1 us catalysts not just functionally, but also
mechanistically.
2 anti-inflammatory effects are not understood
mechanistically.
3 Mechanistically,
5-HT2CRs are positioned to influence bo
4 Mechanistically,
a cytoplasmic form of CCN3 interacted w
5 Mechanistically,
acid-induced epithelial MV miR-17/221 p
6 Mechanistically,
addition of exogenous alpha-ketoglutara
7 Mechanistically,
additional results indicated that the R
8 Mechanistically,
ADORA2A activation promotes the transcr
9 Mechanistically,
AIBP triggered relocalization of gamma-
10 Mechanistically,
Akt1 physically interacted with and pho
11 Mechanistically,
AMOTL2 binds to AKT pleckstrin homology
12 ssociated protein (SAP) was functionally and
mechanistically analyzed for its contribution to PD-1 in
13 Mechanistically and evolutionarily, they unite not only
14 Ammonia-lyases and aminomutases are
mechanistically and structurally diverse enzymes which c
15 nts and provide a novel in vivo platform for
mechanistically and therapeutically exploring SF3B1 muta
16 Mechanistically,
Bassoon was found to interact with Atg5
17 Mechanistically,
beta-catenin regulates expression of do
18 Mechanistically,
Bi(OTf)3 serves as a stable and easy to
19 Mechanistically,
BIM deficiency improved mitochondrial f
20 Mechanistically,
both glomerular cathepsin L and heparan
21 Mechanistically,
BRCA1-BARD1 promotes the assembly of th
22 Mechanistically,
BRD4 is required for cyclin-dependent k
23 Mechanistically,
C/EBPalpha or c-Fos overexpression in t
24 Mechanistically,
calmodulin-dependent protein kinase I p
25 Mechanistically,
cardiac pathology was attributed to mCa
26 Mechanistically,
CD2AP is required for mechanosensitive
27 orted single knockout models of Ssb1 or Ssb2
Mechanistically,
cDKO HSPCs showed altered replication f
28 Here we uncover and
mechanistically characterize the NLR Nlrp9b that is spec
29 w meiotic drive loci have been identified or
mechanistically characterized.
30 Mechanistically,
chromatin occupancy of serine 2-unphosp
31 Mechanistically,
cold-induced MT depolymerization experi
32 Mechanistically,
combination therapy efficacy stemmed fr
33 Here, we present in vivo genetic evidence
mechanistically connecting preleukemic ETV6-RUNX1 expres
34 This work illustrates the potential of
mechanistically constrained global fitting of binding da
35 e overlapping thermodynamic processes, while
mechanistically constrained models enable hypothesis tes
36 Reduced 5-LO expression in TAMs was
mechanistically coupled to an attenuated T cell recruitm
37 Mechanistically,
covR mutation significantly altered the
38 Mechanistically,
COX2/PGE2 signaling induced promoter me
39 Mechanistically,
CpG increased the number of circulating
40 Mechanistically,
CTLA4 binding promoted activation of th
41 Mechanistically,
CTRP6 regulates local inflammation and
42 Mechanistically,
CX3CL1-mediated engagement of the CX3CR
43 Mechanistically,
demethylation of H3K4me3 is required fo
44 otein kinase kinase and Bcl-XL targeting, we
mechanistically demonstrated concomitant down-regulation
45 Mechanistically,
DEX-bound GR recruits histone H3K27 ace
46 Mechanistically,
DHA did not directly target B cells to
47 characterize the concurrent effects of these
mechanistically different pathways using PL measurements
48 Mechanistically,
DISC1 regulates Ndel1's kinetochore att
49 The results of this study suggest
mechanistically distinct and potentially nonredundant ro
50 ough most E2s can work with any of the three
mechanistically distinct classes of E3s, the E2 UBCH7 is
51 on the discovery and development of a set of
mechanistically distinct compounds, indoximod, epacadost
52 approach, we determined that CAT tailing is
mechanistically distinct from canonical translation, tha
53 ates autophagy and lifespan extension across
mechanistically distinct longevity nematode models.
54 Here, the chemistry of 9
mechanistically distinct methods for radiolabeling nanop
55 hermal (heat, cold) stimulation in multiple,
mechanistically distinct models of inflammatory and neur
56 DOX produced two
mechanistically distinct phases of extracellular signal-
57 ow show that the loss of S100A4 produces two
mechanistically distinct phenotypes with regard to macro
58 that the DCM and CM degradation pathways are
mechanistically distinct.
