ライフサイエンスコーパス: mechanism through which

1 y provide novel insights about the molecular mechanisms through which 17beta-estradiol modulates hipp

2 is essential to determine the physiological mechanisms through which 5-HT neurons in the dorsal raph

3 Importantly, our work defines a mechanism through which a scaffold protein can be regula

4 The mechanism through which a single transmembrane helix is

5 n and circuit modelling to reveal the neural mechanisms through which a zebrafish performs phototaxis

6 riments will facilitate the understanding of mechanisms through which A20-mediated inflammatory signa

7 The mechanisms through which aberrant ANG levels promote spe

8 r findings thus propose a potential cellular mechanism through which abnormal TCF7L2 activity predisp

9 ards in alcohol-consuming rats, suggesting a mechanism through which adolescent alcohol exposure may

10 nitial results suggest a specific biological mechanism through which adversity contributes to altered

11 In this study, we investigated the mechanism through which AMPK modulates inflammatory dise

12 r future focus is to identify key underlying mechanisms through which APP metabolites contribute to F

13 individual Tfh cells, revealing a potential mechanism through which appropriate class-switching can

14 However, the mechanisms through which arousal and metabolic states in

15 e have now identified a putative cytoplasmic mechanism through which ASO gapmers silence their target

16 However, the mechanism through which ATP hydrolysis by SecA is couple

17 describe proteomic analyses that identified mechanisms through which ATR kinase inhibitors induce un

18 We identified a new mechanism through which bacterial compounds directly but

19 These combined findings highlight a novel mechanism through which BAFF promotes humoral autoimmuni

20 ur study uncovers a noncanonical thermogenic mechanism through which beige fat controls whole-body en

21 In this study, the mechanisms through which Bifidobacterium longum strain B

22 These results indicate mechanisms through which both non-pathological and oncog

23 se observations offer fresh insight into the mechanisms through which BRMS1 regulates the development

24 inghvi et al. uncover cellular and molecular mechanisms through which C. elegans glia shape sensory n

25 However, the neuronal and molecular mechanisms through which CBD may exert these effects are

26 ution of Whi5 by cell growth--as a molecular mechanism through which cell size controls proliferation

27 Although kin recognition is a fundamental mechanism through which cells might interact, microbiolo

28 on in health and disease; however, the exact mechanisms through which changes in the microenvironment

29 prevention technologies, which are important mechanisms through which child mortality can be reduced.

30 The current study presents a neuroimmune mechanism through which chronic opioids disrupt the vent

31 light a novel circuit and CGRP/glutamatergic mechanism through which cisplatin-induced malaise and en

32 However, the mechanisms through which clinically targeted pathways ar

33 system have opened insight into fundamental mechanisms through which clocks program energy transfer

34 ce the fate of a cell lineage: we describe a mechanism through which coccal (round) cells rise to the

35 quire a sense of number does not specify the mechanisms through which cognitive control plays a role

36 est that the mTORC1/SREBP pathway is a major mechanism through which common oncogenic signaling event

37 Our results shed crucial insights into the mechanisms through which common early perinatal experien

38 Our findings provide a mechanism through which CSCs persist in hostile environm

39 ortical actin in CTLs, providing a potential mechanism through which CTLs control cortical actin dens

40 However, the mechanism through which CYLD interacts with HOIP is uncl

41 Our results reveal a novel mechanism through which D-aa-tRNAs interfere with transl

42 The current study reports on a synaptic mechanism through which D1-like receptors (D1LRs) modula

43 Recently, we described a new mechanism through which D2R activation can enhance the e

44 d DNAm as a potentially important biological mechanism through which developmental environments shape

45 and sleep are integrated and suggest a novel mechanism through which diet-induced obesity during pube

46 revealed the critical intrinsic and synaptic mechanisms through which different neuromodulators actin

47 al behaviours in response to stress, but the mechanisms through which DISC1 affects stress responses

48 al amaurosis would assist in determining the mechanisms through which disruptions in NMNAT1 lead to r

