ライフサイエンスコーパス: mechanosensing

1 tracellular matrix (ECM) in a process termed mechanosensing.

2 gionally modified by, and contribute to, ECM mechanosensing.

3 ting cell migration, adhesive signaling, and mechanosensing.

4 e for cytokinesis, all are required for full mechanosensing.

5 inase plays a mechanistic role in neutrophil mechanosensing.

6 steps are well poised to facilitate cellular mechanosensing.

7 by reacting molecules, crack propagation and mechanosensing.

8 ult that has broad implications for cellular mechanosensing.

9 (FN), which are believed to control cellular mechanosensing.

10 ganelle dedicated to signal transduction and mechanosensing.

11 A traction oscillation to drive efficient FA mechanosensing.

12 n function and constrain models for cellular mechanosensing.

13 s a critical modulator of cell migration and mechanosensing.

14 in simulations support its proposed role in mechanosensing.

15 tion in the context of cellular adhesion and mechanosensing.

16 focal adhesions, such as talin, can exhibit mechanosensing.

17 regulatory mechanisms, proline switches and mechanosensing.

18 lin dimer orientations constitutes a mode of mechanosensing.

19 onsiderably reduces fouling by deceiving the mechanosensing ability of mussels, deterring secretion o

20 ovide new insights into the mechanism of YAP mechanosensing activity and qualify this Hippo effector

21 Targeting this mechanosensing alpha6(beta1)-integrin offers a novel ant

22 ciated ACAFAs as major mediators of cellular mechanosensing and a critical element of the physical pa

23 be of interest for the study of cancer cell mechanosensing and cancer metastasis.

24 nase G (PKG) in controlling cardiac systolic mechanosensing and determined their pathophysiological r

25 of CD44, which is imposed downstream of ECM-mechanosensing and determines if cells couple or uncoupl

26 oblastic leukemia 1-mediated (MKL1-mediated) mechanosensing and inhibits AC phagocytosis by MZMs.

27 ironment, we hypothesized that cells utilize mechanosensing and mechanical feedback to sense and corr

28 diseases result, in part, from dysfunctional mechanosensing and mechanoregulation of the extracellula

29 alphaVbeta3 integrin in osteocyte-polarized mechanosensing and mechanotransduction.

30 support a key role for sdc-1 in endothelial mechanosensing and regulation of endothelial phenotype.

31 n HUVECs, providing insight into the primary mechanosensing and signal transduction mechanisms.

32 istic effect of YAP/TAZ activity between the mechanosensing and the Hippo pathways can be explained b

33 nctions are well-established contributors to mechanosensing and transduction machinery; however, the

34 ium, each cell division is associated with a mechanosensing and transmission event that controls MyoI

35 ith Gli1 and Gli3, may act as a link between mechanosensing and Wnt signaling.

36 X, which may possibly contribute to platelet mechanosensing and/or shear resistance of VWF-platelet i

37 fening of F-actin networks, partner binding, mechanosensing, and mechanoprotection properties of FLNa

38 n has been divided into mechanotransmission, mechanosensing, and mechanoresponse, although how a cell

39 and adapt to extracellular mechanical cues (mechanosensing), as well as suppresses force-mediated ex

40 namics, as well as mitophagy, is affected by mechanosensing at the transcriptional level, and muscle

41 This mechanosensing-based regulation of the thick filament ma

42 Mechanosensing bone osteocytes express large amounts of

43 Mechanosensing by flagella is thought to trigger bacteri

44 e investigate how this heterogeneity impacts mechanosensing by modelling the cell as an idealized loc

45 nvestigate the role of the primary cilium in mechanosensing by osteoblasts.

46 This report demonstrates mechanosensing by T cells, using polyacrylamide gels pre

47 icant role in the upstream regulation of the mechanosensing cascade.

48 Blocking signaling through mechanosensing cation channels using GsMTx4 negated the

49 segregation, gene expression, cell division, mechanosensing, cell adhesion and biofilm formation.

50 e loss treatments by directly modulating the mechanosensing cells in bone.

51 The discovery of mechanosensing channels has changed our understanding of

52 d the transcriptional coactivator TAZ form a mechanosensing complex in osteoblasts.

