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1 egulation of Cyp27b1 expression represents a mechanism whereby 1,25(OH)2D3 can fulfill separate funct
3 se findings unveil a previously unrecognized mechanism whereby a core circadian clock output signal c
4 of the intestinal epithelium is a potential mechanism whereby a dysbiotic enteric microbiota can lea
5 dentify the JNK/S6K1 axis as a key molecular mechanism whereby a high fat/sucrose diet impairs insuli
8 distinctive feature in their transcriptional mechanism whereby a specific Spliced Leader (SL) sequenc
9 P*(Mg(2+))2 structure highlights a two-metal mechanism, whereby: a ligase-bound "catalytic" Mg(2+)(H2
10 Collectively, our studies reveal molecular mechanisms whereby A20 deubiquitinase activity and ubiqu
20 ning of 17alpha-hydroxypregnenolone offers a mechanism whereby allosteric binding of cytochrome b5 mi
23 a by the TCR represents a previously unknown mechanism whereby alphabeta T cells indirectly sense sel
26 , Rivera-Chavez et al. (2016) identify a new mechanism whereby antibiotic-mediated depletion of anaer
27 findings, we propose a model for an in-vivo mechanism whereby antibody-mediated disruption of the bi
28 the AR-regulated morphogenetic genes and the mechanisms whereby AR controls prostate development are
30 suggests a new, unifying 'Brownian ratchet' mechanism, whereby ATP binding and hydrolysis bias the d
34 findings are consistent with a dual toxicity mechanism, whereby both arginine-rich proteins and repea
38 e Flt3 transactivation may identify a unique mechanism whereby cancer chemotherapy with receptor tyro
39 oss and Slug upregulation, providing a novel mechanism whereby cancer stem cells acquire metastatic p
40 Hence, this may represent one of the primary mechanisms whereby cannabinoids induce disruptions in at
41 presents evidence suggesting that one of the mechanisms whereby cannabinoids induce psychosis is thro
44 revious studies have established recruitment mechanisms whereby Cdc45-Mcm2-7-GINS (CMG) helicase bind
46 e, switch-like mitotic entry due to a second mechanism, whereby Cdk1:CycB inhibits its counteracting
47 ophagy is a fundamental cellular homeostatic mechanism, whereby cells autodigest parts of their cytop
49 s, it has become important to understand the mechanisms whereby certain therapies are more prone to H
51 in and other vanilloid ligands, suggesting a mechanism whereby chemical or thermal stimuli elicit cha
52 ors of thermal and chemical stimuli, but the mechanisms whereby chemical ligands impact on TRP channe
55 ide a novel example of a potentially general mechanism whereby climate change-mediated range shifts c
57 Our results point toward a transcriptional mechanism whereby cocaine alters specific gene networks
59 r, our results reveal an important molecular mechanism whereby coordinated cytoskeletal dynamics cont
61 ontext retrieval on each trial, suggesting a mechanism whereby cues trigger retrieval of context, whi
63 A decapping scavenger enzyme (DcpS), but the mechanism whereby DcpS inhibition leads to therapeutic b
65 , we explore how this computation provides a mechanism whereby dendritic spiking contributes to orien
68 (s) of arrestins vary between receptors, the mechanism whereby different GPCRs specify these divergen
70 esis and muscle disease, and uncover a novel mechanism whereby disruption of the LINC complex may con
74 apid delayed rectifier (IKr ) is the primary mechanism whereby drugs prolong individual action potent
76 of Neuron, Stempel et al. (2016) describe a mechanism whereby endocannabinoid production leads to a
78 etics, and our findings define an epigenetic mechanism whereby EPAS1 is silenced during sarcoma progr
79 sly unrecognized extrinsic tumor-suppressive mechanism, whereby epithelial polarity proteins dictate
82 f DNA into strings of nucleosomes is a major mechanism whereby eukaryotic cells regulate gene express
83 his study, we critically review the proposed mechanisms whereby exemplary misfolded proteins associat
84 o bypass this limitation, cells have evolved mechanisms whereby exposure to mild stress increases the