49 e commonly used as anticancer therapies, the mechanisms through which DNA damage produces a therapeut

50 However, the mechanisms through which DNMT3A normally suppresses mali

51 populations provides unique insight into the mechanisms through which DOM source and environmental pr

52 insufficiency (HI) is the best characterized mechanism through which dominant mutations exert their e

53 dings may also provide new insights into the mechanisms through which drugs targeting mGlu II recepto

54 study, we identified the operative molecular mechanisms through which dynamic tensile loading (DL) re

55 This work demonstrates mechanisms through which dysregulation of complement cau

56 gs provide novel insights into the molecular mechanisms through which E2 mediates dendritic spine den

57 These findings illustrate an array of mechanisms through which EBV achieves functional diversi

58 Here, the authors unravel a mechanism through which EGF stimulation induces MIIP pho

59 However, the mechanisms through which Elg1 may regulate cohesion and

60 ese findings provide novel insights into the mechanism through which emotional stressors can lead to

61 omains, important regularities appear in the mechanisms through which emotions influence judgments an

62 Together, these data uncover a novel mechanism through which endodermal-myocardial communicat

63 Studies need to elucidate the mechanisms through which endogenous erythropoietin level

64 etes (MKR mouse) was used to investigate the mechanisms through which endogenous hyperinsulinemia pro

65 Understanding the mechanisms through which energy and nutrients flow throu

66 Together, our study delineates a mechanism through which environmental sensory cues regul

67 in hormone response; discovery of biological mechanisms through which environmental chemicals may con

68 The biochemical mechanisms through which eosinophils contribute to asthm

69 Next, to define neurophysiologic mechanisms through which ES affects repair, microarray a

70 The molecular mechanisms through which established risk factors, such

71 These findings elucidate a mechanism through which ethanol may globally disinhibit

72 However, the mechanisms through which excitability is enhanced follow

73 However, little is known about the mechanisms through which excitatory activity can affect

74 In this review, we discuss the various mechanisms through which exercise training promotes mito

75 Mediation analyses demonstrate one plausible mechanism through which expansiveness is appealing: Expa

76 However, the mechanism through which FAK functions in the complex is

77 Collectively, these results identify mechanisms through which FGF signaling regulates inner c

78 bound states, and uncovers a novel molecular mechanism through which FGFR-linked pathologies can aris

79 patic specification are well understood, the mechanisms through which FGFs induce hepatic character w

80 minogen binding did not to occur by the same mechanism through which FnBPB binds to fibrinogen.

81 We identify four mechanisms through which food policies can affect diet:

82 Together, these data identify a novel mechanism through which gamma-Pcdh control of a signalin

83 ological correlates associated with specific mechanisms through which gamma oscillations are hypothes

84 Our findings reveal a mechanism through which gammaherpesviruses antagonize ho

85 The mechanisms through which GDF15 reduces body weight remai

86 itecture of neural phenotypes and the neural mechanisms through which genetic risk for psychopatholog

87 However, the mechanisms through which genetic susceptibility to obesi

88 PrediXcan that directly tests the molecular mechanisms through which genetic variation affects pheno

89 ontribute to our understanding of the neural mechanisms through which genetic variation and stress in

90 better understand the cellular and molecular mechanisms through which GM-CSF enhances antifungal host

91 In this study, we identified a novel mechanism through which Gp1 mGluR mediates protein trans

92 Our study defines a CD91-dependent mechanism through which gp96 controls dichotomous immune

93 These findings reveal a novel metaplastic mechanism through which group II mGlu receptors modulate

94 s as protein kinase inhibitors and suggest a mechanism through which guard cell CO2 signaling control

95 ylation in intestinal DCs could be important mechanisms through which helminths induce regulatory DCs

96 There are several mechanisms through which high iron status during pregnan

97 pinal cord, which might represent a flexible mechanism through which higher-cognitive representations

98 We evaluated the mechanism through which HIV-activated pDCs produce IFN a

99 However, the mechanisms through which HRVs modulate the immune respon

100 ese findings provide novel evidence that the mechanism through which HSPCs promote repair after strok

