ライフサイエンスコーパス: mechanism of

1 , this study investigated the transformation mechanisms of 20 OMPs during the methanogenic step of AD

2 dy reveals a potential underlying biological mechanism of a novel risk gene for major mood disorders

3 ay be associated with the original secretion mechanism of a particular growth factor.

4 is highly complex and driven by synergistic mechanisms of a complex compound mixture (of which many

5 Here, I examine several potential mechanisms of abiotic CO2 uptake in arid and semiarid so

6 target identification and elucidation of the mechanism of action (MoA) of hits from these noisy high-

7 Here, we investigate their mechanism of action and show that mobile small RNAs gene

8 migraine therapy, although its efficacy and mechanism of action are unclear.

9 analysis reveals remarkable conservation in mechanism of action between SVP genes of taxonomically d

10 Snail1-dependent manner, indicating that the mechanism of action for NA in cell migration is evolutio

11 nhibitor, modulates tau acetylation, a novel mechanism of action for this class of compounds.

12 maging agents, thereby confirming an earlier mechanism of action hypothesis.

13 ew approach but better understanding of this mechanism of action is needed.

14 As the mechanism of action of ABMA is restricted to host-endoso

15 We propose that the primary mechanism of action of acylation is to control membrane

16 The mechanism of action of DEXxDSy was assessed.

17 and metabolomics were used to determine the mechanism of action of ER-beta and its ligands.

18 oligodendrocyte glycoprotein (MOG)35-55 The mechanism of action of GM-CSF in EAE is poorly understoo

19 e to a certain degree, partly explaining the mechanism of action of local hyperthermia to treat viral

20 annels and correctly identified the accepted mechanism of action of nifedipine, a calcium-channel blo

21 regulates molecular events implicated in the mechanism of action of rapid-acting antidepressant ketam

22 ose of the study is to discuss the potential mechanism of action of rifaximin, a minimally absorbed a

23 The proposed mechanism of action of the modifiers includes proton tra

24 To uncover the mechanism of action of ZnO NPs on CT activity, here we u

25 smission and dopamine reuptake, the specific mechanism of action remains obscure.

26 of the Notch signaling pathway, although its mechanism of action remains unclear.

27 ic agents for metastatic melanoma, yet their mechanism of action remains unclear.

28 rmatitis; however, the specific antipruritic mechanism of action remains unclear.

29 Microarray-based initial studies on the mechanism of action suggest that compound 8 blocks trans

30 Allosteric modulators offer an alternative mechanism of action to traditional alpha1-adrenergic lig

31 h hormone-releasing hormone (GHRH) and their mechanism of action were investigated in diabetic retino

32 fficulty in using such structures to infer a mechanism of action, especially in the case of membrane

33 nctionality, presumably due to the different mechanism of action.

34 this study provide insight into nivolumab's mechanism of action.

35 n microtubule dynamics suggesting a distinct mechanism of action.

36 effects in models of adult fibrosis, but the mechanisms of action are unclear.

37 Several mechanisms of action have been proposed, including thiol

38 ction via frequently encountered promiscuous mechanisms of action including inhibition of the QcrB su

39 However, its mechanisms of action remain poorly understood.

40 )-binding to their two C2 domains, but their mechanisms of action remain unclear.

41 were investigated in vitro and in vivo, and mechanisms of action were suggested.

42 ributed to three independent and synergistic mechanisms of action, only one of which requires d-Ala-d

43 New drugs with novel mechanisms of action, such as cardiac myosin activators,

44 velopment, with particular emphasis on their mechanisms of action.

45 ubunit of V-ATPase or have poorly understood mechanisms of action.

46 for future studies to better define specific mechanisms of action.

47 ication of additional RIBE factors and their mechanisms of action.

48 BACE-1-targeted compounds with more complex mechanisms of actions and improved efficacy.

49 mors, but its presence, functional role, and mechanisms of actions in prostate cancer (PCa)-the most

50 However, the mechanism of activation is not understood.

51 We gained insights into the mechanism of acyl hydrolysis by observing differing arra

52 nd reveal an electrophysiological regulatory mechanism of adipocyte function.

