ライフサイエンスコーパス: mechanistic insight

1 ta, can be used to make predictions and give mechanistic insight.

2 humans, animal models have been employed for mechanistic insight.

3 actions, but usually falls short of enabling mechanistic insight.

4 l data with a conformational view to provide mechanistic insight.

5 n, and the therapeutic implications of those mechanistic insights.

6 the genital proteome and microbiome to gain mechanistic insights.

7 iptional repression have yielded significant mechanistic insights.

8 r and have provided important functional and mechanistic insights.

9 to undertake subgroup analyses, and to gain mechanistic insights.

10 or noninvasive biomarker discovery and novel mechanistic insights.

11 By using mechanistic insight, a new ligand (EPhos) for the pallad

12 protein and DNA synthesis provides necessary mechanistic insight about proteins apportioned for newly

13 o-electrochemical approach is used to derive mechanistic insights about electrocatalysis that are not

14 Though mechanistic insights about the epigenome remain sparse,

15 pounds is important, and providing atomistic mechanistic insights about the reaction mechanism of try

16 Our mechanistic insights allowed us to predict and validate

17 branches of science, but our ability to gain mechanistic insight and effectively conduct numerical ev

18 ereocontrol in the polymerization, providing mechanistic insight and explaining why the chirality of

19 The lack of an adequate animal model hampers mechanistic insight and the development of new therapeut

20 verse prognostic outcomes, may provide novel mechanistic insights and facilitate clinical trials of d

21 ues, exploration of which will generate both mechanistic insights and facilitate future psychobiotic

22 These data offer both mechanistic insights and may potentially guide developme

23 ls and standard cell cultures with regard to mechanistic insights and prediction of toxic effects in

24 s, with emphasis on methodology development, mechanistic insight, and catalyst-controlled chemodiverg

25 perimental approaches has provided important mechanistic insights, and call for a more expansive use

26 Mechanistic insights are elucidated and therapeutic dose

27 19.4 kcal/mol), suggesting that the obtained mechanistic insights are reasonable.

28 The model presented here gives mechanistic insight as to why surgery may be unsuccessfu

29 These findings thus provide the first mechanistic insights both into how chlamydial Incs hijac

30 These novel mechanistic insights bridge different scientific domains

31 Here, we provide mechanistic insights by examining the viral and cellular

32 These structural and mechanistic insights culminated in GSK065(C1) and GSK366

33 ary cells or cancer cell lines, assumes that mechanistic insights derived from the models would have

34 arbyne transfer methodology and the detailed mechanistic insight enabled the design of a bifunctional

35 iring rates and local field potentials; this mechanistic insight explains previous behavioral finding

36 Here we outline mechanistic insights, focusing on translational relevanc

37 ria for the three-component reaction provide mechanistic insight for the development of this methodol

38 Together, our work provides mechanistic insight for the regulation of the Las1 endor

39 Mechanistic insights for both steps are provided based o

40 these single-cell tools have uncovered novel mechanistic insights for canonical signaling pathways th

41 irection of information flow can provide new mechanistic insights for K-Ras targeting.

42 allosteric dynamics provides structural and mechanistic insights for the activation and modulation o

43 Our data provide a rationale and mechanistic insights for the role of Nipbl in the neurol

44 l consequences of splicing factor mutations, mechanistic insights from animal models, and implication

45 these data reveal the potential to gain new mechanistic insights from nonfitness measures of gene-dr

46 Discovering mechanistic insights from phenotypic information is crit

47 The mechanistic insights gained from this study may serve as

48 Mechanistic insights gleaned from para-hydrogen induced

49 tems have been studied and a great wealth of mechanistic insight has been developed using this techni

50 Considerable mechanistic insight has been gained into amyloid aggrega

51 entified using mammalian models, much of the mechanistic insight has emerged from Caenorhabditis eleg

52 This mechanistic insight has significance for the development

53 Collectively, our work provides mechanistic insight in atomic detail into the release of

54 Our data provide mechanistic insight in how critical processes such as ao

55 es with non-natural reactions, providing new mechanistic insights in protein science.

