ライフサイエンスコーパス: mechanism

1 sically incompetent, raising interest in the mechanism.

2 limited by the incomplete knowledge of their mechanism.

3 ation as a critical process in the circadian mechanism.

4 inhibit verinurad binding via a competitive mechanism.

5 at this may occur through an attention-based mechanism.

6 exual development through a hitherto unknown mechanism.

7 ry cytokines via a Wnt5a signaling-dependent mechanism.

8 the concept of estrogen's positive feedback mechanism.

9 HPV E6 and E7 hinders HR through a distinct mechanism.

10 membrane in an obligatorily cotranslational mechanism.

11 1) O2 generation and subsequent ROS mediated mechanism.

12 iary plasma membrane by an unknown molecular mechanism.

13 endosome through a pH-triggered disassembly mechanism.

14 ICE) can be utilized as an effective sensing mechanism.

15 ldehyde 3-phosphate (d-G3P) by an unresolved mechanism.

16 insights into a potentially unique reaction mechanism.

17 ine receptor CXCR4 promote epithelial repair mechanisms.

18 e individuals, suggesting similar pathogenic mechanisms.

19 iolet (UV) light induced sunburn via unknown mechanisms.

20 e for investigating the underlying molecular mechanisms.

21 sential prerequisite for proposing catalytic mechanisms.

22 cer formation via both physical and chemical mechanisms.

23 cies Phragmites australis and the underlying mechanisms.

24 fate alternatives are excluded by different mechanisms.

25 ccharomyces cerevisiae to help clarify these mechanisms.

26 th, but little is known about the underlying mechanisms.

27 ndicating orthogonal transcriptional control mechanisms.

28 n excitation and inhibition through distinct mechanisms.

29 nt of iNKT cells through multiple epigenetic mechanisms.

30 nd water are driven by distinct tissue-based mechanisms.

31 and could elucidate shared molecular genetic mechanisms.

32 le-agent activity in certain tumors, but the mechanisms accounting for hypersensitivity are poorly un

33 Opioid, serotonin and NMDA mechanisms acting in rostral ventromedial medulla promot

34 Other mechanisms also affect coral-macroalgal interactions und

35 ly mainly or exclusively on other protective mechanisms, although non-human primate (NHP) studies as

36 ited for a variety of excitation and readout mechanisms, among them optomechanical approaches.

37 M family members represent a disease-driving mechanism and an explanation for RAG off-target cleavage

38 C virus (HCV) infection, but the underlying mechanism and relevance to other viruses or in vivo infe

39 SH3 domains, they display different binding mechanisms and affinities for their interaction with the

40 Here, we investigate mechanisms and determinants of PVEM induction and its po

41 ns a challenge, as seizures manifest through mechanisms and features that span spatial and temporal s

42 rite (from 0.1 to 20mM) was analyzed and the mechanisms and kinetic laws of tryptophan N-nitrosation

43 hould give insight on the particle formation mechanisms and may lead to better-controlled synthesis p

44 ormation on cell culture viability, cellular mechanisms and multicellular movements.

45 models to explore these recently-identified mechanisms and therapeutic interventions are being teste

46 antibodies, link this to the TRIM21 effector mechanism, and highlight how this work is exposing the p

47 sis of TRPC6 is thought to be the underlying mechanism, and recent studies showed that sKlotho intera

48 where connectivity exists without a nursing mechanism, and the biological meaning of such connectivi

49 The apidaecins have special antibacterial mechanisms, and are non-toxic for human cells, a prerequ

50 can exhibit resistance due to many different mechanisms, and many different mobile elements are capab

51 ic variants can lead to understanding causal mechanisms, and to disentangling reverse causation in ep

52 th in type 1 diabetes mellitus, although the mechanisms are incompletely understood.

53 Finally, we show why the described mechanisms are relevant not only in hypertension, but al

54 n diverse bacterial lineages, the underlying mechanisms are still incompletely understood.

55 Epigenetic mechanisms are thought to be important for balancing eff

56 calcification is reversible and the possible mechanisms are unclear.