53 oprene SOA in the troposphere, understanding mechanisms of adverse health effects through inhalation

54 st study that describes the use and reaction mechanism of aforementioned modifiers for enhancement of

55 DNA cleavage mechanism of AgeI is novel among Type IIP restriction en

56 ity declines is the most frequently reported mechanism of Allee effects in animals.

57 es were collected from mice and analyzed for mechanisms of allergy development.

58 Isoform-specific mechanisms of alpha3beta4*-nicotinic acetylcholine recep

59 This is because the mechanism of altering focus, termed accommodation, is no

60 Further studies are needed to evaluate the mechanism of and opportunities for prevention of the cog

61 arget gene demonstrating a positive feedback mechanism of androgenic signalling in CRPC.

62 d CpG's likely serves as an adjunct to other mechanisms of ANO1 activation.

63 escribed as an FFA4 antagonist; however, its mechanism of antagonism remains unknown.

64 ntigen to CD4+ T cells suggesting that other mechanism of antigen presentation are driving the robust

65 s reveal an important and previously unknown mechanism of antitumor immune regulation and provide new

66 degradation pathway and has emerged as a key mechanism of antiviral immunity in metazoans, including

67 ility of such measurements, and explored the mechanism of any plaque DOTATATE activity with immunohis

68 We investigated the effects and mechanism of AS II on intestinal wound healing in both i

69 dings provide new insight on the microscopic mechanisms of atomic desorption from organic coatings.

70 The mechanism of axon degeneration is incompletely understoo

71 delineated an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity that required

72 The precise molecular mechanisms of beta-adrenergic activation of cardiac CaV1

73 Force is a fundamental regulatory mechanism of biomolecular interactions driving many cell

74 lay an important role in natural remediation mechanisms of carbamates.

75 indings help to shed light on the underlying mechanisms of cardiac alternans especially when the rela

76 how S-nitrosation occurs in vivo and on its mechanisms of cardioprotection and modulation of energy

77 provides a unique opportunity to investigate mechanisms of carotenoid coloration.

78 of diet-derived carotenoid pigments, yet the mechanisms of carotenoid uptake and transport are not we

79 whenever possible, to describe the enzymatic mechanisms of catalysis within the context of their synt

80 In this study, we investigated the mechanism of Cd induced stress response of L. plantarum

81 e-associated microglia are removed by a dual mechanism of cell egress and apoptosis to re-establish t

82 e studies, we uncover a sequential, two-step mechanism of cellular reprogramming in which repression

83 To determine whether the mechanism of ceramide-induced membrane leakage is consis

84 tory DNA evolution is likely the predominant mechanism of change, it was recently shown that Tbrain,

85 n immune cartilage destruction; however, the mechanisms of chondrocyte recognition by NK cells remain

86 te ciliary protein composition; however, the mechanisms of ciliary gating and the dynamics of the gat

87 6 g L(-1))-to gain a genome-wide view of the mechanism of citrate accumulation.

88 n with cisplatin-based chemotherapy, suggest mechanisms of clinical resistance, and inform developmen

89 n, the tissue distribution or the underlying mechanism of clonal expansion in vivo.

90 ur study provides insight into the molecular mechanisms of cocaine's contribution to key components i

91 We describe new mechanisms of coding and noncoding alteration and identi

92 lls, which may be an important target in the mechanism of complex 1-deficient vision loss.

93 put data has been profiled to understand the mechanism of complex diseases.

94 The DNA-organizing mechanism of condensin depends on the energy of ATP hydr

95 The mechanism of conduction has been determined using (1)H a

96 egulation of protein-coding genes is a major mechanism of controlling cellular functions.

97 ilitating bacterial persistence via the same mechanism of controlling proinflammatory T cell response

98 sults do not support the proposed glymphatic mechanism of convective solute transport in brain parenc

99 for the enzymatic reaction suggest a similar mechanism of cyclization within the enzyme active site;

100 se channel (RyR) gating and is used to study mechanisms of DAD variability.