56 in regulating hCPC survival and establishes mechanistic insights in the function of CYGB.

57 rough the transcription cycle, providing new mechanistic insight indicating that SEC recruitment to c

58 The structure of the complex also provides mechanistic insight into a class of disruptive IgE inhib

59 calculations have been performed to provide mechanistic insight into a series of Cp*Co(III)- and Cp*

60 Thus, these data not only provide mechanistic insight into Abl/Arg regulation during melan

61 Altogether, our study provides new mechanistic insight into AD-associated autophagic stress

62 odent models have also enabled unprecedented mechanistic insight into addiction, revealing plasticity

63 Our data provide mechanistic insight into an autocrine regulatory signali

64 s a pharmacological intermediate and provide mechanistic insight into attenuated dopamine tone follow

65 mal thioboration reaction of alkynes to gain mechanistic insight into B-chlorocatecholborane (ClBcat)

66 Our findings provide mechanistic insight into Ca(2+)/calpain regulation of gr

67 prove clinical bone regeneration and provide mechanistic insight into canonical Wnt pathway activity

68 esent kinetic approach can be useful to gain mechanistic insight into carotenoid bioaccessibility as

69 hat the global bias encapsulates fundamental mechanistic insight into cellular behavior.

70 erminally differentiated neurons and provide mechanistic insight into cognitive abnormalities associa

71 rm intervesicular SNARE complexes, providing mechanistic insight into compound fusion at ribbon-style

72 This study provides a mechanistic insight into defective neutrophil maturation

73 ltogether, these data provide phenotypic and mechanistic insight into durable hematopoietic dysregula

74 We also uncovered mechanistic insight into Foxp1 function by demonstrating

75 cus-specific regulatory composition provides mechanistic insight into genome structure and function i

76 This work provides mechanistic insight into how a history of infection can

77 To probe for mechanistic insight into how AC up-regulation can impact

78 This study provides new mechanistic insight into how an NLR can coordinate an im

79 esentations-a finding that provides critical mechanistic insight into how and why hippocampal represe

80 s and intracellular proliferation, providing mechanistic insight into how bacterial exploitation of h

81 hways to NF-kappaB through Bcl3 and provides mechanistic insight into how Bcl3 functions as an oncopr

82 rognosis in cancer, although there is little mechanistic insight into how cells harness ZBTB33 transc

83 Our results provide a mechanistic insight into how cellular stress and nutriti

84 ect to well-defined target tissues and offer mechanistic insight into how diversity and connectivity

85 sis of H3-G34R mutant fission yeast provides mechanistic insight into how G34R mutation may promote g

86 studies in mice are now beginning to obtain mechanistic insight into how high-fat diets perturb stem

87 This study provides mechanistic insight into how IL-15 controls the generati

88 We sought to gain mechanistic insight into how IL-17A can influence IL-13-

89 Our results provide mechanistic insight into how LHX2 acts as a necessary an

90 Here, we provide mechanistic insight into how overexpression of CKS prote

91 f DSB repair in PD-L1 expression and provide mechanistic insight into how PD-L1 expression is regulat

92 Mechanistic insight into how polycations disrupt and cro

93 ct effects on VTA DA neurons, thus providing mechanistic insight into how social interactions can gen

94 This work provides important mechanistic insight into how spatiotemporal expression o

95 To gain mechanistic insight into how SPIN1 functions as a transc

96 This study provides mechanistic insight into how the complement system, a ke

97 These findings provide mechanistic insight into how the intestinal microbiota r

98 Taken together, these results provide mechanistic insight into how the microdeletion results i

99 A new study by Guryanova et al. sheds mechanistic insight into how the most common DNMT3A vari

100 Our data offer a mechanistic insight into how the nervous system mediates

101 This study provides a unique mechanistic insight into how the tight control of spatia

102 cytoneme involvement in morphogen transport, mechanistic insight into how they are regulated is limit

103 h sexes, thereby significantly expanding our mechanistic insight into HPG activity.

