ライフサイエンスコーパス: maximal concentration

1 nonreceptor-mediated lytic activity at this maximal concentration.

2 IL-1beta cytotoxicity even at 300 pg/ml, the maximal concentration.

3 ed, reaching 20% (median, 5%) of the initial maximal concentration.

4 (median, 13%), respectively, of the initial maximal concentrations.

5 P being the most potent agonist tested (half-maximal concentration, 0.13 microM) and 10-fold more pot

6 ve rather than additive or potentiating with maximal concentrations (100 nM) of EGF, suggesting that

7 thylene-ATP mimicked the action of ATP (half-maximal concentrations 6 and 161 microM, respectively).

8 of CTL019 in peripheral blood, with greater maximal concentration and area under the curve values co

9 t dose-proportional increase in tirapazamine maximal concentration and area under the curve(last) was

10 )C-labeled peptides, 3F(14) reaches a higher maximal concentration and has a longer half-time of elim

11 Cmpk by salicylate and GdCl3 revealed a half-maximal concentration and Hill coefficient of 1.6 mM and

12 (V)2.2 channels, guangxitoxin (GxTX)-1 (half-maximal concentration approximately 1 nmol/l), has been

13 t the apoE4 folding intermediate reached its maximal concentration ( approximately 90% of the mixture

14 y) after acute cocoa consumption and reached maximal concentrations by 2 h (41 +/- 4 nmol/L, 5.92 +/-

15 ha-tocopherol AUC from 0 to 72 h, as well as maximal concentrations (Cmax: 2.04 +/- 0.14 compared wit

16 pendent and partially reversible with a half-maximal concentration constant IC(50) of 2.6 microm.

17 ximal current density and increased the half-maximal concentration derived from GABA dose-response cu

18 e reactions oscillate accordingly, attaining maximal concentration during the middle of their respect

19 tions do not affect the Km for ATP, the half-maximal concentration (EC50) for the C2 domain of type I

20 larly by PUVA following PAR1 (effective half-maximal concentration (EC50), 8.4 +/- 1.1 versus 4.3 +/-

21 exhibit potent inhibitory activity with half-maximal concentrations (ED50) of 320 nM and 460 nM, resp

22 by homoduplex and heteroduplex DNA, the half-maximal concentration for activation by heteroduplex DNA

23 ment ends in direct binding assays; the half-maximal concentration for binding of adducin to gelsolin

24 The observed geometric mean maximal concentration for linezolid was 6425 ng/mL.

25 However, the half-maximal concentration for P(i) binding to metalloenzyme

26 tion tendency, secondary structure, and half-maximal concentration for supramolecular assembly, chann

27 The half-maximal concentration for this effect was 6.4 nM, with m

28 Half-maximal concentrations for FFA-induced reduction of junc

29 ols, in a dose-dependent manner, with a half-maximal concentration (IC50) value of 8 micromol/l.

30 in response to both LPS and TNF, with a half-maximal concentration in the range of 0.1 to 0.6 microM.

31 ATP occurred more rapidly and reached higher maximal concentrations in the mitochondria of micu mutan

32 + concentration exceeds 3 microM, and a half-maximal concentration is produced at a free Ca2+ concent

33 scence with a Hill coefficient of 2 and half-maximal concentration (K(Na)(0.5)) of 49 mM at -90 mV.

34 he Hill equation to yield values of the half maximal concentrations (K1/2), and the Hill coefficients

35 The data yielded a half-maximal concentration, K1/2 = 19 +/- 3 mM and a Hill coe

36 of #x223c;40%, and when applied together at maximal concentrations, no additional spine loss resulte

37 is in the purified Q783A mutant, with a half-maximal concentration of 0.06 micrometer, essentially id

38 that was concentration dependent with a half-maximal concentration of 1 nM.

39 36% at the hMC4R, and 11% at the hMC5R at a maximal concentration of 10 microM.

40 that was concentration dependent with a half-maximal concentration of 2 nM.

41 urrent by 75% (Kd = 3.3 mM, 5 cells) while a maximal concentration of 4-aminopyridine (4-AP; 10 mM) b

42 rrent in a dose-dependent manner with a half-maximal concentration of 4.6 +/- 0.5 mm.

