ライフサイエンスコーパス: mechanochemical

1 lowed us to interrogate the mechanism of the mechanochemical [2 + 2] cycloreversion.

2 Mechanochemical activation achieved by grinding, shearin

3 The mechanochemical activation of cis-gem-difluorocyclopropa

4 We report that mechanochemical activation of the polymer under tension

5 oGEF) analyses allowed us to interrogate the mechanochemical activation of these adducts.

6 nt shifts in molecular weight thresholds for mechanochemical activation that depend on the structure

7 r substitution pattern leading to successful mechanochemical activation.

8 t high resolution and will shed light on the mechanochemical activity of G-quadruplex-binding machine

9 gation of the endocytic profiles require the mechanochemical activity of the myosins-I.

10 s five domains that together orchestrate its mechanochemical activity.

11 dynein at five separate points in the dynein mechanochemical and transport cycles.

12 The products were obtained via a mechanochemical approach by simple grinding of 1-haloalk

13 We describe the development of a mechanochemical approach for Ru-catalyzed olefin metathe

14 tion of planetary ball mills has extended to mechanochemical approaches.

15 areas exceeding 1,000 m(2) g(-1), based on a mechanochemical assembly between polyphenol-metal comple

16 Many questions remain about how the kinesin mechanochemical ATPase cycle is fine-tuned for specific

17 We propose that ARB1 functions as a mechanochemical ATPase to stimulate multiple steps in th

18 AAA(+) proteins are ubiquitous mechanochemical ATPases that use energy from ATP hydroly

19 belong to the extensive AAA+ superfamily of mechanochemical ATPases.

20 , X = Cl, Br, or I) are prepared by a simple mechanochemical ball-milling method, which allows low-co

21 rtwist of 0.2 degrees /subunit underlies the mechanochemical basis for the extension of this actin sp

22 tin binding and contribute critically to the mechanochemical behavior of stress fibers, actin arcs, a

23 ophore, dichlorocyclopropane, resulting in a mechanochemical cascade reaction.

24 Here, we present a comprehensive mechanochemical characterization of a homomeric ring ATP

25 This finding implies the existence of a mechanochemical checkpoint regulating the transition of

26 ched sister chromosomes to facilitate robust mechanochemical checkpoint signaling.

27 erstanding of the mechanisms and pathways of mechanochemical cocrystal formation.

28 rate and increasing product diversity during mechanochemical cocrystallization reactions.

29 azoacetate derivatives can be achieved under mechanochemical conditions using metallic silver foil an

30 lvent-free pyrrole synthesis performed under mechanochemical conditions with a TMSOTf-catalyzed oxoni

31 rolysis and may function to couple dynamin's mechanochemical conformational changes to membrane desta

32 Integrin adhesion complexes (IACs) form mechanochemical connections between the extracellular ma

33 In particular, we follow the mechanochemical construction of a two-component cocrysta

34 nsionally integrated (tensegrity) systems of mechanochemical control.

35 Although their mechanism of mechanochemical conversion is beginning to be understood

36 is directly pulled, suggesting that it is a mechanochemical converter.

37 prototypical dynamin, Drp1 is composed of a mechanochemical core consisting of the GTPase, middle, a

38 Furthermore, the mechanochemical core of Drp1, absent of the variable dom

39 Based on these insights, we propose a mechanochemical coupled triggering hypothesis to explain

40 Finally, regiochemical effects on mechanochemical coupling are characterized, and increasi

41 eversibly in either direction requires tight mechanochemical coupling between the catalytic domain an

42 emonstrate that such interfacially-triggered mechanochemical coupling can be recapitulated in vitro b

43 The mutated residue acts like a mechanochemical coupling element--it transmits changes b

44 This may indicate a distinct type of mechanochemical coupling for this group of myosin motors

45 The general principles of this mechanochemical coupling have been established; however,

46 analyte recognition and signal reporting by mechanochemical coupling in a single-molecule DNA templa

47 gnificant involvement of the DELSEED-loop in mechanochemical coupling in ATP synthase.

