ライフサイエンスコーパス: mechanical allodynia

1 by von Frey hairs compared with young rats (mechanical allodynia).

2 e-dependent increase in pain-like responses (mechanical allodynia).

3 responsible for chronic pain states such as mechanical allodynia.

4 halamic bursts attenuated cortical theta and mechanical allodynia.

5 RG prevented but did not reverse SNL-induced mechanical allodynia.

6 oglial toxin, l-alpha-aminoadipate, reversed mechanical allodynia.

7 BPbeta using siRNA against C/EBPbeta reduced mechanical allodynia.

8 contribute importantly to the persistence of mechanical allodynia.

9 ay 10 after surgery also reduces established mechanical allodynia.

10 ats produces an early onset and long-lasting mechanical allodynia.

11 stimulation and thereby increase symptoms of mechanical allodynia.

12 ng sodium channels without producing heat or mechanical allodynia.

13 ept (1 mg, i.p., every third day) attenuated mechanical allodynia.

14 D-L1 neutralization or PD-1 blockade induced mechanical allodynia.

15 and hindlimbs indicating the development of mechanical allodynia.

16 goat IgG (30 or 100 mg/kg) did not attenuate mechanical allodynia.

17 re known to mediate thermal hyperalgesia and mechanical allodynia.

18 significance in the pathogenesis of chronic mechanical allodynia.

19 maintenance of zymosan and formalin-induced mechanical allodynia.

20 ereby demonstrating thermal hyperalgesia and mechanical allodynia.

21 (-/-) mice in severity of paclitaxel-induced mechanical allodynia.

22 s interpreted as mechanical hyperalgesia and mechanical allodynia.

23 ing and that this contributes to neuropathic mechanical allodynia.

24 lls delayed recovery from paclitaxel-induced mechanical allodynia.

25 ivelastat) in WT mice attenuated neuropathic mechanical allodynia.

26 alretinin neurons, which we show also convey mechanical allodynia.

27 rve fibers (C-fibers) has limited effects on mechanical allodynia.

28 nents of the elusive dorsal horn circuit for mechanical allodynia.

29 rine completely reversed oxaliplatin-induced mechanical allodynia.

30 f chronic pain without affecting the sensory mechanical allodynia.

31 pyramidal neuron hyperactivity and reversed mechanical allodynia.

32 Rs play a critical role in the expression of mechanical allodynia.

33 but have increased thermal hyperalgesia and mechanical allodynia.

34 amplitudes, but also alleviated SNI-induced mechanical allodynia.

35 -mediated mechanotransduction contributes to mechanical allodynia.

36 uch-sensitive neuronal type recruited during mechanical allodynia.

37 mg/kg) provided an 11.2-fold attenuation of mechanical allodynia.

38 flammatory heat hyperalgesia and neuropathic mechanical allodynia.

39 spinal TRPV1, leading to the development of mechanical allodynia.

40 e TRPA1 of ensheathed nociceptors to sustain mechanical allodynia.

41 and 13-HODE by antibodies blocks CFA-evoked mechanical allodynia.

42 induction of diabetes, and protects against mechanical allodynia.

43 zed linoleic acid metabolites rapidly evokes mechanical allodynia.

44 VZ+434 protected against mechanical allodynia 8 weeks after STZ injection.

45 eeks after nerve injury, effectively reduced mechanical allodynia, a cardinal feature of late-phase n

46 potently prevented and reversed SNL-induced mechanical allodynia, a major symptom of neuropathic pai

47 also attenuates capsaicin-induced secondary mechanical allodynia, a pain behavior reflecting hyperse

48 orphine withdrawal-like behavioral signs and mechanical allodynia, activates NR1 and NR2 receptors, a

49 The development of thermal hyperalgesia and mechanical allodynia after CCI also was prevented in adr

50 lagellin/QX-314) dose-dependently suppresses mechanical allodynia after chemotherapy, nerve injury, a

51 in attenuating both thermal hyperalgesia and mechanical allodynia after chronic nerve constriction in

52 est (20-30%) and nonsignificant reduction of mechanical allodynia after intraplantar Freund's adjuvan

53 neurons may contribute to the development of mechanical allodynia after L5 spinal nerve ligation.

54 in the generation of ectopic discharges and mechanical allodynia after peripheral nerve injury.