85 reporters, and synthetic promoters support a mechanism whereby expression at the top of the SHORTROOT
86 es an elegant and remarkably straightforward mechanism whereby extracellular factors control gene exp
87 s of a new model for NHEJ that describes the mechanism whereby filament-forming proteins bridge DNA D
89 ciated with drug resistance, demonstrating a mechanism whereby fitness costs associated with resistan
93 nds of puberty initiation over time, and the mechanisms whereby genetic, metabolic, and other factors
94 esults presented herein lead us to propose a mechanism whereby genomic ssDNA secondary structure form
95 cell-cell signaling (induction) or a derived mechanism whereby germ cells are specified by using germ
96 genes in tumor cells revealed an unexpected mechanism whereby Gli1 regulates ATR-mediated Chk1 phosp
100 eases and H. pylori gene expression, and the mechanisms whereby H. pylori regulates NO synthesis by h
101 Together, these results provide a possible mechanism whereby H3K23me3-binding by KDM4B directs loca
105 V-infected individuals, although the precise mechanisms whereby HIV infection impedes successful T ce
106 dies provide new insights into the molecular mechanisms whereby HMGNs affect chromatin structure.
107 oteins is likely an evolutionarily conserved mechanism whereby HopAF1 orthologs from multiple plant p
108 ypanosomes in vivo to identify the molecular mechanism whereby human trypanolytic APOL1 variants evad
111 uces plaque vulnerability, providing a novel mechanism whereby IGF-1 exerts antiatherogenic effects.
113 iesis in IL-33- and ST2-deficient mice and a mechanism whereby IL-33 supports EoMs by driving both sy
114 ciated with more severe asthma; however, the mechanisms whereby IL-17A can contribute to IL-13-driven
115 human tendinopathy and thereafter, explored mechanisms whereby IL-17A mediated inflammation and tiss
116 iously suggested in autoimmune diseases, the mechanisms whereby IL-2 mitigates autoimmunity and preve
117 Collectively, these findings identify new mechanisms whereby impaired lysosomal targeting can impa
124 for UB development and may represent a novel mechanism whereby integrins regulate signaling pathways.
125 Together, these findings highlight a novel mechanism whereby interactions between Cat-1 and its bin
128 Rather, HD6 possesses a unique innate immune mechanism whereby it self-assembles into oligomers that
131 an NMDA receptor antagonist, has identified mechanisms whereby ketamine reverses the effect of stres
132 r etiology of nemaline myopathy and reveal a mechanism whereby KLHL41 stabilizes sarcomeres and maint
134 s cell proliferation; however, the molecular mechanism whereby La supports cell proliferation is not
135 suggest that Rad4/XPC uses a kinetic gating mechanism whereby lesion selectivity arises from the kin
136 y was to gain further insight into molecular mechanisms whereby ligand-activated RXR can affect or re
137 lacking nuclear localization uncover a novel mechanism whereby lipid phosphatase activity in the nucl
138 xpression in vivo These data uncover a novel mechanism whereby loss of serine protease inhibition lea
142 specifically addresses a potential unifying mechanism whereby marijuana could exert rewarding and ad
143 ken together, these findings suggest a novel mechanism whereby MCs may contribute to HRV-induced asth
144 rlin and Ezrin are essential components of a mechanism whereby mechanical forces associated with the
145 hese data support a novel ligand-independent mechanism whereby mechanical stretch allosterically stab
146 Here, we provide experimental evidence for a mechanism whereby membrane tension reduction initiates m
148 these findings collectively unravel a novel mechanism whereby menin suppresses cell proliferation, a
150 ly affect gut and systemic diseases, but the mechanism whereby microbiota affect systemic diseases is
151 vel insights into the cellular and molecular mechanisms whereby mitochondria control neurotransmitter
152 article provides an overview of the cellular mechanisms whereby mitochondria may promote maladaptive
153 nuclease roles in DSB repair, and support a mechanism whereby MRE11 endonuclease initiates resection