48 heorized conserved element for long distance mechanochemical coupling in kinesin, myosin, and F(1)-AT

49 Here we present a current understanding of mechanochemical coupling in this essential molecular mac

50 Our findings indicate a mechanochemical coupling in which physical forces regula

51 eration enables detailed explorations of the mechanochemical coupling mechanisms in experiment and si

52 The determined tight mechanochemical coupling of 1.1 +/- 0.2 ATP consumed per

53 11 from S. cerevisiae and the mechanisms for mechanochemical coupling of substrate degradation and de

54 ted in vesicular traffic, RNA transport, and mechanochemical coupling of the actin and microtubule-ba

55 In living cells, mechanochemical coupling represents a dynamic means by w

56 hich nonmotor proteins work collectively via mechanochemical coupling to propel cargos-an ingenious s

57 the scissile bond in the mechanophore (i.e., mechanochemical coupling).

58 nts involved in motor-substrate interaction, mechanochemical coupling, and intersubunit coordination.

59 onger carbon-sulfur bond is ascribed to poor mechanochemical coupling, at least in part as a result o

60 The mechanism that underlies such "mechanochemical coupling," especially the causal relatio

61 salient points that aid our understanding of mechanochemical coupling.

62 duct becomes inert under tension due to poor mechanochemical coupling.

63 ng the P-loop arginine in ATP hydrolysis and mechanochemical coupling.

64 ting intermediates and the complexity of the mechanochemical cross-bridge cycle have impeded a quanti

65 has prevented a complete description of its mechanochemical cycle and limited insight into how seque

66 ay and converter domains is essential to the mechanochemical cycle and sarcomere assembly.

67 ds and low ATP concentrations, a coordinated mechanochemical cycle in the three catalytic sites of th

68 stepping by the tethered head, leading to a mechanochemical cycle in which processivity is determine

69 nd it to be a processive motor; however, its mechanochemical cycle is different from that of conventi

70 rthermore, the role of these contacts in the mechanochemical cycle is unknown.

71 methodologies have been used to dissect the mechanochemical cycle of a dimeric motor, Eg5-513, to be

72 of the N- and C-terminal regions during the mechanochemical cycle of all kinesins and kinesin-relate

73 tiple motors to derive information about the mechanochemical cycle of individual ncd motors.

74 Therefore, the mechanochemical cycle of kinesin-14 (ncd) is still under

75 main plays essential roles in modulating the mechanochemical cycle of SMC proteins.

76 The full mechanochemical cycle of the motor, in which the ATPase

77 Finally, we propose a minimal mechanochemical cycle of this DNA-translocating ATPase t

78 how SMCs structure chromosomes and how their mechanochemical cycle regulates their interactions with

79 sophila myosin V molecule spends most of its mechanochemical cycle time detached from actin, therefor

80 acting muscle is in a different stage of its mechanochemical cycle, and so temporal measurements are

81 During the myosin mechanochemical cycle, ATP-induced twisting of the relay

82 lucidating the broad features of the kinesin mechanochemical cycle, molecular details of the force ge

83 the multiple steps constituting the kinesin mechanochemical cycle, one of the most interesting event

84 biological motors which walk by repeating a mechanochemical cycle.

85 by directly blocking the progression of its mechanochemical cycle.

86 erization of the individual states along the mechanochemical cycle.

87 and reproduce the energetics of the complete mechanochemical cycle.

88 large conformational changes during Hsp90's mechanochemical cycle.

89 would be significantly disrupted during the mechanochemical cycle.

90 ompanied by a greater load dependence in the mechanochemical cycle.

91 r than from a fundamental change in dynein's mechanochemical cycle.

92 AA core of the motor and the MTBD during the mechanochemical cycle.

93 domains have distinct functions in dynein's mechanochemical cycle.

94 k angle that may reflect linkage to dynein's mechanochemical cycle.

95 ity of the enzyme and offer insight into its mechanochemical cycle.

96 motor proteins that operate in a continuous mechanochemical cycle.

97 le for force sensitivity in this step of the mechanochemical cycle.

98 nd Ncd towards physical understanding of its mechanochemical cycle.

