused on the implications of a maturing innate immune system for the inflammatory respo

134 on ( 40% tyrosine hydroxylase (TH) positive, maturing into 25% cells exhibiting mDA neuron-like spiki

135 s physiologically relevant and is capable of maturing into a complete 50S particle.

136 riteria, it also suggested the potential for maturing into a predictive algorithm if provided with a

137 Sporulation involves an inner cell maturing into a spore and an outer cell nurturing the de

138 y arresting the normal process of phagosomes maturing into acidified phagolysosomes.

139 , but not veins, contain pre-HSCs capable of maturing into dHSCs in the presence of exogenous interle

140 transdifferentiating into myofibroblasts or maturing into lens fiber cells.

141 ls (OPCs) can repair demyelinated lesions by maturing into myelin-producing oligodendrocytes.

142 human genome copy number variation (CNV) are maturing into useful resources for complex disease genet

143 In conclusion, vaspin expression by maturing KCs modulates cutaneous immune responses and ma

144 a2 or Exo1 is required to supplement FEN1 in maturing lagging strands at telomeres.

145 ese processes do not occur in the absence of maturing leaves but can be restored by application of C(

146 the phosphorylation of lamin A/C and LFCD in maturing LFCs in vivo, as well as in dividing HLECs.

147 AERD is associated with eosinophils maturing locally in a high IFN-gamma milieu.

148 The fusion of maturing low-cost lithographic techniques with newer opt

149 to mediate transport from early endosomes to maturing LROs.

150 cell reconstitution, particularly within the maturing M1 and M2 NK-cell subsets in association with e

151 septin GTPases associate preferentially with maturing macropinosomes in a phosphatidylinositol 3,5-bi

152 line in the cell replacement capacity of the maturing mammalian ear.

153 We globally assessed IR in primary maturing mammalian erythroid and megakaryocyte (MK) line

154 ex, dynamic IR pattern has been described in maturing mammalian granulocytes, but it is unknown wheth

155 d progressive DNA methylation differences in maturing megakaryocytes.

156 endosomal tubular transport intermediates to maturing melanosomes and thereby promote cargo delivery

157 pathway from recycling endosomal domains to maturing melanosomes.

158 es made frequent and prolonged contacts with maturing melanosomes; in contrast, tubules from BLOC-2-d

159 s undergoing the morphological transition of maturing mesoderm, as we demonstrate with a direct measu

160 ut precludes discriminating neovascular from maturing microvasculature.

161 om its development and early challenges to a maturing modality that has provided unique insights into

162 ulate the expression of >8000 transcripts in maturing mouse dendritic cells (DCs) via regulation of s

163 In the maturing mouse enamel, the association of these residual

164 eloblastin and amelogenin interaction in the maturing mouse enamel.

165 amily localize to the developing acrosome of maturing mouse germ cells.

166 In summary, cpPNPase has a major role in maturing mRNA and rRNA 3'-ends, but also participates in

167 The scanning of maturing mRNAs by ribosomes plays a key role in the mRNA

168 Maturing MS/DB neurons in naive brain slices PD 4-16 sho

169 anglion cells, and late-stage progenitors or maturing Muller glia.

170 Maturing mutissues increased systolic force while simult

171 lated along the length of the stereocilia in maturing Myo6 mutant mice.

172 nt of actin regulators cortactin and Arp3 to maturing N-cadherin junctions of differentiating cells,

173 Wid and Wt1 are coexpressed in podocytes of maturing nephrons.

174 An alternative hypothesis posits that maturing neurons "indirectly" contribute to memory encod

175 lurane significantly decreased the number of maturing neurons and increased the number of astrocytes

176 ological development of synaptic inputs onto maturing neurons has restricted our understanding of how

177 related activity patterns among ensembles of maturing neurons in the lateral geniculate nucleus (LGN)

178 l neurons is required for the integration of maturing neurons into the coordinated CPG network.

179 in contrast to astrocytes or young neurons, maturing neurons possess negligible Nrf2-dependent antio

180 llowing downregulation of programming TFs in maturing neurons remains unknown.

181 esults identify a unique strategy evolved by maturing neurons that uses a single microRNA to inhibit

182 endritogenesis-associated gene expression in maturing neurons through delayed binding of NFI proteins

183 as developmentally regulated specifically in maturing neurons, correlating with HBII-85 nucleolar acc

184 ms to be required for proper development: in maturing neurons, ectopic Nrf2 expression inhibits neuri

185 e into robust typological distinctions among maturing neurons.

186 ew enhancers bound by clusters of Onecut1 in maturing neurons.

187 y before birth, both in progenitor cells and maturing neurons.