101 To examine the mechanisms of DAT filopodial targeting, we used quantita

102 The mechanism of dendritic cells (DCs) recruitment across th

103 Xu and McPherson now identify a novel mechanism of DENND3 intramolecular binding that is regul

104 Understanding the molecular genetic mechanisms of development and function in the vocal appa

105 Our data suggest an unanticipated mechanism of developmental compensation whereby cerebell

106 in five ARS genes, which points to a shared mechanism of disease.

107 Mechanisms of disease leading to neurodevelopmental defi

108 monitor EGFR-TKI resistance and to discover mechanisms of drug resistance.

109 Mechanisms of DVT remain incompletely understood.

110 letrozole, the findings suggest sex-specific mechanisms of E2 signaling.SIGNIFICANCE STATEMENT The ba

111 ys-emphasizes the need to integrate multiple mechanisms of ecological self-organization.

112 a foundation for understanding the molecular mechanism of EGCG as a neurotoxicity inhibitor.

113 However, the mechanism of EGFR-induced NF-kappaB activation is not fu

114 irectly the charge dynamics of this peculiar mechanism of electron transfer.

115 h resonant Bragg gratings as an example, the mechanism of enhancing or suppressing the resonant trans

116 LB signaling is a therapeutically targetable mechanism of escape from NRAS oncogene addiction in AML.

117 may be a common but relatively understudied mechanism of evolution for new gene functions, particula

118 nomes have been very informative about basic mechanisms of evolution, speciation, hybridization, dome

119 compartment to the sarcolemma as the primary mechanism of excessive myocellular lipid import.

120 Our results implicated a novel mechanism of exosome-mediated intercellular communicatio

121 e our limited understanding of the molecular mechanisms of filament assembly, we have used a syntheti

122 model in whorl specification, the underlying mechanism of fine-tuning double flower formation remains

123 Knowledge of the mechanism of formation, levels and toxicological profile

124 The mechanisms of formation of the distinct sensory organs o

125 This mechanism of FoxP3 control may allow escape from dominan

126 irst time to our knowledge-the existence and mechanisms of functional interactions between the endoge

127 l processes controlled by a GPCR-independent mechanism of G protein activation mediated by cytoplasmi

128 examine the neural connections and cellular mechanisms of GLP-1R signaling on PVT-to-nucleus accumbe

129 Jozic et al. describe mechanisms of glucocorticoid (GC) downregulation of woun

130 the first report providing insight into the mechanism of host lipid catabolism by an M. tuberculosis

131 Thus, our data reveal an important mechanism of how p97 maintains lysosomal homeostasis, an

132 The molecular mechanism of how TPX2 stimulates MT assembly remains unk

133 stems illuminates highly conserved molecular mechanisms of how cohesin and condensin establish the fu

134 Importantly, this mechanism of HR is independent of RAD51, which encodes t

135 uggest that altering ADP inhibition may be a mechanism of Hsp90 regulation.

136 llectively, these findings establish a novel mechanism of humoral protection in the eye involving FcR

137 has allowed the characterization of a novel mechanism of ICOS regulation.

138 level characterization of the genome release mechanism of iflaviruses.

139 To decipher the mechanisms of IgM assembly, we investigated its biosynth

140 suggesting the involvement of complex viral mechanisms of immune evasion.

141 AF-associated genetic variants act through a mechanism of impaired muscle cell differentiation and ti

142 These findings reveal novel mechanisms of incisor renewal and illustrate how gene co

143 h direct ischaemic effects of haemorrhage as mechanisms of infarct development.

144 lex and biochemical studies to elucidate the mechanism of inhibition of MMP9 by GS-5745.

145 analogs explain the FD44 specificity and the mechanism of inhibition, in which the small molecule sta

146 Small molecules with novel and defined mechanisms of inhibition are thus needed to functionally

147 Some considerations regarding the mechanisms of inhibition of the lipid peroxidation in mi

148 These less acknowledged mechanisms of interaction and molecular control might ha

149 Elucidation of the mechanism of intracellular dynamics of IAV assembly is n

150 d with many biological pathways, the genetic mechanism of ischemic stroke is still unclear.