101 empirical support for behavioural and immune mechanisms through which human-provided resources alter

102 oordinate stress and arousal and suggest one mechanism through which hyperarousal or altered metaboli

103 nd procedural memory, provides an anatomical mechanism through which hypoxia may cause deficits in wo

104 These results suggest an anatomical mechanism through which hypoxia may cause previously rep

105 of hypoxia and marine fauna suggest multiple mechanisms through which hypoxia can skew a population's

106 Our data demonstrate a mechanism through which ID domain of the steroid recepto

107 The molecular mechanisms through which IF2 and IF3 collaborate to regu

108 long been linked to asthma exacerbations, a mechanism through which IgE impairs rhinovirus immunity

109 efine an immune component of the pleiotropic mechanisms through which IGFBP7 suppresses HCC.

110 e-dependent antigen presentation and a novel mechanism through which IL-12 and IL-7 synergistically c

111 We sought to identify the mechanisms through which IL-10 rapidly and directly supp

112 The mechanisms through which immune responses are generated

113 This result provides a mechanism through which individual foraging strategies m

114 have identified at least 30 AF loci, but the mechanisms through which individual variants lead to alt

115 The mechanisms through which infiltrating lymphocytes cause

116 al novelty signals may represent a plausible mechanism through which inflammation impairs motivationa

117 Nevertheless, the neural mechanisms through which inflammation constrains novelty

118 Although the mechanisms through which inflammation promotes cancer ar

119 erall objective of the study was to identify mechanisms through which intercellular adhesion molecule

120 suppression of calbindin by DeltaFosB is one mechanism through which intermittent seizures drive pers

121 Together, these results define a mechanism through which intestinal microbes govern a cen

122 bed hypoxia sensing and signaling provides a mechanism through which iron deficiency may be detriment

123 The platelet surface target of MMP-2 and the mechanism through which it primes platelets to respond t

124 nesis as the primary outcome measure and the mechanisms through which it acts.

125 hila melanogaster strains, but the molecular mechanisms through which it does so have remained elusiv

126 er, its clinical relevance and the molecular mechanisms through which it mediates HNSCC progression a

127 kemic transformation; however, the molecular mechanisms through which it promotes leukemogenesis rema

128 helices help guide RNA tertiary folding, the mechanisms through which junctions influence folding rem

129 results specify the neural and psychological mechanisms through which learning interacts with empathy

130 for ethanol-induced CTA, and point towards a mechanism through which LHb firing may regulate voluntar

131 ivision in response to nutrients, defining a mechanism through which Lin-28 controls the adult stem c

132 mouse embryonic fibroblasts, suggesting one mechanism through which loss of feedback inhibition of A

133 Herein, we investigate the mechanisms through which loss of the BRMS1 gene contribu

134 n in the bone marrow and they reveal a novel mechanism through which LOX-driven IL6 production by col

135 Moreover, mechanisms through which LRH-1 is activated by synthetic

136 The mechanisms through which lymphomas initially resist or g

137 The precise mechanism through which lysoPC activates TRPC6 channels

138 However, the mechanism through which mammalian cells are able to acco

139 h and connectivity are thought to be a major mechanism through which many gene variants cause neurolo

140 posure are also hypothesized to underlie the mechanism through which maternal stress may disrupt feta

141 ased vectors as a model, we investigated the mechanisms through which microglia recognize and respond

142 nsion of Hras mutated cells and identifies a mechanism through which microRNA-203 antagonizes Hras-me

143 ed that highly chiral cell shape is a robust mechanism through which microscale swimmers can achieve

144 Therefore, elucidating the physiological mechanisms through which midbrain 5-HT neurons modulate

145 Although we could not resolve the mechanism through which miR-148a-3p impacts OS, we ident

146 In this study, we unraveled the mechanisms through which miR-124 acts in this setting.

147 Moreover, we focus on the emerging mechanisms through which miRNAs contribute to different

148 Our aim was to determine the mechanisms through which MKP-1 deficiency in monocytes a

149 Currently, the mechanism through which MRN inhibits AAV and other virus

150 Ox-LDL may reflect core mechanisms through which MS components develop and progr

151 eate an elegant histamine-dependent feedback mechanism through which myeloid bone marrow cells restor

