ライフサイエンスコーパス: mechanistic target of rapamycin

1 in synthesis relies on the activation of the mechanistic target of rapamycin.

2 inactivating, a negative regulator of Ulk1, mechanistic target of rapamycin.

3 The kinase complex mechanistic target of rapamycin 1 (mTORC1) plays an impo

4 Here we show that mechanistic target of rapamycin 2 (mTORC2) and Tricorner

5 stood, and here we examine the role of mTOR (mechanistic target of rapamycin), a central metabolic pa

6 alian target of rapamycin (mTOR; also called mechanistic target of rapamycin), a well-established mas

7 tor and mitogen activated protein kinase and mechanistic target of rapamycin activator (LAMTOR) compl

8 r pH with acidification dependent on 621-101 mechanistic target of rapamycin activity and net hydroge

9 cal inhibition of cathepsin B down-regulated mechanistic target of rapamycin activity and prevented c

10 ort that endocytic recycling requires active mechanistic target of rapamycin (aka mammalian target of

11 es insights into the spatial organization of mechanistic target of rapamycin and MAPK signal transduc

12 activity-dependent mRNA translation through mechanistic target of rapamycin and mitogen-activated pr

13 way, namely IGF-1, IGF-1 receptor, mammalian/mechanistic target of rapamycin and ribosomal protein S6

14 Phosphorylation of Akt, mechanistic target of rapamycin, and 70S6K was determine

15 of murine M1 macrophage markers through Akt2/mechanistic target of rapamycin-C1/70S6K pathway and act

16 d 2, Elk-1, p38, Akt, focal adhesion kinase, mechanistic target of rapamycin, C10 regulator of kinase

17 has been demonstrated to result in increased mechanistic target of rapamycin C2 (mTORC2) nucleation a

18 ich are directly involved in suppressing the mechanistic target of rapamycin cell growth signaling pa

19 te the protein kinase complex referred to as mechanistic target of rapamycin complex (mTORC) 1.

20 tion of Cox-1 involves the activation of the mechanistic target of rapamycin complex (mTORC).

21 Here, we report that although the mechanistic target of rapamycin complex 1 (mTORC1) activ

22 sure to Hcy resulted in up-regulation of the mechanistic target of rapamycin complex 1 (mTORC1) activ

23 rophoblast cells to test the hypothesis that mechanistic target of rapamycin complex 1 (mTORC1) and 2

24 ed in mice and cells after activation of the mechanistic target of rapamycin complex 1 (mTORC1) and i

25 Hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) and i

26 tioning in mice, we investigated the role of mechanistic target of rapamycin complex 1 (mTORC1) and i

27 discovered as an endogenous regulator of the mechanistic target of rapamycin complex 1 (mTORC1) and m

28 We identified that the activation of the mechanistic target of rapamycin complex 1 (mTORC1) by In

29 this site releases PRAS40 from the mammalian/mechanistic target of rapamycin complex 1 (mTORC1) compl

30 The mechanistic target of rapamycin complex 1 (mTORC1) contr

31 The mechanistic target of rapamycin complex 1 (mTORC1) contr

32 Mechanistic target of rapamycin complex 1 (mTORC1) contr

33 The mechanistic target of rapamycin complex 1 (mTORC1) coord

34 The activity of the mechanistic target of rapamycin complex 1 (mTORC1) decre

35 urs through the convergent activation of the mechanistic target of rapamycin complex 1 (mTORC1) downs

36 The mechanistic target of rapamycin complex 1 (mTORC1) has e

37 t study aimed to investigate the role of the mechanistic target of rapamycin complex 1 (mTORC1) in th

38 The mechanistic target of rapamycin complex 1 (mTORC1) integ

39 Mechanistic target of rapamycin complex 1 (mTORC1) integ

40 Mechanistic target of rapamycin complex 1 (MTORC1) is a

41 The mechanistic target of rapamycin complex 1 (mTORC1) is a

42 The mechanistic target of rapamycin complex 1 (mTORC1) is a

43 The mechanistic target of rapamycin complex 1 (mTORC1) is a

44 The mechanistic target of rapamycin complex 1 (mTORC1) is a

45 The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is a

46 The mechanistic target of rapamycin complex 1 (mTORC1) is re

47 The multi-component mechanistic target of rapamycin complex 1 (mTORC1) kinas

48 ent synaptic protein synthesis downstream of mechanistic target of rapamycin complex 1 (mTORC1) known