154 hepatocyte degeneration, suggesting a 2-hit mechanism whereby mutant hepatocytes cannot accommodate
155 tein and many hypotheses as to the molecular mechanisms whereby mutant huntingtin leads to cellular d
156 enetic basis has become well-understood, the mechanisms whereby mutations translate to arrhythmia sus
157 beta in osmoregulation and identify multiple mechanisms, whereby mutations of HNF-1beta produce defec
158 odulus-controlled morphogenesis and define a mechanism whereby neuronal cells respond to environments
161 by noradrenaline in nociceptive neurons is a mechanism whereby noradrenaline may suppress incoming no
162 ied-rather than backbone atoms and propose a mechanism whereby not only their charge sign but also th
164 hus we describe a novel endosomal signalling mechanism whereby one signal output, Rac1, is stimulated
165 immune arthritis model, we elucidate a novel mechanism whereby oral AM80 administration suppressed lu
167 pathway for AT1 activation and suggest a new mechanism whereby oxLDL may be promoting risk for cardio
170 nditions, deciphering chemical and molecular mechanisms whereby pathogens can influence vectors, expa
176 previous studies, these findings document a mechanism whereby permafrost degradation can lead to loc
177 receptor-alpha in sepsis and to identify the mechanism whereby peroxisome proliferator-activated rece
180 ndent inactivation of RhoA, thus providing a mechanism whereby PKA- and RhoA-dependent signaling path
183 hought to have antihypertensive effects, the mechanism whereby pomegranate extract lowers blood press
184 d 2 p45-related factor 2 (Nrf2) pathway as a mechanism whereby pomegranate extract reduces oxidative
189 n can therefore provide insight into general mechanisms whereby protein disorder regulates events tha
190 robability and fusion kinetics and suggest a mechanism whereby proteins (Munc13 or RIM) may control p
192 We used Rras-deficient mice to study the mechanism whereby R-Ras contributes to autoimmunity usin
193 ent study both provides new insight into the mechanisms whereby RA induces differentiation of B cells
195 o, there is still no consensus regarding the mechanisms whereby root elongation rate is initially red
197 urther research should carefully explore the mechanisms whereby rural residence might increase suicid
201 of IL-17 in malignant T cells, suggesting a mechanism whereby SEA-producing bacteria promote activat
205 ovide important structural insights into the mechanisms whereby sigmas initiate promoter opening.
206 vide evidence for a positive auto-regulatory mechanism whereby signaling through the injury-responsiv
207 ollectively, the results demonstrate a novel mechanism whereby SK1 lipid signaling is regulated by ep
208 understanding of the complex neurobiological mechanisms whereby some individuals switch from controll
209 We then identified the underlying molecular mechanism whereby SORLA promotes insulin-induced suppres
212 r-prone disposition of PrimPol, we propose a mechanism whereby SSBs greatly restrict the contribution
213 de new data that extend our knowledge on the mechanisms whereby Streptococcus pneumoniae is cleared b
214 eatest change in gene expression, offering a mechanism whereby stress timing might lead to markedly d
216 hought to occur through a 'molecular corset' mechanism, whereby structural elements within the epithe
217 rnating subunit half-of-the-sites reactivity mechanism whereby substrate binding to one subunit is co
218 gether, results of our study support a novel mechanism whereby sumoylation of La promotes cell prolif
219 endrix, and colleagues illuminate a cellular mechanism whereby T cells that infiltrate the brain afte
221 ative rounds of screening, we reveal a novel mechanism whereby target engagement by Argonaute 2 (AGO2
222 heimer's disease (AD), however, the cellular mechanism whereby tau accumulation causes neurodegenerat
223 These results identify a cellular immune mechanism whereby TGF-beta signaling blockade licenses t
226 rs authentic transport vesicles via the same mechanism whereby the ALPS motif senses lipid-packing de
