ライフサイエンスコーパス: mechanism of action

1 n microtubule dynamics suggesting a distinct mechanism of action.

2 identification and reveals potential drug's mechanism of action.

3 standard antitumor agents indicate a unique mechanism of action.

4 only or multiple chemicals grouped solely by mechanism of action.

5 dentify the causal variant and elucidate its mechanism of action.

6 d at 4 hr by doripenem alone, reflecting its mechanism of action.

7 vity and resistance relevant to the compound mechanism of action.

8 ng after ischemia/reperfusion and define its mechanism of action.

9 ion, but little is known about its molecular mechanism of action.

10 istant melanoma and provide insight into the mechanism of action.

11 one mechanism is likely to be the definitive mechanism of action.

12 nctionality, presumably due to the different mechanism of action.

13 cellular responses with a poorly understood mechanism of action.

14 , suggesting mitochondrial uncoupling as its mechanism of action.

15 ve along channels that are predicated on its mechanism of action.

16 human colon cancer cells and determine their mechanism of action.

17 lease IV, which provides clues regarding the mechanism of action.

18 ive antidepressant with a previously unknown mechanism of action.

19 structural features critical to a pathogen's mechanism of action.

20 this study provide insight into nivolumab's mechanism of action.

21 Cs was negligible, which implies a paracrine mechanism of action.

22 pairs often vary even for drugs with similar mechanism of actions.

23 l potency and provide additional synergistic mechanisms of action.

24 y to understand their molecular and cellular mechanisms of action.

25 re effective antiangiogenic drugs with novel mechanisms of action.

26 d over the past decade with a focus on their mechanisms of action.

27 on, likely with hemodynamic/metabolic-driven mechanisms of action.

28 wo compounds may share some aspects of their mechanisms of action.

29 nto the involvement of TSP-1 in the BMP-2/-4 mechanisms of action.

30 MS response and suggest their involvement in mechanisms of action.

31 g enzymes (LMEs) are the most often reported mechanisms of action.

32 actions of these phenylalkylamines and their mechanisms of action.

33 ubunit of V-ATPase or have poorly understood mechanisms of action.

34 velopment, with particular emphasis on their mechanisms of action.

35 treatment regimens, and different treatment mechanisms of action.

36 r- and mixture-specific effects and possible mechanisms of action.

37 retic drug with only incompletely understood mechanisms of action.

38 ough the development of new drugs with novel mechanisms of action.

39 monstrate therapeutic promise based on novel mechanisms of action.

40 t signaling pathway in bone through multiple mechanisms of action.

41 tic drugs toward new agents endowed with new mechanisms of action.

42 for future studies to better define specific mechanisms of action.

43 ll membrane but suggested slightly different mechanisms of action.

44 haemorrhage and investigated the underlying mechanisms of action.

45 s to identify and validate agents with novel mechanisms of action.

46 ication of additional RIBE factors and their mechanisms of action.

47 need for new antibiotic backbones with novel mechanisms of action.

48 hat HAP2 is the gamete fusogen and suggest a mechanism of action akin to viral fusion, indicating a w

49 Despite different mechanisms of action, all three SARDs degraded wild-type

50 This novel mechanism of action also may be occurring in normal cell

51 However, its mechanism of action and biomarkers associated with respo

52 ophysiology of acute RV failure and both the mechanism of action and clinical data exploring the util

53 s, preferentially acting through a different mechanism of action and directed against novel targets,

54 ophenes that target DNA gyrase with a unique mechanism of action and have activity against a range of

55 With their well-defined mechanism of action and high proteomic specificity, the

56 gated and found to display an ago-allosteric mechanism of action and increased stability in compariso

57 ministered to alleviate MH symptoms, but its mechanism of action and its influence on the Ca(2+) tran

58 Here, we investigate their mechanism of action and show that mobile small RNAs gene

59 Despite a seemingly clear mechanism of action and solid rationale for their use in

60 However, information about its mechanism of action and specific biochemical roles for t

61 de A methyl ester (13), have now facilitated mechanism of action and structure-activity relationship