49 ytoplasm, which assists in activation of the mechanistic target of rapamycin complex 1 (mTORC1) on th

50 how the stimulatory effect of leucine on the mechanistic target of rapamycin complex 1 (mTORC1) pathw

51 The mechanistic target of rapamycin complex 1 (mTORC1) pathw

52 Mechanistic target of rapamycin complex 1 (mTORC1) promo

53 The mechanistic target of rapamycin complex 1 (mTORC1) prote

54 The mechanistic target of rapamycin complex 1 (mTORC1) prote

55 Here we show that mechanistic target of rapamycin complex 1 (mTORC1) regul

56 Given that mechanistic target of rapamycin complex 1 (mTORC1) regul

57 The mechanistic target of rapamycin complex 1 (mTORC1) sense

58 The mechanistic Target of Rapamycin complex 1 (mTORC1) sense

59 Instead, mechanistic target of rapamycin complex 1 (mTORC1) signa

60 nsitivity, restores normal placental insulin/mechanistic target of rapamycin complex 1 (mTORC1) signa

61 rmodel mice may be explained by dysregulated mechanistic target of rapamycin complex 1 (mTORC1) signa

62 PV) type 16 (HPV16) E6 protein can stimulate mechanistic target of rapamycin complex 1 (mTORC1) signa

63 Calorie restriction acts by reducing mechanistic target of rapamycin complex 1 (mTORC1) signa

64 yte and macrophage differentiation, requires mechanistic target of rapamycin complex 1 (mTORC1) signa

65 In response to growth signals, mechanistic target of rapamycin complex 1 (mTORC1) stimu

66 The mechanistic target of rapamycin complex 1 (mTORC1) suppo

67 We found that the activity of the mechanistic target of rapamycin complex 1 (mTORC1), a ke

68 TFEB nuclear translocation independently of mechanistic target of rapamycin complex 1 (mTORC1), a kn

69 th the availability of nutrients through the mechanistic target of rapamycin complex 1 (mTORC1), a ma

70 Mechanistic target of rapamycin complex 1 (mTORC1), defi

71 Rapamycin, an inhibitor of mechanistic target of rapamycin complex 1 (mTORC1), exte

72 hrough signaling systems including mammalian/mechanistic target of rapamycin complex 1 (mTORC1), gene

73 Mechanistic target of rapamycin complex 1 (mTORC1), nece

74 This metabolic switch activates mechanistic target of rapamycin complex 1 (mTORC1), whic

75 cessary for amino acid-induced activation of mechanistic target of rapamycin complex 1 (mTORC1), whic

76 ction triggered by T cell help activates the mechanistic target of rapamycin complex 1 (mTORC1), whic

77 mulation of SREBP-1c processing requires the mechanistic target of rapamycin complex 1 (mTORC1), whic

78 a deletion potentiates hepatic activation of mechanistic target of rapamycin complex 1 (mTORC1), whic

79 mice, which required D1 receptors (D1Rs) and mechanistic target of rapamycin complex 1 (mTORC1).

80 cial in the regulation of metabolism via the mechanistic Target of Rapamycin Complex 1 (mTORC1).

81 eneral control nonderepressible 2 (GCN2) and mechanistic target of rapamycin complex 1 (mTORC1).

82 e oxygen species (ROS) and inhibition of the mechanistic target of rapamycin complex 1 (mTORC1).

83 naling through a protein kinase known as the mechanistic target of rapamycin complex 1 (mTORC1).

84 (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1).

85 hat dictate the regulation of cell growth by mechanistic target of rapamycin complex 1 (mTORC1).

86 es leading to constitutive activation of the mechanistic target of rapamycin complex 1 (mTORC1).

87 n and other stresses is amino-acid-dependent mechanistic target of rapamycin complex 1 (mTORC1).