55 ively reversed both thermal hyperalgesia and mechanical allodynia although each individual dose alone

56 a-fibers, have previously been implicated in mechanical allodynia, an A-fiber-selective pharmacologic

57 tochondria-targeted O2(.-)scavenger) reduced mechanical allodynia and decreased pCREB and pC/EBPbeta.

58 ere exists a reciprocal relationship between mechanical allodynia and depression-like behavior and th

59 Here we report that both mechanical allodynia and depression-like behavior were s

60 all mice receiving verum treatment developed mechanical allodynia and distinct gait alterations.

61 se-dependently attenuated paclitaxel-induced mechanical allodynia and heat hyperalgesia.

62 nto deep tissues results in a longer-lasting mechanical allodynia and heat hypoalgesia compared with

63 n injected into skin resulted in a secondary mechanical allodynia and heat hypoalgesia lasting approx

64 alidomide (50.0 mg/kg) reduced taxol-induced mechanical allodynia and hyperalgesia whereas minocyclin

65 at are normally innocuous or mildly painful (mechanical allodynia and hyperalgesia) occurs during inf

66 ted several nociceptive behaviors, including mechanical allodynia and hyperalgesia, cold allodynia, s

67 ective in decreasing the behavioral signs of mechanical allodynia and hyperalgesia, followed by cold

68 that EA would relieve the paclitaxel-induced mechanical allodynia and hyperalgesia, which was assesse

69 ripheral mGlu1alpha receptors contributes to mechanical allodynia and inflammatory pain but not therm

70 trated significantly increased and sustained mechanical allodynia and loss of motor function.

71 se oligodeoxynucleotide against CREB reduced mechanical allodynia and lowered pC/EBPbeta.

72 /kainate receptor antagonist, alleviated the mechanical allodynia and lowered the threshold of respon

73 eptive Adelta fibers, giving rise to dynamic mechanical allodynia and mechanical hyperalgesia.

74 ry, almost completely abolished the signs of mechanical allodynia and ongoing pain behaviors, and it

75 exaenoic acid, prevents nerve injury-induced mechanical allodynia and ongoing pain in mice.

76 zation, including CFA- and capsaicin-induced mechanical allodynia and osteoarthritic pain.

77 in astrocyte-specific trkB.T1 KO mice; using mechanical allodynia and pain-related measurements on th

78 hronic debilitating disease characterized by mechanical allodynia and spontaneous pain.

79 wo weeks after SNI, wild-type mice developed mechanical allodynia and the functionality of mu-opioid

80 ity was diminished in cKO mice, but both the mechanical allodynia and the microgliosis generated by n

81 the relationship between the development of mechanical allodynia and the reorganization of primary a

82 r of mTOR, significantly blocked CFA-induced mechanical allodynia and thermal hyperalgesia 1 day post

83 eceptive dorsal horn neurons, and attenuated mechanical allodynia and thermal hyperalgesia after SCI.

84 y at T13 results in development of permanent mechanical allodynia and thermal hyperalgesia due to int

85 urgery, produced a long-duration reversal of mechanical allodynia and thermal hyperalgesia for at lea

86 ition of acute pain perception, and reversed mechanical allodynia and thermal hyperalgesia in a model

87 Proteasome inhibitors blocked mechanical allodynia and thermal hyperalgesia in all thr

88 ed the clinical scores of EAE and attenuated mechanical allodynia and thermal hyperalgesia in EAE.

89 ate and opioid receptors are involved in the mechanical allodynia and thermal hyperalgesia that devel

90 vector protected the animals from developing mechanical allodynia and thermal hyperalgesia throughout

91 Behavioral responses assessed by mechanical allodynia and thermal hyperalgesia were almos

92 iors interpreted as mechanical hyperalgesia, mechanical allodynia and thermal hyperalgesia, which are

93 degrees C to the rat sciatic nerve produces mechanical allodynia and thermal hyperalgesia.

94 selective L5 spinal nerve ligation reversed mechanical allodynia and thermal hyperalgesia; the antia

95 etermine whether it is possible to attenuate mechanical allodynia and/or alter spinal glial activatio

96 e oligodeoxynucleotide against TNFRI reduced mechanical allodynia, and decreased mtO2(.-), pCREB and

97 ing of PKCdelta attenuated spontaneous pain, mechanical allodynia, and heat hyperalgesia in TOW mice.

98 vant (CFA) produced peripheral inflammation, mechanical allodynia, and thermal hyperalgesia in vector

99 trocytes was sufficient to induce persistent mechanical allodynia, and this allodynia was suppressed

100 te peripheral neuropathic pain that includes mechanical allodynia are limited.