104 ver LGR5 internalization inhibitors and gain mechanistic insight into LGR5 internalization.

105 Our combined data provide mechanistic insight into long-range coupling effects and

106 This study provides mechanistic insight into MMF-mediated cytoprotection via

107 These observations provide direct mechanistic insight into NP-plant interactions, and reve

108 Overall, our results provide mechanistic insight into NRP1 function within and potent

109 Mechanistic insight into presynaptic factors that establ

110 aling in mammalian neurogenesis and provides mechanistic insight into recently identified complement

111 Beyond providing mechanistic insight into reovirus replication, our findi

112 Our study gives mechanistic insight into RNA networks controlled by RNA-

113 Our data provide mechanistic insight into RNR biology, highlighting RRM2B

114 beta cell-specific T cells, we have limited mechanistic insight into self-reactive autoimmune T cell

115 Taken together, our findings provide a mechanistic insight into SWCNT-induced carcinogenesis an

116 Our studies provide mechanistic insight into telomerase-deficiency diseases

117 is and quantum chemical calculations provide mechanistic insight into the basis for this profound eff

118 y reaction for a range of ushers and provide mechanistic insight into the beta-barrel assembly pathwa

119 The present work provides mechanistic insight into the complex photophysics of Ant

120 future functional studies, giving us unique mechanistic insight into the complex process of transcri

121 Our work provides mechanistic insight into the contribution of IL-21 to th

122 s an effector of Rab35, thus providing novel mechanistic insight into the coupling of neuronal activi

123 Our data add mechanistic insight into the crosstalk between epigeneti

124 To gain mechanistic insight into the CYP121-catalyzed reaction,

125 Mac-1-dependent manner, providing additional mechanistic insight into the diverse functions of neutro

126 These data provide new mechanistic insight into the environmental fate of hydra

127 These findings provide novel mechanistic insight into the function of MSA for regulat

128 These epigenetic adaptations provide mechanistic insight into the gene-specific regulation of

129 These data provide the first mechanistic insight into the heightened caries susceptib

130 propensity at the Tcrb locus and provide new mechanistic insight into the historic immunological conu

131 Here, we provide mechanistic insight into the interplay between sirtuin 2

132 This study provides new mechanistic insight into the known contribution of myelo

133 and colleagues (pp. 2222-2234) provides new mechanistic insight into the molecular basis by which Nu

134 Our study provides new mechanistic insight into the pathologic aggregation of m

135 The characterization of Tric1/2 provides mechanistic insight into the process of tRNA import into

136 To gain mechanistic insight into the process, we analyzed the ki

137 our experimental data very well and provides mechanistic insight into the processes.

138 ctionalization with molecular iodine provide mechanistic insight into the rate-determining step and t

139 e-derived radical reactions, and it provides mechanistic insight into the reaction mechanisms for the

140 on and thus, beta-cell excitability provides mechanistic insight into the recently reported insulinot

141 Our results provide a mechanistic insight into the regulation of angiogenesis

142 Together, our findings provide a novel mechanistic insight into the regulation of CSCs via SLUG

143 hTERT expression but also provide a possible mechanistic insight into the regulation of gene expressi

144 biological epistasis in humans and provides mechanistic insight into the regulation of IL7R exon 6 s

145 Our results provide novel mechanistic insight into the regulation of PSD-95 in den

146 Together, these data provide mechanistic insight into the regulation of VM and sugges

147 By strategically modifying key positions, a mechanistic insight into the ribozyme-mediated cleavage

148 These findings may provide mechanistic insight into the role of FLCN in regulating

149 Our results provide novel, mechanistic insight into the short-term fate of N in the

150 We believe this study provides the first mechanistic insight into the vulnerability of the adoles

151 Together, our current results provide a mechanistic insight into the way CPE regulates the canon

152 ies to provide functional, quantitative, and mechanistic insight into this complex ecosystem.

