ライフサイエンスコーパス: measles

1 hose aged 17 years or younger susceptible to measles).

2 rol of vaccine-preventable diseases, such as measles.

3 cephalitis (SSPE) is a fatal complication of measles.

4 broader range of clinical signs typical for measles.

5 c health responses on limiting the spread of measles.

6 es, mumps, and rubella (MMR) vaccination and measles.

7 younger children to decrease mortality from measles.

8 administration of PEP following exposure to measles.

9 Neonatal: maternal ratio (NMR) was found in measles (1.042) and the ratios for the other pathogens r

10 orkers likely facilitate the transmission of measles across regions.

11 Complications of measles affect most organ systems, with pneumonia accoun

12 al was associated with an increased risk for measles among people who refuse vaccines and among fully

13 udy of risk factors for laboratory-confirmed measles among young adults living in Ulaanbaatar.

14 ctors present during the acute rash phase of measles and associations with outcome and human immunode

15 ies, such as the Ebola outbreak response and measles and meningitis outbreaks; and strengthening the

16 Admissions for measles and mumps encephalitis have decreased substantia

17 ny important human viral infections, such as measles and mumps, may have their ancestry traced back t

18 Immunity to measles and receipt of PEP was determined for contacts.

19 Vaccine-induced measles and rubella antibody responses are not negativel

20 ies (SIAs) is an important benefit of global measles and rubella elimination and polio eradication st

21 , and transitioning existing capabilities to measles and rubella elimination efforts allows for optim

22 and resources that should be transitioned to measles and rubella elimination efforts.

23 ork to be replicated to independently verify measles and rubella elimination in the regions and globa

24 in strategies between polio elimination and measles and rubella elimination include the use of an ex

25 Measles and rubella elimination strategies rely heavily

26 tion, the program has diversified to address measles and rubella elimination, data management and qua

27 Measles and rubella eradication is feasible and cost sav

28 ntries, ranging from adding surveillance for measles and rubella to integrated disease surveillance f

29 esources are already connected with those of measles and rubella, and transitioning existing capabili

30 etanus, diphtheria, and acellular pertussis, measles and rubella, or measles, mumps, and rubella) dur

31 reventable diseases (VPDs), including polio, measles and rubella, yellow fever, Japanese encephalitis

32 ine immunization programs and the control of measles and rubella.

33 in the countries with the highest burden of measles and rubella.

34 of age and for vaccination responses against measles and tetanus.

35 Objective: To provide an overview of measles and vaccination for health care professionals.

36 d IL-1beta than HIV-uninfected children with measles, and lower levels of interleukin 4 and 5.

37 one of the twice-vaccinated cases had severe measles, and none had onward transmission, consistent wi

38 aemophilus influenzae type b), yellow fever, measles, and tuberculosis.

39 reak period, vaccination coverage for polio, measles, and yellow fever continued to decrease, whereas

40 cases had clinically compatible symptoms and measles antibody detection in cerebrospinal fluid (CSF)

41 Measles antibody titers were measured by enzyme-linked i

42 ts born to mothers with history of wild-type measles, antibody responses among children born to vacci

43 Complications of measles are of high frequency and severity.

44 systems, with pneumonia accounting for most measles-associated morbidity and mortality.

45 to dramatic declines in the global burden of measles, but the virus remains persistent in much of the

46 In 2006, China committed to eliminating measles by 2012; to this end, the country enhanced its m

47 .7%, and 72.2% of newborns were positive for measles, CA16 and EV71 antibodies respectively.