62 Its mechanism of action and the basis for its selectivity ha

63 netic profiles, shedding more light on their mechanism of action and the importance of association ra

64 reduce the development cost, to clarify the mechanism of action and ultimately to support the demons

65 We will discuss potential mechanisms of action and examine safety and efficacy dat

66 approved analgesic with opioid and nonopioid mechanisms of action and low abuse potential, is effecti

67 g the anxiolytic effects of scopolamine, its mechanisms of action and side effects.

68 offers a better understanding regarding VP's mechanisms of action and suggests caution when one studi

69 BACE-1-targeted compounds with more complex mechanisms of actions and improved efficacy.

70 ornerstone of NS management for decades, the mechanism of action, and target cell, remain poorly unde

71 ule, enabling more specific targeting, novel mechanisms of action, and higher clinical efficacies.

72 de insight into the unique functional roles, mechanisms of action, and synergistic relationships amon

73 and in vivo activity, selectivity, relevant mechanisms of action, and therapeutic potential.

74 Few treatments with a distinct mechanism of action are available for patients with plat

75 anisms of action, similar themes in proposed mechanism of action are seen in the gastric and small bo

76 migraine therapy, although its efficacy and mechanism of action are unclear.

77 est that focused therapies that target known mechanisms of action are critical to the success of prop

78 The proposed mechanisms of action are emphasized.

79 Yet the mechanisms of action are still unknown.

80 y other bacteria are less studied, and their mechanisms of action are unclear.

81 effects in models of adult fibrosis, but the mechanisms of action are unclear.

82 hloroquinoxaline sulfonamide, share the same mechanism of action as indisulam.

83 screening inhibitors and understanding their mechanisms of action, as well as defining new interactio

84 ated with blood lipid levels and clarify the mechanism of action at previously identified lipid loci,

85 These initiatives and a mechanism of action-based approach to drug development w

86 analysis reveals remarkable conservation in mechanism of action between SVP genes of taxonomically d

87 ukaryotic ribosome and implicate pleiotropic mechanisms of action beyond decoding.

88 ndicating that A-867744 may have a different mechanism of action compare with other alpha7-selective

89 Furthermore, the mechanism of action correlated with reduced nuclear fact

90 a promising approach for treating MM, with a mechanism of action different than those of standard MM

91 Though distinct in their mechanisms of action, doxorubicin, paclitaxel, and 5-FU

92 miting antitumor responses and we review its mechanisms of action during the cancer immunity cycle.

93 quality trials to answer questions about the mechanisms of action, effectiveness on subgroups, dose-r

94 , we discuss the chemistry of AMDs and their mechanisms of action, emphasizing how they may impact mu

95 The mechanism of action employed by PF-06446846 reveals a pr

96 fficulty in using such structures to infer a mechanism of action, especially in the case of membrane

97 This mechanistic insight reveals a bimodal mechanism of action for a single antibiotic on different

98 supporting a hypomorphic or gain-of-function mechanism of action for Actr2(p.R258G) Our findings iden

99 This signaling bias results in a dual mechanism of action for compound (R,R)-68, demonstrating

100 Defining the mechanism of action for licensed drugs, for which no tar

101 vity or androgen synthesis remains the major mechanism of action for most existing anti-androgen agen

102 Snail1-dependent manner, indicating that the mechanism of action for NA in cell migration is evolutio

103 In summary, our results reveal a new mechanism of action for sorafenib as a mitocan and sugge

104 Our findings unveil a novel mechanism of action for the drug metformin with implicat

105 nactive state, which underlies the molecular mechanism of action for the inverse agonists reported he

106 receptor antagonist with a potentially novel mechanism of action for the treatment of anxiety disorde

107 microscopy (TEM) suggested a membrane lytic mechanism of action for these peptides.