88 Mechanistic target of rapamycin complex 1 (TORC1) integr

89 The mechanistic target of rapamycin complex 1 activates Cxcl

90 ng to the inhibition of high glucose-induced mechanistic target of rapamycin complex 1 activity and m

91 inhibited high glucose-induced activation of mechanistic target of rapamycin complex 1 and laminin ga

92 ptor/Rictor mutant mouse models, we identify mechanistic target of rapamycin complex 1 as the major I

93 sematous changes in the lung correlated with mechanistic target of rapamycin complex 1 hyperactivatio

94 treatment of emphysema mouse models with the mechanistic target of rapamycin complex 1 inhibitor rapa

95 Furthermore, activation of the mechanistic target of rapamycin complex 1 pathway by Ang

96 11%/d); this was reflected by dampened acute mechanistic target of rapamycin complex 1 signaling resp

97 e suggests that sestrins may inhibit mTORC1 (mechanistic target of rapamycin complex 1) through inhib

98 rough the modulation of pathways such as the mechanistic target of rapamycin complex 1, calcium/calmo

99 In contrast to mechanistic target of rapamycin complex 1-dependent cano

100 receptor activation and was mediated by the mechanistic target of rapamycin complex 1-S6K pathway an

101 We describe the relationship between the mechanistic target of rapamycin complex 1/2 protein subu

102 Here, we report that mechanistic target of rapamycin complex 2 (mTORC2) funct

103 g the duration of Smad2/3 activation via the mechanistic target of rapamycin complex 2 (mTORC2).

104 influence mitochondrial function, activating mechanistic target of rapamycin complex 2 (mTORC2)/AKT s

105 x 1 as the major IEC regulatory pathway, but mechanistic target of rapamycin complex 2 also contribut

106 orylated at Ser181 in neurons in a mammalian/mechanistic target of rapamycin complex 2-, Src kinase-,

107 The rapid activation of the mechanistic target of rapamycin complex-1 (mTORC1) by gr

108 is, in turn, inhibited by mTORC1 [mTOR (the mechanistic target of rapamycin) complex 1] mediated pho

109 by means of pharmacologic inhibition of the mechanistic target of rapamycin counterregulates cell de

110 The MTOR (mechanistic target of rapamycin) gene and pathways relat

111 ved activation of the protein kinase B (Akt)-mechanistic target of rapamycin growth and proliferation

112 These effects are dependent on TSC2-mediated mechanistic target of rapamycin inactivation.

113 thology, and management including the use of mechanistic target of rapamycin inhibition and costimula

114 Mechanistic target of rapamycin inhibition by either nut

115 d whether the dual phosphoinositide 3-kinase/mechanistic target of rapamycin inhibitor BEZ235 (BEZ) p

116 significantly greater in patients receiving mechanistic target of rapamycin inhibitor-based immunosu

117 corticosteroids, calcineurin inhibitors, and mechanistic target of rapamycin inhibitors.This review p

118 c anti-GBM properties when combined with the mechanistic target of rapamycin kinase inhibitor PP242.

119 ase mammalian target of rapamycin (mTOR) (or mechanistic target of rapamycin), leading to dephosphory

120 Subsequent inactivation of the mechanistic target of rapamycin mobilizes autophagy, whi

121 esence of inhibitors of the PI3K --> Akt --> mechanistic target of rapamycin (mTOR) --> S6 kinase or

122 easome inhibition, stress kinase activation, mechanistic target of rapamycin (mTOR) activation, loss

123 CD5 promoted Treg cell induction by blocking mechanistic target of rapamycin (mTOR) activation.

124 kdown in these muscles also enhanced AKT and mechanistic target of rapamycin (mTOR) activities, which

125 In response, mechanistic target of rapamycin (mTOR) activity is downr

126 The mechanistic target of rapamycin (mTOR) acts as a highly

127 ases its affinity for IGF-I, is regulated by mechanistic target of rapamycin (mTOR) and casein kinase

128 The mechanistic target of rapamycin (mTOR) and Hippo signali

129 We hypothesized that MNR inhibits placental mechanistic target of rapamycin (mTOR) and insulin/IGF-I

130 r dependent, in part, on the activity of the mechanistic target of rapamycin (mTOR) and the peroxisom

131 Protein kinase B (also known as AKT) and the mechanistic target of rapamycin (mTOR) are central regul

132 Inhibitors of the mechanistic target of rapamycin (mTOR) are currently use

133 The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1

134 The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1

135 Currently approved agents inhibit mechanistic target of rapamycin (mTOR) complex 1 (mTORC1

136 ors is associated with dynamic regulation of mechanistic target of rapamycin (mTOR) complex 1 (mTORC1

