ライフサイエンスコーパス: mechanistic

1 We use a mechanistic admixture model to compare the sex-specifica

2 ("ampetoids") are structural, functional and mechanistic analogs of helical, cationic AMPs, which off

3 Mechanistic analyses reveal that IFN-gamma induces CD70

4 Mechanistic analyses revealed that each tumor cell line

5 Mechanistic analyses suggest that CD70 expressed by host

6 Here we establish a novel system for mechanistic analysis of the plasticity of developing neu

7 Overall, this mechanistic analysis of the tumor-suppressive function o

8 e identified and elucidated by complementary mechanistic and density functional theory (DFT) studies.

9 progress made in H2S signaling that affects mechanistic and functional aspects of several biological

10 RP-1 in DNA damage detection and repair, the mechanistic and functional understanding of the role of

11 m attractive candidates for further in vitro mechanistic and in vivo studies and future vector-center

12 ence, these electrodes allow for the in situ mechanistic and kinetic characterization of electrochemi

13 New quantitative approaches that apply mechanistic and statistical models in a systems-wide app

14 Mechanistic and X-ray evidence is presented that support

15 Kinetic, mechanistic, and in situ spectroscopic studies establish

16 We use a mechanistic approach supplemented by empirical data to c

17 We advocate this more mechanistic approach to the categorization of ACS to pro

18 We consider the predictions made by these mechanistic approaches for the stratification and develo

19 These results provide novel mechanistic arguments as to why AES may exert context-sp

20 human disease and has been used to elucidate mechanistic aspects of a virus induced biliary cholangio

21 Mechanistic aspects of Fe/S protein biogenesis continue

22 chemistry techniques to describe kinetic and mechanistic aspects of ion-pair formation, and we obtain

23 ahda cold sensitivity, and characterized the mechanistic basis by which these suppressors alleviated

24 this phenomenon is frequently observed, the mechanistic basis for homotypic binding site synergy is

25 omosome organization and compaction, but the mechanistic basis for its functions remains obscure.

26 nents, and Loqs-PD truncations, we provide a mechanistic basis for Loqs-PD functions.

27 roach to assess the drug combinations with a mechanistic basis for selection, which suggests that com

28 This work provides a mechanistic basis for the association of SLC39A8 with wh

29 Accordingly, we provide a mechanistic basis for the dominantly protective effect o

30 ed a transcriptional network that provides a mechanistic basis for the observed cell fate decisions a

31 These data provide a mechanistic basis for the protective effects of the anti

32 This view provides a mechanistic basis for the TNM staging system and is the

33 hematopoietic specification, and provides a mechanistic basis for WNT-mediated definitive hematopoie

34 ral treatment options and elucidation of the mechanistic basis of disease pathogenesis will depend on

35 pens new opportunities for understanding the mechanistic basis of host discrimination and host shifts

36 he N- and C-terminus of TDP-43; however, the mechanistic basis of the contribution of individual doma

37 The current study provides a mechanistic basis to explain how matrix controls the ant

38 This study provides evidence about the mechanistic basis underlying differences between the SW

39 unctional constraints in determining folding-mechanistic behaviors, and the design principles orchest

40 vant cardiac tissue-like in vitro models for mechanistic biological research, disease modelling, ther

41 To understand the mechanistic changes caused by pathogenic mutations in th

42 pid identification of parameters that reveal mechanistic characteristics.

43 Here, through the discovery and mechanistic characterization of a small molecule, (amino

44 oteases belonging to the four major protease mechanistic classes-serine, cysteine, aspartyl, and meta

45 address how social immunity emerges from its mechanistic components to produce colony-level disease a

46 Our data reveal a novel mechanistic connection between AIBP-mediated cholesterol

47 While the mechanistic connection remains elusive, our results impl

48 aling pathway, and define its functional and mechanistic connection with Pom1 signaling for cell pola

49 oints and recent results on the temporal and mechanistic connections between hyperinsulinemia, obesit

50 emical interconversion, and biosynthetic and mechanistic considerations.

