ライフサイエンスコーパス: mechanism by which

1 However, the mechanism by which 53BP1 facilitates deletional CSR and

2 Central to this problem is the mechanism by which a brain region adjusts its activity a

3 ious work and shows, for the first time, the mechanism by which a chemical-physical treatment abolish

4 sponse pathway that regulates food-uptake, a mechanism by which a common signaling pathway translates

5 We describe a molecular mechanism by which a microbial community affects animal

6 These data reveal the molecular mechanism by which a missense variant in APOC3 causes re

7 e of Cell, Hattori et al. describe a circuit mechanism by which a novel stimulus that initially inter

8 More generally, we demonstrate a mechanism by which a single lesion can cause a complex n

9 These results demonstrate an lncRNA-mediated mechanism by which a transcriptional factor conveys a ge

10 Determining the mechanisms by which a species adapts to its environment

11 n-induced lung injury model, we explored the mechanisms by which acid exposure initiates macrophage r

12 However, the neurophysiological mechanisms by which acupuncture impacts accepted subject

13 gulation of tfpi expression is one potential mechanism by which adtrp1 regulates primitive myelopoies

14 However, the mechanisms by which aging contributes to neurodegenerati

15 These findings identify a mechanism by which alterations in cellular glucose metab

16 Our data also reveal the potential mechanisms by which alveolar macrophages mediate protect

17 These findings uncover new mechanisms by which AMPK could potentially maintain cell

18 Here, we show a mechanism by which an IDP can allosterically control fun

19 ctivate innate immunity to provide a pivotal mechanism by which an organism can respond to damaged se

20 We describe a mechanism by which Ang II stimulates protein kinase C-de

21 These studies reveal a crucial circuit mechanism by which animals adjust their dietary strategy

22 eview describes our current knowledge of the mechanisms by which antifungal drug resistance evolves i

23 dependent, and therefore, our data reveal a mechanism by which antigen presentation controls the inn

24 cardiac mitochondria, we demonstrate a novel mechanism by which antimycin-inhibited complex III gener

25 Together, these results provide a unique mechanism by which AR can either increase or decrease cc

26 elioma (MM) and asbestos exposure, the exact mechanism by which asbestos induces this neoplasm and ot

27 The mechanisms by which Atgl is induced during adipogenesis

28 To explore additional mechanisms by which ATP6V1A overexpressed in GCs, we inv

29 Our study proposes a mechanism by which autophagic degradation of Id proteins

30 ated by follicular helper T (TfH) cells, the mechanism by which B cells initially seed germinal cente

31 The mechanism by which bacteria divide is not well understoo

32 ntact-dependent growth inhibition (CDI) is a mechanism by which bacteria exchange toxins via direct c

33 ollectively, these results shed light on the mechanism by which beta-III-spectrin, and likely similar

34 changes in gene expression may be a possible mechanism by which BSJYD provides myocardial protection

35 the type 1 interferon pathway as a molecular mechanism by which c-MPL mediates immune stimulation in

36 However, the mechanisms by which C3a and C5a modulate IFN-beta expres

37 Together, our findings reveal a novel mechanism by which Ca(2+) overload disrupts myofibril in

38 Taken together, our results reveal a novel mechanism by which CAMK2gamma antagonizes mTORC1 activat

39 e lost along with pluripotency, suggesting a mechanism by which cancer cells reacquire properties tha

40 The molecular mechanism by which cancer-associated fibroblasts (CAFs)

41 We also propose potential mechanisms by which cardiomyopathy-causing mutations may

42 First, we identified a self-feeding mechanism by which CCL1 produced by Treg cells at an aut

43 Here, we report a mechanism by which cell density activates the Hippo path

44 d experimental analysis reveals a regulatory mechanism by which cells can encode information about en

45 ce, post-translational modification may be a mechanism by which cells control physiological assembly

46 this tri-nuclease complex provides a unique mechanism by which cells ensure chromosome segregation a

47 olysis controls septin assembly, and uncover mechanisms by which cells construct defined septin compl