57 it has remained largely unknown what neural mechanisms are used by the primate auditory cortex to ex

58 Convection provides the mechanism behind plate tectonics, which allows oceanic l

59 val in patients with heart failure (HF), the mechanisms behind this protection are not fully understo

60 a proton relay mechanism between a ketone-like oxygen and a pyridine-li

61 pylori deregulates mitochondria by two novel mechanisms, both rather associated with host cell surviv

62 Central to this problem is the mechanism by which a brain region adjusts its activity a

63 More generally, we demonstrate a mechanism by which a single lesion can cause a complex n

64 These results demonstrate an lncRNA-mediated mechanism by which a transcriptional factor conveys a ge

65 cardiac mitochondria, we demonstrate a novel mechanism by which antimycin-inhibited complex III gener

66 -state structures of the beta2AR reveals the mechanism by which Cmpd-15 modulates agonist binding aff

67 In summary, we describe a mechanism by which increased cytosolic Ca(2+) negatively

68 osin structures and represents an intriguing mechanism by which natural product diversity arises.

69 The mechanism by which Suc affects the circadian oscillator

70 The precise mechanism by which the bacterial SRP receptor, FtsY, int

71 moting AVI formation, and, consequently, the mechanism by which they form.

72 However, mechanisms by which central serotonin action leads to fa

73 The mechanisms by which chronic stress promote the developme

74 s; however, the neural circuits and synaptic mechanisms by which distinct populations of RVM neurons

75 tudies lay the groundwork for exploration of mechanisms by which gap junction nexus stability modulat

76 logy is principally focused on the molecular mechanisms by which hematopoietic cells initiate and mai

77 Understanding the mechanisms by which immune-related events in the periphe

78 l forms of use-dependent plasticity, but the mechanisms by which it controls vesicle fusion and plast

79 Together, our findings provide additional mechanisms by which lysine methylation signaling impacts

80 However, the mechanisms by which manganese (Mn), a common dietary sup

81 ve effector proteins induced by RBM3 and the mechanisms by which mRNAs encoding cold shock proteins e

82 In this study, we aimed to define the mechanisms by which noninflammatory SF modulate Th cell

83 ostasis and disease, and also revealed novel mechanisms by which TGFbeta signals are transduced.

84 ctivity, and defects in one or more of these mechanisms can lead to a breakdown of tolerance.

85 FOXC1-elicited non-canonical WNT5A signaling mechanism comprising NF-kappaB and MMP7 that is essentia

86 tudies are needed to address whether similar mechanisms contribute to the increased risk for calcium

87 l for improving our understanding of disease mechanisms contributing to risk and resilience.

88 en shown that posttranscriptional regulatory mechanisms control PD-L1 expression in cancer, it remain

89 Deciphering the fundamental mechanisms controlling cardiac specification is critical

90 To investigate whether such a mechanism could be an endogenous trigger for autoimmunit

91 We observed that the renal concentration mechanism couples natriuresis with correspondent renal w

92 ce, but the role of sulfur vacancies and the mechanism determining the reaction kinetics are still un

93 We illustrate how distinct signalling mechanisms direct stress-dependent versus homeostatic re

94 pain depends on the pain type or underlying mechanism (eg, painful cramps, nociceptive pain, or neur

95 A new control mechanism employing two-beam refraction and one solenoid

96 Both mechanisms fail in CFTR(-/-) swine, suggesting that cyst

97 The rebound mechanism for alkane hydroxylation was invoked over 40 y

98 It suggests a mechanism for associating landmarks to or dissociating t

99 We uncover a retrograde extension mechanism for axon growth, and reveal the aetiology of a

100 This newly uncovered mechanism for Ca(2+) mobilization by beta2AR has broad i

101 ir initial activation and identifies a novel mechanism for controlling thrombosis.

102 ss the results in the context of a four-step mechanism for HCCS, whereby HCCS mutants such as E159A a

103 itochondrial cristae density as a regulatory mechanism for increasing metabolic power in human skelet

104 The structures suggest a mechanism for iron mineral formation at the protein inte

105 supports social cohesion by providing a key mechanism for minimizing mutual interference.