59 example, exploits amine catalysis to promote
mechanistically diverse carboligations.
60 Mechanistically,
Dnmt3a promotes the expression of epide
61 Mechanistically,
doxorubicin-induced DNA damage in c-kit
62 This suggests that population change is not
mechanistically driven by the negative effects of asynch
63 This knowledge may open a path for the
mechanistically driven design of the next generation of
64 Mechanistically,
E46K can increase alphaS vesicle bindin
65 Mechanistically,
elevated ILF2 expression exerts resista
66 Mechanistically,
enhanced NLRP3 inflammasome expression
67 Ligand metathesis of Pd(II) complexes is
mechanistically essential for cross-coupling.
68 Here, we develop a simple model to
mechanistically explain the emergence of periodic change
69 hage resistance to L. major replication, and
mechanistically explain the previously described endosom
70 Mechanistically,
expression of CNP-hEGFR increased SCP/n
71 Mechanistically,
fluorescence-recovery-after-photobleach
72 Mechanistically,
FTY720 enhanced extramedullary hematopo
73 Mechanistically,
functional PTEN stimulates the GSK3beta
74 Mechanistically,
gain of Arid1a function promoted initia
75 Mechanistically,
GAS5 competitively bound Smad3 protein
76 Mechanistically,
gene array analysis showed that ATF6, w
77 Mechanistically,
global knockout of PLD4 modulated innat
78 Mechanistically,
glucose triggers KATP channel-dependent
79 Mechanistically,
glutamine provided nitrogen for asparag
80 Mechanistically,
GR and ACTN4 interact in the nucleus of
81 Mechanistically,
GRM3 antagonizes TGFbeta-mediated activ
82 new data identify a molecule suitable for a
mechanistically grounded development into a marker and t
83 Mechanistically,
HDAC3 activity is largely responsible f
84 Mechanistically,
HETEs activated the Ca(2+)-induced open
85 Mechanistically,
however, this process is poorly underst
86 Mechanistically,
IAFGP binds the terminal d-alanine resi
87 Mechanistically,
Id proteins specify cardiac cell fate b
88 Mechanistically,
IFN-gamma disassembled a subset of enha
89 Mechanistically,
Igf1 levels likely account for increase
90 Mechanistically,
IL-17R interacts with NOTCH1 via the ex
91 Mechanistically,
IL-27 feeds back on keratinocytes to st
92 Mechanistically,
IL-35 promotes ICAM1 overexpression thr
93 ough experiments on gram scale in palladium,
mechanistically important additional Pd- and phosphine-c
94 have roots in ancient evolution and could be
mechanistically important in co-chaperoning the assembly
95 of the levels and activity of tankyrases is
mechanistically important in controlling Wnt signaling.
96 Neutrophils and IL-17A have been linked
mechanistically in models of allergic airways disease an
97 Mechanistically,
in both primary human and murine cells,
98 Mechanistically,
inflammation has been strongly linked t
99 Mechanistically,
inhibiting VEGFR2 or AMP-activated prot
100 Mechanistically,
inhibition of mitochondrial function in
101 Mechanistically,
intracellular mature IL-37 directly bou
102 se interaction to lung fibrosis has not been
mechanistically investigated.
103 Mechanistically,
IRF4 repressed PD-1, Helios, and other
104 Mechanistically,
it acts by targeting G1-S transition ge
105 Mechanistically,
it is thought that the C2A domain of Mu
106 Mechanistically,
JAGGED-1, a transmembrane ligand for th
107 Mechanistically,
LINC00305 interacted with lipocalin-1 i
108 Here, we
mechanistically link caspase-8-dependent apoptosis to HC
109 opose that these polyphosphate nanoparticles
mechanistically link the procoagulant activity of platel
110 During the last 10 years, studies have
mechanistically linked obesity and an obese tumor microe
111 ether these two epigenetic histone marks are
mechanistically linked remains unclear.
112 transcription factor binding sites have been
mechanistically linked to mQTLs and hap-ASM.
113 Hyperexcitable neuronal networks are
mechanistically linked to the pathologic and clinical fe
114 s, indicating that the two processes are not
mechanistically linked.
