ライフサイエンスコーパス: maximal effect

1 er, one serine is bound to each interface at maximal effect.

2 ing was observed, with spermine exerting the maximal effect.

3 otency and, in the case of propofol, reduced maximal effect.

4 had to be added within the first 24 h for a maximal effect.

5 ,5)P3 was more potent and exhibited a larger maximal effect.

6 with IFN-gamma for at least 8 h to obtain a maximal effect.

7 activate G protein with no alteration in the maximal effect.

8 agnitude without significantly affecting the maximal effect.

9 on stimulation of FGF8b are required for the maximal effect.

10 s, and levels of intake optimized to produce maximal effects.

11 ypophysial BK channel activity (EC50, 22 mM; maximal effect, 100 mM).

12 sidue mutated to cysteine (voltages for half-maximal effect -107, -94 and -73 mV for positions 361, 3

13 e NO donor sodium nitroprusside reduced tau (maximal effect, -14+/-2%, n=5, P<0.001), and this lusitr

14 The time to maximal effect (20, 50, and 90 min) and duration of effe

15 th intrapulmonary IL-1beta production with a maximal effect 7 days after instillation of the adenovir

16 The maximal effect (80 +/- 6% reduction in probability of fi

17 are standardized from 0 (no effect) to 100 (maximal effect); a scale score is the average of respons

18 e Bmax of scuPA binding 4-fold with the half-maximal effect achieved at a peptide concentration of 50

19 ted G1 phase progression within 12 h, with a maximal effect after 72 h.

20 ein expression by >90% with maximal and half-maximal effects after 8 and 2 h, respectively.

21 of the core increased with temperature, with maximal effect around 116 degrees C.

22 tter-gated ion channels have a wide range of maximal effects as well as Hill slopes, suggesting that

23 imum (6.6 +/- 1.4)-fold increase with a half-maximal effect at 0.3 nM.

24 e slower as [MgADP] was increased, with half-maximal effect at 0.5 mM [MgADP]; the pre- and post-T-ju

25 an EC(50) of approximately 245 nM and had a maximal effect at 0.5-2 microM and required the presence

26 id hydrolysis stimulated by basic FGF with a maximal effect at 1 microg ml-1.

27 phine was concentration-dependent, reached a maximal effect at 1 micromol/L, and was reversed by nalo

28 sponse to TGF-beta1 was dose-dependent, with maximal effect at 1 ng/mL, and was associated with immun

29 ndent inhibition of the lectin pathway, with maximal effect at 10 microg/mL.

30 eversible and concentration dependent with a maximal effect at 10 microM.

31 e-dependent decreases in retinal blood flow (maximal effect at 10(-)(6) M, P < 0.05).

32 TPase activity of ABCR 3-4-fold, with a half-maximal effect at 10-15 microM.

33 hypoxia and simulate preconditioning, with a maximal effect at 100 nM.

34 xpression, as did rosiglitazone, with a half-maximal effect at 100 nm.

35 resistance in a dose-dependent manner with a maximal effect at 120 minutes of 6.8 Omega whereas VEGF-

36 enerate potent antinociception more rapidly (maximal effect at 1h postinjection) but also lose their

37 the messenger RNA and protein levels, with a maximal effect at 2 hours (P < 0.05; n >/= 3).

38 ependent manner (IC50 = 0.5 mumol/L), with a maximal effect at 2.5 to 5.0 mumol/L.

39 ration of [14C]glucose into glycogen, with a maximal effect at 30 nmol/l leptin.

40 t a concentration as low as 10 nmol/l with a maximal effect at 5 micromol/l.

41 enhanced the activity of the enzyme, having maximal effect at 50 and 75 mM, respectively.

42 These effects were dose-dependent (half-maximal effect at 7 microM), saturable and specific (i.e

43 n by IAC was inhibited by SKF10047 with half-maximal effect at 7 microM.