106 ces metaplasticity that can provide a robust mechanism for mitigating the tradeoff between adaptabili

107 e PE with the myocardium constitutes a third mechanism for PEC translocation to myocardium, and obser

108 Our study provides a potential mechanism for the effects of sildenafil that, through ad

109 On this basis, we propose a mechanism for the formation of doping-gradients toward g

110 a CDK4-PIN1-p53-RS-c-Myc pathway as a novel mechanism for the GOF of p53-RS in HCC.

111 These data reveal a mechanism for the involvement of this region in breast c

112 f nicotinic receptors, which is a prevailing mechanism for use-dependent inhibition in the nucleus ac

113 Gram-negative bacteria, indicating a common mechanism for Z-ring assembly.

114 The currently known mechanisms for active forgetting include neurogenesis-ba

115 We show that the photochemical reaction mechanisms for alpha-keto acids in aqueous solution are

116 Resistance mechanisms for Candida and Aspergillus species have been

117 rent that the immune system evolved multiple mechanisms for controlling self-reactivity, and defects

118 Our findings suggest that molecular mechanisms for epigenetic regulation within the spinal c

119 thropoietin (EPO) were measured as potential mechanisms for exercise-induced EPCs mobilization.

120 sed herein is the ability to adapt biology's mechanisms for innovation and optimization to solving pr

121 Here, we asked whether this mechanism generalizes to OFF-selective T5 cells and to a

122 The mechanisms giving rise to this response remain unclear.

123 Nevertheless, the underlying mechanisms governing this hepatoprotection remain obscur

124 geneity and poor understanding of pathogenic mechanisms hampers the identification of therapeutic tar

125 attenuate muscle atrophy, but the underlying mechanism has not been fully investigated.

126 This mechanism has served as the predominant model of GR-medi

127 addictive behaviors, but underlying circuit mechanisms have been poorly explored by genetic approach

128 For 11 out of these 12, NHI mutation mechanisms have been reported.

129 a sets to develop new hypotheses for disease mechanisms, identify new disease biomarkers, and reposit

130 -derived cellular models to study epigenetic mechanisms impacting on health and disease.

131 (GPR) signaling as a prominent EVI1 effector mechanism in breast carcinoma.

132 ur Article "Evidence of the hydrogen release mechanism in bulk MgH2", Surrey et al. assert that the M

133 at oncogenic enhancers is a novel regulatory mechanism in human pancreatic cancer.

134 comparisons demonstrate that the initiation mechanism in mitochondria is distinct from that in the w

135 , suggests a possible role for an allosteric mechanism in TCR signalling.

136 rved, which possibly acted as a compensatory mechanism in the face of the elevated endogenous tone.

137 In conclusion, our results suggest a mechanism in which MEF2 transcriptional activity is diff

138 ocation to myocardium, and observed a fourth mechanism in which PECs migrate along the surface of the

139 Our study identifies a potential "two-hit" mechanism in which tau acetylation disengages tau from M

140 ration and PARP-1 activation as an important mechanism in Zn(2+)-induced TRPM2 channel activation and

141 yperplasia for health, critical pathways and mechanisms in (involuntary) adipose tissue loss as well

142 ll suited for understanding hypoxia-mediated mechanisms in cancer disease and other biological proces

143 To facilitate the study of cellular mechanisms in human cells, we established several human

144 al scenarios that activate these stabilizing mechanisms in neural networks of mature animals remain e

145 The mechanism involved enhanced activity of defence related

146 , providing new insights into the underlying mechanisms involved in KIR2DS1-related disorders.

147 an attempt to illustrate the dynamin-related mechanisms involved in the above-mentioned disorders and

148 However, the mechanisms involved remain controversial, especially for

149 erosclerosis, and the molecular and cellular mechanisms involved.

150 its function(s) are controlled by regulatory mechanisms involving crosstalk between different PTMs.