48 This may underlie the mechanisms by which cells sense directional physical cue

49 However, mechanisms by which central serotonin action leads to fa

50 The mechanisms by which CGIs are protected from de novo meth

51 This identifies a novel mechanism by which changes of the amplitude of the systo

52 To identify the mechanism by which ChAT activity is increased, we sought

53 Elucidation of the mechanism by which chemical denaturants unfold proteins

54 Collectively, these findings establish a mechanism by which chronic TNF-alpha signaling orchestra

55 The mechanisms by which chronic stress promote the developme

56 stered inside a normal resting cell, and the mechanism by which circulating anti-PE antibodies access

57 Little is known about the molecular mechanism by which CITED2 displaces the tightly bound HI

58 -state structures of the beta2AR reveals the mechanism by which Cmpd-15 modulates agonist binding aff

59 We here detail the mechanism by which co-translational signal-peptide cleav

60 Our results illustrate a mechanism by which cocaine, acting on a key neuromodulat

61 tomical background for studies that seek the mechanisms by which cognitive and motor dysfunctions ari

62 Together, these results uncover a mechanism by which competitive recruitment of DNA-bindin

63 ollowed by processive enlargement provides a mechanism by which condensin complexes compact and resol

64 However the mechanism by which CTCF haploinsufficiency contributes t

65 However, the molecular mechanism by which DENND3 becomes activated has remained

66 The mechanism by which DENV induces lipophagy is unknown.

67 Here we identify a potential mechanism by which desmosomes assist the de-neddylating

68 These results provide evidence for a mechanism by which devaluation modulates a cognitive map

69 In this article, we report a new mechanism by which dietary FAs, in particular, saturated

70 Our data provide novel insights into the mechanisms by which different tissues manage genome stab

71 s; however, the neural circuits and synaptic mechanisms by which distinct populations of RVM neurons

72 ing on marine ecosystems, suggesting a novel mechanism by which diversity confers resilience.

73 An enhanced understanding of the mechanisms by which DSA causes allograft injury, and eff

74 However, the cellular and molecular mechanisms by which dysfunction of TDP-43 contributes to

75 These findings reveal a new mechanism by which E/I balance is controlled in neurons

76 eveloping networks that underlie memory, the mechanisms by which early-life seizures influence them,

77 Together, these results reveal a novel mechanism by which EBF2 cooperates with a tissue-specifi

78 The structural and biochemical mechanisms by which EBNA1 allows the long-term persisten

79 Our findings highlight an important mechanism by which EC contribute to atherogenesis under

80 The mechanism by which elastic inhomogeneity reduces the yie

81 Understanding the mechanisms by which Entamoeba histolytica drives gut inf

82 bules influence cell expansion; however, the mechanisms by which environmental signals impinge upon m

83 gastrointestinal tract, and identifies novel mechanisms by which epicutaneous tolerance can suppress

84 e results provide insight into the molecular mechanism by which ErbB2-positive breast cancer escapes

85 ease and highlights new avenues for defining mechanisms by which ExPEC strains colonize the mammalian

86 Although the mechanism by which extracellular vesicles are internaliz

87 However, the mechanisms by which EZH2 is regulated in PCa and CRPC re

88 activate or repress expression, however, the mechanisms by which factors find targets remain unclear.

89 its associated motor and offer an unexpected mechanism by which filaments of the cytoskeletal network

90 In an effort to determine the mechanism by which FMRP mediates protein translation and

91 We report a previously unknown molecular mechanism by which folate regulates trophoblast cell fun

92 n and FVIII, and reveal a range of molecular mechanisms by which FVIII missense mutations lead to mod

93 Our data therefore support an additional mechanism by which GABABRs are able to modulate fast syn

94 However, the mechanism by which Galpha13 signals to actin cytoskeleta

95 tudies lay the groundwork for exploration of mechanisms by which gap junction nexus stability modulat

96 s found in a range of bacteria and reveals a mechanism by which gastrointestinal pathogens directly t

97 complex traits should be expanded to include mechanisms by which genetic variation shapes the environ

98 ctions of GLIS3 in the thyroid gland and the mechanism by which GLIS3 dysfunction causes hypothyroidi