48 Measles can be eliminated from a population; this outcom

49 lytic model to three decades of age-specific measles case reporting in six provinces in China to quan

50 population distribution with high-resolution measles case reports to develop a dynamic model that ill

51 Economic costs per measles case were obtained from the literature.

52 nt to be able to rapidly distinguish between measles cases and vaccine reactions to avoid unnecessary

53 The age distribution of measles cases changes in response to both demographic an

54 ld result in an estimated 3-fold increase in measles cases for children aged 2 to 11 years nationally

55 A substantial proportion of the US measles cases in the era after elimination were intentio

56 Annual measles cases in the United States and the associated pu

57 To estimate the number of measles cases in US children and the associated economic

58 The model was calibrated to annual measles cases in US children over recent years, and the

59 of vaccine from wild-type strains in suspect measles cases is a valuable epidemiological tool that in

60 e population (i.e., serosurveys) or incident measles cases occur may provide a way to limit the size

61 Among measles cases reported to CDPH during 1988-1991, the inc

62 March 1-September 30, 2015, 20 077 suspected measles cases were reported; 14 010 cases were confirmed

63 Among 22 confirmed measles cases, 5 secondary cases occurred in HCWs.

64 umented 27,695, 52,656, and 42,874 confirmed measles cases.

65 Eight HCWs were notified as measles cases; 6 were vaccinated with measles vaccine tw

66 is complex connection renders eradication of measles challenging in China despite its high overall va

67 t measles elimination by 2020, yet continued measles circulation makes that goal seem elusive.

68 An unvaccinated, young, female patient with measles confirmed by direct epidemiologic link was hospi

69 duling of MMRV vaccine as the second dose of measles-containing vaccine (MCV) in Australia.

70 Measles continues to be a major cause of child mortality

71 ng at 2-5 y intervals is the core of current measles control and elimination efforts.

72 light on the role of school-aged children in measles cross-scale dynamics, as we illustrate with refe

73 ike the regular limit cycles seen in the UK, measles cycles in US cities consistently exhibit spontan

74 Admissions for measles decreased by 97% (from 0.32 to 0.009) and admiss

75 viridae, and Togaviridae families, including measles, dengue, West Nile, Zika, and chikungunya viruse

76 Measles detection in CSF was performed by serology at th

77 easles remains a risk for travelers, with 94 measles diagnoses reported to the GeoSentinel network fr

78 and 1:609 for children <12 months at time of measles disease.

79 of MMR and IG PEP among children exposed to measles during an outbreak in New York City (NYC) in 201

80 se and assist in prevention of the spread of measles during an outbreak.

81 ative strand (NNS) RNA viruses (e.g. rabies, measles, Ebola) contains five collinear sequence element

82 No contact who received IG PEP developed measles; effectiveness of IG PEP was 100% (approximated

83 le patches, will facilitate progress towards measles elimination and eradication.

84 veal regional differences in the progress to measles elimination and the impact of vaccination contro

85 All WHO regions currently target measles elimination by 2020, yet continued measles circu

86 The measles elimination goal may require a careful balance b

87 We assessed the status of measles elimination in the United States using outbreak

88 However, during a measles epidemic in 2013-2014, MMR vaccination was also

89 lowered to 12 months because of the European measles epidemic.

90 enhance vaccine performance, contributing to measles eradication efforts.

91 Children with measles had higher levels of innate cytokines tumor necr

92 The force of infection of measles has declined dramatically (90%-97% reduction in

93 les outbreaks and provider inexperience with measles, HCWs face increased risk for occupational expos

94 tomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rub

95 Measles IgG antibody was detected using ELISA assay, neu

96 S reminders before scheduled pentavalent and measles immunisation visits.

97 ation campaigns triggered when low levels of measles immunity are observed in a sample of the populat

98 To describe how providers assessed the measles immunity status of departing U.S. adult traveler

99 emonstrates the high human cost of "natural" measles immunity.

100 not affected, nor were anti-tetanus and anti-measles immunoglobulin G levels.

101 estimates due to the stochastic elements of measles importation and sensitivity of some model inputs

102 Eight (67%) children were exposed to measles in California.

103 There have been continued outbreaks of measles in countries in which measles is considered to b

104 Cases were laboratory-confirmed measles in HCWs from hospital X during weeks 12-20 of 20

105 also mapped contributions to this number for measles in San Diego County's 638 elementary schools and

106 oordination are likely required to eliminate measles in the region.