151 The exact mechanism of its action has yet to be determined, but it

152 erentiation factor 11 (GDF11) and an unusual mechanism of its inactivation in TNBC.

153 n chlorine and thus, an understanding of the mechanism of its introduction into organic molecules is

154 unctionalities establish a continuum under a mechanism of Kap-centric control.

155 Here we report a mechanism of KCC2 regulation by GABAA receptor (GABAAR)-

156 s, our studies provide new insights into the mechanism of ligand recognition by this enigmatic family

157 adation enabled by precipitation as the main mechanism of litter decomposition.

158 beginning to be recognized and the molecular mechanism of lncRNA-mediated gene regulation remains lar

159 Improved understanding of the mechanism of long-distance iron signaling will allow imp

160 To gain insights into the molecular mechanisms of Lrp4 function in modulating Wnt signaling,

161 is disease has improved understanding of the mechanisms of lung fibrosis, and offers hope that simila

162 ure may not be closely linked to the genetic mechanisms of major psychiatric disorders.

163 This study therefore defines a novel mechanism of MAPK activation requiring binding of an act

164 However, the mechanisms of mechanotransduction remain elusive.

165 timely provide very useful insights into the mechanism of meiotic recombination and the process of ge

166 To better understand the mechanisms of memory maintenance in CD8(+) T cells, we p

167 criptional and post-translational regulatory mechanisms of metabolic processes.

168 The mechanisms of metal release from the articulation at the

169 To investigate the regulatory mechanism of mIDH2 (mouse mitochondrial IDH2), we used l

170 owledge of the functions and pathobiological mechanisms of most genes.

171 of the PP2A complex STRIPAK(SLMAP) as a key mechanism of MST1/2 activation.

172 researchers and clinicians for interrogating mechanisms of mutation-dependent drug response, which wi

173 We study two distinct motility mechanisms of Myxococcus xanthus, namely, twitching and

174 Furthermore, the mechanisms of natural evolution leading to improved or n

175 These findings provide a mechanism of NCoR1 in intestinal homeostasis during deve

176 The mechanism of NE uptake, however, remains unknown.

177 ability of the nociceptive system is a basic mechanism of neuropathic pain.

178 evidence supports a conceptual shift in the mechanisms of neurovascular coupling, from a unidimensio

179 The mechanisms of Ni-catalyzed C-H arylation, alkylation, an

180 Therefore, this review will discuss the mechanism of NO in overcoming MDR and recent progress of

181 Understanding the role and the underlying mechanisms of NRs in the context of energy balance contr

182 Here, we review some of the emerging mechanisms of nuclear mechanosensing, which range from c

183 onventionally considered negative regulatory mechanisms of olfactory transduction also play a role in

184 The oncogenic mechanisms of overnutrition, a confirmed independent can

185 Previous work has elucidated the regulatory mechanisms of p300 acetyltransferase activity, but it is

186 important means of revealing the underlying mechanism of pathogenesis and identifying clinical bioma

187 spite its significance in global health, the mechanisms of pathogenesis associated with giardiasis re

188 ajor source of information to explore shared mechanisms of pathogenesis between disorders.

189 These results translate risk into potential mechanisms of pathogenesis.

190 or concepts about physiological function or mechanisms of pathogenesis.

191 We studied key aspects of the mechanism of Pd-catalyzed C-CN bond activation and intra

192 Next, we discuss the molecular mechanisms of phosphatidylserine exposure during necropt

193 These results presented a novel mechanism of PKA and IkappaB pathway, which may be targe

194 These results might reveal generic mechanisms of plasticity in cognitive networks and infor

195 metallic glass and can shed new light on the mechanisms of polyamorphism and structural evolution in

196 derpinnings provide insights into biological mechanisms of polysaccharide degradation.