99 Here we investigated mechanisms by which GLP-1 and serotonin interact at the

100 In this Perspective, an overview of the mechanisms by which GLP-1R activation exerts its effects

101 Here we investigated the mechanism by which glucagon and insulin increased FGF21

102 gether, our study not only shed light on the mechanism by which glucocorticoid imparts its beneficial

103 Although the mechanisms by which glucose regulates insulin secretion

104 Here, we review the mechanisms by which gonadal hormones and sex chromosome

105 antly contribute to our understanding of the mechanism by which GRKs regulate the function of activat

106 dynamic modeling were performed to probe the mechanisms by which guanidinium (Gnd(+)) salts influence

107 powerful and generalizable tool to probe the mechanisms by which H3 tails are read out by effector pr

108 However, the mechanism by which H3K4me3 modifiers affect longevity, a

109 ium was developed to determine the transport mechanism by which HCO3(-) ions are secreted at concentr

110 detailed experimental investigation into the mechanism by which HdeA unfolds and activates.

111 logy is principally focused on the molecular mechanisms by which hematopoietic cells initiate and mai

112 sed functional HCO models to investigate the mechanism by which heme E degrees ' modulates oxidase ac

113 The mechanisms by which hepcidin and hypoferremia modulate h

114 lans in the brain.SIGNIFICANCE STATEMENT The mechanism by which humans adapt eye movements in respons

115 The mechanisms by which immune checkpoint blockade modulates

116 known to affect cancer development, yet the mechanisms by which immune signaling drives transformati

117 Understanding the mechanisms by which immune-related events in the periphe

118 In summary, we describe a mechanism by which increased cytosolic Ca(2+) negatively

119 mmalian reovirus, we highlight the molecular mechanism by which infection with a dsRNA virus results

120 Although inflammation promotes PAH, the mechanisms by which inflammation and BMPR-II dysfunction

121 new avenue of research into the fundamental mechanisms by which inflammation impacts local cellular

122 Selective inhibitors could help unveil the mechanisms by which inhibition of poly(ADP-ribose) polym

123 ermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to i

124 However, the mechanism by which IRAK4 activity regulates the producti

125 s a next step toward an understanding of the mechanism by which IreB regulates resistance, we initiat

126 into the biosynthesis of crochelins and the mechanism by which iron may be removed upon import of th

127 de an overview of the cellular and molecular mechanisms by which islet inflammation develops and caus

128 s epileptic seizures; however, the molecular mechanism by which it achieves this effect is still larg

129 e basis for TIRAP membrane insertion and the mechanism by which it is removed from membranes to avoid

130 intraspecific chemical communication and the mechanisms by which it can be inherited.

131 l forms of use-dependent plasticity, but the mechanisms by which it controls vesicle fusion and plast

132 x-determination gene doublesex (dsx) and the mechanisms by which it mediates sex-specific development

133 s the most frequent target of mutations, the mechanism by which its inactivation promotes tumorigenes

134 wheat and demonstrate the unique regulatory mechanism by which Iw1 acts to suppress a carboxylestera

135 Together, these data outline a new signaling mechanism by which KCa1.1 regulates beta1-integrin funct

136 In brief, our findings reveal a novel mechanism by which KDM3A promotes ovarian CSCs, prolifer

137 These results demonstrate a novel mechanism by which Kdm4d regulates DNA replication by re

138 ion by Kr-h1 and dFOXO may represent a broad mechanism by which Kruppel-like factors integrate with i

139 Together, our results demonstrate a novel mechanism by which laminins modulate vascular branching

140 Thus, we define a new memory mechanism by which learning reverses microRNA-mediated s

141 ghts recent findings and discusses molecular mechanisms by which LFA-1 signaling influence T lymphocy

142 families with the R246Q mutation, though the mechanisms by which LMX1BR246Q causes a renal-specific p

143 cal activity states, and reveal the cellular mechanisms by which local inhibitory microcircuits regul

144 evidence in human participants regarding the mechanisms by which loss of estradiol contributes to thi

145 Together, our findings provide additional mechanisms by which lysine methylation signaling impacts

146 dynamic decision making is a new behavioral mechanism by which MA rigidly biases choice behavior.