107 We map measles incidence and incidence rates for each of the 34

108 ugh vaccination, and the major reductions in measles incidence and mortality have renewed interest in

109 We base our analysis on a comparison of measles incidence in 80 major cities in the prevaccinati

110 Measles incidence was simulated using stochastic age-str

111 models in settings conducive to high or low measles incidence, roughly reflecting demographic contex

112 Independent risk factors for measles included being unvaccinated (adjusted matched od

113 The management of patients with measles includes provision of vitamin A.

114 Measles infection leads to immune suppression for weeks

115 n older patients with no specific history of measles infection.

116 Importance: Measles is a highly communicable viral infection with se

117 Measles is a highly contagious and severe disease.

118 Measles is a highly contagious disease that results from

119 Measles is a highly contagious, acute viral illness.

120 ection of this important pathogen.IMPORTANCE Measles is a significant disease in humans and is estima

121 Measles is an acute viral disease associated both with i

122 Apart from its public health importance, measles is an excellent test bed for such an analysis.

123 Measles is best prevented through vaccination, and the m

124 d outbreaks of measles in countries in which measles is considered to be eliminated, such as the Unit

125 Vaccination against measles is effective, cost-effective, and safe.

126 The incubation period for typhoid, polio, measles, leukemia and many other diseases follows a righ

127 Twelve (71%) cases had a history of measles-like illness; all 12 had illness prior to 15 mon

128 Young adults with laboratory-confirmed measles, living in the capital city of Ulaanbaatar, were

129 How measles manages to spread in China-the world's largest p

130 ort of children not fully vaccinated against measles, measles-susceptible individuals accumulate in t

131 own structures of homologous proteins in the measles, mumps, and Nipah viruses.

132 vaccine hesitancy, using the case example of measles, mumps, and rubella (MMR) vaccination and measle

133 Routinely, the first measles, mumps, and rubella (MMR) vaccine dose is given

134 nts who had received one or two doses of the measles, mumps, and rubella (MMR) vaccine; and proportio

135 Measles, mumps, and rubella vaccine (MMR) or immune glob

136 acellular pertussis, measles and rubella, or measles, mumps, and rubella) during pregnancy, confirmin

137 condary infections per infectious person for measles, mumps, and rubella.

138 ong those considered eligible to receive the measles, mumps, rubella (MMR) vaccine.

139 Conversely, completion by age 2 years of measles, mumps, rubella, and varicella immunization may

140 dence (RI) of FSs in toddlers given MMRV and measles-mumps-rubella (MMR) and a national cohort study

141 nogenicity of a 2-dose pediatric schedule of measles-mumps-rubella (MMR) or measles-mumps-rubella-var

142 Measles-mumps-rubella (MMR) vaccination coverage with at

143 To protect young infants, measles-mumps-rubella (MMR) vaccination was offered to t

144 relation to introduction of PCR testing and measles-mumps-rubella (MMR) vaccination.

145 Measles-mumps-rubella (MMR) vaccinations have been offer

146 st disappeared following introduction of the measles-mumps-rubella (MMR) vaccine in 1988.

147 The effect of a third dose of the measles-mumps-rubella (MMR) vaccine in stemming a mumps

148 Here, we collected and geocoded tweets about measles-mumps-rubella vaccine and classified their senti

149 itors in mice exposed to the live-attenuated measles-mumps-rubella vaccine regardless of route of adm

150 c schedule of measles-mumps-rubella (MMR) or measles-mumps-rubella-varicella (MMRV) vaccine was asses

151 orporating combination vaccines, such as the measles-mumps-rubella-varicella (MMRV) vaccine, into imm

152 ve- and positive-sense RNA genome were used: measles (MV) and chikungunya (CHIKV).

153 okines in Zambian children hospitalized with measles (n = 148) and control children (n = 44).