151 d suggest that release from this suppressive mechanism is a fundamental requirement for subsequent in

152 The translocation mechanism is likely conserved for other AAA+ ATPases.

153 This mechanism is not based on an ordered sarcomeric organiza

154 replication in DCs, although the underlying mechanism is still unclear.

155 he anti-leukemic agent asparaginase, but the mechanism is unknown.

156 basis underlying these distinctive transport mechanisms is puzzling because CLC channels and transpor

157 Dysregulation of this mechanism leads to numerous human neurodegenerative or n

158 These results suggest a novel candidate mechanism linking histone modifications to hESC fate dec

159 en together, these findings identify a novel mechanism linking IL-6 trans-signaling and angiogenesis

160 its revealed in this study suggest that this mechanism may be useful in applications across various f

161 Involved mechanisms may be correlated to restoration of ERK and A

162 n the consequence of an underlying molecular mechanism measuring a fixed amount of growth.

163 Cell-biological mechanisms mediating delamination are, however, poorly u

164 oglial lineage genes, and reveals unexpected mechanisms mediating tumor viability and invasion, inclu

165 rget, and deep understanding of neutralizing mechanisms, multiple vaccine strategies have advanced to

166 Here, we investigate their mechanism of action and show that mobile small RNAs gene

167 maging agents, thereby confirming an earlier mechanism of action hypothesis.

168 oligodendrocyte glycoprotein (MOG)35-55 The mechanism of action of GM-CSF in EAE is poorly understoo

169 ic agents for metastatic melanoma, yet their mechanism of action remains unclear.

170 h hormone-releasing hormone (GHRH) and their mechanism of action were investigated in diabetic retino

171 n microtubule dynamics suggesting a distinct mechanism of action.

172 ity declines is the most frequently reported mechanism of Allee effects in animals.

173 ility of such measurements, and explored the mechanism of any plaque DOTATATE activity with immunohis

174 lls, which may be an important target in the mechanism of complex 1-deficient vision loss.

175 put data has been profiled to understand the mechanism of complex diseases.

176 for the enzymatic reaction suggest a similar mechanism of cyclization within the enzyme active site;

177 may be a common but relatively understudied mechanism of evolution for new gene functions, particula

178 compartment to the sarcolemma as the primary mechanism of excessive myocellular lipid import.

179 l processes controlled by a GPCR-independent mechanism of G protein activation mediated by cytoplasmi

180 Thus, our data reveal an important mechanism of how p97 maintains lysosomal homeostasis, an

181 has allowed the characterization of a novel mechanism of ICOS regulation.

182 erentiation factor 11 (GDF11) and an unusual mechanism of its inactivation in TNBC.

183 This study therefore defines a novel mechanism of MAPK activation requiring binding of an act

184 this study, we investigated their origin and mechanism of recruitment.

185 al framework for understanding the formation mechanism of S(0) aerosols in different environments.

186 Despite this, the mechanism of the innate immune response has been less we

187 the unique molecular architecture and export mechanism of the Pel apparatus, a widespread exopolysacc

188 erein, we further investigate the underlying mechanism of this conformational rearrangement and its i

189 We reveal that the underlying mechanism of this intriguing gas-like adhesion is the co

190 The mechanism of this novel observation was further investig

191 ts extend the understanding of the molecular mechanism of transcription regulation on cellular stress

192 Although their mechanism of transcriptional repression has been well st

193 B ARRs in regulating the cytokinin response, mechanism of type-B ARR activation, and basis by which c

194 -Abs to internal proteins may be a potential mechanism of universal vaccine design.

195 However, the mechanism of Vps34 in tumorigenesis remains elusive.

196 New drugs with novel mechanisms of action, such as cardiac myosin activators,

197 ubunit of V-ATPase or have poorly understood mechanisms of action.

198 BACE-1-targeted compounds with more complex mechanisms of actions and improved efficacy.

199 how S-nitrosation occurs in vivo and on its mechanisms of cardioprotection and modulation of energy

200 whenever possible, to describe the enzymatic mechanisms of catalysis within the context of their synt

201 We describe new mechanisms of coding and noncoding alteration and identi

202 Mechanisms of disease leading to neurodevelopmental defi

203 suggesting the involvement of complex viral mechanisms of immune evasion.