188 elopment may be profoundly influenced by the maturing neurovascular and autoregulatory systems of the

189 Gene expression in maturing neutrophils requires combinatorial actions of l

190 droxyacetone (DHA) to methylglyoxal (MGO) in maturing New Zealand manuka honey, the kinetics of forma

191 ivering cells into the lung scaffold and for maturing newly formed endothelium through co-seeding of

192 how sequential conformational changes in the maturing nucleocapsid control the ordered binding, first

193 Nug2 binds the inter-subunit face of maturing, nucleoplasmic pre-60S particles, and the locat

194 An involvement in the maturing of cytolytic peptides is very likely, due to hi

195 rst example of a PQM protease, essential for maturing of spider venom neurotoxins.

196 f recombinant toxic peptides, adapted to the maturing of spider venom toxins.

197 Maturing of the cream caused a transition from alpha- to

198 s myelination in OLP-neuron co-cultures, and maturing oligodendrocytes in spinal cord white matter di

199 During Drosophila oogenesis, RCs connect the maturing oocyte to nurse cells supporting its growth.

200 Because maturing oocytes and early embryos lack appreciable tran

201 In the maturing oocytes and eggs of the frog Xenopus laevis, hi

202 Isolated maturing oocytes autonomously synthesized betaine in vit

203 also describes the stage specific growth of maturing oocytes within the ovary and permits the presen

204 38 and Rab32, to facilitate transport to the maturing organelle.

205 cles containing dense granule cargo with the maturing organelle.

206 As for a maturing organism, PCa's epigenome is plastic and evolve

207 stress during intrauterine development of a maturing organism.

208 therefore restrict regenerative capacity in maturing organisms without compromising gene functions r

209 d deletion of RBPjk in skeletal progenitors, maturing osteoblasts, and committed chondrocytes.

210 e cells, and this concept may be expanded to maturing other PSC-derived cell types, including those c

211 response phase above 10 Hz when present: (1) maturing (P7-P9) type I hair cells acquired low-voltage-

212 fferentiation process and drive migration of maturing PCs through the dark zone and out of the GC.

213 However, in maturing pea (Pisum sativum) seeds, the level of the chl

214 late maturers had caught up with their early-maturing peers.

215 s by imparting a specific structure into the maturing peptide that facilitates the ensuing reaction.

216 Endogenous caveolin-1 was recruited to maturing phagolysosomes in RPE cells in culture.

217 s (associated with an inability to evade the maturing phagosome) and were significantly attenuated in

218 We show that in DCs, maturing phagosomes extend numerous long tubules several

219 se (NOX2), which generates superoxide within maturing phagosomes, has also been shown to regulate act

220 ith the surfaces of extending pseudopods and maturing phagosomes, whereas inactivating guanosine trip

221 ection and progressively degrade them within maturing phagosomes.

222 ctor-free derivatives exhibited an expedited maturing phenotype with canonical responsiveness to adre

223 pressed with rhodopsin and red cone opsin in maturing photoreceptors and demonstrate that Rx binds to

224 o, this regulation occurs selectively in the maturing plexus of the mouse developing retina, where An

225 ialylation of nephrin and podocalyxin in the maturing podocyte where it is required during the format

226 avonoids and their transport to the adjacent maturing pollen as the coat to serve various functions.

227 Cdc42 signaling induce the rearrangement of maturing pouch cells into bilayers through junctional lo

228 signaling increases junctional E-cadherin in maturing pouches.

229 The later-maturing prefrontal cortex is more sensitive to adolesce

230 lts' but not adolescents' engagement of late-maturing prefrontal cortex regions correlated positively

231 ccumulation of presynaptic material at large maturing presynaptic boutons.

232 tive to adolescent exposure than the earlier-maturing, primary somatosensory cortex.

233 ion of this membrane network is conserved in maturing primitive and definitive erythroblasts despite

234 We conclude that maturing primitive erythroblasts initially navigate the

235 surface phenotype and molecular identity of maturing primitive erythroid cells.

236 In these embryos, the maturing pulmonary venous plexus does not anastomose uni

237 number and total dendritic branch length in maturing rat neurons and is sufficient to promote dendri

238 of adult neurogenesis--but was restricted to maturing, rather than proliferating, neuronal precursor

239 tabolic changes that uniquely characterize a maturing red blood cell.

240 ry of moderate levels of IDUAe1 derived from maturing red blood cells, 2% to 3% of normal brain IDUA

241 Ts have been constructed by combining slower-maturing red fluorescent proteins (redFPs) with the fast

242 proteins (greenFPs) while keeping the slower-maturing redFP constant (mCherry).

243 on of the miRNA-processing enzyme Dicer from maturing renal tubules produces tubular and glomerular c

244 INGS: Because tortoises are long-lived, late-maturing reptiles, we assessed the progress of the trans

245 ates expression of Rax in the developing and maturing retina.

