ライフサイエンスコーパス: maximal activation

1 lifetime of the complex necessary to achieve maximal activation.

2 orylation, synergize functionally to achieve maximal activation.

3 ing increased Ca(2+) sensitivity but reduced maximal activation.

4 All three Nck SH3 domains are required for maximal activation.

5 s the only compound tested that demonstrated maximal activation.

6 cing signals and IFN-gamma are necessary for maximal activation.

7 regulatory factors in addition to SREBPs for maximal activation.

8 rotein combinations show different levels of maximal activation.

9 K required a change to a pH lower than 2 for maximal activation.

10 nd the hydrophobic motif site (Ser-473), for maximal activation.

11 n, indicating these two signals converge for maximal activation.

12 r Ala, highlighting that Trp is required for maximal activation.

13 ess could not be induced, suggesting already maximal activation.

14 ing phosphorylation of the kinase domain and maximal activation.

15 to integrate multiple cooperative inputs for maximal activation.

16 d increases the actin concentration for half-maximal activation.

17 but a length of 10 nucleotides is needed for maximal activation.

18 but not Smad1, significantly contributes to maximal activation.

19 that hyperpolarization to -147 mV gives half-maximal activation, 123 mV more negative than WT.

20 dy, the cGMP concentration required for half-maximal activation (A(50)) of wild-type PKG type Ibeta (

21 ensembles was recruited incrementally, with maximal activation achieved after four laps a day for 4

22 decane, a lipid-solubilizing agent, with 50% maximal activation achieved at approximately 10 microM D

23 ed NF-kappaB in a dose-dependent manner with maximal activation after 2-4 h.

24 equency and amplitude from the location with maximal activation and from the location of the MRS voxe

25 Half-maximal activation and inactivation occurred at -23.9 an

26 We examined the influence of k(off) on maximal activation and relaxation in myofibrils because

27 Instead, maximal activation and thus full-range control of kinase

28 rgoing infection with B. bacilliformis, with maximal activation and translocation to the plasma membr

29 , which requires micromolar calcium for half-maximal activation, and the m-calpain, or calpain II, wh

30 ant Y1771A, BTX shifted the voltage for half-maximal activation approximately 40 mV in the hyperpolar

31 rmed these 4-AP-sensitive currents with half maximal activation at -13.85 +/- 1.17 mV and half maxima

32 activates and inactivates rapidly with half-maximal activation at -18 mV and half-maximal fast inact

33 ctivating and inactivating current with half maximal activation at -27.08 +/- 3.48 mV and -25.51 +/-

34 ctance showed a threshold at -50 mV and half-maximal activation at -81 mV.

35 phosphorylated recombinant enzyme, with half-maximal activation at 0.16 mM, which results in a decrea

36 imited range of concentrations of PCMB, with maximal activation at 0.3-1 mM.

37 operative dose-dependent manner, with a half-maximal activation at 0.47 microM and a maximal increase

38 equation with a slope factor of 2.5 and half-maximal activation at 1.6 microM intracellular Ca2+.

39 romoted adducin binding to F-actin with half-maximal activation at 110 nM.

40 oximately 200 microM phospholipid, with half-maximal activation at 15-20 microM.

41 n, with a threshold of 20-50 microM and half-maximal activation at 190 microM.

42 he Hill equation (Hill coefficient 2.7, half maximal activation at 2.0 muM [Ca(2+)](i)).

43 was facilitated by the free L2 domain (half-maximal activation at 3.3 microm L2).

44 orylated in response to 0.3 ng/ml IL-11 with maximal activation at 30 ng/ml IL-11.

45 ivity in promoting adducin binding with half-maximal activation at 50 nM.

46 essentially identical in EPI and ENDO (half-maximal activation at 9-10 mM [Na(+)](i) or approximatel

47 ram in the presence of Ca2+ and reaches half-maximal activation at about 3 x 10(-7) molar free Ca2+,

48 neurons in a dose-dependent manner with half-maximal activation at approximately 16 nM.

49 ey (HEK) 293 cells expressing GLIC show half-maximal activation at pH 6, close to the pK(a) of histid

50 IC1 is gated by external protons with a half-maximal activation at pHo 5.6 and a half-maximal inactiv

51 s of REGalpha-gamma chimeras were needed for maximal activation because exchanged carboxyl-terminal s

52 4-yl-PL between membrane leaflets, with half-maximal activation between 20 and 60 microM Ca2+ (satura

53 eviously reported, much more sensitive, with maximal activation by 1 nm CCK.