44 onsumption in beta-HC9 cells (15-30%) with a maximal effect at 8 mmol/l for glucose and at 250 nmol/l

45 With trypsin, CB2 showed a maximal effect at 8 mol of tOspB to 1 mol of mAb.

46 aC at actin/gelsolin ratios of <32:1, with a maximal effect at an actin/gelsolin ratio of 2:1.

47 e static quenching is saturable and has half-maximal effect at approximately 20 mM nucleoside or NTP,

48 a concentration-dependent manner with a half-maximal effect at approximately 5 ng/mL.

49 Dex had maximal effect at concentrations above 0.01 microM and w

50 enistein inhibited bone resorption with half maximal effects at 0.5 and 10 micromol/L and complete in

51 n the levels of COX-2 mRNA and protein, with maximal effects at 8-12 and 12-24 h, respectively.

52 Inhibition was dose-dependent with half-maximal effects at approximately 15-20 muM.

53 hanical allodynia from day 1 to day 10, with maximal effects at early time points.

54 on this measure, with OFQ/N(1-11) displaying maximal effects at higher (15-30 nmol) doses and OFQ/N(1

55 (15-30 nmol) doses and OFQ/N(1-7) displaying maximal effects at lower (0.15-1.5 nmol) doses.

56 pathology (e.g., dystrophic neurites), with maximal effects attained with approximately 1 mug/d dose

57 nt and was detectable at 0.3 nm insulin with maximal effect between 1 and 3 nm.

58 in a dose-dependent manner with an apparent maximal effect between 3 and 6 h after intravenous admin

59 progesterone produced approximately 1/2 the maximal effect but as little as 10 nM progesterone produ

60 euronal cultures with picomolar potency with maximal effects comparable to nerve growth factor.

61 Further, the half-maximal effect concentration of C5a and the predicted do

62 an effect size greater than or equal to the maximal effect derived from linear modeling.

63 xone-reversible manner with good potency and maximal effect equivalent to that of the mu-opioid agoni

64 timulation, although this was lower than the maximal effect exhibited by the minimal mouse enhancer (

65 bitat intensity of 200 lux, for example this maximal effect (eyes always open versus always closed) w

66 glucagon receptor, Cpd 1 increased the half-maximal effect for glucagon stimulation of adenylyl cycl

67 ive, were elevated across the CF range, with maximal effects for CFs in the 10 kHz region.

68 The D50 (concentration producing half-maximal effect) for cocaine and U-50,488H was 10.3 and 1

69 ED50 (the dose producing half-maximal effect) for insulin's effect on leptin and FFA w

70 ere much more potent and/or had an increased maximal effect in inhibiting adenylyl cyclase and in act

71 ecombinant GluN1/GluN3A receptors, with half-maximal effect in the physiologic pH range.

72 te extension is severely limited after 24 h, maximal effect is reached at 36 h and recovery is only p

73 The Na+ effect was concentration-dependent (maximal effect, </=12.5 mM) and was specific for shear s

74 ted that TLK19780 acted very rapidly, with a maximal effect observed 2 min after addition to insulin-

75 is decrease was dose-dependent with the half-maximal effect observed at 0.5 microg/100 g of body weig

76 crease in [3H]thymidine incorporation with a maximal effect observed at 30 nm.

77 t relaxation of precontracted vessels with a maximal effect observed at 90 minutes.

78 peptides was dose and time dependent, with a maximal effect observed at 96 h (87 +/- 16% [mean +/- SE

79 ine CE cell N-cadherin mRNA levels, with the maximal effect observed between 10(-10) (1.47 +/- 0.06-f

80 ression in human PBMCs and monocytes, with a maximal effect observed when IL-10 was added from 20 h b

81 s-like positive nuclei in rat forebrain with maximal effects observed 2 h post-dose.

82 in high-intensity tail-flick latencies with maximal effects observed at a dose range of 0.75-3 nmol,

83 sed A(2A)AR in a time-dependent manner, with maximal effects observed by 1 day, and continued down-re

84 as measured by RNase protection assays, with maximal effects observed in early stages of HSC activati

85 osphotyrosine content of p38 MAP kinase with maximal effects observed within 5 min.