204 Small molecules with novel and defined mechanisms of inhibition are thus needed to functionally

205 researchers and clinicians for interrogating mechanisms of mutation-dependent drug response, which wi

206 The oncogenic mechanisms of overnutrition, a confirmed independent can

207 ajor source of information to explore shared mechanisms of pathogenesis between disorders.

208 These results translate risk into potential mechanisms of pathogenesis.

209 derpinnings provide insights into biological mechanisms of polysaccharide degradation.

210 ecule toolbox to investigate the biophysical mechanisms of RNA folding and unfolding, its interaction

211 results provide new insights into regulatory mechanisms of seed vigor and reveal distinct requirement

212 in germinal centers to explicitly define the mechanisms of selection in this complex evolutionary pro

213 sistant subclones, to discover the molecular mechanisms of sensitivity.

214 of this study is to determine the underlying mechanisms of sequential energy transfer from laser ligh

215 l as part of the toolbox for delineating the mechanisms of sulfur signaling.

216 ld potentially help to elucidate the complex mechanisms of the disease and lead to the development of

217 Yet, the exact molecular mechanisms of their function in complexes are largely un

218 The mechanisms of these SET reactions are discussed, and the

219 resistance to T-DM1 occurs through multiple mechanisms, one of which is impaired lysosomal proteolyt

220 tabolic profile are causal, via intrauterine mechanisms, or due to shared familial factors.

221 n of naloxone, suggesting an opioid-mediated mechanism; pharmacological and genetic data suggest the

222 evidence for nephrotoxicity and its possible mechanisms, provide recommendations for risk mitigation,

223 However, the mechanisms regulating BACE1 distribution in axons and be

224 However, its primary molecular mechanisms remain incompletely understood in plants and

225 al populations; yet, the underlying biologic mechanisms remain uncertain.

226 However, the underlying disease-causing mechanism remains uncertain.

227 y prone to IIT-induced hypoglycemia, but the mechanism remains unknown.

228 of MS is driven by the very same pathogenic mechanisms responsible for the disease, the autoimmune a

229 However, little is known about the mechanism(s) by which this feedback occurs.

230 umber of rival males in the pool, suggesting mechanisms selecting for consistent differences in behav

231 the possible role of a current-gain inducing mechanism similar to those seen in photodetectors.

232 ostasis may be ensured in any system through mechanisms similar to those that we describe here.

233 rgetically more feasible than other possible mechanisms such as single electron transfer, halogen ato

234 Mechanisms supporting human ultra-cooperativeness are ve

235 dent as well as sortilin-independent sorting mechanisms target aggregated Golgi membrane proteins for

236 RK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel activation.

237 egulation constitutes a global 'silent code' mechanism that controls the functional diversity of prot

238 iac disease, these results suggest a general mechanism that could contribute to immune-mediated disea

239 y, by modulating the channel availability, a mechanism that critically links cellular properties of T

240 onical, transcription-independent signalling mechanism that drives assembly of adherens junctions, an

241 logically relevant NMDA-receptor-independent mechanism that drives increased AMPA receptor recycling

242 We propose a general mechanism that enables the fine-tuning of the Fermi velo

243 xpansion via a regulatory T cell-independent mechanism that involves caspase-dependent T cell apoptos

244 also treats culture as more than a proximate mechanism that is directly controlled by genes.

245 In this study, we report on a novel mechanism that promotes the proinflammatory function of

246 es a human skeletal dysplasia, identifying a mechanism that regulates chondrogenesis via modulation o

247 Our findings thus unveil a global physical mechanism that sustains tissue separation independently

248 an RS structural subunit with an additional mechanism that uses cross-talk between the two NDK monom

249 ads to myocardial lipid accumulation through mechanisms that are incompletely resolved.

250 However, the mechanisms that direct atrial versus ventricular specifi

251 ces, arguing for the existence of additional mechanisms that interfere with GR binding at promoters.