54 inactivation by 11 mV, shifts the V(1/2) for maximal activation by 40 mV, and reduces the voltage dep

55 The concentration for half-maximal activation by agonists was considerably reduced

56 Maximal activation by CRP HL159 KE101 KN52 EK58 is achie

57 sing discharge to increasing pressures, with maximal activation by crushing or tearing stimuli that c

58 ption 3 (STAT3) are known to be required for maximal activation by diverse stimuli.

59 lf-association defects and were required for maximal activation by ExsA.

60 With maximal activation by thrombin, 15 900 +/- 2800 molecule

61 rom both the calcium concentrations for half-maximal activation (Ca(1/2)) and the shift in the calciu

62 e calcium concentration associated with half-maximal activation (Ca(1/2)) of the Ca-ATPase, 290 +/- 1

63 hip revealed an [Ca2+]i required for 50 % of maximal activation (Ca50) of 0.95 +/- 0.08 microM, a Hil

64 reperfusion, the [Ca2+] required for 50% of maximal activation (Ca50) was increased in both intact (

65 ltured in low glucose (LG; 2.5 mm), the half-maximal activation concentration (A(0.5)) of glucose 6-p

66 The half-maximal activation concentration for glucose 6-phosphate

67 ked response was dose-dependent, with a half-maximal activation concentration of 4.8 nM.

68 ncentration, with Hill coefficients and half-maximal activation concentrations very close to the valu

69 Cation concentrations for half-maximal activation decrease by >100-fold with each incre

70 Ca50 (-log of [Ca(2+)]free required for half-maximal activation), decreased in McTnT1-44 (alpha-Tm) f

71 The difference in pCa required for half-maximal activation (DeltapCa50) at short and long SL was

72 rents in the same cell, but the time to half-maximal activation for MagNuM was about two to three tim

73 ween the two choriocarcinoma cell lines, but maximal activation in both cell lines resided within the

74 rotein phosphatases 1 and 2A decreased Ih at maximal activation in hippocampal CA1 pyramidal dendrite

75 f multiple input signals in order to achieve maximal activation in many effector molecules.

76 that Sp1 DNA binding sites are essential for maximal activation in Schwann cells.

77 At maximal activation in skeletal fibers, the W7 concentrat

78 [Ca(2+)]free concentration required for half-maximal activation), increased significantly at both sho

79 Maximal activation is pH- and FAD-dependent; two groups

80 rease in Ca(2+) spark frequency, with a half-maximal activation (K) of 1.1 micro M, a Hill coefficien

81 Compared with WT cGK, half-maximal activation (Ka) of mutant cGKs by cGMP was incre

82 We estimate that under conditions of maximal activation less than 15% of PERK molecules in th

83 ne phosphorylation decreased Ih amplitude at maximal activation (maximal Ih ), without altering HCN1

84 he amount of UreE provided is critical, with maximal activation observed at a concentration equal to

85 The maximal activation occurred at pH 6.5 to 6.8, and the cu

86 d similar concentration dependence with half-maximal activation occurring at 0.02 mol of pigment/mol

87 three Akt isoforms (Akt1 > Akt2 > Akt3) with maximal activation occurring at 2.5 min and returning to

88 ) increased sharply with raised [Ca(2+)](i), maximal activation occurring at a [Ca(2+)](i) of about 1

89 Half-maximal activation occurs at a PO2 of 24 mmHg (s.d., 2)

90 tes; their effects were dose-dependent, with maximal activation of 2.8- and 4.4-fold, respectively.

91 ly p46/54(JNK), p38(MAPK), and ERK-1/2, with maximal activation of 20-, 25-, and 3-fold, respectively

92 arger increases in promoter activity until a maximal activation of 5-fold is obtained.

93 r-abl and occurred rapidly, concomitant with maximal activation of a temperature-sensitive mutant of

94 The concentration of GABA producing half-maximal activation of A-type neurons is somewhat less (1

95 dulated the transporter, with a PO2 for half-maximal activation of about 41 mmHg (n = 3).