99 o motor domains remain out of phase for many mechanochemical cycles and provides an efficient and ada

100 the motor for a significant portion of their mechanochemical cycles at low loads.

101 e maintenance of this coordination over many mechanochemical cycles has never been explained, because

102 d to the microtubule through the hundreds of mechanochemical cycles necessary to achieve this remarka

103 been used with great success to explore the mechanochemical cycles of processive motor proteins such

104 requires gating mechanisms to coordinate the mechanochemical cycles of the two motor heads to sustain

105 od which features coordinate, or "gate," the mechanochemical cycles of the two motor heads.

106 in and class V and VI myosins coordinate the mechanochemical cycles of their motor domains for proces

107 The mechanochemical decellularization system removed 93% of

108 Mechanochemical derivatizations of N- or C-protected ami

109 putational model provides the first complete mechanochemical description of the motor protein dynein,

110 affinity conformations demonstrates a common mechanochemical design in which biologically applied ten

111 cal principles that underlie both artificial mechanochemical devices and natural mechanisms of allost

112 and biophysical assays, we have undertaken a mechanochemical dissection of the microtubule-bound MKLP

113 aracterized myosins and clearly demonstrates mechanochemical diversity within the myosin family.

114 blicly available software package, named the Mechanochemical Dynamics of Active Networks (MEDYAN), fo

115 cular the cell cytoskeleton, exhibit complex mechanochemical dynamics that are still not well underst

116 A rationale for the mechanochemical effect on this photoisomerization mechan

117 cal action can produce dramatic physical and mechanochemical effects when the energy is spatially or

118 Thus, the mechanochemical efficiencies of different motor types ma

119 g the ATP hydrolysis cycle may be crucial to mechanochemical energy transduction in ABC transporters.

120 us to construct a dynamical theory for this mechanochemical engine consistent with our experimental

121 The GTPase dynamin is a mechanochemical enzyme involved in membrane fission, but

122 istic action of structural coat proteins and mechanochemical enzymes to deform and sever the plasma m

123 tuations, indicating our experiments were in mechanochemical equilibrium.

124 explore the basic principles that coordinate mechanochemical events during animal cell migration, par

125 esulting from a well-coordinated sequence of mechanochemical events--suggests a complex emergent beha

126 iation of graphite in styrene results in the mechanochemical exfoliation of graphite flakes to single

127 are frequently used as force transducers in mechanochemical experiments and identified DIBAC (azadib

128 , our findings support the argument that the mechanochemical features of a molecular motor are shaped

129 tured like a control system characterized by mechanochemical feedback loops that regulate myosin II l

130 ish epithelial keratocyte-to define a set of mechanochemical feedback loops underlying actin network

131 Finally, we focus on mechanochemical feedback, where signaling proteins can e

132 We propose that the mechanochemical feedbacks underlying wave generation in

133 and external stimuli such as heat, light or mechanochemical force cause such structural transformati

134 and external stimuli such as heat, light or mechanochemical force cause such structural transformati

135 Here, we incorporate a mechanochemical free-energy-based approach to elucidate

136 e relationship between protein structure and mechanochemical function of enzymes in this class.

137 htly faster in S217A than in WT myosin V and mechanochemical gating of the rates of dissociation of A

138 ynthesized via room-temperature solvent-free mechanochemical grinding.

139 namin-related protein 1 (Drp1) is a critical mechanochemical GTPase that drives constriction during m

140 escent protein (GFP)-tagged dynamin, a large mechanochemical guanosine triphosphate (GTP)ase implicat

141 These results provide new mechanochemical insights into the influences and the mec

142 This mechanochemical integration allows for the rapid product

143 tailed insight into the kinetics of myosin's mechanochemical interaction with actin.

144 The model demonstrates that in principle, mechanochemical interactions are sufficient to drive pat

145 g and experimental perturbation to show that mechanochemical interactions are sufficient to generate

146 HC, which eventually leads to alterations in mechanochemical interactions between microtubules and th

147 he thick filament that appears to tune these mechanochemical interactions by its N-terminal domains t

148 ymer of gated gDCC than of free gDCC for the mechanochemical isomerization gDCC to proceed at equal r

149 elates the continuum equations to a discrete mechanochemical kinetic model while retaining many of th

150 ntitatively, the results agree with a simple mechanochemical kinetics model.