197 These data also demonstrate that the mechanisms of pore gate-opening-induced and relaxation-i

198 he lung, thereby providing insights into the mechanisms of progression of Tgfbr2-deficient invasive t

199 We have recently discovered a new molecular mechanism of prostate cancer docetaxel chemoresistance m

200 ST progressively disabled a host mechanism of protection by inducing endogenous neuramini

201 The mechanism of protection was found to be a novel pathway

202 Insight into the mechanisms of protection of these variants may facilitat

203 tive Ag in susceptible C57BL/6 mice, but the mechanism of protective immunity remains undefined.

204 To better understand the mechanism of Prp activity, we analyzed Prp enzyme kineti

205 s that they control to the known etiological mechanisms of psychiatric and neurological synaptopathie

206 spite decades of research on neurobiological mechanisms of psychostimulant addiction, the only effect

207 netic model was established to elucidate the mechanisms of radical generation and mineral surface com

208 To better understand the mechanism of recovery following nerve injury in this spe

209 this study, we investigated their origin and mechanism of recruitment.

210 um and uncovered core metabolic pathways and mechanisms of regulation that drive the angiogenic proce

211 der, but many questions remain regarding the mechanisms of replication timing establishment and regul

212 ese findings establish SETD2 alteration as a mechanism of resistance to DNA-damaging chemotherapy, co

213 present study establishes a widely prevalent mechanism of resistance to gemcitabine in pancreatic can

214 Mechanisms of resistance include activation of the mTOR,

215 iring properties of the nucleobases, and the mechanisms of ribosomal decoding contributed to the posi

216 ecule toolbox to investigate the biophysical mechanisms of RNA folding and unfolding, its interaction

217 al framework for understanding the formation mechanism of S(0) aerosols in different environments.

218 Overall, our findings uncover a mechanism of SAC inactivation required for timely mitoti

219 results provide new insights into regulatory mechanisms of seed vigor and reveal distinct requirement

220 ies in efficiency between allotypes, but the mechanism of selection is unknown.

221 in germinal centers to explicitly define the mechanisms of selection in this complex evolutionary pro

222 of evolutionary theory, exploring potential mechanisms of selection that maintain high linkage diseq

223 sistant subclones, to discover the molecular mechanisms of sensitivity.

224 of this study is to determine the underlying mechanisms of sequential energy transfer from laser ligh

225 Our study clarified the specific anti-Ebola mechanism of SERMs, even the cationic amphiphilic drugs

226 nse, revealing reduction-oxidation-dependent mechanisms of signal transducer and activator of transcr

227 d state properties and the photodissociation mechanism of SiH2OO, a silicon analogue of the parent Cr

228 The major mechanism of skin injury common to these exposures is ra

229 Finally, the mechanisms of skyrmion creation and annihilation are pro

230 t have elucidated the central neuroendocrine mechanism of sleep during sickness.

231 formed to understand the ion-molecule growth mechanism of small acetylene clusters (up to hexamers).

232 rs bound to their cognate chain types reveal mechanisms of specificity and a K11 cross-reactivity in

233 ouse malaria model, here we investigated the mechanisms of splenic cell death and their relationship

234 To test this and to explore the mechanism of spontaneous membrane translocation, we synt

235 simulations, we characterized the molecular mechanism of ssDNA association with SSB.

236 mmetrical division is the best characterized mechanism of stem cell replacement, but other mechanisms

237 The mechanism of strain-specific cell tropism is unknown.

238 he study provides critical insights into the mechanisms of strain relaxation of suspended few-layered

239 Knowing the rate and mechanisms of subsea permafrost degradation is a prerequ

240 CC1-XPF-DNA complex has been determined, the mechanism of substrate recognition remains elusive.

241 l as part of the toolbox for delineating the mechanisms of sulfur signaling.

242 We aimed to clarify the underlying molecular mechanisms of suspected RM in the skin of a patient with

243 The unclear mechanism of tDCS likely depends on tDCS intensity, and

244 The location of the region suggests a mechanism of temperature-dependent gating of thermal TRP

245 l phenomenon, indicating that the underlying mechanisms of temporal integration generalize across spe

246 ption and, more importantly, uncover a novel mechanism of TFIID recruitment and gene activation.