137 ivity toward Rheb, this complex inhibits the mechanistic target of rapamycin (mTOR) complex 1 (mTORC1

138 The mechanistic target of rapamycin (mTOR) complex 1 is regu

139 that the activity of the recently discovered mechanistic target of rapamycin (mTOR) complex 2 (mTORC2

140 Here, we show that mechanistic target of rapamycin (mTOR) complex 2 has a n

141 The mechanistic target of rapamycin (mTOR) comprises 2 struc

142 Mechanistic target of rapamycin (MTOR) cooperates with H

143 The mechanistic target of rapamycin (mTOR) coordinates eukar

144 While inhibition of mechanistic target of rapamycin (mTOR) effectively slows

145 Mechanistic target of rapamycin (mTOR) enhances immunity

146 The mechanistic target of rapamycin (mTOR) exists in two com

147 We show that inhibition of mechanistic target of rapamycin (mTOR) extends the lifes

148 Here we show that mechanistic target of rapamycin (mTOR) functions as a fo

149 The mechanistic target of rapamycin (mTOR) has a key role in

150 Signaling via mechanistic target of rapamycin (mTOR) has been implicat

151 In recent years, the serine/threonine kinase mechanistic target of rapamycin (mTOR) has emerged as a

152 g evidence highlights a central role for the mechanistic target of rapamycin (mTOR) in bridging immun

153 we show that brief exposure to inhibitors of mechanistic target of rapamycin (mTOR) in DCs during the

154 reen using a label-free assay and found that mechanistic target of rapamycin (mTOR) influenced purino

155 lation of senescence as a novel way by which mechanistic target of rapamycin (mTOR) influences reprog

156 Mechanistic target of rapamycin (mTOR) inhibition or blo

157 ermore, we find that exposure of Treg to the mechanistic target of rapamycin (mTOR) inhibitor rapamyc

158 ith an mGluR5 negative allosteric modulator, mechanistic target of rapamycin (mTOR) inhibitor, and in

159 hentic sites, generating a mitosis-specific, mechanistic target of rapamycin (mTOR) inhibitor-resista

160 So far, mechanistic target of rapamycin (mTOR) inhibitors and an

161 Mechanistic target of rapamycin (mTOR) inhibitors can at

162 SBI-0206965 greatly synergized with mechanistic target of rapamycin (mTOR) inhibitors to kil

163 stoma (GBM) tumor cells that is resistant to mechanistic target of rapamycin (mTOR) inhibitors.

164 The serine/threonine kinase mammalian/mechanistic target of rapamycin (mTOR) integrates variou

165 The mechanistic target of rapamycin (mTOR) is a central cell

166 The mechanistic target of rapamycin (mTOR) is a central medi

167 The mechanistic target of rapamycin (mTOR) is a central regu

168 The mammalian/mechanistic target of rapamycin (mTOR) is a key integrat

169 Mechanistic target of rapamycin (mTOR) is a serine-threo

170 The mechanistic target of rapamycin (mTOR) is activated in C

171 In contrast, the mammalian/mechanistic target of rapamycin (mTOR) is active when th

172 The protein kinase mammalian or mechanistic target of rapamycin (mTOR) is an atypical se

173 Mammalian/mechanistic target of rapamycin (mTOR) is emerging as an

174 The mechanistic target of rapamycin (mTOR) is hyperactivated

175 sphatidylinositol 3-kinase (PI3K) and AKT to mechanistic target of rapamycin (mTOR) is prominently dy

176 The mechanistic target of rapamycin (mTOR) is recognized as

177 urthermore, we show that the nutrient sensor mechanistic target of rapamycin (mTOR) is required for e

178 Hyperactivation of the mechanistic target of rapamycin (mTOR) kinase, as a resu

179 Mechanistic target of rapamycin (mTOR) links nutrient av

180 of phosphatase and tensin homolog (PTEN), a mechanistic target of rapamycin (mTOR) negative regulato

181 Inhibition of mechanistic target of rapamycin (mTOR) or activation of

182 kinase subunit beta (IKKbeta), but not PI3K, mechanistic target of rapamycin (mTOR) or mitogen-activa