152 terol-rich diet and uncover a PDL1-dependent mechanism through which MZB cells use their innate immun

153 We investigate the mechanism through which N-cadherin disruption alters the

154 pect of plant reproduction because it is the mechanism through which nonmotile sperm cells are delive

155 However, the mechanisms through which normal tissue fibroblasts are r

156 el is an essential component of the cellular mechanism through which noxious stimuli evoke pain.

157 terol trafficking defect, but the pathogenic mechanisms through which NPC1 deficiency causes neuronal

158 These findings provide a novel mechanism through which O-GlcNAcylation regulates ischem

159 hat inflammation is a central and reversible mechanism through which obesity promotes cancer risk and

160 However, the mechanisms through which oncogenes alter lipid metabolis

161 The mechanism through which oxygenated hypothermic machine p

162 The circuit mechanisms through which oxytocin modifies olfactory pro

163 evolution approach to examine the molecular mechanisms through which P4-ATPases discriminate substra

164 nt mice has impeded our understanding of the mechanisms through which PAG exerts its negative-regulat

165 Although the exact mechanism through which palytoxin congeners exert their

166 on along the auditory pathway, we describe a mechanism through which paracrine ATP signalling enhance

167 However, the precise mechanisms through which PARP1 is activated and PAR is r

168 ver, little is understood about the cellular mechanism through which paternal mitochondria, delivered

169 We call the mutual sequestration mechanism through which pCPI-17 and MLCP interact inhibi

170 ing between communicators and receivers as a mechanism through which perceptions of value can be tran

171 of transgenic mice, pointing to a potential mechanism through which pericytic Tcf7l2 activity affect

172 C1alpha is known to bind and activate LRH-1, mechanisms through which PGC1alpha changes LRH-1 conform

173 We discuss mechanisms through which PGM48 could possibly accelerate

174 in the onset and progression of OA, yet the mechanisms through which physiologic or pathologic mecha

175 egulated by renal, intestinal, and endocrine mechanisms through which Pi intake stimulates parathyroi

176 lthough we have not identified the molecular mechanism through which PKD regulates viral replication,

177 unction assembly and uncover a new molecular mechanism through which PLEKHA7 recruits PDZ-binding mem

178 In this review, we consider multiple mechanisms through which polysaccharides mediate aspects

179 sal of an innovative approach to clarify the mechanism through which poor cognitive performance in ad

180 mice, and they likely are a key part of the mechanism through which positive emotions trigger catapl

181 presentation within the hippocampus, suggest mechanisms through which prefrontal cortex and the hippo

182 One mechanism through which presence/absence variation can a

183 positively affect IBS symptoms, although the mechanisms through which probiotics exert their benefici

184 fector functions has emerged as an important mechanism through which protection is achieved in vivo.

185 However, the mechanisms through which PTN mediates these responses re

186 gene for depression and offer insights into mechanisms through which RCL1 may be relevant for depres

187 Based on these results, we propose a mechanism through which RecQ helicases achieve recombina

188 Here we identify mechanisms through which reduced ANK3 exon 1b isoform ex

189 s demonstrate a cortical pattern suppression mechanism through which remembering adaptively shapes wh

190 To elucidate the mechanism through which RPA unfolds telomeric G4s, we st

191 However, the molecular mechanisms through which S1P enhances excitatory activit

192 The mechanism through which Sal-1 promotes Salmonella surviv

193 findings provide the first insights into the mechanisms through which SCCRO family members cooperativ

194 The mechanism through which SEAL increases local recurrence

195 Here we report an epigenetic mechanism through which seizures chronically suppress hi

196 Taken together, our results provide a mechanism through which serial dependence can promote th

197 These findings uncover a novel mechanism through which Shp2 regulates osteoclastogenesi

198 n in the ventral visual circuitry suggests a mechanism through which signals of social approach (ie,

199 t that accelerated biological aging may be a mechanism through which sleep influences risk.