108 nhibitor, modulates tau acetylation, a novel mechanism of action for this class of compounds.

109 mental effects on toxicity suggest different mechanisms of action for copper and cadmium, and highlig

110 dermatitis, although the biologic target and mechanism of action had been unknown.

111 Arabidopsis overexpression lines, but their mechanism of action has remained obscure.

112 egulators of bone metabolism, although their mechanisms of action have been poorly understood.

113 Several mechanisms of action have been proposed, including thiol

114 Despite extensive investigations, the mechanisms of action have not been fully elucidated, esp

115 s is why several new agents, with innovative mechanisms of action, have been investigated in this con

116 discovery strategies to generate data-driven mechanism-of-action hypotheses.

117 maging agents, thereby confirming an earlier mechanism of action hypothesis.

118 ur results provided evidence that curcumin's mechanism of action in attenuating AD pathology is throu

119 regulate HH pathway function, although their mechanism of action in HH signaling remains unclear.

120 RPAf is widely applicable to investigate its mechanism of action in processes such as DNA replication

121 r 2H-WS2 particles, so as to elucidate their mechanism of action in test conditions similar to those

122 scover new anti-tubercular agents with novel mechanisms of action in order to tackle the scourge of d

123 This report details unique mechanisms of action in the cervix and serves as a catal

124 mors, but its presence, functional role, and mechanisms of actions in prostate cancer (PCa)-the most

125 ction via frequently encountered promiscuous mechanisms of action including inhibition of the QcrB su

126 reen to identify actinonin as having a novel mechanism-of-action inhibiting apicoplast biogenesis.

127 ed the nematicidal factors and the modes and mechanisms of action involved in nematode control by Pae

128 ysalin acts on Gram-positive bacteria with a mechanism of action involving cell membrane damage with

129 wo decades express their cytotoxicity with a mechanism of action involving, among others, a ligand-ex

130 Understanding an adjuvant's mechanism of action is a critical component for preclini

131 mor-associated antigens (TAAs) is that their mechanism of action is dominated by signal blocking or t

132 -specific pathway in which a molecular-level mechanism of action is formulated based on pharmacologic

133 sess mechanosensory properties, though their mechanism of action is fully unknown.

134 ge responses in melanoma cells; however, its mechanism of action is largely unknown.

135 targets; however, our understanding of their mechanism of action is limited by the lack of structural

136 ew approach but better understanding of this mechanism of action is needed.

137 hown to improve symptoms of CIU/CSU, but its mechanism of action is not currently understood.

138 gulatory cell (Treg) population, the precise mechanism of action is obscure.

139 necrosis in vivo and exploring its molecular mechanism of action is of great importance.

140 ains at least 14 subunits, but its molecular mechanism of action is poorly understood, because curren

141 ivity, coupled with a closed-state dependent mechanism of action is required for strong efficacy and

142 Elucidation of the BaP mechanism of action is required in order to understand h

143 Their basic mechanism of action is simple.

144 s, but a detailed structural basis for their mechanism of action is still lacking.

145 protein, MxiC, in Shigella As its molecular mechanism of action is still poorly understood, we used

146 ction of secreted AGR2, especially its exact mechanism of action is still poorly understood.

147 Their primary mechanism of action is the lowering of serum cholesterol

148 Their primary mechanism of action is thought to be the inhibition of p

149 ction and is tested in field trials, but the mechanism of action is unclear.

150 However, their mechanism of action is unknown.

151 ritable bowel syndrome (IBS); however, their mechanism of action is unknown.

152 lack of new antifungal compounds with unique mechanisms of action is a concern for therapeutic manage

153 response, but a detailed synthesis of OIT's mechanisms of action is lacking.