53 The model uses the molecular mechanosensing complex of latent TGF-beta attached to th

54 Here we tested, how filamin mechanosensing contributes to oogenesis in Drosophila.

55 ent study provides the first indication that mechanosensing could be modified pharmacologically durin

56 of force transfer to the nucleus through the mechanosensing cytoskeletal machinery in the regulation

57 Mechanosensing describes the ability of a cell to sense

58 KEY POINTS: Myosin filament mechanosensing determines the efficiency of the contract

59 Myosin filament mechanosensing determines the efficiency of the contract

60 13 helical bundles, plays important roles in mechanosensing during cell adhesion and spreading.

61 Nuclear mechanosensing encompasses biophysically complex pathway

62 Mechanosensing followed by mechanoresponses by cells is

63 ocal adhesions are restrictively involved in mechanosensing for extremely soft substrates.

64 plant hormone ethylene requires two signals: mechanosensing for spatial resolution and ROS for cell d

65 l multiscale modelling, we decipher cortical mechanosensing from molecular to cellular scales.

66 nsure robust left and right determination by mechanosensing, given the large spatial variability of t

67 Mechanosensing governs many processes from molecular to

68 of palladin in cellular force generation and mechanosensing has not been studied.

69 how that integrins play an important role in mechanosensing in addition to their involvement in cell

70 that primary cilia play a role in mediating mechanosensing in bone cells through an unknown mechanis

71 ndings implicate Vinculin-dependent cadherin mechanosensing in endothelial processes such as leukocyt

72 are crucial for adhesion, morphogenesis, and mechanosensing in nonmuscle cells.

73 Mechanosensing in NP cells from nondegenerated discs occ

74 Here, we describe a second mode of talin mechanosensing in which the talin dimer itself can adopt

75 We previously described one mode of talin mechanosensing in which the vinculin-binding site of tal

76 nd to the nuclear envelope are important for mechanosensing, including activation of the Yes-associat

77 We identify alpha6-integrin as a mechanosensing integrin subunit that mediates matrix sti

78 model includes three key mechanotransducers: mechanosensing ion channels, integrins, and G protein-co

79 Receptor-mediated cell mechanosensing is a multistep process that is initiated

80 faces, this report further demonstrates that mechanosensing is more strongly associated with CD3 rath

81 erge to regulate mesenchymal stem cell (MSC) mechanosensing is not fully understood.

82 mechanical stimulation of EC but its role in mechanosensing is still incompletely understood.

83 We show that large-scale mechanosensing leads to an adaptative response of cell m

84 Impaired mechanosensing leads to heart failure and a decreased ra

85 Endothelial pressure-dependent mechanosensing may occur without a requirement for a con

86 d provide important details of a novel early mechanosensing mechanism in bone and advances our unders

87 We identified a mechanosensing mechanism in isolated mesenteric arteries

88 rmation of the cell membrane, the underlying mechanosensing mechanism inside RBCs is still controvers

89 Our results unveil a mechanosensing mechanism mediated directly by nuclear po

90 ell-cell contacts, we propose an alternative mechanosensing mechanism that coordinates actomyosin dyn

91 sponse to substrate stiffness may serve as a mechanosensing mechanism whereby cells use pericellular

92 yonic cell sorting and suggesting a putative mechanosensing mechanism, the physical differences point

93 es are summarized with emphasis on potential mechanosensing mechanisms and the relationship between m

94 be highly mechanosensitive, and a number of mechanosensing mechanisms have been proposed as mediator

95 Targeting the mechanosensing mechanisms of joint tissue may offer new

96 s blood flow in vivo in part through unknown mechanosensing mechanisms.

97 anisms they form) is the result of cycles of mechanosensing, mechanotransduction, and mechanoresponse

98 contributes to compliance and dimensionality mechanosensing-mediated regulation of MT growth dynamics

99 es are thought to be detected by specialized mechanosensing molecules linked to the cytoskeleton, an

100 r the cell, making them prime candidates for mechanosensing molecules.

101 hypothesized that ER plays a central role in mechanosensing of atherosusceptible shear stress (SS) by

102 rp2/3, whereas FAK phosphorylation modulates mechanosensing of ECM stiffness during spreading.

103 llate in time and space, and govern the cell mechanosensing of ECM stiffness.

104 , consequently, is a prime candidate for the mechanosensing of fluidic shear stresses.

105 Mechanosensing of surfaces in bacteria is a process that

106 six bacterial species as models of flagellar mechanosensing of surfaces to understand the current sta

107 rk and stress fibers, which are critical for mechanosensing of the environment.