115 Mechanistically linking movement behaviors and ecology i
116 Mechanistically,
LKB1 could bind to the VEGF transcripti
117 Mechanistically,
LncHIFCAR forms a complex with HIF-1alp
118 Mechanistically,
loss of Grail enhances anti-tumour reac
119 Mechanistically,
loss of KLF10 in PDAC is shown to incre
120 Mechanistically,
loss of Smad2/3 from tissue-resident fi
121 Mechanistically,
loss of UNC-45A results in increased le
122 Mechanistically,
lowering BAFF levels also diminished th
123 Mechanistically,
Lpd promotes actin polymerization by in
124 Mechanistically,
LRP4 functions via the conserved kinase
125 Mechanistically,
MC1-R activation upregulated the levels
126 Mechanistically,
mdivi-1 reduced mitochondrial fragmenta
127 Mechanistically,
microRNA-146a reduced its target DLST-t
128 Mechanistically,
miR-128-3p induces mesenchymal and stem
129 Mechanistically,
miR-31 increased the sensitivity of T c
130 Mechanistically,
miR-520f inhibited tumor cell invasion
131 The system was
mechanistically modeled to predict the time evolution of
132 Mechanistically,
mTORC1 engaged glucose metabolism and i
133 Mechanistically,
mutant p53 interacts with Rac1 and inhi
134 Mechanistically,
Myr attenuated diabetes-induced Nrf2 in
135 Mechanistically,
NCoR1 protects positively selected thym
136 Mechanistically,
Nek7 interacts with and phosphorylates
137 Mechanistically,
network perturbation analyses showed eI
138 Mechanistically,
neuroligin deletions decreased the syna
139 Mechanistically,
Nrp1 deletion activates the nuclear fac
140 Mechanistically,
nutlin-3a-induced antitumor immunity wa
141 Mechanistically,
our data indicate that the NF-kappaB si
142 Mechanistically,
our data showed that exposure of esopha
143 Mechanistically,
our findings indicate an important role
144 Mechanistically,
overexpression of IL-33 promoted expans
145 Mechanistically,
overexpression of miR-200a in metastati
146 Mechanistically,
Panx1 (-/-) Apoe (-/-) mice showed impa
147 Mechanistically,
PAXX promotes the accumulation of KU at
148 Mechanistically,
peripheral nerve injury induces DNA dem
149 Mechanistically,
PHB forms protein complexes with HIRA,
150 Mechanistically,
phosphorylation of SIRT1 at Ser-164 sub
151 Mechanistically,
PI3K blockade by BKM120 attenuated HR c
152 Mechanistically,
PLXNB2 mediates intracellular RNA proce
153 Mechanistically,
PPARgamma transcriptionally activates P
154 Mechanistically,
PRDM15 modulates WNT and MAPK-ERK signa
155 c cellular compartments may offer effective,
mechanistically precise interception of pro-inflammatory
156 ers identifying patients at-risk, or guiding
mechanistically-
precise therapies.