183 the phosphatidylinositol-3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) pathway and decre

184 studies revealed that IL-7 activates the Akt/mechanistic target of rapamycin (mTOR) pathway in human

185 These results show that the mechanistic target of rapamycin (mTOR) pathway in neuron

186 induced alterations in signaling through the mechanistic target of rapamycin (mTOR) pathway in the ce

187 ytes and macrophages, p38alpha activated the mechanistic target of rapamycin (mTOR) pathway in vitro

188 The mechanistic target of rapamycin (mTOR) pathway integrate

189 However, given that the PI3K/Akt/mechanistic target of rapamycin (mTOR) pathway is also k

190 sitol 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) pathway is one of

191 The mechanistic target of rapamycin (mTOR) pathway serves as

192 atx-2 regulates the mechanistic target of rapamycin (mTOR) pathway, downstre

193 eptors towards anabolism by upregulating the mechanistic target of rapamycin (mTOR) pathway.

194 ds, an effect we traced to regulation of the mechanistic target of rapamycin (mTOR) pathway.

195 Noncanonical mechanistic target of rapamycin (mTOR) pathways remain p

196 Mechanistic target of rapamycin (MTOR) plays a critical

197 stimulated canonical Smad 3 and noncanonical mechanistic target of rapamycin (mTOR) promote increased

198 As a critical regulator of cell growth, the mechanistic target of rapamycin (mTOR) protein operates

199 Mechanistic target of rapamycin (mTOR) regulates long-te

200 Mechanistic target of rapamycin (mTOR) regulates stem an

201 Pharmacologic inhibition of the mechanistic target of rapamycin (mTOR) represents a stre

202 ta have shown that signaling mediated by the mechanistic target of rapamycin (mTOR) serine/threonine

203 d glucose uptake and use, despite persisting mechanistic target of rapamycin (mTOR) signaling and upr

204 The mechanistic target of rapamycin (mTOR) signaling cascade

205 We aimed to clarify the role of mechanistic target of rapamycin (mTOR) signaling in hepa

206 Furthermore, mechanistic target of rapamycin (mTOR) signaling is down

207 Mechanistic target of rapamycin (mTOR) signaling is nece

208 Mechanistic target of rapamycin (mTOR) signaling is the

209 The mechanistic target of rapamycin (mTOR) signaling pathway

210 ases, mitochondrial metabolism in aging, the mechanistic target of rapamycin (mTOR) signaling pathway

211 that rapamycin, a specific inhibitor of the mechanistic target of rapamycin (mTOR) signaling pathway

212 The mechanistic target of rapamycin (mTOR) signaling pathway

213 scence, owing to hypoxia-associated impaired mechanistic target of rapamycin (mTOR) signaling via the

214 uster includes genes associated with Ras and mechanistic target of rapamycin (mTOR) signaling, a find

215 In this article, we report crucial roles for mechanistic target of rapamycin (mTOR) signaling, especi

216 fold protein effector Homer, which regulates mechanistic target of rapamycin (mTOR) signaling, was ab

217 ns, AMP-activated protein kinase (AMPK), and mechanistic target of rapamycin (mTOR) signaling.

218 ubiquitinating TSC2 and regulating mammalian/mechanistic target of rapamycin (mTOR) signaling.

219 termine whether the mechanical activation of mechanistic target of rapamycin (mTOR) signalling is ass

220 ticosterone upregulated the stress-inducible mechanistic target of rapamycin (mTOR) suppressor, Redd1

221 Inhibition of the mechanistic target of rapamycin (mTOR) using rapamycin p

222 e we show that blocking the kinase mammalian/mechanistic target of rapamycin (mTOR) with clinically a

223 We performed loss-of-function studies of mechanistic target of rapamycin (mTOR), a highly conserv

224 The mechanistic target of rapamycin (mTOR), a kinase that is

225 the PI3K/Akt pathway, which acts upstream of mechanistic target of rapamycin (mTOR), a major driver o

226 ere we report that the partial inhibition of mechanistic target of rapamycin (mTOR), a major nutrient

227 has been colocalized to mitochondria and the mechanistic target of rapamycin (mTOR), a suppressor of

228 s of DR as well as manipulations of insulin, mechanistic target of rapamycin (mTOR), AMP-activated pr