51 However, the actual mechanistic contributions of the motor system to sensory

52 Mechanistic data are consistent with metal-mediated Cl a

53 onds have been reported recently, but little mechanistic data on these processes are available.

54 in regulatory risk assessments, and without mechanistic data, an endocrine mode of action cannot be

55 Together, our findings provide the first mechanistic description of how visual cortical neurons s

56 of key intermediates and allowed a complete mechanistic description to be presented, including off-c

57 results provide important insights into the mechanistic design of the ptRNase superfamily, and prese

58 These observations provide mechanistic detail of how dislocations nucleate and migr

59 mical methods were utilized to elucidate the mechanistic details and evolutionary trade-offs created

60 However, the mechanistic details governing OM-induced modulation of X

61 esource for understanding GC biology and the mechanistic details of GR-regulated transcription.

62 For insight into the mechanistic details of hm(5)C function to be obtained, t

63 However, the mechanistic details of how mural cells stabilize vessels

64 ncreased tumor growth and metastasis but the mechanistic details of this interaction are still unclea

65 These results afford the mechanistic details required for efficient utilization o

66 Despite this mechanistic difference, both inhibitors convergently ind

67 This synthetic system will enable detailed, mechanistic dissection of MCC generation and checkpoint

68 onstants can be recovered and used to assign mechanistic effects and their relative magnitudes with a

69 -dependent regulation of RyR2 as well as the mechanistic effects of arrhythmogenic CaM mutations.

70 ocessors to better understand the associated mechanistic events is technically challenging.

71 Finally, we provide mechanistic evidence that KSRP promotes the down-regulat

72 Here, we develop a more particularistic and mechanistic evolutionary neuroscience approach to cumula

73 hese transformations is discussed as well as mechanistic experiments describing proposed intermediate

74 The mechanistic experiments suggest that the rate and select

75 Based on the observations in humans, mechanistic experiments were designed in a mouse model o

76 Taken together, our findings offer a mechanistic explanation for exercise-dependent suppressi

77 polymerization-condensation dynamics creates mechanistic explanation for how cells properly respond t

78 These results provide a mechanistic explanation for the behavioural changes in h

79 (5.3-fold change, P < .001) which provides a mechanistic explanation for this feature.

80 ts to their amplitude, in order to provide a mechanistic explanation the dependence of MPR on the ICa

81 a coordinates homeostasis of CPCs, providing mechanistic explanations for some nongenetic causes of C

82 ce and in time, which often defy traditional mechanistic explanations.

83 rt precision medicine, disease modeling, and mechanistic exploration.

84 processes in childhood present new areas for mechanistic explorations of this disease.

85 e present review is primarily focused at the mechanistic features of the oxidation by Fe(V)O of hydro

86 Our mechanistic findings in rat models and exploratory study

87 We derive a mechanistic framework to explain the stepwise spacer int

88 We hope that this conceptual mechanistic framework will stimulate fruitful research t

89 YA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies.

90 s extraction for a wide range of elements by mechanistic geochemical modeling.

91 These findings provide mechanistic guides to aid in design of vaccine strategie

92 arm temperatures, so we used Niche Mapper, a mechanistic heat-balance model, to convert macroclimate

93 on of gene-regulatory changes suggest strong mechanistic hypotheses for disease risk, but we conclude

94 ir synthetic counterparts and to discuss the mechanistic hypotheses for those reactions that are curr

95 The authors evaluated both mechanistic hypotheses in two sets of experiments at the

96 Thus, we are able to generate testable mechanistic hypotheses of the molecular changes that dri

97 Lastly, we present a preliminary mechanistic hypothesis characterized by intramolecular h

98 tal function, and they provide a preliminary mechanistic hypothesis for opposite responses by sex.

99 lusion and beyond reasonable enthusiasm, the mechanistic implementation and clinical relevance of mic

100 te these unexpected findings and discuss the mechanistic implications in the design and application o

101 in a region-specific manner has significant mechanistic implications regarding sex biases in NDDs.