157 The ability to
mechanistically predict gS and A in response to atmosphe
158 Mechanistically,
preventing multi-site phosphorylation e
159 Mechanistically,
prevention of puberty by hormonal block
160 Mechanistically,
PRMT5 is recruited to the AR promoter b
161 Mechanistically,
Pten deletion increases Akt phosphoryla
162 Mechanistically,
PTX3 mediated the hepatic stellate cell
163 Mechanistically,
PYK2 inhibition facilitated the proteas
164 Mechanistically,
RANK rewires energy homeostasis in huma
165 Mechanistically,
RARRES2 overexpression in ACC cells inh
166 Mechanistically,
reactivation of functional hNIS express
167 Mechanistically,
recruitment of mannosidase-II vesicles
168 By focused profiling of a
mechanistically relevant circulating T-cell subpopulatio
169 Mechanistically,
responses to venetoclax correlated with
170 Mechanistically,
RetSat depletion reduces the activity o
171 Mechanistically,
RNAi-mediated attenuation of DUSP4 acti
172 Mechanistically,
Rpn11 inhibition in MM cells activates
173 Mechanistically,
Runx2 bound to the promoter of SAM-poin
174 ed states of the nitrogenase active site are
mechanistically significant since substrate reduction is
175 Mechanistically,
silencing MICU1 activates pyruvate dehy
176 Although
mechanistically similar, PutAs vary widely in domain arc
177 Mechanistically,
single-particle tracking revealed that
178 Mechanistically,
Sirt6 inhibits Notch1 and Notch4 transc
179 Mechanistically,
Skp2 interacted with Twist and promoted
180 Mechanistically,
SMARCE1 drives invasion by forming a SW
181 Mechanistically,
SMURF2 regulates RANKL expression by di
182 Mechanistically,
SNGD-mediated gene editing requires lon
183 Mechanistically,
sphingosine ameliorates transforming gr
184 Mechanistically,
SRC impacts on syndecan endocytosis and
185 Mechanistically,
SRPK2 promotes SR protein binding to U1
186 Mechanistically,
STAG1 loss abrogates sister chromatid c
187 Mechanistically,
Stat3 transcriptionally regulated Jab1/
188 Mechanistically,
stimulation with FPR2 ligands resulted
189 Mechanistically,
STRAP competitively disrupted associati
190 Mechanistically,
stroma-activated cancer cells show wide
191 We
mechanistically studied tTreg cell generation in the atr
192 microsystem provides an enabling platform to
mechanistically study transfusion-associated pulmonary v
193 ropose that this cross-frequency interaction
mechanistically subserves the attentional control of sti
194 Mechanistically,
sumoylation of Rpc82 is important for a
195 Mechanistically,
SUMOylation promoted ubiquitin-mediated
196 Mechanistically,
T cell receptor (TCR) signaling molecul
197 Mechanistically,
T63 activated both BMPs and WNT/beta-ca
198 Mechanistically,
TCR stimulation induced rapid sodium in
199 Mechanistically,
the absence of Cav-1 increased cAMP/PKA
200 Mechanistically,
the antiangiogenic effects of sorafenib
201 Mechanistically,
the attenuated virulence of 10-del ZIKV
202 Mechanistically,
the bulb presents an interesting case s
203 Mechanistically,
the Ccr4-Not complex preferentially int
204 Mechanistically,
the chromatin-bound LEDGF, through its
205 Mechanistically,
the core component of Hippo pathway (YA
206 Mechanistically,
the defect in NAD(+) and ATP synthesis
207 Mechanistically,
the diol targeted the cell membrane to
208 Mechanistically,
the expression of these microRNAs is po
209 Mechanistically,
the GDH1 product alpha-KG activates Cam
210 Mechanistically,
the luminal Vps10p domain of sortilin i
211 Mechanistically,
the mitosis regulator LIN9 was a direct
212 Mechanistically,
the observed enantioselectivity was sho
213 Mechanistically,
the PC7A NP achieves efficient cytosoli
214 Mechanistically,
the PGE2 EP4 interaction causes MuSC ex
215 Mechanistically,
the relatively immobile G-actin pool in
216 Mechanistically,
the Runx3-CBFbeta transcription factor
217 Mechanistically,
the synergy was based on a lapatinib in
218 Mechanistically,
the tension sensing cell-matrix adhesio
219 Mechanistically,
the TRAF2 E3 ubiquitin ligase promotes
220 Understanding
mechanistically their differential actions may advance o
221 Mechanistically these genetic lesions result in increase
222 Mechanistically,
these alterations were found to be due
223 Mechanistically,
these defects are produced in part by m
224 Mechanistically,
these pseudoviruses activate the NLRP3
225 Mechanistically,
this could be explained by changes in t
226 Mechanistically,
this metabolic rewiring stems from mTOR
227 Mechanistically,
this occurs through alteration of endot
228 Mechanistically,
this process involves the challenging o
229 Mechanistically,