229 e growth factor 1 (IGF-1) signaling pathway, mechanistic target of rapamycin (mTOR), and adenosine mo

230 t analysis revealed involvement of PI3K/Akt, mechanistic target of rapamycin (mTOR), and MEK/ERK path

231 uli converge on the conserved protein kinase mechanistic target of rapamycin (mTOR), existing in two

232 Rapamycin, an inhibitor of mechanistic target of rapamycin (mTOR), has the stronges

233 that p70S6K1 (S6K1), a downstream target of mechanistic target of rapamycin (mTOR), phosphorylates P

234 h CSF and LN correlated with upregulation of mechanistic target of rapamycin (mTOR), proinflammatory,

235 87% of proximal tubular cells with activated mechanistic target of rapamycin (mTOR), which prevents a

236 ncer cells have defects in signaling via the mechanistic target of rapamycin (mTOR), which regulates

237 mouse models of inflammation, we found that mechanistic target of rapamycin (mTOR)-dependent metabol

238 Mechanistic target of rapamycin (mTOR)-specific inhibito

239 rylation of serine-threonine kinases Akt and mechanistic target of rapamycin (mTOR).

240 tide-3-kinase (PI3K) effectors Akt/mammalian/mechanistic target of rapamycin (mTOR).

241 e the central regulator of protein synthesis mechanistic target of rapamycin (mTOR).

242 f-ERK1/2 and phosphoinositol 3-kinase (PI3K)-mechanistic target of rapamycin (mTOR).

243 complex 1 (TSC1) and TSC2 are suppressors of mechanistic target of rapamycin (mTOR).

244 pathway are both involved in activating the mechanistic target of rapamycin (mTOR).

245 the nutrient response pathway defined by the mechanistic target of rapamycin (mTOR).

246 anism independent of reduced activity of the mechanistic target of rapamycin (mTOR).

247 f both nuclear factor-kappaB (NF-kappaB) and mechanistic target of rapamycin (mTOR).

248 2 (TSC1/2) is an endogenous regulator of the mechanistic target of rapamycin (mTOR).

249 e to bicalutamide results from activation of mechanistic target of rapamycin (mTOR).

250 actor (IGF) signaling (IIS) pathway, and the mechanistic target of rapamycin (mTOR).

251 Mammalian (or mechanistic) target of rapamycin (mTOR) regulates a wide

252 and Leu both increased anabolic signalling (mechanistic target of rapamycin; mTOR), this was more pr

253 se-RAC-alpha serine/threonine-protein kinase-mechanistic target of rapamycin pathway increased the as

254 uses a sustained increase in activity in the mechanistic target of rapamycin pathway, and that inhibi

255 tive targeting is related to intrinsic mTOR (mechanistic target of rapamycin) pathway activity in ind

256 way, which converges with the PI3K/Akt/mTOR (mechanistic target of rapamycin) pathway at the level of

257 osphatidylinositol 3-kinase (PI3K)-Akt-mTOR (mechanistic target of rapamycin) pathway, and activation

258 from effects of phosphoinositol 3-kinase-Akt-mechanistic target of rapamycin (PI3K-Akt-mTOR) and Jak-

259 Here we show that Protein Kinase B-mechanistic Target of Rapamycin (PKB/AKT-mTOR) signaling

260 Clinical studies have implicated the mechanistic target of rapamycin (serine/threonine kinase

261 Mechanistically, aberrant activation of mechanistic target of rapamycin signaling and phosphoryl

262 riments in vitro suggested that unequal PI3K/mechanistic target of rapamycin signaling drives intracl

263 tions enhanced AMPK activation and inhibited mechanistic target of rapamycin signaling in mouse embry

264 th both drugs was required to fully suppress mechanistic target of rapamycin signaling, a known effec

265 d Abeta and p-Tau(Ser-202) accumulation, Akt/mechanistic target of rapamycin signaling, levels of ion

266 was accompanied by deactivation of oncogenic mechanistic target of rapamycin signaling.

267 acellular signal-regulated kinase) and mTOR (mechanistic target of rapamycin) signaling regulate prot

268 inhibition of the phosphoinositide 3-kinase/mechanistic target of rapamycin survival pathway, which

269 senger function of PA is mTOR, the mammalian/mechanistic target of rapamycin, which integrates both n