246 ystem, little is known about their action in maturing retina.

247 In maturing retroviral virions, CA protein assembles to for

248 as a marker for functional abnormalities in maturing rod photoreceptors.

249 sis of the transport of PAH in postnatal and maturing rodent kidney.

250 -scale 'elephant trap' predominantly removes maturing savanna trees in the 5-9 m height range.

251 y transferred from growing inflorescences to maturing seeds, allowing offspring control over maternal

252 Although maturing sequencing technologies allow these experiments

253 hat CD16 is rapidly shed from the surface of maturing slanDCs, resulting from the combined action of

254 Kdm3a localizes to cytoplasmic structures of maturing spermatids affected in Kdm3a mutant mice, which

255 the epididymal fluid can be cytotoxic to the maturing spermatozoa resulting in male infertility.

256 nearly perfect gain scaling by virtue of the maturing spike-generating currents alone.

257 , vascular bundles and rind dissected from a maturing stalk internode of sugarcane, identifying ten c

258 ferentially in the storage parenchyma of the maturing stalk internode.

259 of water soluble carbohydrates (WSCs) in the maturing stem of temperate cereals and are an important

260 pment of top-down inhibitory modulation from maturing subcortical and cortical brain networks.

261 were more likely than adults to engage early-maturing subcortical structures during threat/safety dis

262 laced from maturing 40S ribosomes, if or how maturing subunits are assessed for fidelity, and what pr

263 luorescent proteins (redFPs) with the faster-maturing superfolder green fluorescent protein (sfGFP).

264 e thymus, driving immunological tolerance in maturing T cells.

265 unlike its Kit(+) "stage E1" progenitors, or maturing Ter119(+) "stage E3" progeny) proved to selecti

266 also show that TgCPL is capable of partially maturing TgCPB in vitro.

267 embly of this nanomaterial by expressing and maturing the EcHyd-1 hydrogenase prior to expression of

268 y weak endogenous ligands produce signals in maturing thymocytes, we generated soluble monomeric and

269 er B cells, bone marrow progenitor cells, or maturing thymocytes.

270 PCR, and show that expression is confined to maturing thymocytes.

271 ons in a stereotypical temporal order before maturing to actively fire action potentials, undergo syn

272 rive in the lungs during a late fetal stage, maturing to alveolar macrophages through a prealveolar m

273 )Foxp3(+) cells that are highly efficient at maturing to CD25(+)Foxp3(+) cells in response to IL-2.

274 Biomarker development is maturing to include a wide array of molecular measuremen

275 B cells maturing to produce autoantibodies in systemic autoimmun

276 eeds are overtly identical to the wild type, maturing to similar size and weight, and in developmenta

277 Nutritional metabolomics is rapidly maturing to use small-molecule chemical profiling to sup

278 ogical recording and regulation tools and is maturing toward applications ranging from life sciences

279 pool," by contrast, contains cells that are maturing toward early differentiation and are likely tra

280 red for downregulation of ERBB2 signaling in maturing trabeculae.

281 inhibition of the CaN/NFATc pathway in CGNs maturing under physiological nondepolarizing conditions

282 ctile waves and their synchronization within maturing, unlabeled induced pluripotent stem cell-derive

283 alves, suggesting that accumulating Axin2 in maturing valves represents negative feedback that restra

284 increased because of the shift toward longer-maturing varieties during last three decades in the Chin

285 We report that modern, longer-maturing varieties have extended the growing period by a

286 ncreased requirement for water by the longer-maturing varieties.

287 ar macromolecular flux and the morphology of maturing vascular segments.

288 uring the lytic phase of the life cycle, the maturing viral particles undergo orchestrated translocat

289 r a model whereby capsid assembly within the maturing virion is dependent on the formation of a speci

290 the immature virion) and CA assembly (in the maturing virion).

291 The transient persistence of CA-SP in maturing virions and the identification of second-site m

292 ur results indicate that efficient egress of maturing virions and, in agreement with studies on murin

293 uggests that capsids assemble de novo inside maturing virions from dissociated capsid (CA) protein, b

294 psid protein (CA) to assemble de novo inside maturing virions.

295 increasing amounts later in infection in the maturing viroplasm, suggesting a conversion of dNSP2 int

296 spawns in the Mediterranean Sea, and a late-maturing western stock, which spawns in the Gulf of Mexi

297 roposed quality measures for colonoscopy are maturing, with increasing emphasis on adenoma detection

298 yadenylation-induced translation of mRNAs in maturing Xenopus oocytes is the cytoplasmic polyadenylat

299 imilar ETC remodeling and glycogen uptake in maturing Xenopus oocytes, suggesting that these processe

300 Similar to M phase progression in maturing Xenopus oocytes, the destruction of CPEB during