147 his review, we discuss the common and unique mechanisms by which macrophages instruct tissue repair i

148 Our results uncover a novel mechanism by which MALAT1 regulates the activity of p53

149 However, the mechanisms by which manganese (Mn), a common dietary sup

150 The mechanism by which mast cells (MCs) are activated in T c

151 However, our understanding of processes and mechanisms by which maternal behavior influences the dev

152 l onset, we would gain new insights into the mechanisms by which maternal UBE3A loss derails neurotyp

153 Our findings provide a novel mechanism by which microbial-derived butyrate promotes b

154 However, the precise mechanisms by which microglia alter the course of AD neu

155 In this study, we examined the mechanism by which Mincle, a C-type lectin receptor, reg

156 However, the mechanisms by which miR response to cutaneous S. aureus

157 As we continue to examine the mechanisms by which miRNAs maintain the balance between

158 We describe mechanisms by which molecules cross endothelial cell (EC

159 ve effector proteins induced by RBM3 and the mechanisms by which mRNAs encoding cold shock proteins e

160 data support a role for a feed-forward loop mechanism by which mTORC2 activity stimulates Rictor tra

161 mine KCC2 activity, we have investigated the mechanism by which N-ethylmaleimide (NEM) enhances trans

162 osin structures and represents an intriguing mechanism by which natural product diversity arises.

163 p70 autoinhibition engaged negative feedback mechanisms by which negative selection and inhibitory re

164 Functioning via a mechanism by which neighbouring iron(ii) sites undergo a

165 n has been developed in female mice to study mechanisms by which Neisseria gonorrhoeae evades host-de

166 These results support a molecular mechanism by which Neto2 phosphorylation at Ser-409 help

167 The mechanisms by which neural circuits perform the computat

168 The mechanisms by which neuroendocrine (NE) cells arises fro

169 These findings reveal new mechanisms by which neuroendocrine nerve terminal Ca(2+)

170 al modification, O-GlcNAcylation, is a novel mechanism by which neuronal and synaptic excitability ca

171 ls are important for motor coordination, the mechanisms by which neurones in the inferior olive integ

172 erized by severe neuronal loss; however, the mechanisms by which neurons die remain elusive.

173 These results establish a novel mechanism by which NF-kappaB and Akt contribute to chemo

174 Our results provide insight into the mechanisms by which NLRC4 inflammasome activation mediat

175 effects of nitric oxide (NO) are known, the mechanism by which NO modulates corneal wound healing re

176 The molecular mechanism by which NO operates at the blood-endothelium

177 In this study, we aimed to define the mechanisms by which noninflammatory SF modulate Th cell

178 However, the mechanisms by which nonmuscle myosin II (NM-II) is recru

179 a(2+)-conducting viroporin and establish the mechanism by which NSP4 disturbs host cell Ca(2+) homeos

180 Collectively, these findings reveal a mechanism by which nuclear-based changes influence the s

181 sport (IFT) protein IFT46, but the molecular mechanism by which ODAs are recognized and transported i

182 l rectus motoneurons, as well as the plastic mechanisms by which one input compensates for the lack o

183 Here, we identify a mechanism by which organismal copper homeostasis is main

184 However, the mechanisms by which ORMDL3 predisposes to asthma are unc

185 One major mechanism by which oxygen regulates cellular function is

186 , our findings identify a previously unknown mechanism by which P. aeruginosa ExoY inhibits the host

187 le treatment outcomes and to investigate the mechanisms by which p16 may regulate radiosensitivity.

188 ly mutated in cancer, our findings provide a mechanism by which p53 loss can promote cancer mutagenes

189 Together, these studies define mechanisms by which p53 regulates thrombus resolution by

190 ement for polymers and suggest a segregation mechanism by which ParA-ATP dimers equilibrate to HDRs s

191 ure provides essential insight into multiple mechanisms by which pathogenic mutations interfere with

192 d respond to mechanical force, the molecular mechanisms by which physical cues are converted to cell-

193 s to reduced fertility in male mice, but the mechanism by which PLAG1 contributes to reproduction is

194 Thus, these findings uncover a novel mechanism by which PML loss may contribute to mTOR activ

195 Our study identifies a novel mechanism by which Polycomb directs the developmental pr

196 The molecular mechanisms by which protein machineries control force tr

197 Here, we report the molecular mechanism by which PS1 modulates betaCTF degradation.

198 r biochemical evidence allow us to propose a mechanism by which Psb28 exerts its protective effect on

199 model of advanced DN and provide a molecular mechanism by which puerarin exerts the anti-oxidative ef

200 and in silico analyses give insight into the mechanism by which radiation modifies glycosylation.

