ライフサイエンスコーパス: maturity-onset diabetes

1 e 1, juvenile diabetes) or relative (type 2, maturity-onset diabetes).

2 diseases including the systemic amyloidoses, maturity onset diabetes, Alzheimer's disease and transmi

3 on 17q12, previously shown to be mutated in maturity-onset diabetes, as well as in a subset of pedia

4 the glucokinase gene have been identified in maturity onset diabetes in the young, a particular form

5 Maturity-onset diabetes mellitus of the young (MODY) is

6 Maturity onset diabetes of the young (MODY) is an autoso

7 s developed diabetes with characteristics of maturity onset diabetes of the young (MODY), regardless

8 due to mutations in known genes involved in maturity onset diabetes of the young (MODY).

9 recently reported locus for a third gene for maturity onset diabetes of the young (MODY).

10 inantly inherited form of diabetes, known as maturity onset diabetes of the young (MODY).

11 weight, transient neonatal hypoglycemia, and maturity onset diabetes of the young (MODY).

12 Mutations of the HNF1alpha gene underlie maturity onset diabetes of the young (MODY3) in humans.

13 ctively: defects in Pdx-1 or HNF4alpha cause maturity onset diabetes of the young (MODY4 and 1, respe

14 x 1 (Pdx1) are associated with both T2DM and maturity onset diabetes of the young (MODY4), and low le

15 ons in HNF4A were identified as the cause of Maturity Onset Diabetes of the Young 1 (MODY1) two decad

16 human HNF4alpha gene found in patients with maturity onset diabetes of the young 1 (MODY1).

17 Alterations in KLF11 function result in maturity onset diabetes of the young 7 (MODY7) and neona

18 KLF) transcription factor, mutated in French maturity onset diabetes of the young patients (MODY7), r

19 ndividuals with an extreme form of diabetes (maturity onset diabetes of the young type 1, caused by m

20 lian glucose sensor that is mutated in human maturity onset diabetes of the young type 2 and the targ

21 or 1-alpha (HNF1A), the gene responsible for maturity onset diabetes of the young type 3 (MODY3).

22 uclear factor-1alpha (HNF-1alpha) gene cause maturity onset diabetes of the young type 3, a form of t

23 r-beta-inducible early gene 2) and MODY VII (maturity onset diabetes of the young VII), regulates tra

24 form of diabetes and suggest that KPD, like maturity onset diabetes of the young, is a rare, phenoty

25 odenal homeobox 1 (PDX1) are associated with maturity onset diabetes of the young, type 4 (MODY4) and

26 Maturity Onset Diabetes of the Young-type 3 (MODY-3) has

27 diabetes, as has been shown in patients with maturity onset diabetes of the young.

28 ntly inherited form of human diabetes called Maturity Onset Diabetes of the Young.

29 Type 1 maturity onset diabetes of young (MODY), which is charac

30 Maturity onset diabetes of youth (MODY) occurs in childr

31 Maturity onset diabetes of youth in whites presents subt

32 in the VNTR (CEL14R) or C563fsX673 CEL (CEL maturity onset diabetes of youth with a deletion mutatio

33 been recently noted in some individuals with maturity-onset diabetes of the young (MODY) and in some

34 MODY3) account for the largest proportion of maturity-onset diabetes of the young (MODY) cases in the

35 tive distribution of the 90 families fitting maturity-onset diabetes of the young (MODY) criteria was

36 The potential contribution of maturity-onset diabetes of the young (MODY) genes to NID

37 t to which common variation in the six known maturity-onset diabetes of the young (MODY) genes, which

38 a monogenic form of diabetes that resembles maturity-onset diabetes of the young (MODY) in many resp