96 Maximal activation of actin-tropomyosin-myosin ATPase in

97 trast, Brn-3a and p53 co-operative to induce maximal activation of another p53 target gene encoding t

98 Early-morning exposure to UV also produced maximal activation of ataxia telangiectasia mutated and

99 Further analysis indicated that maximal activation of ATP hydrolysis by DnaK requires tw

100 ads to nearly complete dephosphorylation and maximal activation of BCKDC in heart, muscle, kidneys, a

101 In contrast, the half-maximal activation of bovine rod PDE6 required markedly

102 The combination also resulted in maximal activation of c-Jun kinase and IL-2 production.

103 AZ heterogeneity whereby the voltage of half-maximal activation of Ca(2+) influx ranged over approxim

104 and wheat germ calmodulin required for half-maximal activation of Ca(2+)-ATPase were tenfold and fou

105 not change during hypertonic depression, but maximal activation of Ca2+ current shifted to a more neg

106 ble of activating phosphodiesterase, and the maximal activation of calcineurin is reduced by 40% as c

107 Maximal activation of CCE did not require complete store

108 The maximal activation of CD14-70Z/3 cells by H. pylori LPS

109 jects infused with epinephrine, the ratio of maximal activation of coagulation and maximal activation

110 argeting of pl10* to the membrane results in maximal activation of downstream responses.

111 ivator CBP/p300, histone H4 acetylation, and maximal activation of E2F target genes.

112 at 1 microM paraquat was sufficient for half-maximal activation of each reporter fusion within 5 min

113 These studies show that Itk is required for maximal activation of early growth responses 2 and 3 and

114 Similarly, maximal activation of endogenous CRAC channels also fail

115 as PLCgamma, RasGAP, Shc, and SHP-2 and for maximal activation of Erk.

116 We also found maximal activation of ERK1/2 in the overexpressing cell

117 MAPK family including Erk1/2, JNK, and p38, maximal activation of Erk5 by G-CSF required the C-termi

118 tio of maximal activation of coagulation and maximal activation of fibrinolysis was reduced by >50%.

119 with other transcription factors to achieve maximal activation of gene expression.

120 0 minutes after platelet activation, whereas maximal activation of GP IIb/IIIa occurred within the fi

121 he Hamp1 promoter are also indispensable for maximal activation of hepcidin transcription.

122 show that Sufu plays a positive role in the maximal activation of Hh signaling that defines the vent

123 oncentration of IIC2-delta 3 to achieve half-maximal activation of IC1 was 0.8 and 1.3 microM when st

124 Maximal activation of ICl,ATP by ATPgammaS or PDBu occlu

125 4 and IRS-2 association is also required for maximal activation of IGF-I signalling and cell prolifer

126 atrial myocytes with 10 nM FSCPX reduced the maximal activation of IKAdo by 60% (7.9 +/- 0.2 to 3.2 +

127 Maximal activation of JNK by lipopolysaccharide requires

128 iments indicate that GCK is required for the maximal activation of JNK by LPS, lipid A, poly(IC), and

129 cent studies showed that Btk is required for maximal activation of JNK, a family of stress-activated

130 he C-terminal region of GLK are required for maximal activation of JNK.

131 Maximal activation of Jun amino-terminal kinase ( JNK) o

132 Half-maximal activation of kainate receptors in hippocampal n

133 tive in vehicle-treated rats produced a near-maximal activation of LC neurons of rats chronically adm

134 MPK, and in adipocytes, this is required for maximal activation of lipolysis.

135 We demonstrate that maximal activation of mitochondrial Ca2+ uptake is evoke

136 Half-maximal activation of mitochondrial Na(+)/Ca(2+) exchang

137 PKC was required for maximal activation of mitogen-activated kinase kinase 1,

138 Maximal activation of MMP-1 transcription requires the c

139 cts independently of its metabolism to allow maximal activation of mTORC1 by growth factors via a mec

140 e and allowing the firing rates required for maximal activation of muscle fibers to be generated by s

141 Demethylation is required for maximal activation of NF-kappaB.

142 combined effects of CpG-A plus IL-15 induced maximal activation of NK cells and further enhanced acti

143 al approach for the therapy of AML, aimed at maximal activation of p53-mediated apoptosis by concomit

144 creating a positive feedback loop to obtain maximal activation of p53.