154 We apply the model to three diseases, measles, norovirus and influenza, to show the feasibilit

155 Measles occurred in 6 twice-vaccinated HCWs, despite 2 h

156 None reported severe measles or onward transmission.

157 indications (-11%), correct definition for a measles outbreak (-21%), and how to treat a child with a

158 We investigated a measles outbreak among healthcare workers (HCWs) by asse

159 The key epidemiologic features of a measles outbreak in the Amish community in Ohio were tra

160 In 2015, a large nationwide measles outbreak occurred in Mongolia, with very high in

161 In 2013-2014, a measles outbreak spread through the Netherlands.

162 d after the 2014-2015 Disneyland, California measles outbreak.

163 In the setting of increasingly common measles outbreaks and provider inexperience with measles

164 Measles outbreaks continue to occur in the United States

165 ation of mass measles vaccination campaigns, measles outbreaks continue to occur regularly in Nigeria

166 through November 30, 2015, for reports of US measles outbreaks that have occurred since measles was d

167 During measles outbreaks, it is important to be able to rapidly

168 ncluding Earth's magnetic field reversal and measles outbreaks.

169 w and better-performing S. sciureus model of measles pathogenesis.IMPORTANCE The characterization of

170 econdary cases had face-to-face contact with measles patients, 8 with prior evidence of immunity.

171 When caring for measles patients, N95 respirator use by healthcare worke

172 rs (or equivalent) when evaluating suspected measles patients.

173 Of these, 4 had direct contact with measles patients; none wore N95 respirators.

174 , current literature on the effectiveness of measles PEP is limited and variable.

175 immune globulin (IG) are routinely used for measles post-exposure prophylaxis (PEP).

176 result of declining birth rates, and reduced measles prevalence, due to improved vaccination, has shi

177 le in diagnosing and managing acute cases of measles, preventing spread during outbreaks, and vaccina

178 evaluated the method independently in three measles reference laboratories using two platforms, the

179 We also extracted data on measles-related Google searches.

180 Measles remains a risk for travelers, with 94 measles di

181 s the United States and the Netherlands, and measles remains endemic in some countries.

182 Conclusions and Relevance: Measles remains of high clinical importance.

183 e may be biased by age-specific variation in measles reporting.

184 specific for diphtheria, tetanus, pertussis, measles, rubella, and Haemophilus influenzae type b vacc

185 gin of 10% for poliovirus seroprevalence and measles, rubella, and yellow fever seroconversion, and (

186 eline and post-vaccination serum samples for measles, rubella, and yellow fever; and the post-vaccina

187 e vaccine, Hepatitis B vaccine (HBV), Polio, Measles, Rubella, Mumps, trivalent MMR vaccine and Haemo

188 As part the 2012 Nepal measles-rubella and polio SIA, we developed an intervent

189 nd immunogenicity of IPV given alongside the measles-rubella and yellow fever vaccines at 9 months an

190 inferiority of concomitant administration of measles-rubella vaccine (MR) and a third dose of human r

191 Use of combined measles-rubella vaccines provides an opportunity to elim

192 support the future co-administration of IPV, measles-rubella, and yellow fever vaccines within the Ex

193 Efforts to reduce travel-associated measles should target all vaccine-eligible travelers, in

194 easles, their infant's saliva was tested for measles-specific antibodies.

195 RT-qPCR assay has been used successfully for measles surveillance in reference laboratories, and it c

196 s to provide technical experience to improve measles surveillance, routine vaccination coverage, and

197 The shift in the age distribution of measles susceptibility in response to demographic and va

198 y-Teen (2008-2013) to estimate the number of measles-susceptible children aged 17 years or younger, a

199 The total number of measles-susceptible children and adolescents in the Unit

200 ildren not fully vaccinated against measles, measles-susceptible individuals accumulate in the popula

201 n 6 and 14 months of age had a lower risk of measles than unvaccinated infants.