43 48.6% in the presence of ethanol with a half-maximal concentration of 4.7 mM.

44 a specific and saturable manner with a half-maximal concentration of 8 nM.

45 significant endothelial toxic effects at the maximal concentration of amphotericin B.

46 lts in a transient pulse of cAMP, reaching a maximal concentration of approximately 10 microm and per

47 The peptide inhibited fusion with a half-maximal concentration of approximately 2 microM; however

48 nhibited by extracellular Ca(2+) with a half-maximal concentration of approximately 20 mum.

49 ve and insensitive myeloma cells with a half maximal concentration of approximately 3 micromol/L.

50 In the presence of a maximal concentration of ATP, both the amount of secreti

51 se phospholipid vesicles and lowers the half-maximal concentration of calcium needed for this fusion

52 Activation of muscarinic receptors with a maximal concentration of carbachol (100 microm) induced

53 the leached cobalt ions does not exceed the maximal concentration of cobalt at the NC surface indica

54 Experiments using a half-maximal concentration of DAMGO demonstrate that nor-BNI

55 is of serum-free C6 culture media revealed a maximal concentration of DARP by culture day 1.

56 zed platelets (150 x 10(3)/microl), the half-maximal concentration of FVIII required to accelerate VW

57 Dialysis with a maximal concentration of inositol 1,4,5-trisphosphate (I

58 radient increased flash frequency, whereas a maximal concentration of nigericin (5 mum) collapsed the

59 A near maximal concentration of the selective 5-HT(2A) antagoni

60 Data were compared to exocytosis evoked by a maximal concentration of the strong secretagogue ionomyc

61 After a single oral dose, the mean +/- SD maximal concentration of thiamine and net area under the

62 Maximal concentration of tumor necrosis factor (TNF)-alp

63 We found previously that the maximal concentration of ultraviolet B radiation (290-32

64 The maximal concentration of virus shedding was higher for p

65 r IXa complex in a biphasic manner with half-maximal concentrations of 0.2 and 1.6 mM while the micel

66 2+ inhibited purinoceptor currents with half-maximal concentrations of 5 mM at the P2X2 receptor, 89

67 reased the amplitude of current activated by maximal concentrations of 5-hydroxytryptamine (5-HT) and

68 pronounced intracellular NO elevation, with maximal concentrations of 7 and 17 nm, respectively.

69 Yet maximal concentrations of all AngsFvs elicited angiogene

70 Co-treatment with maximal concentrations of either IGF-1 or BDNF enhanced

71 eased by more than 2-fold in the presence of maximal concentrations of either of the inhibitors of TG

72 The maximal concentrations of genomic and replicative-interm

73 4-GFP translocation at either sub-maximal or maximal concentrations of insulin.

74 The effects of maximal concentrations of lithium and valproate on gluta

75 ctivity was independent of cGMP and the half-maximal concentrations of NADP and NA needed were about

76 The geometric mean maximal concentrations of PNU-100480, PNU-101603, and PN

77 Maximal concentrations of serum SLPI correlate significa

78 The effects elicited by maximal concentrations of the A2aR agonist 2-[4-(2-carbo

79 Maximal concentrations of the MOR-selective agonist DAMG

80 Cl- cotransport 80% to 89% of stimulation by maximal concentrations of these drugs.

81 Similar peak responses were observed with maximal concentrations of these four agonists and with t

82 Maximal concentrations ranged from 2.2 to 2.8 and 1.5 to

83 hesion-dependent oxidative burst with a half-maximal concentration similar to that for adhesion.

84 left [L] = 2.9 +/- 1.5 min, the time of half maximal concentration [T1/2max] R = 8.8 +/- 3.7 min, T1/

85 sfully obtained in healthy rats (the time of maximal concentration [Tmax] right [R] = 2.8 +/- 1.2 min

86 area under the concentration-time curve and maximal concentration values increased linearly with dos

87 Maximal and half-maximal concentrations were approximately 20 and approxi

88 lease rate decreased (2-10 ng/day) and lower maximal concentrations were observed (1-10 micrograms/ml

89 zed at about day 3 of development, reaches a maximal concentration with the formation of the first-st