145 d the Ca(2+) concentration required for half-maximal activation of PDP1 from 3 to 1 microM, but this

146 es, mediated by the WDXNWD motif, results in maximal activation of phosphatase activity.

147 centration of calmodulin-2 required for half-maximal activation of phosphodiesterase is 2- and 6-fold

148 Maximal activation of phzA and phzR fused to lacZ and ui

149 l phosphorylation of IR or IRS-1 and <50% of maximal activation of PI3K, 2) a novel PI3K-independent

150 phosphorylation of RII subunits, persistent maximal activation of PKA results in a phosphatase-depen

151 phorylation of both residues is required for maximal activation of PKB.

152 Maximal activation of PKC by 100 nM phorbol 12, 13-dibut

153 Maximal activation of PKC by a brief application of phor

154 Maximal activation of PKC using the phorbol esters, 4bet

155 d the Ca(2+) concentration required for half-maximal activation of PLCdelta1 from 5.4 to 0.5 microM.

156 tion of phosphatidylserine resulting in half-maximal activation of protein kinase C.

157 GTP loading is similar for IL-8 and C5a, the maximal activation of Raf-1 and B-Raf is approximately 2

158 Depletion of endogenous C/EBPbeta decreased maximal activation of RCAN1-4 expression by calcineurin,

159 duced promoter demethylation is relevant for maximal activation of reelin and GAD67 transcription.

160 mitochondrial signaling complex required for maximal activation of RIG-I-mediated signaling, consisti

161 The maximal activation of rRNA transcription in vitro by 18-

162 lasmic shuttling of mTOR is required for the maximal activation of S6K1.

163 Thus, HNO increases the maximal activation of SERCA via S-glutathiolation at cys

164 either Y343 or Y401 is sufficient to mediate maximal activation of STAT5; tyrosine residues Y429 and

165 erge with Pyk2-dependent pathways to provide maximal activation of Stat5B.

166 by independent protein kinase activities for maximal activation of target gene transcription.

167 Phosphorylation at this site is required for maximal activation of the actin-activated Mg2+-ATPase ac

168 K activity has been shown to be required for maximal activation of the canonical Ras/Raf/MEK/ERK Map

169 The voltage required for half-maximal activation of the channels (V1/2) shifted in the

170 ession and activates the cIL-6 promoter, and maximal activation of the cIL-6 promoter by vFLIP requir

171 by showing that while TRAF1 is required for maximal activation of the classical NF-kappaB pathway do

172 sed both the affinity of GCAP1 for RetGC and maximal activation of the cyclase.

173 Half-maximal activation of the enzyme was obtained with 0.6 m

174 Half-maximal activation of the FRET-GCK sensor was estimated

175 coccal lipid A was structurally required for maximal activation of the human macrophage TLR4 pathway

176 expression in T cells are also required for maximal activation of the IL-2 gene in FcepsilonRI-stimu

177 uires collaboration with the JNK pathway for maximal activation of the NFLC gene in PC12 cells throug

178 Half-maximal activation of the nimodipine-sensitive current o

179 n or shuttling rate for mTOR is required for maximal activation of the nuclear S6K2.

180 arrestin-interacting domain are required for maximal activation of the p38 mitogen-activated protein

181 with the endogenous Ih, the voltage for half-maximal activation of the PAIH-evoked current was depola

182 n the amount of CaM necessary to obtain half-maximal activation of the PM-Ca-ATPase, indicating that

183 on the CaM concentration necessary for half-maximal activation of the PM-Ca-ATPase.

184 tion block in these cells can be overcome by maximal activation of the PPAR pathway.

185 tive regulatory mechanism(s) which prohibits maximal activation of the Ras-dependent signaling events

186 studies identify a novel mechanism by which maximal activation of the rat SREBP-1c gene expression b

187 eosome removal while concurrently inhibiting maximal activation of the same enhancers by recruiting h

188 ly), the calcium concentration at which half maximal activation of the thin filament is achieved can

189 McTnT1-44, but not McTnT45-74, attenuated maximal activation of the thin filament.

190 ype II fibers could communicate centrally by maximal activation of their entire pool of presynaptic O

191 The maximal activation of these channels by divalent cation-

192 tered to cancer patients, and if so, whether maximal activation of these T cells with the combination

193 isoproterenol (Iso), genistein caused a near-maximal activation of this current.