153 Mechanistic insight into this deprotection methodology d

154 To gain mechanistic insight into this non-intuitive finding, we

155 vel of both Axin and APC2, providing further mechanistic insight into TNKS inhibition as a potential

156 This variant provides valuable mechanistic insight into triterpenoid synthesis and reve

157 These results offer important mechanistic insight into two critical steps in polymeriz

158 in hematopoietic gene activation and provide mechanistic insight into which Nup98 leukemic fusion pro

159 Our results provide mechanistic insight into why human neoplastic translocat

160 sistance in self-immunity genes and provides mechanistic insights into a fascinating tRNA-dependent a

161 dentifying candidate biomarkers and provides mechanistic insights into aging-associated immunodeficie

162 Together, our results provide new mechanistic insights into allogeneic GVT, validate the i

163 this study are of significance providing new mechanistic insights into angiogenesis and providing bet

164 usly determined McjD structure provided some mechanistic insights into antibacterial peptide efflux.

165 In conclusion, this study provides mechanistic insights into atrial proarrhythmia with SQT3

166 Fabs reported here reveal, as probes, novel mechanistic insights into BAX inhibition and provide a b

167 Together these data add new mechanistic insights into both Wnt signalling and adult

168 ctions are disturbed in CD and thus provides mechanistic insights into CD pathogenesis.

169 elements of the biologist's toolkit to gain mechanistic insights into cellular processes.

170 computational tools can provide fundamental mechanistic insights into complex organometallic reactio

171 The present study provides mechanistic insights into cooperation between p17 and si

172 n of CPR5 with bZIP60 and bZIP28, we provide mechanistic insights into CPR5-mediated modulation of UP

173 h as cognition and emotion can provide novel mechanistic insights into disorder pathogenesis.

174 typic analysis of the mutant cells can yield mechanistic insights into driver events relevant to huma

175 These data provide mechanistic insights into GATA3-mediated chromatin repro

176 Mechanistic insights into gene and immune regulation in

177 The examples discussed provide some mechanistic insights into glycan regulation of autophagy

178 This model may provide mechanistic insights into hepatic antiviral immunity, a

179 Here, we provide mechanistic insights into high-level resistance to chlor

180 lex involved in leaf senescence and provides mechanistic insights into how a histone deacetylase alon

181 Computational studies provided mechanistic insights into how acetylation alters the int

182 Together, these studies provide new mechanistic insights into how cells recover from activat

183 Our data provide mechanistic insights into how Chil1 regulates P. aerugin

184 This study provides the first mechanistic insights into how exposure to urban air poll

185 These findings provide mechanistic insights into how hypoxia promotes Notch sig

186 Taken together, our studies provide mechanistic insights into how neurons are specified in a

187 Recent findings provide fresh mechanistic insights into how regional cell behaviours m

188 Our work provides critical structural and mechanistic insights into how Siglec-8 selectively recog

189 hemical and structural studies have revealed mechanistic insights into how TET and TDG mediate active

190 These results reveal mechanistic insights into how the catalytic performance

191 This study provides mechanistic insights into how the distal heme ligand in

192 ace and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized a

193 The present work provides mechanistic insights into how UGN influences energy home

194 us gK cell surface expression, providing new mechanistic insights into how UL20 palmitoylation regula

195 formational dynamics of VDRRXRalpha and give mechanistic insights into how VDRRXRalpha controls the t

196 gative regulator of IRF3 activation provides mechanistic insights into innate antiviral defense and p

197 Globally, our findings provide new mechanistic insights into innate immunity through the ac

198 context of climate change to gain essential mechanistic insights into insect invasions.