200 oaches, namely, investigation of the precise mechanisms through which so-called music-specific or aes

201 Understanding mechanisms through which social disadvantage becomes bio

202 cells, illustrating bidirectional regulatory mechanisms through which sodium and the immune system co

203 This study aimed to determine the mechanism through which soil carbonates restrict transpo

204 vely, these data describe a novel regulatory mechanism through which STAT3 and the Ikaros zinc finger

205 iative emotional learning and is a candidate mechanism through which subsets of BLA neurons (commonly

206 The specific mechanisms through which such extremes and climate regim

207 In this study, we discovered a novel mechanism through which SWI/SNF influences resistance to

208 Our results reveal a novel mechanism through which symbionts can benefit their host

209 However, the exact mechanism through which synapses can rapidly recruit new

210 We explore mechanisms through which synaptic plasticity, engrams, a

211 These analyses provide insight into the mechanisms through which T2D association signals are med

212 However, the underlying mechanisms through which TAAR1 activation mediates these

213 Furthermore, we characterized the mechanism through which Taf14 suppresses taf2(ts) allele

214 ic and biochemical techniques to examine the mechanism through which temperature variation affects Ar

215 Therefore, the findings provide a neural mechanism through which the brain may translate inherent

216 e results delineate an epigenomic regulatory mechanism through which the circadian clock governs skel

217 Our results reveal an important new mechanism through which the DC cytoskeleton regulates re

218 Our studies uncover a novel mechanism through which the dioxin-AHR axis interacts wi

219 earch could focus on identifying the precise mechanism through which the effects emerge.

220 onal signalling circuit provides a selective mechanism through which the enteric nervous system and i

221 It also provides a mechanism through which the glycosylation variants of FS

222 The molecular mechanism through which the interaction of a clonotypic

223 pendent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sen

224 ant, but not wild-type, PDGFRA, suggesting a mechanism through which the oncogenic activity of the mu

225 These results reveal a mechanism through which the postsynaptic signaling scaff

226 In summary, we have identified a novel mechanism through which the PRMT5/WDR77 complex maintain

227 activated by RhoA/ROCK, establishing a novel mechanism through which the RCP-alpha5beta1 pathway repr

228 Our results demonstrate a novel evolutionary mechanism through which the recipient organism may acqui

229 me inactivation as a previously unidentified mechanism through which the stringent response functions

230 Our studies suggest a mechanism through which the structure, function, and fat

231 Though DBS is effective for treating ET, the mechanism through which the therapeutic effect is obtain

232 We propose a novel mechanism through which the TOP2 CTD regulates the CPC v

233 We report a mechanism through which the transcription machinery dire

234 kine-induced IKKbeta signaling, suggesting a mechanism through which the tumor microenvironment contr

235 complex, and we introduce a novel molecular mechanism through which the VE-cadherin complex controls

236 isorders and help us begin to understand the mechanisms through which the 'p factor' contributes to r

237 We experimentally identify two competing mechanisms through which the A-site cation influences th

238 ext challenge consists of designing specific mechanisms through which the action of individual molecu

239 To gain insight into potential regulatory mechanisms through which the effects of variants at four

240 Identifying biological mechanisms through which the experience of adversity eme

241 into cell biology analyses to elucidate the mechanisms through which the genetic variants operate.

242 Type 2 immunity encompasses the mechanisms through which the immune system responds to h

243 udies were used to investigate the molecular mechanisms through which the LTCC Cavbeta2 chaperone reg

244 putational simulations, we identify specific mechanisms through which the suppression of DG affects m

245 e to therapeutics; little is known about the mechanisms through which the tumour cell co-opts a norma

246 rovide valuable opportunities to uncover the mechanisms through which the weather influences populati

247 rved protein domains, highlighting potential mechanisms through which their effect may be exerted.