101 Therefore, NGF-evoked thermal and mechanical allodynia are mediated by spatially distinct

102 mal hyperalgesia) and light tactile stimuli (mechanical allodynia) are rapidly induced after gp120 ad

103 ed and reversed oxaliplatin-induced cold and mechanical allodynia as well as social interaction impai

104 g antibody, normal goat or normal rat IgG on mechanical allodynia associated with L5 spinal nerve tra

105 d in a reduction of thermal hyperalgesia and mechanical allodynia associated with persistent neuropat

106 ous pain responses during the first hour and mechanical allodynia at 6 h and 1 day following injectio

107 us (thermal and mechanical) and non-noxious (mechanical allodynia) behavioral paradigms.

108 rin3A coexpression with NGF led to decreased mechanical allodynia but no significant reductions in th

109 al goat and rat IgG significantly attenuated mechanical allodynia, but not at higher doses (0.08-0.00

110 Mice that lack Ccr2 also developed mechanical allodynia, but this started to resolve from 8

111 and scales basal mechanical sensitivity and mechanical allodynia by regulating auxiliary voltage-gat

112 TRPV1 agonists that evoke the development of mechanical allodynia by this receptor.

113 enduringly reduced thermal hyperalgesia and mechanical allodynia caused by inflammation, nerve injur

114 cord are associated with the pathogenesis of mechanical allodynia, changes in cortical circuits also

115 different pain behavior tests (representing mechanical allodynia, cold allodynia, ongoing pain exace

116 The mechanical allodynia depends on early activation of the

117 Following sciatic CCI neuropathy, mechanical allodynia developed in the corresponding foot

118 eased response threshold to tactile stimuli (mechanical allodynia) develops in rats after microinject

119 Piezo2 axis has a role in the development of mechanical allodynia during neuropathic pain.

120 85 mg/kg, i.p.), capsaicin-induced secondary mechanical allodynia (ED(50) approximately 100 mg/kg, i.

121 ical changes in the PNS were associated with mechanical allodynia, even in the absence of nerve injur

122 It was not correlated with mechanical allodynia, extent of L4 fiber damage [ATF3 (a

123 In the SNL model, mechanical allodynia failed to develop 1 and 2 weeks pos

124 nd neuroimmune modulation in the etiology of mechanical allodynia following peripheral nerve injury.

125 in, the effects of this drug were studied on mechanical allodynia following unilateral spinal nerve l

126 led to significant (P < 0.0001) reversal of mechanical allodynia for >/=3 months.

127 reatments were more effective in alleviating mechanical allodynia for peripheral nerve injury than ne

128 ible, dose-dependent attenuation of hind paw mechanical allodynia for up to 1h after administration,

129 L5 nerve transection induced mechanical allodynia from day 1 to 7 which correlated wi

130 before the SNL surgery, reduces SNL-induced mechanical allodynia from day 1 to day 10, with maximal

131 ated that, by six weeks after STZ injection, mechanical allodynia had developed (mechanical withdrawa

132 response threshold to light tactile stimuli (mechanical allodynia) have been reported.

133 ns of the anterior cingulate cortex (ACC) on mechanical allodynia/hyperalgesia after L5 ligation or o

134 Our data indicate that EA at 10 Hz inhibits mechanical allodynia/hyperalgesia more potently than doe

135 dergoing spared nerve injury (SNI) developed mechanical allodynia in 1 wk; nerve blockade with a sing

136 presentative compound effectively attenuated mechanical allodynia in a rat model of neuropathic pain.

137 A-803467 also dose-dependently reduced mechanical allodynia in a variety of rat pain models inc

138 sia and, to a lesser extent, also diminishes mechanical allodynia in CCI in female mice.

139 Mechanical allodynia in diabetic rats was determined by

140 We observed persistent mechanical allodynia in mice lacking MKP-3 (postoperativ

141 ction of CXCL13-activated astrocytes induced mechanical allodynia in naive mice.

142 of hypoxia with hyperbaric oxygen alleviated mechanical allodynia in nerve-injured animals.

143 lated with enhanced thermal hyperalgesia and mechanical allodynia in Pap(-/-) mice.

144 (5+) produced naloxone-sensitive reversal of mechanical allodynia in rats following chronic constrict

145 nd the responses to thermal hyperalgesia and mechanical allodynia in streptozotocin-treated rats betw

146 emisection that correlated with emergence of mechanical allodynia in the hind limbs of rats.