39 We sequenced seven genes for maturity-onset diabetes of the young (MODY) in well-phen

40 Maturity-onset diabetes of the young (MODY) is a clinica

41 Maturity-onset diabetes of the young (MODY) is a genetic

42 The disease maturity-onset diabetes of the young (MODY) is a genetic

43 Carboxyl-ester lipase (CEL) maturity-onset diabetes of the young (MODY) is a monogen

44 Maturity-onset diabetes of the young (MODY) is a subtype

45 Maturity-onset diabetes of the young (MODY) is a subtype

46 associated with MODY with reduced penetrance.Maturity-onset diabetes of the young (MODY) is the most

47 ave suggested that variants in the genes for maturity-onset diabetes of the young (MODY) may confer s

48 ht to identify INS mutations associated with maturity-onset diabetes of the young (MODY) or nonautoim

49 tability GK mutants that explain in part the maturity-onset diabetes of the young (MODY) phenotype in

50 One form of maturity-onset diabetes of the young (MODY) results from

51 tions in its prototypical member HNF1A cause maturity-onset diabetes of the young (MODY) type 3.

52 loss-of-function HNF1A mutations causal for maturity-onset diabetes of the young (MODY) would displa

53 e encoding this enzyme are a common cause of maturity-onset diabetes of the young (MODY), a form of n

54 Maturity-onset diabetes of the young (MODY), a single-ge

55 sed before 2 years of age, 296 probands with maturity-onset diabetes of the young (MODY), and 463 pat

56 tor (HNF)-1beta are the cause of one form of maturity-onset diabetes of the young (MODY), type 5 (MOD

57 To find novel genetic causes of maturity-onset diabetes of the young (MODY), we sequence

58 clear factor (HNF)-4alpha are known to cause maturity-onset diabetes of the young (MODY), which is ch

59 eened 18 diabetic probands with unelucidated maturity-onset diabetes of the young (MODY).

60 reviously been identified as a rare cause of maturity-onset diabetes of the young (MODY).

61 the HNF1A gene are the most common cause of maturity-onset diabetes of the young (MODY).

62 n the alternatively spliced HNF4A gene cause maturity-onset diabetes of the young (MODY).

63 nuclear factor-4alpha (HNF-4alpha) result in maturity-onset diabetes of the young (MODY).

64 a group of unrelated Japanese subjects with maturity-onset diabetes of the young (MODY).

65 r (HNF)-1alpha are the most common causes of maturity-onset diabetes of the young (MODY).

66 se a mild hereditary form of diabetes termed maturity-onset diabetes of the young (MODY)2 or GCK-MODY

67 nd HNF-1beta are the causes of four forms of maturity-onset diabetes of the young (MODY1 and 3-5, res

68 The underlying gene was mapped to the maturity-onset diabetes of the young (MODY2) homology re

69 Maturity-onset diabetes of the young (MODY3), a monogeni

70 s in the HNF-1alpha gene are responsible for maturity-onset diabetes of the young (MODY3), which is c

71 r (HNF)-1 alpha are the cause of one form of maturity-onset diabetes of the young (MODY3).

72 or (HNF)-1alpha are the cause of one form of maturity-onset diabetes of the young (MODY3).

73 s in the HNF-4alpha gene are responsible for maturity-onset diabetes of the young 1 (MODY1), which is

74 ha (HNF-4alpha), the gene that is mutated in Maturity-Onset Diabetes of the Young 1 (MODY1).

75 We have also screened the gene for maturity-onset diabetes of the young 1, hepatic nuclear

76 Maturity-onset diabetes of the young 3 (MODY3) is a type

77 Mutations in HNF1A are associated with maturity-onset diabetes of the young 3 (MODY3).

78 of HNF1alpha leads to development of MODY3 (maturity-onset diabetes of the young 3).

79 defect of beta-cell function referred to as maturity-onset diabetes of the young 4.

80 in two forms of early-onset type 2 diabetes (maturity-onset diabetes of the young [MODY]), MODY3 and

81 use autosomal forms of early-onset diabetes (maturity-onset diabetes of the young [MODY]).