199 opening reaction of a spiropyran, we provide mechanistic insights into its multipath reaction pathway

200 during DNA replication and provide potential mechanistic insights into its tumor suppressor role in c

201 atomically detailed analyses provide unique mechanistic insights into K-Ras dimer formation and memb

202 Detailed mechanistic insights into molecular signaling pathways r

203 ct measurements of molecular binding provide mechanistic insights into organo-mineral interactions, w

204 Our results provide new mechanistic insights into our understanding of IAV infec

205 These data provide mechanistic insights into outer membrane nutrient import

206 The study findings provide novel mechanistic insights into PD and autoimmune diseases and

207 These results provide new mechanistic insights into positive-strand RNA virus repl

208 ntense therapeutic targeting, structural and mechanistic insights into receptor complexes mediated by

209 disease.Significance: These findings provide mechanistic insights into regulation of the tumor suppre

210 edite production of recombinant reovirus for mechanistic insights into reovirus protein function and

211 This study is the first to report novel mechanistic insights into simultaneous targeting of rece

212 Our study provides mechanistic insights into Slc26a6, a unique cardiac elec

213 s unexpected signaling nodes and may provide mechanistic insights into some divergent phenotypes asso

214 Our results provide mechanistic insights into species-specific metabolism an

215 esults, both established and new, and offers mechanistic insights into spike-triggered conditioning.

216 o neuronal ovulatory stimuli, thus providing mechanistic insights into steroid signaling in Drosophil

217 This work provides tools and fundamental mechanistic insights into subcellular adrenergic signall

218 Together, these data provide important mechanistic insights into the activation of IL-36gamma a

219 Overall, our work provides mechanistic insights into the AML-NK dysfunction and a p

220 concurrent multi-omics analyses provide new mechanistic insights into the complex molecular networks

221 Altogether, our study provides new mechanistic insights into the complex regulation of BACE

222 This work provides mechanistic insights into the consequences of cancer-rel

223 This report provides mechanistic insights into the critical roles of Ca(2+)/C

224 The present study provides deep mechanistic insights into the dioxygen reduction process

225 This study provides mechanistic insights into the emergence of plant chemica

226 Our findings provide mechanistic insights into the evolution of plasticity in

227 te between their biological roles, providing mechanistic insights into the evolutionary, biochemical,

228 Together, these data provide critical mechanistic insights into the function of FOXP1 in the d

229 Mechanistic insights into the function of the pro-apopto

230 However, mechanistic insights into the HSR in higher eukaryotes,

231 moral immunity, our observations provide new mechanistic insights into the immunogenicity of PF4/hepa

232 Molecular mechanistic insights into the inflammatory reflex and ot

233 The present paper describes new fundamental mechanistic insights into the inherent challenges of per

234 Our study provides new mechanistic insights into the maintenance of axonal mito

235 lic precursor protein and provided important mechanistic insights into the maturation of sunflower pr

236 Together, our study provides novel mechanistic insights into the pathogenic mechanisms of a

237 ications for cancer therapy, and provide new mechanistic insights into the plasticity of cancer cells

238 Together, our data provide mechanistic insights into the procancer effect of chemot

239 These studies provide mechanistic insights into the processes that cause genom

240 These findings provide new mechanistic insights into the regulation and function of

241 ol II progression and splicing could provide mechanistic insights into the regulation of gene express

242 These data provide novel mechanistic insights into the regulation of MeCP2-mediat

243 This work provides new mechanistic insights into the regulation of rDNA silenci

244 Taken together, we provide mechanistic insights into the regulation of SG formation

245 DNA methylation and gene expression provide mechanistic insights into the relationship between DNA m

246 These findings provide mechanistic insights into the renewal and potency of olf

247 These results provide novel mechanistic insights into the role of IL-22 in the regul

248 ion reactions and, where possible, describes mechanistic insights into the role played by the ancilla

249 Our findings provide both new mechanistic insights into the still enigmatic phenomenon

250 Computational studies have provided mechanistic insights into the tail-to-tail dimerization

251 Our study provides critical mechanistic insights into the virulence activity of YopJ

252 Recent studies have provided deeper mechanistic insights into their catalysis, activation, a

253 To gain mechanistic insights into their different roles, we dire

254 oding disease-associated mutations to obtain mechanistic insights into their functional impact.