227 mutagenic studies, we propose an allosteric mechanism whereby the binding of fructose 1,6-bisphospha
228 observed after stress reflect a compensatory mechanism whereby the brain drives neural systems to cou
229 We also reveal an evolutionarily conserved mechanism whereby the cell redirects its energy from mai
230 epressor complex activity as a key molecular mechanism whereby the environment influences DSL ligand
231 ectively, the findings are consistent with a mechanism whereby the excess CRF that characterizes stre
241 ng to mPFC input provides a safety-signaling mechanism whereby the mPFC taps into the microcircuitry
243 d us to suggest a replication fork unwinding mechanism whereby the N-terminal and AAA+ tiers of the M
247 on of the translocation process as well as a mechanism whereby the reported SERT stoichiometry can be
248 rk reveals a previously undescribed invasive mechanism whereby the secretion of a glutathione-depende
251 al studies indicate a bifunctional catalytic mechanism whereby the thioimidate activates the carbonyl
253 rate a cooperative, self-chaperone refolding mechanism, whereby the beta-subunits independently refol
255 tion of IgE and IgG could generate a natural mechanism, whereby the significant variation in syk expr
256 regions and the availability of one or more mechanisms whereby the absorbed photon energy can be dis
259 his pervasiveness, little is known about the mechanisms whereby the frequency and power of oscillator
260 These receptors represent one of the main mechanisms whereby the gut microbiome affects vertebrate
261 w describes the current understanding of the mechanisms whereby the lung is known to resolve fibrosis
262 these observations is that they indicate new mechanisms whereby the microenvironment in normal lympho
265 sm, metabolic fine-tuning involves feed-back mechanisms whereby the output of a pathway controls its
266 lite oxidation states and elucidation of the mechanisms whereby the redox state influences circadian
268 e present study, we aimed at identifying the mechanisms whereby the vitamin A metabolite all-trans re
270 B virus (HBV) pathogenesis to understand the mechanisms whereby these cells home to the liver, recogn
273 m-negative pathogens with a unique virulence mechanism whereby they grow a needle-like structure in o
274 w genetic risk factors and understanding the mechanisms whereby they influence disease development is
275 ed individuals and we provide evidence for a mechanism whereby this might contribute to the TD phenot
276 cess of macroautophagy, although the precise mechanism whereby this occurs has not been identified.
278 mulation of lipid in hepatocytes, though the mechanisms whereby this leads to hepatocyte dysfunction,
279 ere, we provide an overview of the different mechanisms whereby three different chaperones, Spy, Hsp7
283 ted data provide insights into the molecular mechanisms whereby transcriptional programs drive cortic
285 e discusses various endogenous and exogenous mechanisms whereby transport is controlled in the gut, p
286 vely, these studies illustrate an additional mechanism whereby Tregs control the immune response to n
287 In this study, we characterized molecular mechanisms whereby trimethoprim treatment results in cel
289 TTP-CNOT interaction that shape an emerging mechanism whereby TTP targets inflammatory mRNAs for dea
291 A detailed understanding of the molecular mechanisms whereby ubiquitin (Ub) recognizes enzymes in
292 uPAR (Plat(GFDhu/GFDhu)) to investigate the mechanism whereby uPA promotes neurorepair in the ischem
293 dy was undertaken to elucidate the molecular mechanism whereby uPAR ligation with its cognate ligand,
294 s taking thiopurines, our findings suggest a mechanism whereby UVA in sunlight may contribute to skin
295 years of experiments, the precise molecular mechanism whereby vacuolar (V-type) ATP synthase fulfill
296 ranule secretion and spreading and suggest a mechanism whereby VAMP-7 links granule exocytosis with a
297 tions and in doing so gain insights into the mechanisms whereby variants affect AF risk, using electr
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