194 Y229, as a major amino acid determinant for maximal activation of transcription by AgrA and provides

195 For maximal activation of Trks by intraventricular NGF injec

196 hermore, we found that DOCK1 is required for maximal activation of two HER2 effectors, c-JUN and STAT

197 ease in effective blood volume that leads to maximal activation of vasoconstrictive systems, renal va

198 ease in effective blood volume that leads to maximal activation of vasoconstrictive systems, renal va

199 region autoinhibition of the VSE to produce maximal activation of Vps4 during ESCRT function.

200 Half-maximal and maximal activations of IKAdo required occupancies of 40%

201 ftward shift (pCa(50) [change in pCa at half-maximal activation]) of 0.09+/-0.02 pCa units while at 2

202 as assessed as the pCa (-log[Ca2+]) for half-maximal activation, or pCa50, decreased to a greater ext

203 vated by decreasing PO2, with a PO2 for half-maximal activation (P50) not significantly different fro

204 sin D significantly reduced the pCa for half-maximal activation (pCa50) at both SLs.

205 of force, i.e. the [Ca2+] required for half-maximal activation (pCa50) increased from pCa 5.85 +/- 0

206 other members of the cdk family require for maximal activation phosphorylation of a Ser/Thr residue

207 e described by activation curves with a half-maximal activation potential (V ) of -93 mV, slope (k) o

208 did not alter macroscopic desensitization or maximal activation rate and only slightly slowed rapid d

209 The maximal activation rate of ensembled single BK channel c

210 by a decrease in agonist affinity, with half-maximal activation rates achieved at 0.77 mM GABA in WT

211 ) (open probability, P(o), about 0.78); half-maximal activation required about 35 mM Na(+)(i).

212 d at the TFIID-TFIIA stage of initiation and maximal activation required the concomitant presence of

213 When K(+)(i) was increased to 70 mM, half-maximal activation shifted to about 70 mM Na(+)(i).

214 than for wild-type strips, whereas at pCa 5 (maximal activation), tension was marginally lower.

215 half-amplitude, 0.5 or 1.0 ms) did not reach maximal activation until the action potential had repola

216 The half-maximal activation (V50) was at -27.29 mV +/- 1.15 (n =

217 nnels was 19.5 pS and the potential for half-maximal activation (Va) was -45 mV.

218 0.55 pA/pF, n = 54; P < .001), yet the half-maximal activation voltage (V0.5), time course of decay,

219 Each SUMO shifts the half-maximal activation voltage (V1/2) of IKs approximately +

220 Half-maximal activation voltage in EBZ was shifted to higher

221 hanges in either HCN conductance or its half-maximal activation voltage resulted in graded changes in

222 voltage-dependence and a more negative half-maximal activation voltage than Cav1.2 and Cav3.1.

223 acutely isolated neurons gave estimated half-maximal activation voltages of -63 and 12 mV for the two

224 At 40 mV, the [Ca2+]i producing half-maximal activation was 273 nM, as opposed to >1.53 micro

225 Maximal activation was at > 5 microM, 50% maximum Ca2+ f

226 centration of calcium ions required for half-maximal activation was increased in the RVH group: 2.64

227 Maximal activation was observed at a PIP(2) molar ratio

228 With 4 mM K(+)(i), maximal activation was recorded with 100 mM Na(+)(i) (op

229 Neither threshold nor half-maximal activation was significantly affected by increas

230 e, the dose of OKT3 required to achieve half-maximal activation was the same using PMA or different c

231 ose-response curve with little effect on the maximal activation when compared with cells expressing t

232 alue with an additional 40% reduction in the maximal activation when compared with cells expressing t

233 U210, WIN55,212, and anandamide all elicited maximal activation, whereas Delta(9)-THC (56 +/- 6%) cau

234 at the 1-44 region of McTnT is essential for maximal activation, whereas the cardiac-specific 45-74 r

235 y a 1:10 peptide:detergent stoichiometry for maximal activation, whereas the inhibitors are effective

236 Maximal activation with 10 microM free Ca2+ induced sust

237 al activation with Ca(2+), or on V(o) during maximal activation with Ca(2+).

238 These kinases exhibited maximal activation with each of these agonists within 15

239 ound source is determined by the position of maximal activation within an array of binaural coinciden

240 h was in contrast to the 100% consistency of maximal activation within the traditional fusiform face