86 the tumor-determinant reactive T cells, with maximal effects obtained by combined anti-CD40 and anti-

87 e light response was about 80%, and the half-maximal effect occurred at 385 nm delta subunit.

88 The maximal effect occurred at 6 hours with 100 nmol/L Ang I

89 ried with the age of astrocyte cultures; the maximal effect occurred at approximately 2 weeks in vitr

90 Maximal effects occurred at a concentration of 3 mmol/L

91 un mRNA, in a time-dependent manner with the maximal effect occurring 2 h after the stimulation and a

92 centration-dependent manner with minimal and maximal effects occurring at 1 and 25 microg/ml, respect

93 sibly inhibited DeltaPsim fluctuations, with maximal effects occurring at 100 microM.

94 trations of ceramide as low as 5 microM with maximal effects occurring at a concentration of 15 micro

95 trast, there was no change in the potency or maximal effect of 2-MeSATP with the S317A mutant recepto

96 predicted these changes and showed that the maximal effect of addition of a sorbent to the dialysate

97 cells, CNP was five times more efficacious (maximal effect of CNP was 497% +/- 44% that of ANP) and

98 Insulin pretreatment increased the maximal effect of DAMGO, but did not change its EC(50) v

99 In these cells, the potency and maximal effect of delta-opioid receptor agonist (SNC80)-

100 dissociated profile by exhibiting 42% of the maximal effect of DEX in a mouse mammary tumor virus (MM

101 expression was 3.5 nM, exhibiting 87% of the maximal effect of dexamethasone (DEX).

102 ese responses were equal in magnitude to the maximal effect of estradiol, and they were inhibited by

103 Such stability suggests that near maximal effect of expiratory TGI could be obtained by ap

104 The simulation set limits to the maximal effect of eyes open all day versus eyes closed a

105 The maximal effect of insulin on tyrosine phosphorylation of

106 e, although the factors were equipotent, the maximal effect of LIF > CNTF.

107 tal SCs, with survival activity equaling the maximal effect of neuregulin, the major peptide SC survi

108 RE and the A/T-rich motif was required for a maximal effect of PLZF on a heterologous promoter and wa

109 in tissue oxygen delivery while awaiting the maximal effect of recombinant erythropoietin on bone mar

110 cited Ca(2+) elevations with a rank order of maximal effect of RTKA >/= SP > RTKC >/= RTKB.

111 sfer regions may result in a decrease in the maximal effect of signal transfer.

112 Maximal effect of the activator requires that the system

113 The maximal effect of the inhibitory compounds is enhanced w

114 A half-maximal effect of the muscarinic agonist carbachol was o

115 157F) had no effect on either the potency or maximal effect of.

116 Pase activity in a dose-related manner, with maximal effects of 29% increase over basal level seen at

117 n a concentration-dependent manner with half-maximal effects of approximately 1 nM.

118 Half-maximal effects of Ca(2+) were observed at approximately

119 Maximal effects of forskolin were observed at 10 micromo

120 The maximal effects of IAA and NPA are between 3.5 and 5 h A

121 The maximal effects of mucosal UDP on [3H]inositol phosphate

122 We find the maximal effects of non-substrate FAs on both huPGHSs occ

123 Maximal effects of these inactivating drugs occurred wit

124 RDLM314S) increased the potency, but not the maximal effect, of GABA potentiation by either propofol

125 system appears quite sensitive, with a half-maximal effect on a Pqrr reporter at 140 pM C8-AHL.

126 ably, PKM2-H391Y co-expressed cells showed a maximal effect on all the studied parameters.

127 In endothelial cells, the maximal effect on angptl4 expression was achieved at 8 h

128 The predicted maximal effect on cardiac output was observed at 1.2 min

129 increased free Ca(2+) concentration at half-maximal effect on channel activation, a reduced steepnes

130 iated with the binding of sugar might have a maximal effect on ChvE's interactions with its distinct

131 he last 2 estradiol pulses best captured the maximal effect on hippocampal CA1 spine density.