82 uclear factor (HNF)-4alpha gene (RW pedigree/maturity-onset diabetes of the young [MODY]-1) have dimi

83 nuclear factor (HNF)-1alpha gene mutations (maturity-onset diabetes of the young [MODY]-3) is charac

84 e six genes causing the most common forms of maturity-onset diabetes of the young allows us to infer

85 GK levels are lowered in patients with maturity-onset diabetes of the young and in some diabeti

86 Maturity-onset diabetes of the young comprises a number

87 r factor 1alpha (HNF-1A) are associated with maturity-onset diabetes of the young form 3 (MODY 3) and

88 l-dominant type 2 diabetes unlinked to known maturity-onset diabetes of the young genes.

89 ely that chromosome 10p12.1-p13 may harbor a maturity-onset diabetes of the young or type 2 diabetes

90 Linkage analysis in 14 nonglucokinase maturity-onset diabetes of the young pedigrees showed a

91 s in the HNF-4A gene are responsible for the maturity-onset diabetes of the young type 1.

92 GK and several mutant forms associated with maturity-onset diabetes of the young type 2 (MODY-2) wer

93 potent stem cells (iPSCs) from subjects with maturity-onset diabetes of the young type 2 (MODY2), whi

94 Maturity-onset diabetes of the young type 3 (MODY3) is c

95 Mutations in HNF-1alpha are associated with maturity-onset diabetes of the young type 3 (MODY3), and

96 An inherited form of diabetes, maturity-onset diabetes of the young type 3 (MODY3), res

97 e nuclear factor 1alpha (HNF-1alpha) lead to maturity-onset diabetes of the young type 3 as a result

98 DX1) are linked to human type 2 diabetes and maturity-onset diabetes of the young type 4.

99 in the human HNF1B gene are associated with maturity-onset diabetes of the young type 5 (MODY5) and

100 omal dominant mutations of HNF-1beta develop maturity-onset diabetes of the young type 5 (MODY5) and

101 anged from congenital renal abnormalities to maturity-onset diabetes of the young type 5.

102 several potentially fatal diseases including maturity-onset diabetes of the young type II (MODY-II) a

103 le for monogenic forms of diabetes (notably, maturity-onset diabetes of the young), and, in patients

104 ctor (HNF)-1alpha and -1beta result in MODY (maturity-onset diabetes of the young).

105 e metabolic genes, have been correlated with maturity-onset diabetes of the young, a monogenic form o

106 Maturity-onset diabetes of the young, a monogenic form o

107 tly found in a white family with one form of maturity-onset diabetes of the young, MODY1.

108 are suspected or known to be associated with maturity-onset diabetes of the young, one is a gene-dese

109 dentified for rate monogenic forms of NIDDM: maturity-onset diabetes of the young, or MODY (which is

110 HNF-4alpha protein mutations are linked to maturity-onset diabetes of the young, type 1 (MODY1) and

111 uclear factor (HNF)-4alpha gene give rise to maturity-onset diabetes of the young, type 1 (MODY1).

112 at influence several human traits, including maturity-onset diabetes of the young, type 2 diabetes, l

113 Mutations of HNF-1beta cause maturity-onset diabetes of the young, type 5 (MODY5), wh

114 Maturity-onset diabetes of the young, type 8 (MODY8) is

115 f1 are associated with human diseases MODY5 (maturity-onset diabetes of the young, type V) and famili

116 d an association between HNF1B mutations and maturity-onset diabetes of the young.

117 ession and for the prevention of one form of maturity-onset diabetes of the young.

118 s important in beta-cell development, causes maturity-onset diabetes of the young.

119 Rare mutations in the HNF4alpha gene cause maturity-onset diabetes of the young.

120 lpha) mutations are the most common cause of maturity-onset diabetes of the young.

121 zed by a subset of mutations associated with maturity-onset diabetes of the young.

122 of progression of glycemia in patients with maturity-onset diabetes of the young.

123 of non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young; gene named MODY1).

124 T1D-GRS was highly discriminative of proven maturity-onset diabetes of young (MODY) (n = 805) and T1

125 >G) are linked to: T2D, depression, anxiety, maturity-onset-diabetes-of the young 3/MODY3, obesity, w