247 The mechanism of the electroreduction of UO2(2+) by the RuNP

248 The mechanism of the flavonoid 2 block to virus entry was de

249 Despite this, the mechanism of the innate immune response has been less we

250 provide invaluable insight on the structural mechanism of the ion pumping process.

251 The mechanism of the oxidation of arylsilanes to phenols has

252 A possible mechanism of the oxidation reaction was proposed and the

253 the unique molecular architecture and export mechanism of the Pel apparatus, a widespread exopolysacc

254 eloped towards understanding the microscopic mechanism of the phase transitions, highlighting the imp

255 The stepwise mechanism of the reduction shows similarities to the Bir

256 However, the cellular basis and pathogenic mechanism of the SLC25A46-related neuropathies are not f

257 The newly identified governing mechanism of the substrate selectivity of a particular p

258 The mechanism of the Ullmann-type reaction between potassium

259 In addition, when comparing the signalling mechanisms of the catecholoestradiols, to 17beta-oestrad

260 ld potentially help to elucidate the complex mechanisms of the disease and lead to the development of

261 Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of essential me

262 These findings reveal ionic mechanisms of the two levels of resting membrane potenti

263 anti-wear (AW) additives, but the formation mechanism of their wear protective tribofilms is not yet

264 Yet, the exact molecular mechanisms of their function in complexes are largely un

265 antitumor activities of innate immune cells, mechanisms of their synergy with adaptive immune respons

266 These results clarify the microscopic mechanism of thermal transport in MgSiO3 pv, and provide

267 We analyzed the mechanisms of these dysfunctions and their relationships

268 Research to understand mechanisms of these risk factors and the impact of dehyd

269 The mechanisms of these SET reactions are discussed, and the

270 The pathogenic mechanisms of these viruses are largely unknown.

271 The mechanism of this conflict remains unclear, besides the

272 erein, we further investigate the underlying mechanism of this conformational rearrangement and its i

273 A thorough understanding of the mechanism of this efficient enzyme will facilitate the d

274 The mechanism of this giant plasmonic resonance is well inte

275 We reveal that the underlying mechanism of this intriguing gas-like adhesion is the co

276 The mechanism of this novel observation was further investig

277 To better understand the underlying mechanism of this process, we performed genetic screens

278 Herein, we investigate the overall mechanism of this reaction using density functional theo

279 The underlying neurobiological mechanisms of this genetic influence are unknown.

280 However, the molecular mechanisms of this interaction are not well understood.

281 ess T cell responses, although the molecular mechanisms of this suppression remain incompletely under

282 icking step has therapeutic promise, but the mechanism of trafficking for the more potent toxin STx2

283 dy describes a hitherto unreported conserved mechanism of transcription of genes with methylated prox

284 ts extend the understanding of the molecular mechanism of transcription regulation on cellular stress

285 Although their mechanism of transcriptional repression has been well st

286 and spectroscopic studies substantiated the mechanism of triplet energy transfer and explained the u

287 The results establish the mechanism of TSS selection by bacterial RNAP and suggest

288 adliest cancers, yet the cells of origin and mechanisms of tumor initiation remain unclear.

289 Here we studied the structures and mechanisms of two anti-gHgL antibodies, CL40 and CL59, t

290 B ARRs in regulating the cytokinin response, mechanism of type-B ARR activation, and basis by which c

291 have characterized secretion components and mechanisms of type VII secretion in pathogenic and envir

292 Understanding the molecular mechanism of ubiquitination in these events is the basis

293 -Abs to internal proteins may be a potential mechanism of universal vaccine design.

294 ble between different doses, indicating that mechanisms of uptake and elimination were not saturated

295 t infections whose analysis might illuminate mechanisms of viral extinction.

296 s, co-opting the host protein functions as a mechanism of virulence.

297 didate therapeutic, and a tool for exploring mechanisms of virus infection inhibition by antibodies.

298 CX3CR1 is not an essential component in the mechanisms of visual cortical development or experience-

299 However, the mechanism of Vps34 in tumorigenesis remains elusive.

300 ment copies result from a combination of two mechanisms, of which the first prevents multiple transpo