132 creases in permeability at 4 h, exerting its maximal effect on sucrose uptake at 24 h.

133 To achieve its maximal effect on the LDL receptor, PCSK9 requires autop

134 logs were more potent and produced a greater maximal effect on the rate of [3H]spiperone dissociation

135 940-tolerant mice are capable of producing a maximal effect on the second messenger system.

136 es, in the majority (13/20), sites producing maximal effects on both variables coincided.

137 chemical shifts throughout the enzyme, with maximal effects on helix I (Val-15), beta-strand 1 of th

138 ced by changes in temperature will have near-maximal effects on pH-dependent conformational equilibri

139 ted a biphasic dose dependent response, with maximal effects on PKA noted at 10(-12)M peptide T.

140 We conclude that LXR is required for maximal effects on plaque CD68+ cell expression of CCR7

141 Nearly maximal effects on Rac activity were obtained with 10% s

142 the residual release is sufficient to exert maximal effects on the target NK-1 receptors.

143 rvilinear when the two drugs differ in their maximal effects or Hill slopes.

144 For maximal effect, (p)ppGpp interacts with the cofactor Dks

145 ative log molar concentration eliciting half-maximal effect [pD2] 9.2 +/- 0.03 and 8.9 +/- 0.03, resp

146 a concentration-dependent manner, with half-maximal effect produced at about 2 nM AODN concentration

147 ill coefficient of approximately two, a half-maximal effect reached by nearly 500 nm Ca(2+) , and Ca(

148 Maximal effects required approximately 200 microM phosph

149 lial electrical resistance for 3 hours (with maximal effect seen at 300 micromol/L H2O2), indicating

150 nce-mediated transcriptional responses, with maximal effects similar to those caused by interleukin-6

151 bacteria required to trigger a response) and maximal effect size according to a logistic equation.

152 ed on the small sample size and the observed maximal effect size of 70%, the power of the study is at

153 s antagonize GLP-1 signaling, decreasing the maximal effect that GLP-1 can elicit on cAMP production

154 with a reversal t1/2 > 6 hours and close to maximal effects that remained for at least 5 hours after

155 We focused on the mutants that had the maximal effects to increase (in alpha4) or reduce (in de

156 At the lowest intensity, 3 lux, this maximal effect was +/- 28%, but it is only 1% at the hig

157 The concentration of UMP required for half-maximal effect was 2.5 microM.

158 The maximal effect was a 150% increase in compliance and a 4

159 izolid considerably, 25-fold on average, and maximal effect was achieved at an exposure equivalent to

160 oltage dependence of hERG1 inactivation, and maximal effect was achieved in channels containing three

161 tionship was apparent in the brain, and near-maximal effect was apparent with doses of 8 mg/kg.

162 NMB had a half-maximal effect was at 0.4 nM and was 30-fold more potent

163 ased directly with pacing frequency, but the maximal effect was blunted with the T286A, consistent wi

164 A expression in a dose-dependent manner: the maximal effect was observed at a concentration of 10 ng/

165 The maximal effect was obtained when the cells were preincub

166 When maximal effect was seen, iNO was discontinued to compare

167 Similar increases to maximal effect were observed after treatment with the ca

168 Similar increases to maximal effect were observed after treatment with the ca

169 Maximal effects were observed at relatively longer time

170 into a beneficial effect on adiposity, with maximal effect when started at the earliest age and main

171 rmed phenotype in vitro all appeared to show maximal effect with 100 MOI AdMnSOD.

172 tical cell cycle regulators in order to have maximal effect with minimal input.

173 during 10 min of treatment, betaPEA induced maximal effects within 1 min.

174 reduced by forskolin treatment, in which the maximal effect yields an 80% reduction in AT1-R mRNA lev