151 The mechanochemical kinetics, single-chain extensibility, to

152 We establish a simple and direct mechanochemical link that shows how calcium quantitative

153 crA helicase and F1-ATPase suggest a similar mechanochemical mechanism at work in both systems.

154 s share a common evolutionary structural and mechanochemical mechanism for force generation.

155 This easy-handling mechanochemical methodology was applied to a large varie

156 d spotlight selected applications of quantum mechanochemical methods to point out their synergistic r

157 onalised Ar-BIAN ligand was carried out by a mechanochemical milling approach, which was advantageous

158 Microwave, ultrasound, sunlight and mechanochemical mixing can be used to augment convention

159 We propose and analyze a new mechanochemical model (called the "Lock, Load & Fire" me

160 Our data are consistent with a mechanochemical model in which PMF-driven motors, simila

161 iour is quantitatively explained by a simple mechanochemical model in which processivity depends on a

162 al conditions is important for identifying a mechanochemical model of a molecular motor.

163 Here, based on a simple mechanochemical model of biological friction, we propose

164 We also present a mechanochemical model that accounts for single-molecule,

165 Here, we propose a simple mechanochemical model that explains the dependence of ce

166 These results lead to a four-state mechanochemical model that provides insights into the me

167 Our results thus support a mechanochemical model where a chemosensory system measur

168 e result is consistent with predictions of a mechanochemical model, and suggests an active mechanical

169 of amoeboid locomotion emerge from a simple mechanochemical model.

170 d computational modeling, especially coupled mechanochemical modeling, has contributed significantly

171 This conclusion challenges mechanochemical models for motor proteins that utilize o

172 imited single-directional chemomechanical or mechanochemical modes.

173 ation of cryptic cysteines in titin mediates mechanochemical modulation of the elasticity of human ca

174 re critical in the propagation of long range mechanochemical motions in T. thermophilus leucyl-tRNA s

175 The finding that condensin is a mechanochemical motor has important implications for und

176 mulations reveal how contraction scales with mechanochemical parameters.

177 Thus, we elucidate a mechanochemical pathway in which arterial shear activate

178 y, fluctuation analysis has helped to define mechanochemical pathways and coupling ratios for the mot

179 al principles of the establishment of active mechanochemical patterns and point toward future directi

180 We also show that the structure of bulk mechanochemical perovskites bears close resemblance to t

181 activity of biological macromolecules from a mechanochemical perspective.

182 The theoretical explanation of mechanochemical phenomena is difficult, as the mechanism

183 s could attenuate (as opposed to facilitate) mechanochemical phenomena.

184 Here we report a mechanochemical phenomenon in graphene oxide membranes,

185 f versatile DNA origami nanostructures, this mechanochemical platform is anticipated to offer a long

186 The model reveals the mechanochemical principles underlying the Fo motor's ope

187 ical response, and lengthening was an active mechanochemical process requiring microtubule polymeriza

188 In this issue, Ulbrich et al. describe a mechanochemical process through which the AAA ATPase Rea

189 ble to acquire directly information during a mechanochemical process.

190 dscape that reproduces the energetics of the mechanochemical process.

191 the key to gain an in-depth understanding of mechanochemical processes at the molecular level.

192 How these mechanochemical processes influence function in vivo is

193 in turn allow more sophisticated analysis of mechanochemical processes, extending the limits of the t

194 eate bead rolling dynamics and show that the mechanochemical properties of ICAM-1-I-domain interactio

195 experiments showing that the load-dependent mechanochemical properties of mutant NM II support effic

196 el for FHC has been widely used to study the mechanochemical properties of mutated cardiac myosin, bu

197 is region plays a general role in tuning the mechanochemical properties of myosins.