102 optimal operating space and to gain maximal mechanistic information about the GC coating of the LPNs

103 racteristic mass changes, providing detailed mechanistic information regarding the folding mechanism.

104 alysis rate and, in some cases, even provide mechanistic information.

105 f previous studies are inconsistent and lack mechanistic information.

106 branches of science, but our ability to gain mechanistic insight and effectively conduct numerical ev

107 calculations have been performed to provide mechanistic insight into a series of Cp*Co(III)- and Cp*

108 Our findings provide mechanistic insight into Ca(2+)/calpain regulation of gr

109 rm intervesicular SNARE complexes, providing mechanistic insight into compound fusion at ribbon-style

110 We sought to gain mechanistic insight into how IL-17A can influence IL-13-

111 Here, we provide mechanistic insight into how overexpression of CKS prote

112 Mechanistic insight into how polycations disrupt and cro

113 These findings provide mechanistic insight into how the intestinal microbiota r

114 Our data provide mechanistic insight into RNR biology, highlighting RRM2B

115 To gain mechanistic insight into the CYP121-catalyzed reaction,

116 These data provide the first mechanistic insight into the heightened caries susceptib

117 propensity at the Tcrb locus and provide new mechanistic insight into the historic immunological conu

118 Our results provide a mechanistic insight into the regulation of angiogenesis

119 biological epistasis in humans and provides mechanistic insight into the regulation of IL7R exon 6 s

120 Together, these data provide mechanistic insight into the regulation of VM and sugges

121 By strategically modifying key positions, a mechanistic insight into the ribozyme-mediated cleavage

122 dies as therapeutic agents for cancer, offer mechanistic insight on proteasomal regulation of tumor-a

123 cificity (microRNA-122 [miR-122]) or provide mechanistic insights (keratin-18 [K18], high mobility gr

124 ls and standard cell cultures with regard to mechanistic insights and prediction of toxic effects in

125 Here, we provide mechanistic insights by examining the viral and cellular

126 l consequences of splicing factor mutations, mechanistic insights from animal models, and implication

127 The present study provides mechanistic insights into cooperation between p17 and si

128 This study provides mechanistic insights into how the distal heme ligand in

129 context of climate change to gain essential mechanistic insights into insect invasions.

130 ct measurements of molecular binding provide mechanistic insights into organo-mineral interactions, w

131 ntense therapeutic targeting, structural and mechanistic insights into receptor complexes mediated by

132 edite production of recombinant reovirus for mechanistic insights into reovirus protein function and

133 This study is the first to report novel mechanistic insights into simultaneous targeting of rece

134 o neuronal ovulatory stimuli, thus providing mechanistic insights into steroid signaling in Drosophil

135 Together, these data provide important mechanistic insights into the activation of IL-36gamma a

136 concurrent multi-omics analyses provide new mechanistic insights into the complex molecular networks

137 Altogether, our study provides new mechanistic insights into the complex regulation of BACE

138 This study provides mechanistic insights into the emergence of plant chemica

139 However, mechanistic insights into the HSR in higher eukaryotes,

140 bacterial RNA capping molecules, and provide mechanistic insights into their incorporation.

141 Here we report mechanistic insights into this association in multiple i

142 To obtain further mechanistic insights into this phenomenon, here we confi

143 Our structure provides novel mechanistic insights of how sulfonylureas and ATP intera

144 pment, homeostasis, and function and provide mechanistic insights on how it works at cellular and mol

145 Finally, the mechanistic insights provided by the novel conformationa

146 The challenge now is to identify the mechanistic integrations of these peptides into biochemi

147 Our study offers a mechanistic interpretation of PRn poly-dipeptide toxicit

148 tial equation) models, which can be used for mechanistic interpretations and reliable dynamic predict

149 HM development in zebrafish that will inform mechanistic interpretations of cardiopharyngeal phenotyp

150 g positive processing, informing targets for mechanistic intervention.