248 A common mechanism through which these alterations induce liver c

249 The mechanism through which these CNVs confer risk for the s

250 well as embryo development to elucidate the mechanism through which these compounds mediate oocyte d

251 iated changes in DNA methylation, suggesting mechanisms through which these alterations might affect

252 create, adopt, and reinforce, as well as the mechanisms through which these categories contribute to

253 However, the mechanisms through which these changes alter the activit

254 microenvironment and the local and systemic mechanisms through which these changes support tumor gro

255 ure work is needed to elucidate the specific mechanisms through which these DRD2 variants operate in

256 erations that recur in ccRCC and discuss the mechanisms through which these events appear to function

257 and stress exposure; however, the biological mechanisms through which these factors interact to confe

258 rstanding of the molecular and physiological mechanisms through which these genes affect disease phen

259 The cellular and molecular mechanisms through which these lineage-promoting transcr

260 etworks, little is currently known about the mechanisms through which these networks assemble into st

261 ver, there is little knowledge regarding the mechanisms through which these surface variations promot

262 These data will ultimately elucidate mechanisms through which these uniquely positioned neuro

263 They exhibit a self-regulatory mechanism through which they act as positive/negative re

264 rfere with FcgammaR function and a potential mechanism through which they could have a sustained effe

265 uence population growth, and the demographic mechanisms through which they act, will vastly improve o

266 ute to immune suppression in cancer, but the mechanisms through which they drive metastatic progressi

267 to support, are designed to work through the mechanisms through which they have greatest effect, and

268 la mediate stimulus-reward learning, but the mechanisms through which they interact are unclear.

269 Fgfr4 is crucial for alveologenesis, but the mechanisms through which they mediate this process remai

270 on development and disease, and the dynamic mechanisms through which they regulate gene expression.

271 via degradation of MRN, we investigated the mechanism through which this DNA damage complex inhibits

272 anol, and we sought to better understand the mechanism through which this occurs and whether chemical

273 tion of RGS4 function may promote AF and the mechanism through which this occurs.

274 This work sheds light on a potential mechanism through which this region influences behavior.

275 biota and their host, highlighting potential mechanisms through which this environment influences cen

276 llular sites of action of this receptor, the mechanisms through which this mediator controls the expr

277 PCP signaling regulates actin dynamics, the mechanisms through which this occurs remain elusive.

278 tion of canonical Wnt signalling, though the mechanisms through which this occurs remain unknown.

279 e that bORNs represent an unsuspected neural mechanism through which time can be accurately measured,

280 These findings demonstrate a novel mechanism through which TLR4, an innate pattern receptor

281 sical morphogens and present a unique direct mechanism through which to relay positional information.

282 hms in body temperature suggest a biological mechanism through which transits of one of the moon's se

283 ified conserved sites of proton binding, the mechanism through which transport is coupled to proton m

284 s fear conditioning and extinction represent mechanisms through which trauma exposure might influence

285 ant cell differentiation and establish a new mechanism through which trophoblast sublineages are spec

286 ults provide new insights into the enzymatic mechanism through which TTPA acts on polysaccharides.

287 The mechanism through which tumors promote the characteristi

288 This model underscores a potential mechanism through which tumour cells retaining elevated

289 In this study, we investigated the mechanisms through which uric acid selectively lowers hu

290 and genomic information can define molecular mechanisms through which variants underlying association

291 We aim at understanding the molecular mechanisms through which VEC triggers the expression of

292 These data provide a novel mechanism through which VS information processing could

293 ther, our findings reveal novel, overlapping mechanisms through which VTA Cav1.3 mediates cocaine-rel

294 tic ADAMTS13 deficiency, we investigated the mechanism through which VWF modulates complement and its

295 This suggests an additional mechanism through which VWF variants may alter hemostasi

296 This provides a mechanism through which widely reported links between pe

297 These results identify a mechanism through which Wnt and ZEB1 transcriptional act

298 We have investigated the mechanism through which Wnt signaling induces osteoblast

299 These observations suggest a novel mechanism through which WT1 regulates the transition fro

300 However, the underlying mechanisms through which ZIKV rapidly and explosively sp