147 urons after nerve injury, and development of mechanical allodynia in the spared nerve injury model is

148 vivo intrathecal injection of 5,6-EET caused mechanical allodynia in wild-type but not TRPA1-null mic

149 d exogenous delivery of SerpinA3N attenuated mechanical allodynia in WT mice.

150 hic pain behaviors (thermal hyperalgesia and mechanical allodynia) induced by chronic constriction ne

151 Mechanical allodynia, induced by normally innocuous low-

152 nal IL-6 levels correlated directly with the mechanical allodynia intensity following nerve injury.

153 stimuli, which suggests that injury-induced mechanical allodynia is transmitted through a circuit th

154 ritoneal pretreatment with l-THP reduced the mechanical allodynia (MA) induced by direct activation o

155 he sympathetic nervous system (SNS) to pain, mechanical allodynia (MA), and hyperalgesia in humans is

156 Thermal hyperalgesia and mechanical allodynia occurred in both hind paws and fore

157 a similar pattern, with heat hypoalgesia and mechanical allodynia occurring simultaneously.

158 inflammatory pain, thermal hyperalgesia, and mechanical allodynia, of which the latter is completely

159 ested doses (15, 30 or 60 mg/kg), it reduced mechanical allodynia only at high doses (30 or 60 mg/kg)

160 ocytes are required during the initiation of mechanical allodynia or thermal hyperalgesia, these cell

161 Persistent thermal hypersensitivity and mechanical allodynia require de novo protein translation

162 lted in exacerbated thermal hyperalgesia and mechanical allodynia reversible by the noncompetitive NM

163 es bone cancer-related thermal hyperalgesia, mechanical allodynia, spontaneous and movement-evoked pa

164 lacking SerpinA3N developed more neuropathic mechanical allodynia than wild-type (WT) mice, and exoge

165 malin showed a spontaneous pain response and mechanical allodynia that persisted for approximately 60

166 niscus, mice developed early-onset secondary mechanical allodynia that was maintained for 16 wk.

167 ction of capsaicin and during post-capsaicin mechanical allodynia (the perception of pain from a norm

168 Mechanical allodynia, the perception of innocuous tactil

169 -induced persistent thermal hyperalgesia and mechanical allodynia to determine the role of transient

170 Lastly, both thermal hyperalgesia and mechanical allodynia to i.t. gp120 were blocked by spina

171 ia peripheral and spinal sites of action and mechanical allodynia via only a spinal site of action.

172 a (tail-flick, TF, and Hargreaves tests) and mechanical allodynia (von Frey and touch-evoked agitatio

173 Behavioral mechanical allodynia was assessed using von Frey filamen

174 Mechanical allodynia was assessed, and glial reactivity

175 uropathic pain where significant reversal of mechanical allodynia was observed at doses that did not

176 Both thermal and mechanical allodynia was observed between 3 and 12 h pos

177 Paclitaxel-induced mechanical allodynia was prolonged in T-cell-deficient (

178 Interestingly, mechanical allodynia was reversed if adenylate cyclase o

179 The SNE-induced mechanical allodynia was reversibly suppressed, partiall

180 erior insular cortex lesion, even though the mechanical allodynia was suppressed.

181 odel of neuropathic pain, the development of mechanical allodynia was totally abrogated in CCR2 knock

182 Thermal hyperalgesia and mechanical allodynia were also present.

183 Additionally, thermal hyperalgesia and mechanical allodynia were enduringly enhanced when PIP(2

184 Pain behaviors (thermal hyperalgesia and mechanical allodynia) were established at one week after

185 ponses: early-phase analgesia and late-phase mechanical allodynia which requires NMDAR; both phases a

186 inistration of NMDA induces GluN2B-dependent mechanical allodynia, which is prolonged in Arrb2-KO mic

187 trocytic mGluR5-signaling pathway suppressed mechanical allodynia, while activating this pathway in t

188 l nerve injury prevented the exacerbation of mechanical allodynia with a concurrent improvement of de

189 heral nerve injury prevented exacerbation of mechanical allodynia with a concurrent improvement of de

190 lted in a long-lasting bilateral (1-4 weeks) mechanical allodynia with a simultaneous unilateral heat

191 cant improvement in potency in vivo, evoking mechanical allodynia with an EC(5)(0) of 14.4 pmol.

192 n, TRPA1 silencing in nociceptors attenuated mechanical allodynia, without affecting macrophage infil