154 ssing sensory neuron excitability, and their mechanisms of action, may allow therapeutic relief for p

155 ompatible with antibiotics that have varying mechanisms of action-meropenem, gentamicin, and ceftazid

156 Identification of drug targets and mechanism of action (MoA) for new and uncharacterized an

157 target identification and elucidation of the mechanism of action (MoA) of hits from these noisy high-

158 , OCVDAE includes 194 CVDs, CVD ingredients, mechanisms of actions (MoAs), and CVD-associated 736 AEs

159 t on the synthesis, biological activity, and mechanism of action of a group of small molecules, calle

160 As the mechanism of action of ABMA is restricted to host-endoso

161 We propose that the primary mechanism of action of acylation is to control membrane

162 Furthermore, we investigated the effects and mechanism of action of agonist peptides targeting adipon

163 Here, we investigated the mechanism of action of an unrelated lysis protein, Lys(M

164 hibition assays were exploited to define the mechanism of action of ANI-7.

165 Using these assays, we establish the mechanism of action of BM212 as a potent MmpL3 inhibitor

166 Detailed understanding of the mechanism of action of CARM1 in oncogenesis has been lim

167 e inhibitory effect, and further explore the mechanism of action of CGRP-mAbs, we tested the effect o

168 biosynthetic advances and shed light on the mechanism of action of clb metabolites.

169 Nevertheless, the in vivo mechanism of action of CNO at DREADDs has never been con

170 also taken into account when identifying the mechanism of action of compounds whose pharmacological t

171 In addition to the previously characterized mechanism of action of CX-5461 (ie, the induction of p53

172 sent or absent, respectively, and define the mechanism of action of dantrolene is to increase the Mg(

173 The mechanism of action of DEXxDSy was assessed.

174 This first-in-class agent, with its novel mechanism of action of disrupting critical protein-prote

175 It enables detailed characterization of the mechanism of action of drugs.

176 and metabolomics were used to determine the mechanism of action of ER-beta and its ligands.

177 However, the signaling and mechanism of action of GDF15 are poorly understood owing

178 To gain insight into the molecular mechanism of action of GLP-1 peptides, here we report th

179 oligodendrocyte glycoprotein (MOG)35-55 The mechanism of action of GM-CSF in EAE is poorly understoo

180 latable paradigm to investigate the mode and mechanism of action of interventions employed in physica

181 (pS6K1) signaling pathways to determine the mechanism of action of itraconazole.

182 Here, the authors review the mechanism of action of ivabradine and salient studies th

183 To unravel the mechanism of action of ketamine, we treated wild-type C5

184 e to a certain degree, partly explaining the mechanism of action of local hyperthermia to treat viral

185 ovides the basis for further elucidating the mechanism of action of LRP1 in a whole and integrated sy

186 ites and oxidative stress is involved in the mechanism of action of many antimalarial drugs.

187 of beta-cardiac myosin-S1, but the molecular mechanism of action of mavacamten has not been described

188 dy-state kinetic analyses to investigate the mechanism of action of mavacamten.

189 resonance (NMR) spectroscopy, we examine the mechanism of action of MOAG-4 by characterizing its inte

190 Understanding the mechanism of action of modulator compounds for the cysti

191 annels and correctly identified the accepted mechanism of action of nifedipine, a calcium-channel blo

192 The mechanism of action of omecamtiv mecarbil also provides

193 ognizable developmental syndrome, though the mechanism of action of pathogenic missense mutations is

194 This review discusses the history and mechanism of action of PCSK9 inhibitors, their metabolic

195 The mechanism of action of PCSK9 monoclonal antibodies on li

196 ale, preparation, biological evaluation, and mechanism of action of phenyl 4-(2-oxo-3-alkylimidazolid

197 Elucidating the target or mechanism of action of potential drugs in the discovery

198 The mechanism of action of promysalin against Gram-negative

199 regulates molecular events implicated in the mechanism of action of rapid-acting antidepressant ketam

200 To clarify the mechanism of action of Rh-alpha4beta7, naive macaques we

201 ose of the study is to discuss the potential mechanism of action of rifaximin, a minimally absorbed a