108 response of this tissue, as a consequence of mechanosensing of the increase in embryonic growth poten

109 integrin-mediated cell spreading and provide mechanosensing on different extracellular matrix conditi

110 Disruption of the mechanosensing organelle, the primary cilium in a progen

111 Primary cilia are chemosensing and mechanosensing organelles that regulate remarkably diver

112 ported that connexin (Cx) 43 hemichannels in mechanosensing osteocytes mediate the release of prostag

113 iated focal adhesions (ACAFAs) dominate cell mechanosensing over a wide range of matrix stiffness, an

114 observed in polyacrylamide, in facilitating mechanosensing over long distances.

115 s designed to validate the importance of FAK mechanosensing, p38, and MMP9 secretion in human cells.

116 Therefore, this mechanosensing pathway is required for the earliest-know

117 (MKL1) transcriptional coactivator-mediated mechanosensing pathway, which was maintained by MZ B cel

118 Thus, compliance and dimensionality ECM mechanosensing pathways independently regulate specific

119 nsduction mechanisms with an emphasis on the mechanosensing pathways involved in creating these signa

120 eomics data, which indicate that some of the mechanosensing pathways relaying signals from the collag

121 An understanding of this mechanosensing process in complex tissues, including fib

122 is described for the receptor-mediated cell mechanosensing process.

123 are utilized in the diverse talin-dependent mechanosensing processes remains poorly understood.

124 tle is known about the role of EGFR in these mechanosensing processes.

125 ia associated mutations of the structure and mechanosensing properties of Filamin were studied by com

126 The mechanosensing properties of TRPC6 channels highly expre

127 highlight the underappreciated diversity of mechanosensing properties within the myosin superfamily.

128 a puncta, active phosphorylated forms of the mechanosensing proteins p130Cas (Cas) and focal adhesion

129 It has been suggested that mechanosensing proteins play an important role in mechan

130 upted by strategies that maintain or enhance mechanosensing signaling in the MZM barrier to prevent f

131 aginated plasma membrane domains involved in mechanosensing, signaling, endocytosis, and membrane hom

132 stioned, leading to discovery of alternative mechanosensing-signalling to MPS.

133 pressure seem likely to require cytoskeletal mechanosensing, Src, phosphatidylinositol 3-kinase, foca

134 scaffold that receives and transmits complex mechanosensing stimuli that regulate normal physiologica

135 icularly suited for juxtacrine signaling and mechanosensing studies.

136 nced during cell spreading and ECM stiffness mechanosensing, suggesting upregulation of this pathway

137 Hippo effectors YAP/TAZ act as on-off mechanosensing switches by sensing modifications in extr

138 rticle discusses the different mechanisms of mechanosensing that have been proposed and reviews the l

139 e mechanism associated with impaired cardiac mechanosensing that leads to heart failure by examining

140 mponent of the EC glycocalyx participates in mechanosensing that mediates NO production in response t

141 Compliance and dimensionality mechanosensing, the processes by which cells sense the p

142 Beyond the epigenetics of mechanosensing, the scaling in cancer of chromosome copy

143 o collisions at a venous shear rate; and 4), mechanosensing through neutrophil beta(2)-integrin/adhes

144 racellular matrix and are thought to mediate mechanosensing through the cytoskeleton-integrin-ECM lin

145 ental cellular processes, leading defects in mechanosensing to be linked to many diseases.

146 d the involvement of microtubules in linking mechanosensing to endothelial cell branching morphogenes

147 l-ECM and cell-cell adhesions participate in mechanosensing to transduce mechanical cues into biochem

148 nment through chemosensing, osmosensing, and mechanosensing using receptors and ion channels in the c

149 l an important role for paxillin in adhesion mechanosensing via myosin II-mediated FAK phosphorylatio

150 s modulated by myosin II-mediated compliance mechanosensing when cells are cultured on two-dimensiona

151 w some of the emerging mechanisms of nuclear mechanosensing, which range from changes in protein conf

152 erase 5A inhibition also normalized abnormal mechanosensing while blunting progressive chamber hypert

153 ene-transformed fibroblasts are defective in mechanosensing while generating similar traction forces

154 macroscopic pressure-dependent, endothelial mechanosensing without the need for a conventional mecha