198 However, the mechanochemical properties of this signaling pathway rem

199 Thus, dynamin's mechanochemical properties on a membrane surface are dyn

200 CNT exhibit unique mechanochemical properties that can be exploited for the

201 measurements of a single motor's elastic and mechanochemical properties.

202 3822P, strongly interfere with dynein's core mechanochemical properties.

203 contiguous cell walls indeed exhibit hybrid mechanochemical properties.

204 omic force microscopy for the observation of mechanochemical proteins onto membranes during action at

205 Mechanochemical proteins rely on ATP hydrolysis to estab

206 terial sigma54-RNA polymerase holoenzyme are mechanochemical proteins that use adenosine triphosphate

207 rtion of sustained pressure, thus forming a "mechanochemical," rather than purely mechanical, rapid a

208 step it takes, the kinesin motor undergoes a mechanochemical reaction cycle that includes the hydroly

209 step occurs relative to other events in the mechanochemical reaction cycle.

210 We report that a mechanochemical reaction in a ball mill exhibits unusual

211 y respond to mechanical stimuli, the default mechanochemical reaction of bulk polymers to large exter

212 The mechanochemical reaction produces macroscopic single cry

213 ows us to directly and locally visualize the mechanochemical reaction.

214 Usually, mechanochemical reactions between solid phases are eithe

215 bones, and it is demonstrated here that such mechanochemical reactions can be used to strengthen a po

216 Mechanochemical reactions effected by milling or grindin

217 he progress in homogeneous and heterogeneous mechanochemical reactions in oxides of various structure

218 ixture must be appreciated to understand how mechanochemical reactions progress.

219 ticomponent nanosystems and peculiarities of mechanochemical reactions.

220 eory was used to understand the mechanism of mechanochemical reactions.

221 y can be potentially utilized to control the mechanochemical reactivity of molecular objects.

222 We demonstrate that the mechanochemical reactivity of naphthopyran is critically

223 tion for a new strategy by which to engineer mechanochemical reactivity.

224 get molecule to any of these probes leads to mechanochemical rearrangement of the origami nanostructu

225 Polymodal nociceptors and mechanochemical receptors gave similar responses to topi

226 mechanical stimulation and noxious heat; and mechanochemical receptors responsive to mechanical and c

227 22 were mechanothermal nociceptors, 18 were mechanochemical receptors, 33 were fast adapting mechani

228 itude and the balance between Rac and Rho in mechanochemical regulation of lung EC barrier.

229 sect the specific interactions mediating the mechanochemical relay, we used affinity purification/mas

230 s, for example, the dynamics of physical and mechanochemical remodeling of loaded materials.

231 this contribution has long been involved in mechanochemical research in both inorganic and organic s

232 The unique dual mechanochemical response of STP makes it of potentially

233 Here we probe the mechanochemical response of two tetra(4-bromophenyl)porp

234 focal adhesions leads to a complex, dynamic, mechanochemical response.

235 ond scission of interest and the nonscissile mechanochemical ring opening of gem-dichlorocyclopropane

236 To probe the dynamics of the mechanochemical ring opening, a series of bicyclo[4.2.0]

237 roducts suggests that the ultrasound-induced mechanochemical scission of the oxime sulfonate mechanop

238 expanded single-molecule platforms in a new mechanochemical sensing strategy.

239 To exploit this mechanochemical sensing technology, it is essential to d

240 Here, we demonstrated mechanochemical sensing that broke the Kd limit by 9 ord

241 that GPCRs are involved in mediating primary mechanochemical signal transduction in endothelial cells

242 l integrity and biochemical scaffolds during mechanochemical signal transductions.

243 Here, we examine mechanochemical signaling in response to direct force ap

244 A central aspect of cellular mechanochemical signaling is a change of cytoskeletal te

245 he networks to integrins while responding to mechanochemical signaling pathways.

246 itive intracellular structures that regulate mechanochemical signaling pathways.

247 adhesions (FAs) serve as the major hubs for mechanochemical signaling via GIV.