151 imultaneous transcriptome-wide screening and mechanistic investigation at large scales.

152 Thus, the mechanistic investigations and DFT calculations categori

153 Mechanistic investigations demonstrated causal roles for

154 In this study, we present detailed mechanistic investigations of the class C rSAM methyltra

155 Mechanistic investigations showed that MCPIP1 regulated

156 However, mechanistic knowledge of how it functions and its intera

157 igher level organismal effects without prior mechanistic knowledge or complex exposure data.

158 Understanding such phenomena at the mechanistic level can facilitate the design of maximally

159 n of early gene expression, which provides a mechanistic link between DNA repair and neurodegeneratio

160 These observations provide a mechanistic link between EPHB receptor mutations and met

161 metabolic stress-induced cardiomyopathy.The mechanistic link between metabolic stress and associated

162 These findings delineate a mechanistic link between obesity and insulin resistance

163 gical and psychiatric diseases; however, the mechanistic link between the human pathology and NMDAR d

164 However, a clear mechanistic link between TMAO and such diseases is not y

165 The mechanistic link from neurochemistry to perception provi

166 of circadian molecular rhythms, providing a mechanistic link to DSPD symptoms.

167 thfinding guided by signal gradients and the mechanistic linkage between tip growth and guidance.

168 is in Arabidopsis thaliana Here, we identify mechanistic links between KIN10, the major SUCROSE NON-F

169 phagy, and illustrate the existence of tight mechanistic links between the cellular stress responses.

170 rited through cell division, with intriguing mechanistic links to histone variants and DNA replicatio

171 del the underlying transmission dynamic in a mechanistic manner.

172 scaffold, providing metabolic support of our mechanistic model for colibactin-induced genotoxicity.

173 over the skeletal TF by Ca(2+) and lead to a mechanistic model for the regulation of the cardiac TF.

174 The essence of this mechanistic model is that the regulatory cues conformati

175 We have developed a data-driven mechanistic model using realistic root geometry and form

176 data acquisition, data-driven modeling, and mechanistic modeling to define new mechanisms of immunol

177 Simplified mechanistic models in ecology have been criticised for t

178 can unambiguously differentiate between two mechanistic modes of chain collapse for every chain cons

179 aches, integrating evolutionary biology with mechanistic molecular biology and ecology, promising app

180 Our study provides important mechanistic neuromuscular insight into walking balance c

181 IgE response was measured, and mechanistic parameters were analysed in the spleen.

182 However, the mechanistic pathway by which this reaction proceeds has

183 Dictyostelium and mammalian phagocytes share mechanistic pathways for chemotaxis and phagocytosis; Di

184 ddition, this methodology may help elucidate mechanistic pathways linking diet to chronic disease ris

185 quality to glucose homeostasis, although the mechanistic pathways remain unclear.

186 on, and of substituent electronic effects, a mechanistic picture involving rapid and reversible forma

187 Here, we provide a complete mechanistic picture of the excited state relaxation of d

188 atalytic inhibitor dexrazoxane (ICRF187) and mechanistic poison teniposide (VM26), can interfere with

189 the model process, we elucidate several key mechanistic principles.

190 Such inhibitors find use as mechanistic probes, chemical biology tools, and therapeu

191 We find that five categories of mechanistic process, including photodegradation, thermal

192 tonia pickettii DTP0602, identifying several mechanistic properties that differ from other enzymes in

193 We present the mechanistic range shift analysis (MRSA), a method to est

194 ilization of causal interaction data enables mechanistic rather than descriptive interpretation of ge

195 Our data provide a mechanistic rationale for the powerful ability of BAP1 t

196 -negative breast cancers, and they provide a mechanistic rationale to explore the repurposing of drug

197 subset.Significance: These findings offer a mechanistic rationale to explore the repurposing of drug