202 The Rosetta KCa3.1 pore model explains the mechanism of action of several KCa3.1 blockers at the mo

203 These results elucidate a molecular mechanism of action of SGs and identify TRPM5 as a poten

204 ute significantly to an understanding of the mechanism of action of SIRT2 inhibitors and to the ident

205 at the expanded CMap can be used to discover mechanism of action of small molecules, functionally ann

206 We elucidate the mechanism of action of squalamine by investigating its i

207 Here, we investigated the activity and mechanism of action of the BTK inhibitor ibrutinib in pr

208 erences regarding patterns that underlie the mechanism of action of the CRISPR-Cas9 system.

209 Proposed mechanism of action of the designed vector accounts for

210 eld, starting with efforts to understand the mechanism of action of the drug rapamycin, which approxi

211 eq) with the shRNA screen to investigate the mechanism of action of the identified candidates.

212 The proposed mechanism of action of the modifiers includes proton tra

213 Here, we characterize the cellular mechanism of action of the most potent and selective com

214 The mechanism of action of the most potent complex, 13, was

215 Here, we describe the mechanism of action of the previously reported capsid-ta

216 esia both preclinically and in patients, the mechanism of action of these agents remains unclear.

217 multi-platform genetic approach to study the mechanism of action of these clinically established plat

218 These findings shed new light on the mechanism of action of these organo-osmium complexes.

219 The mechanism of action of this behavioral effect has been a

220 We determined biological function and mechanism of action of this FZD4-miR-SNP biomarker in a

221 ew, we discuss current models describing the mechanism of action of this hexameric transcription term

222 Here we report and dissect the molecular mechanism of action of three classes of KMO inhibitors w

223 This may shed new light on the mechanism of action of topical steroids, and demonstrate

224 The mechanism of action of tPA is affected by the number of

225 is needed to deepen our understanding of the mechanism of action of tranexamic acid.

226 antibodies is crucial for understanding the mechanism of action of vaccines and for enabling antigen

227 While the mechanism of action of VapA remains elusive, we show tha

228 description of the expression, function and mechanism of action of VCP in the mammalian heart in viv

229 R2C, TPH1, TPH2) potentially involved in the mechanism of action of venlafaxine.

230 erature is due to the predominantly physical mechanism of action of WS2, while the best antiwear perf

231 ischemic stroke patients and to explore the mechanism of action of XXMT.

232 To uncover the mechanism of action of ZnO NPs on CT activity, here we u

233 advances in our understanding of the diverse mechanisms of action of cationic AMPs and the bacterial

234 ught to characterize the functional role and mechanisms of action of CD151 in IAV infection of the up

235 To evaluate the efficacy and the mechanisms of action of CD19 monoclonal antibody therapy

236 Here, we investigated the mechanisms of action of Ctn and Ctn(15-34) against Gram-

237 Elucidating the mechanisms of action of docosanoids will contribute to m

238 o be extremely useful, for the prediction of mechanisms of action of drugs or the responses of an org

239 he recent advances in defining the roles and mechanisms of action of KSHV miRNAs in KS development.

240 roved for treatment of obesity; however, the mechanisms of action of liraglutide are incompletely und

241 sic neurophysiological principles, potential mechanisms of action of tCS, and the complicated regulat

242 the model to predict the receptor sites and mechanisms of action of the dihydropyridine nifedipine a

243 The primary known mechanisms of action of the parent scaffold are not resp

244 The mechanisms of action of the rapid antidepressant effects

245 nd identify previously unknown functions and mechanisms of action of these cytokines.

246 drug discovery research, although the exact mechanisms of action of these species are not well known

247 tification that is needed to investigate the mechanisms of actions of dietary treatments in both mous

248 e, or its internal target, the difference in mechanism of action on gram-negative and gram-positive b

249 Despite its well-characterized mechanism of action on several established cancer-relate

250 ributed to three independent and synergistic mechanisms of action, only one of which requires d-Ala-d

251 However, not much is known about the mechanism-of-action or the detailed ILEI structure.

252 We describe their mechanism of action-plasmatic membrane pore-forming acti

253 However, its mechanism of action remain elusive.

254 ted in HR, although its precise function and mechanism of action remain elusive.