202 the epidemiologic features of an outbreak of measles that originated from two unvaccinated Amish men

203 For self-reported measles, the unadjusted and adjusted VE was 67% (40%-82%

204 When parent(s) suspected measles, their infant's saliva was tested for measles-sp

205 ated by a four-step, telescoped synthesis of measles therapeutic, AS-136A, in a total residence time

206 ed the age distribution of susceptibility to measles throughout China.

207 A suggested increase in measles transmissibility since elimination warrants cont

208 Measles transmissibility was assessed by estimation of t

209 fforts, we analyze the geospatial pattern of measles transmission across China during 2005-2014.

210 A mathematical model of measles transmission and vaccine sentiment predicts the

211 ggest that multiple highly connected foci of measles transmission coexist in China and that migrant w

212 pid public health outbreak response to limit measles transmission following case identification.

213 Elimination of endemic measles transmission is maintained in the United States.

214 These outbreaks have not led to sustained measles transmission; however, with each birth cohort of

215 There is no specific antiviral treatment for measles; treatment with vitamin A is recommended for you

216 ve birth cohorts systematically initiated to measles vaccination <15 months of age.

217 There is no link between the measles vaccination and autism.

218 ss Lessler and colleagues' modeling study on measles vaccination and the implications for triggered a

219 Despite implementation of mass measles vaccination campaigns, measles outbreaks continu

220 ive changes occurred in correct knowledge of measles vaccination contraindications (-11%), correct de

221 lyses, we found that a sustained decrease in measles vaccination coverage from 91.9% (2013 level) to

222 roughly reflecting demographic contexts and measles vaccination coverage of four heterogeneous count

223 toring and emphasizes the importance of high measles vaccination coverage throughout the population.

224 We used age-specific measles vaccination data from the National Immunization

225 Countries with high rates of measles vaccination experience outbreaks by virtue of im

226 tive models, we quantify spatial patterns of measles vaccination in ten contiguous countries in the A

227 confirming that widespread use of childhood measles vaccination since 1963 resulted in a decrease in

228 als also play an important role in uptake of measles vaccination through establishing trusting relati

229 Expanded access to measles vaccination was among the most successful public

230 s after randomization to age 9 months, early measles vaccination was associated with reductions in ma

231 Among the 1592 children, early measles vaccination was not associated with a higher ris

232 Children in Guinea-Bissau receive measles vaccine (MV) at 9 months of age, but studies hav

233 inst nonvaccine infections, as described for measles vaccine (MV), or increased susceptibility to inf

234 sed on earlier administration of their first measles vaccine dose at </=12 vs >/=15 months of age.

235 Among 5542 children given a first measles vaccine dose at 11, 12, 13-14, and 15-22 months

236 nicity data among children given their first measles vaccine dose between 11 and 22 months of age wer

237 Negative effects of earlier age at first measles vaccine dose persisted after the second dose.

238 es (ARs) by vaccination status and estimated measles vaccine effectiveness as 1 - [ARvaccinated/ARunv

239 Ws) by assessing laboratory characteristics, measles vaccine effectiveness, and serological correlate

240 .001), whereas GMCs increased with older age measles vaccine initiation (P < .001).

241 atitis virus, alphavirus-based chimeras, and measles vaccine Schwarz strain (MV/Schw) have been descr

242 a rapid, easily adoptable method to identify measles vaccine strains in suspect cases.

243 uantitative PCR [RT-qPCR]) that can identify measles vaccine strains rapidly, with high throughput, a

244 stagnating global coverage with two doses of measles vaccine through advocacy, education, and the str

245 ied as measles cases; 6 were vaccinated with measles vaccine twice, 1 was vaccinated once, and 1 was

246 ine, three doses of pentavalent vaccine, and measles vaccine) by 12 months of age constituted the pri

247 ide despite the availability of an effective measles vaccine.

248 efore the introduction and widespread use of measles vaccine.

249 ed infants to this problem, more immunogenic measles vaccines are highly desirable.