198 Collectively, these results provide a strong mechanistic rationale to investigate the therapeutic eff

199 Mechanistic rationalization of the observed behavior is

200 These findings expand the structural and mechanistic repertoire of flavoenzymes with oxidoreducta

201 cell types in vivo, and the need to conduct mechanistic research that identifies drugs performing we

202 Overall, our results suggest a complex mechanistic response in Daphnia characterized by interac

203 etic manipulation of PTEN status confirmed a mechanistic role for PTEN in determining the functional

204 minations, and outcomes strongly support the mechanistic role of biatrial rotors and focal sources in

205 However, the mechanistic role of EEA1 is not yet known.

206 The mechanistic role of HbF in podocyte injury was studied i

207 Recent investigation has demonstrated the mechanistic role of leukotriene B4 (LTB4) in the molecul

208 Here we provide detailed insight into the mechanistic role of TTC19, by investigating a Ttc19(?/?)

209 and structural analyses, we propose possible mechanistic roles of these critical residues in PI3Kalph

210 We also propose a plausible mechanistic scenario based on the experimentally observe

211 We discuss two mechanistic scenarios that are consistent with the data:

212 ates the temporal order, functional role and mechanistic separation of NuRD-associated enzymatic acti

213 We use a mechanistic, spatially explicit, stochastic, individual-

214 function (diastolic or systolic), which lack mechanistic specificity, paradigms of cardiac disease ha

215 The mechanistic statistical model based on ecological diffus

216 activation mediated by mu-receptors as a key mechanistic step required for morphine potentiation of P

217 mporal and spatial resolution to resolve key mechanistic steps leading to Cas3 recruitment.

218 ly used in preclinical mouse models for both mechanistic studies and screening of new cell based ther

219 ain: purely descriptive reports outnumbering mechanistic studies and slow translation of experimental

220 Mechanistic studies are consistent with an inner-sphere

221 Mechanistic studies are consistent with SN2 attack by I(

222 Confirmatory and mechanistic studies are needed.

223 Although mechanistic studies are ongoing, we propose that CuH-cat

224 Additional mechanistic studies confirm that the assemblies of the s

225 Mechanistic studies demonstrated that adiponectin and ni

226 Initial mechanistic studies have suggested that mavacamten prima

227 Molecular mechanistic studies indicate that rauwolscine interacts

228 Mechanistic studies of deregulated ERG in prostate cance

229 is approach has the high potential to enable mechanistic studies of initiation and progression of cli

230 ement inhibitory compound, termed cmp-5, and mechanistic studies of the cmp-5 inhibitory mode reveale

231 k matter," which will in turn allow detailed mechanistic studies of the effects of these molecules on

232 This thrilling journey began with mechanistic studies on a beta-globin enhancer- and promo

233 y protein of interest, provide new tools for mechanistic studies on redox-active Ys in proteins and o

234 However, mechanistic studies on the relationship of neurogenesis

235 Our mechanistic studies reveal that association of Mll2's CX

236 Mechanistic studies revealed a decrease in peroxisomal b

237 Mechanistic studies show 3 acts directly in catalysis wi

238 Mechanistic studies show that this diamination reaction

239 Mechanistic studies showed that HNK inhibited Stat3-phos

240 Mechanistic studies showed that KDM1A inhibitors induce

241 Expression profiling and in vitro mechanistic studies showed that stimulation of PC-3 cell

242 Mechanistic studies suggest that this reaction does not

243 Mechanistic studies suggested that TA induced KLF2 expre

244 Mechanistic studies that have utilized pharmacologic and

245 The reported data will guide mechanistic studies to determine the role of BTA121 in t

246 r, these data underscore the requirement for mechanistic studies to identify bacterial components and

247 inophen-hepatotoxicity and may inform future mechanistic studies to identify specific molecular targe

248 Mechanistic studies were carried out in a mouse model of

249 epidemic of childhood obesity and encourage mechanistic studies.

250 ses, and cell types that can be targeted for mechanistic study and therapeutic targeting of peanut al

251 with potent anticancer activity for further mechanistic study and translation to clinical trials.