255 ng adenocarcinoma (LUAD), where its role and mechanism of action remain unknown.

256 olecular sensors of aberrant mRNAs and their mechanism of action remain unknown.

257 lecular identities of RIBE factors and their mechanisms of action remain poorly understood.

258 However, its mechanisms of action remain poorly understood.

259 migration, adhesion, and spreading, but its mechanisms of action remain uncertain.

260 )-binding to their two C2 domains, but their mechanisms of action remain unclear.

261 smission and dopamine reuptake, the specific mechanism of action remains obscure.

262 nstay of therapy in most cases, though their mechanism of action remains poorly understood.

263 ates hepcidin suppression by anemia, but its mechanism of action remains uncertain.

264 rmatitis; however, the specific antipruritic mechanism of action remains unclear.

265 However, the exact underlying mechanism of action remains unclear.

266 of the Notch signaling pathway, although its mechanism of action remains unclear.

267 ic agents for metastatic melanoma, yet their mechanism of action remains unclear.

268 uity in developing renal tubules, though its mechanism of action remains unknown.

269 cess precursor ribosomal RNA (rRNA), yet its mechanism of action remains unknown.

270 irst line anti-tubercular drug for which the mechanism of action remains unresolved.

271 Investigation into the mechanism of action revealed a preferential physical int

272 nd although individual EBMTs may have unique mechanisms of action, similar themes in proposed mechani

273 Mechanism-of-action studies indicated that sorafenib tar

274 selective antiproliferative activities, and mechanisms of action studies show they inhibit the activ

275 The mechanism of action study of 12f by confocal laser scann

276 New drugs with novel mechanisms of action, such as cardiac myosin activators,

277 Microarray-based initial studies on the mechanism of action suggest that compound 8 blocks trans

278 hese results we discuss implications for the mechanism of action, taking Doxil pharmacokinetics into

279 ket-modified vancomycin analog with a second mechanism of action that is independent of d-Ala-d-Ala/d

280 show that one such compound, C4, exhibits a mechanism of action that is similar to the parent HDP up

281 These results suggest a novel mechanism of action that may avoid the common route in a

282 for smoking cessation medication with novel mechanisms of actions that differ from those of currentl

283 r determining resistance mutations and their mechanisms of action.The antibiotic pyrazinamide is cent

284 provide insights into the anti-inflammatory mechanism of action, through COX-2 inhibition by the phe

285 a bioassay correlating with the drug's known mechanism of action to ensure its potency and activity.

286 The exact mechanism of action to induce beta-cell proliferation is

287 Allosteric modulators offer an alternative mechanism of action to traditional alpha1-adrenergic lig

288 so proposed for repositioning based on their mechanism of action to treat asthma and allergy.

289 1120 small molecules with well-characterized mechanisms of action to detect those that affect the abu

290 This potential anti-inflammatory mechanism of action, together with the development of a

291 8 (54%) of the 89 class-waivered drugs had a mechanisms of action warranting paediatric development.

292 To determine a mechanism of action, we examined the NF-kappaB pathway,

293 To elucidate ketamine's mechanism of action, we tested whether the clinical time

294 h hormone-releasing hormone (GHRH) and their mechanism of action were investigated in diabetic retino

295 onal PAC-related toxicity pathways and novel mechanisms of action were identified in two avian specie

296 everal targets were identified and different mechanisms of action were suggested.

297 were investigated in vitro and in vivo, and mechanisms of action were suggested.

298 Its mechanism of action, whether as an activator or a repres

299 This suggested a novel mechanism of action, which was confirmed by chemoproteom

300 d-targeting compounds that display different mechanisms of action, which in part reflects the require