201 RAS controls are well known, but the precise mechanisms by which RAS proteins function are less clear

202 However, the mechanism by which remodellers discriminate between diff

203 fluenza, but evidence of association and the mechanism by which risk is conferred remain controversia

204 ic activity and defines a previously unknown mechanism by which S. aureus may influence skin diseases

205 However, the mechanism by which SagS accomplishes both functions is u

206 These data define a molecular mechanism by which Saureus cells sense the host environm

207 However, the molecular mechanism by which SERINC5 restricts HIV-1 particle infe

208 We discuss some of the mechanisms by which SES may influence behaviour.

209 , our data identify a previously unsuspected mechanism by which sIgM deficiency aggravates atheroscle

210 To investigate the mechanism by which signaling through IRS-1 and IRS-2 res

211 In efforts to uncover the mechanism by which SLFN5 promotes GBM tumorigenesis, we

212 This provides a mechanism by which slow-wave activity might bias synapse

213 We investigated the mechanisms by which SMAD6 and another inhibitory SMAD (S

214 However, the mechanism by which Spata2 regulates the activation of RI

215 However, the mechanisms by which spatially distributed brain regions

216 in auditory neuroscience is to identify the mechanisms by which specific motifs within inter-connect

217 The mechanisms by which sporopollenin is anchored onto micro

218 The mechanisms by which SS4 determines granule number and mo

219 Elucidating the cellular mechanisms by which steroids modulate brain development

220 These pathways are intimately tied to the mechanisms by which strains interact and compete across

221 The mechanisms by which stressful life events increase the r

222 gy and have begun to illuminate the distinct mechanisms by which structurally, chemically, and functi

223 The mechanism by which Suc affects the circadian oscillator

224 The mechanism by which such peptides emerge from linear prec

225 ALS) and frontotemporal dementia, though the mechanisms by which such expansions cause neurodegenerat

226 and nitrile hydratases (NHases), and yet the mechanisms by which sulfurs are oxidized by these enzyme

227 s bidirectional in that it showed not only a mechanism by which T cells become pathogenic before ente

228 f the intestinal mucosa and investigated the mechanism by which T-UCR uc.173 regulates epithelial ren

229 ed on the induction of T cell responses, the mechanisms by which targeting improves Ab responses are

230 The mechanisms by which tau organizes microtubule networks r

231 862-875) provide new insights into the mechanisms by which temporal and spatial regulators are

232 ostasis and disease, and also revealed novel mechanisms by which TGFbeta signals are transduced.

233 llectively, our results reveal the molecular mechanism by which TH functions during red blood cell fo

234 The precise mechanism by which the bacterial SRP receptor, FtsY, int

235 propose that CRP K100 acetylation could be a mechanism by which the cell downwardly tunes CRP-depende

236 Here, we investigated the mechanism by which the Chlamydia-containing vacuole, ter

237 n and mammalian cell culture, we elucidate a mechanism by which the coincidence of PI(4,5)P2 and PI(3

238 Next, we identified the mechanism by which the engulfment of erythrocytes with e

239 Therefore, cathelicidins provide a novel mechanism by which the immune system can discriminate be

240 tide incorporation assays to investigate the mechanism by which the model Y-family polymerase, Dpo4,

241 However, the mechanism by which the PAR4-P2Y12 dimer controls beta-ar

242 Our findings unveil a new mechanism by which the pericardial AT coordinates immune

243 We investigated the regulatory mechanism by which the pre-apoptotic proteins translocat

244 gen-experienced CD8(+) T cells and provide a mechanism by which the presence of T1-IFN potentiates di

245 otubule motor dynein in HIV-1 infection, the mechanism by which the viral core containing the viral g