248 development, a detailed characterization of mechanochemical signaling via the GPCR pathway will be r

249 phorylation is required for TFP function and mechanochemical signaling, it is not required for polar

250 ric shape cues can play in orchestrating the mechanochemical signals and paracrine/autocrine factors

251 affects many physiological processes through mechanochemical signals from focal adhesion (FA) complex

252 rotubule catastrophe events, we performed 3D mechanochemical simulations that account for interaction

253 Here, we describe a novel mechanochemical specialization of the A1-GPIbalpha bond

254 ic routes, i.e., electrochemical, microwave, mechanochemical, spray drying and flow chemistry synthes

255 nbinding probabilities corresponding to each mechanochemical state of kinesin are modeled.

256 repeatable transformations, involving eight mechanochemical states and incorporating self-righting b

257 he geometrical placement of the intermediate mechanochemical states of the enzymatic cycles relative

258 On one hand, mechanochemical stimulation has been used to direct the

259 on mechanisms may support the translation of mechanochemical stimulation into the clinic as an emergi

260 opose that spindle length is controlled by a mechanochemical switch at the poles that regulates the d

261 that the PSGL-1-P-selectin bond behaves as a mechanochemical switch where force history selects betwe

262 hemical signals, chemists dream of designing mechanochemical switches integrated into materials.

263 as a key step for a deeper understanding of mechanochemical symmetry breaking in Hydra.

264 The results show that mechanochemical syntheses and transformations of ZIFs ar

265 Soluble porous coordination polymers from mechanochemical synthesis are presented through a coordi

266 Mechanochemical synthesis has the potential to provide m

267 We report a mechanochemical synthesis in which slow compression at r

268 Although mechanochemical synthesis is becoming more widely applie

269 In this review, the mechanochemical synthesis of catalysts is discussed, wit

270 In recent years, the mechanochemical synthesis of organic compounds was added

271 We report a mechanochemical synthesis of structurally well-defined i

272 o provide a broad but digestible overview of mechanochemical synthesis, i.e. reactions conducted by g

273 e marriage of concepts of supramolecular and mechanochemical synthesis, including organocatalysis, de

274 pective as compared to conventional, gradual mechanochemical synthesis, where thermal effects are gen

275 taneously observed with COF formation during mechanochemical synthesis.

276 als were prepared by solvent evaporation and mechanochemical synthesis.

277 In mitosis, a mechanochemical system recognizes tension that is genera

278 In this paper, emergent laws for describing mechanochemical systems are investigated for processive

279 tical formalisms are widely used in modeling mechanochemical systems such as protein motors: continuu

280 nsight for how patterns emerge in stochastic mechanochemical systems, while also informing understand

281 of the electrostatic basis of proton-driven mechanochemical systems.

282 ions, reinforcing predictive capabilities in mechanochemical systems.

283 However, mechanochemical techniques can also alter chemical react

284 Monitoring of mechanochemical thiocarbamoylation by in situ Raman spec

285 e applied mechanical force and its effect on mechanochemical transduction along the reaction coordina

286 which hold promise both as tools for probing mechanochemical transduction and as anticancer agents.

287 Thus, the mechanism by which cells perform mechanochemical transduction and the implications of the

288 Mechanochemical transduction by myosin motors on actin i

289 Mechanochemical transduction enables an extraordinary ra

290 Finally, we show that mechanochemical transduction in metallosupramolecular po

291 etworks ensures that various molecular scale mechanochemical transduction mechanisms proceed simultan

292 We describe studies in mechanochemical transduction that probe the activation o

293 milar structures for the domains involved in mechanochemical transduction--including switch-1 and the

294 Here, we report that mechanochemical transductions can be achieved in metallo

295 These mechanochemical transformations in a two-dimensional sys

296 s, this work defines a consensus sequence of mechanochemical transitions that can be used to understa

297 y improved by adding Ti as a catalyst and by mechanochemical treatment, with the decomposition produc

298 Our design is based on the facile mechanochemical unzipping of polyladderene, a polymer in

299 enes to enable both their polymerization and mechanochemical unzipping to yield semiconducting polyac

300 scopically, this scenario would arise if the mechanochemical wave that propagates along the spasmonem