252 Our results reveal the intracellular mechanisms that mediate DAT endocytic recycling followin

253 Mechanisms that orchestrate these events remain poorly u

254 Host discrimination mechanisms that reduce the fitness of uncooperative symb

255 However, the mechanisms that regulate stem cell fates under such wide

256 ILCs (ILC2s) have been implicated in repair mechanisms that restore tissue integrity after injury.

257 Therefore it is imperative to explore the mechanisms that result in LSC survival and develop new t

258 is is placed on reaction types and catalytic mechanisms that showcase both the chemical diversity in

259 However, the transcriptional mechanisms that specify human microglia phenotypes are l

260 This identification of transcriptional mechanisms that support long-term survival and different

261 owing the two effects are due to independent mechanisms that tune the surface properties.

262 s in understanding the systemic and cellular mechanisms that underlie the regulation of iron homeosta

263 Because tumorigenesis is a complex mechanism, the regulatory architecture of the immune sys

264 nd loaders are phylogenetically related, the mechanisms they use for accomplishing similar tasks have

265 eported to produce H2 catalytically via EECC mechanism through a Ni-centered hydride intermediate lik

266 terol-rich diet and uncover a PDL1-dependent mechanism through which MZB cells use their innate immun

267 Collectively, these results identify mechanisms through which FGF signaling regulates inner c

268 ytoplasmic tail may function as a regulatory mechanism to impact ovarian cancer metastatic success.

269 rast, AptRank utilizes an adaptive diffusion mechanism to improve the performance of BirgRank.

270 ndent neutrophil recruitment as an essential mechanism to increase colon carcinogenesis.

271 e this conserved phospho-regulatory feedback mechanism to optimize the balance of growth and stress r

272 in self-acetylation as an important feedback mechanism to regulate acetyltransferases.

273 However, the contribution of both regulation mechanisms to oxygen up-regulation likely varies over de

274 Plants have mechanisms to recognize and reject pollen from other spe

275 hold voltage-activated currents might be the mechanism underlying defective repetitive firing.

276 (KATP)-channels, thus suggesting a possible mechanism underlying KCC2-dependent insulin release.

277 d flow has been considered to be the primary mechanism underlying such impedance based microflow sens

278 The mechanism underlying the effect of ILT3.Fc on tumor cell

279 Here we explored the genetic mechanism underlying the expression of discrete mating s

280 In this study, we elucidated the neuronal mechanism underlying the response at an anatomical, func

281 We identified 3 mechanisms underlying local progression in the remnant p

282 3 oncogenic gain of function but also on the mechanisms underlying nonmutational wtp53 inactivation,

283 However, the neural circuit mechanisms underlying persistent neuronal encoding withi

284 Unlike in mouse models, the mechanisms underlying SAg-associated immunosuppression i

285 technological advances, it is expected that mechanisms underlying several disease states involving t

286 -signaling network in order to elucidate the mechanisms underlying signal integration.

287 e the first to reveal the neurocomputational mechanisms underlying subjective cost-benefit valuation

288 However, the mechanisms underlying the formation, storage, and expres

289 essential in this process, but the molecular mechanisms underlying the influence of experience on int

290 d to elucidate clinically relevant molecular mechanisms underlying the pathogenesis of most monogenic

291 The molecular mechanisms underlying the regulation of MCU, in conditio

292 However the mechanisms underlying these changes are unknown.

293 age in autophagosome formation, review basic mechanisms used to sense this curvature, and then summar

294 The oxidative addition-reductive elimination mechanism via an unstable Cu(III) intermediate is energe

295 The formation mechanism was attributed to the conformational change dr

296 l species involved within the photocatalytic mechanisms were also explored through use of scavenger r

297 to the cellulosome via a single-binding mode mechanism with an adaptor scaffoldin.

298 d have suggested the existence of resistance mechanisms with the need to identify predictive factors

299 n/peptide folding, unfolding and aggregation mechanisms, with the resulting amyloid structure and fun

300 er understanding of the underlying molecular mechanisms would be of help, but unlike the model plant