this requires local dendritic Ca(2+) in
230 Mechanistically,
this was due to the absence of CXCL9/10
231 Mechanistically,
this was linked to increased respirator
232 Mechanistically,
this was not solely the result of a cla
233 Mechanistically,
Tmem30a-mutant mouse embryonic fibrobla
234 we still do not know how these mutations act
mechanistically to increase lifespan and healthspan, and
235 er in normal human lung fibroblasts in vitro
Mechanistically,
TRPV4 modulated matrix remodeling in th
236 Mechanistically,
UBE2O specifically targets AMPKalpha2 f
237 Mechanistically,
UDP-Glu stimulation enhanced the activa
238 e (FEL) of a thioglycoside strongly favors a
mechanistically uninformative (4)C1 conformation within
239 onfer resistance to several structurally and
mechanistically unrelated classes of antibiotics and enh
240 Mechanistically,
upon CXCL12 exposure, SC down-regulated
241 t aldol addition was probed structurally and
mechanistically using a combination of IR and NMR spectr
242 selectivity can be optimized and understood
mechanistically using the familiar tools of organometall
243 Mechanistically,
USP49 deubiquitinates and stabilizes FK
244 Mechanistically,
VEC exerts this effect by inhibiting po
245 Mechanistically,
we could exclude canonical Tie2 signall
246 Mechanistically,
we demonstrate that HDAC6 influences sy
247 Mechanistically,
we demonstrate that Nedd4-1 is required
248 Mechanistically,
we demonstrate that NHE9 localizes to r
249 Mechanistically,
we demonstrate that nuclear factor kapp
250 Mechanistically,
we demonstrate that PRMT5-directed meth
251 Mechanistically,
we demonstrate that the HDAC8 protein i
252 Mechanistically,
we demonstrate that this protumoral eff
253 Mechanistically,
we demonstrated in vitro that lymphocyt
254 Mechanistically,
we demonstrated that ectopic expression
255 Mechanistically,
we demonstrated that HDAC6 maintains Ku
256 Mechanistically,
we demonstrated that RCN2 interacted wi
257 Mechanistically,
we demonstrated that, in FANCM-depleted
258 Mechanistically,
we determined that miR-27 represses sev
259 Mechanistically,
we determined that SIRT2 maintains cell
260 Mechanistically,
we determined that sunitinib modulates
261 Mechanistically,
we discovered that five bacterial mutan
262 Mechanistically,
we established that TGFbeta is required
263 Mechanistically,
we find that mutp53 augments insulin-in
264 Mechanistically,
we find that the ZEB1 (zinc finger E-bo
265 Mechanistically,
we found that ABHD5 knockdown induces e
266 Mechanistically,
we found that cancer-cell-derived C3 ac
267 Mechanistically,
we found that DMF treatment reduced nuc
268 Mechanistically,
we found that DsbA-L is localized in mi
269 Mechanistically,
we found that increased HOTAIR expressi
270 Mechanistically,
we found that p53 controls specific and
271 Mechanistically,
we found that Peg3 induced the secretio
272 Mechanistically,
we found that SMAPs act by binding to t
273 Mechanistically,
we found that TAT-Kalpha2 peptide desta
274 Mechanistically,
we have identified a direct interaction
275 Mechanistically,
we identified an interaction between mo
276 Mechanistically,
we identified FOXO1 as a bona fide tran
277 Mechanistically,
we identified TBK1 as a key regulator o
278 Mechanistically,
we identified that Lactobacillus-derive
279 Mechanistically,
we linked greater Irf4 abundance with i
280 Mechanistically,
we observed that IL-15-mediated protect
281 Mechanistically,
we report that FcgammaRIIB-mediated inh
282 Mechanistically,
we show for the first time that IL10 su
283 Mechanistically,
we show that B cells, which express BCR
284 Mechanistically,
we show that HEC factors transcriptiona
285 Mechanistically,
we show that KDM3A regulates MCAM expre
286 Mechanistically,
we show that mitochondria in senescent
287 Mechanistically,
we show that MIWI binds the histone ubi
288 Mechanistically,
we show that the oncogenic activity of
289 Mechanistically,
we show that the up-regulated expressio
290 Mechanistically,
we show that these effects are dependen
291 Mechanistically,
we show that TNFalpha primes directly t
292 Mechanistically,
we show that VEGF activates YAP/TAZ via
293 Mechanistically,
we showed that BocaSR regulates the exp
294 Mechanistically,
we showed that FAK phosphorylates Becli
295 Mechanistically,
we showed that the enzymatic activity o
296 Mechanistically,
while they have no clear effect on kina
297 Mechanistically,
WNV NS1 targets RIG-I and melanoma diff
298 Mechanistically,
Y1 receptor signaling inhibits the prod
299 Mechanistically,
YAP promotes the expression of BCAR4, w
300 Mechanistically,
ZEB1 expression in TAMs induced their p