246 The mechanisms by which the constraint of a hard pericarp de

247 However, the concrete mechanisms by which the core transducer of NF-kappaB sig

248 The mechanisms by which the deep ocean circulation changed,

249 However, the mechanisms by which the human brain updates specific goa

250 d mathematical models to study two different mechanisms by which the immune system can select for bro

251 The mechanisms by which the lymphatic system extracts fluid

252 essant drugs, but the cellular and molecular mechanisms by which their therapeutic action is initiate

253 However, the mechanism by which these determinants are delivered and

254 features around the world [1]; however, the mechanism by which these organisms produce the mineral i

255 However, very little is known about the mechanism by which these structures are formed.

256 studies are necessary to further explore the mechanisms by which these genes affect adipocyte biology

257 have been identified; however, the molecular mechanisms by which these GFs regulate the survival, pro

258 tterning of developing embryos; however, the mechanisms by which these gradients are interpreted rema

259 We review the mechanisms by which these gut bacteria, fungi, and virus

260 The molecular mechanisms by which these ligands affect the exhausted s

261 ical epithelial barrier and to elucidate the mechanisms by which these miRNAs modify cervical epithel

262 nhedonia through actions in the PFC, but the mechanisms by which these receptors act are not known.

263 Our findings provide plausible mechanisms by which these sequences could alter RNA gran

264 t the source of inflammatory signals and the mechanisms by which these signals regulate the disruptio

265 We report here a mechanism by which they are activated in cancer cells, i

266 moting AVI formation, and, consequently, the mechanism by which they form.

267 pathway activity, but the precise molecular mechanism by which they function is still poorly underst

268 pital costs following major surgery, but the mechanism by which they increase cost and the categories

269 However, their functions and the mechanisms by which they act are not fully understood.

270 pathways governing their abundance, and the mechanisms by which they affect the function of neural c

271 function of these glycans in planta, and the mechanisms by which they are depolymerized in microbial

272 s and their oligomeric precursors and of the mechanisms by which they are formed and proliferate to g

273 and photochemistry to describe the molecular mechanisms by which they function.

274 late adult hippocampal neurogenesis, but the mechanisms by which they increase neurogenesis and modul

275 ense at host/environment interfaces, yet the mechanisms by which they interact with CD4(+) T cells ha

276 The mechanisms by which they perform this function have been

277 It has been speculated that the mechanism by which thick filament length is controlled i

278 ic index food when consumed together and the mechanism by which this might occur.We compared the acut

279 However, the mechanism by which this occurs is distinct from that of

280 The mechanism by which this occurs is unknown.

281 Herein we evaluate the mechanism by which this synthetic C-terminal amphiphilic

282 We used blockade of IL-21 to dissect the mechanisms by which this cytokine promotes autoimmunity

283 festation and provide insight into potential mechanisms by which this intronic retroelement may induc

284 a trachomatis and Neisseria gonorrhoeae, the mechanisms by which this pathogen elicits inflammation,

285 e systems that undergo phase separation, the mechanisms by which this phase transition occurs, and th

286 s mycobacteria in human populations, but the mechanisms by which this polymorphism affects TLR2 signa

287 ll gene expression patterns to determine the mechanisms by which TL1A regulates cytokine production,

288 ntrolled stimulus paradigm to understand the mechanisms by which top-down processes (expectation and

289 However, the mechanism by which transcription termination is achieved

290 We report novel mechanisms by which TRMs regulate T cell activities at t

291 The mechanism by which TRP channels participate in pruritoge

292 opic approaches are needed to understand the mechanisms by which TRPV1 translates diverse stimuli int

293 amic tumour-immune cell interactions and the mechanisms by which tumour cells evade antitumour immuni

294 We also identify a PKG-dependent mechanism by which valsartan/sacubitril, a combination d

295 gical contexts is required to understand the mechanisms by which variation in non-coding genetic sequ

296 Still, CsMPs provide a mechanism by which volatile and low-volatility radionucl

297 The mechanisms by which WNV enters the central nervous syste

298 gs underscore two distinct but complementary mechanisms by which XPC influences gene regulation by co

299 ken together, our study not only reveals the mechanism by which YAP reprograms glucose metabolism, bu

300 0 (miR-200) family and ZEB1, but the precise mechanisms by which ZEB1-dependent EMT promotes malignan