252 Preliminary mechanistic study favors an Ir-C migratory insertion pat

253 The reactivity of arylamines and the mechanistic study for the formation of benzoquinoline wa

254 The mechanistic study indicates that knockdown of IRE1alpha

255 A mechanistic study of the Pd-catalyzed enantioselective 1

256 onation, but also illustrates a strategy for mechanistic study that can be applied to other oxidoredu

257 ort that endocytic recycling requires active mechanistic target of rapamycin (aka mammalian target of

258 easome inhibition, stress kinase activation, mechanistic target of rapamycin (mTOR) activation, loss

259 Mechanistic target of rapamycin (MTOR) cooperates with H

260 The mechanistic target of rapamycin (mTOR) coordinates eukar

261 Mechanistic target of rapamycin (mTOR) enhances immunity

262 However, given that the PI3K/Akt/mechanistic target of rapamycin (mTOR) pathway is also k

263 Mechanistic target of rapamycin (mTOR) signaling is nece

264 s of DR as well as manipulations of insulin, mechanistic target of rapamycin (mTOR), AMP-activated pr

265 uli converge on the conserved protein kinase mechanistic target of rapamycin (mTOR), existing in two

266 h CSF and LN correlated with upregulation of mechanistic target of rapamycin (mTOR), proinflammatory,

267 Here we show that Protein Kinase B-mechanistic Target of Rapamycin (PKB/AKT-mTOR) signaling

268 Mechanistic target of rapamycin complex 1 (MTORC1) is a

269 The mechanistic target of rapamycin complex 1 (mTORC1) is a

270 The mechanistic target of rapamycin complex 1 (mTORC1) prote

271 Instead, mechanistic target of rapamycin complex 1 (mTORC1) signa

272 Mechanistic target of rapamycin complex 1 (TORC1) integr

273 In contrast to mechanistic target of rapamycin complex 1-dependent cano

274 We describe the relationship between the mechanistic target of rapamycin complex 1/2 protein subu

275 Mechanistic target of rapamycin inhibition by either nut

276 th both drugs was required to fully suppress mechanistic target of rapamycin signaling, a known effec

277 acity for small molecule-like tunability and mechanistic tractability available to transition metal c

278 mental studies in mice to identify plausible mechanistic triggers of pathological scarring in skin wo

279 Our findings demonstrate a mechanistic underpinning for the recently developed abla

280 g prevalence of hypertension, clarifying the mechanistic underpinnings of hypertension-induced altera

281 However, detailed mechanistic understanding and evidence for efficacy and

282 o support experimental designs and to gain a mechanistic understanding at system scales.

283 Mechanistic understanding of CARs was used to expand rea

284 cells repair themselves is important for our mechanistic understanding of cell biology.

285 number of experiments, have provided limited mechanistic understanding of differences in ecosystem se

286 A mechanistic understanding of early organoid formation is

287 idoglycan substrates, as foundational to the mechanistic understanding of emerging PBP2a resistance m

288 study provides a structural framework for a mechanistic understanding of eukaryotic ribosome assembl

289 A detailed mechanistic understanding of how environmental microbes

290 This study provides a mechanistic understanding of how MCPH1 controls neural s

291 this adverse drug reaction will further our mechanistic understanding of its development and potenti

292 oblematic human memories, we lack a detailed mechanistic understanding of memory updating.

293 espite this evident physiological relevance, mechanistic understanding of NET formation is poor.

294 ned by slow release of nutrients, although a mechanistic understanding of nutrient storage in biochar

295 nterneurons remain largely unknown, limiting mechanistic understanding of olfaction.

296 Our findings provide new insights for a mechanistic understanding of prion replication and suppo

297 Taken together, this study provided a mechanistic understanding of the dynamic nature of the p

298 The mechanistic understanding of the functional modulation o

299 ges in future climates, which will require a mechanistic understanding of the trade-offs that determi

300 Step 5 was to look for mechanistic understanding, starting with examining evide