250 ), and awareness of how long a reconstituted measles vial can be used before it must be discarded (+1

251 -PCR (RT-PCR) method specific for genotype A measles virus (MeV) (MeVA RT-quantitative PCR [RT-qPCR])

252 ldwide that have caused localized outbreaks, measles virus (MeV) has regained importance as a pathoge

253 nhuman primates are naturally susceptible to measles virus (MeV) infection.

254 Clearance of measles virus (MeV) involves rapid elimination of infect

255 Measles virus (MeV) is known to be highly contagious, wi

256 Measles virus (MeV) neutralizing antibody concentrations

257 e fusion and syncytium formation mediated by measles virus (MeV).

258 th a microbial sensor and entry receptor for measles virus (MeV).

259 Measles virus (MV) infection causes an acute illness tha

260 Measles virus (MV) infection is undergoing resurgence an

261 Imported measles virus (MV) outbreaks are maintained by poor vacc

262 ous disease that results from infection with measles virus and is still responsible for more than 100

263 , respectively, had seroprotective levels of measles virus antibodies; 100.0% and 99.6%, respectively

264 The measles virus antibody avidity indexes were high for all

265 The measles virus antibody titer, however, is a potency requ

266 since 1963 resulted in a decrease in average measles virus antibody titers among plasma donors, which

267 To mitigate the decline in measles virus antibody titers in IVIGs and to ensure con

268 Neutralizing measles virus antibody titers were above the threshold f

269 Antiviral agents against measles virus are not commercially available but could b

270 unosuppression as well as the application of measles virus as an oncolytic therapeutic.

271 he characterization of mechanisms underlying measles virus clinical disease has been hampered by the

272 to the membrane interaction data of HRC4, a measles virus entry inhibitor peptide, revealing its inc

273 h significantly impacts our understanding of measles virus evolution.

274 The measles virus hemagglutinin (MeV-H) protein is the main

275 ve investigated the steps governing entry of measles virus into SLAMF1-positive cells and identified

276 evolution of new MeV subgenotypes.IMPORTANCE Measles virus is a paradigmatic RNA virus, as the antige

277 Measles virus is transmitted by the respiratory route an

278 e in the age-specific force of infection for measles virus over time.

279 Measles virus remains a significant cause of mortality i

280 Measles virus spreads rapidly and efficiently in human a

281 gavirales, which also includes rabies virus, measles virus, and respiratory syncytial virus.

282 The causative agent, measles virus, is a small enveloped RNA virus that infec

283 virus, varicella-zoster virus, mumps virus, measles virus, lyssavirus, herpes simplex viruses 1 and

284 Paramyxovirus pathogens include measles virus, mumps virus, human respiratory syncytial

285 ortions of the samples were seropositive for measles virus, mumps virus, or rubella virus antibodies,

286 many medically important viruses, including measles virus, mumps virus, parainfluenza viruses, respi

287 Few public health laboratories sequence measles virus-positive specimens to determine genotype,

288 ikelihood of importation and transmission of measles virus.

289 ups of individuals who are not immune to the measles virus.

290 the avidity of antibodies were measured for measles virus.

291 ate of the X domain of phosphoprotein (P) of measles virus.

292 t is increasingly difficult to differentiate measles viruses (MeVs) relating to certain outbreaks on

293 sing either live viruses (dengue, mumps, and measles viruses) or nucleic acid material (Nipah and chi

294 e unadjusted VE against laboratory-confirmed measles was 94% (95% confidence interval [CI], 79%-98%).

295 Therefore, acute measles was characterized by activation of macrophages a

296 S measles outbreaks that have occurred since measles was declared eliminated in the United States (af

297 Although measles was eliminated in the United States in 2000, imp

298 ainst laboratory-confirmed and self-reported measles was estimated using Cox regression, with VE calc

299 ated from two unvaccinated Amish men in whom measles was incubating at the time of their return to th

300 The spread of measles was limited almost exclusively to the Amish comm

301 tal intrapartum-related events, malaria, and measles were responsible for 61% of the total reduction

302 ectiveness [(1 - relative risk of developing measles) x 100] was calculated for MMR, IG, and any PEP