255 bacterial RNA capping molecules, and provide mechanistic insights into their incorporation.

256 late donor is critical to both pathways, and mechanistic insights into these biologically relevant pr

257 te a broader systems-level understanding and mechanistic insights into these integrative practices th

258 hn's disease, colitis, and colon cancer, but mechanistic insights into these processes and diseases a

259 ith amelioration of allergic reactivity, but mechanistic insights into this association are lacking.

260 Here we report mechanistic insights into this association in multiple i

261 ransport of both endocannabinoids, providing mechanistic insights into this complex process.

262 ies of Lgt and LspA have yielded significant mechanistic insights into this essential biosynthetic pa

263 Here, we report mechanistic insights into this oxygen-induced photodegra

264 To obtain further mechanistic insights into this phenomenon, here we confi

265 Here we review recent mechanistic insights into tolerance and the development

266 Overall, our results provide mechanistic insights into TOPBP1's role in HR, with pote

267 tem cells from mouse fibroblasts and reveals mechanistic insights into underlying reprogramming proce

268 cificity (microRNA-122 [miR-122]) or provide mechanistic insights (keratin-18 [K18], high mobility gr

269 Our structure provides novel mechanistic insights of how sulfonylureas and ATP intera

270 The mechanistic insights of these cyclocondensation reaction

271 dies as therapeutic agents for cancer, offer mechanistic insight on proteasomal regulation of tumor-a

272 Based on this new mechanistic insight on the utilization of solid-state br

273 rD4 in type IV secretion, our study provides mechanistic insights on a process that mediates the dang

274 induced Tie2 dimerization in cis and provide mechanistic insights on Ang2 antagonism, Tie1/Tie2 heter

275 pment, homeostasis, and function and provide mechanistic insights on how it works at cellular and mol

276 Lack of mechanistic insights on Ni-catalyzed C(sp(3))-H activati

277 ly, biomarkers are used currently to provide mechanistic insight or an objective measure of disease s

278 Providing mechanistic insights, our data reveal that Set1 and Jhd2

279 resistance against Enterobacteriaceae, these mechanistic insights point to the metabolism of epitheli

280 The obtained mechanistic insights provide valuable information for op

281 f the catalysis through NMR monitoring, with mechanistic insight provided by NMR (including DOSY) exp

282 Finally, the mechanistic insights provided by the novel conformationa

283 The mechanistic insights revealed CXCR2-driven protein kinas

284 This mechanistic insight reveals a bimodal mechanism of actio

285 t in CD36 knockout mice, Our results provide mechanistic insights showing that CIH exposures during s

286 tural description of Spy1 provides important mechanistic insights that may be utilized for targeting

287 Mechanistic insights, therapeutic options, and knowledge

288 This work provides mechanistic insight to allosteric NMDA receptor inhibiti

289 Our findings provide the first mechanistic insight to how defects impact kinesin-based

290 AD risk factors across life span and provide mechanistic insight to the processes by which neuropsych

291 utility of canine diabetes to provide novel mechanistic insights to the human disorder.

292 These structural and mechanistic insights, together with phylogenetic analysi

293 The mechanistic insight toward the aldol-type cyanomethylati

294 ecular mimics may be important for providing mechanistic insights towards the hydrogen evolution reac

295 sociated with IPF susceptibility and provide mechanistic insight using gene and protein expression an

296 In light of this mechanistic insight, we studied the effects of G-quadrup

297 To gain mechanistic insights, we performed nutritional analysis

298 Mechanistic insights were gained on the different antiar

299 Further mechanistic insights were provided by chromatin immunopr

300 atabases is often descriptive and of limited mechanistic insight, which poses difficulties for reliab