ライフサイエンスコーパス: mechanosensitivity

1 is so essential for cell form, motility and mechanosensitivity.

2 ole of subunit composition in observed NMDAR mechanosensitivity.

3 pr signaling is a negative modulator of bone mechanosensitivity.

4 umor vessel maturation via modulation of TEC mechanosensitivity.

5 us to gain additional insights into the cell mechanosensitivity.

6 ein (MLP ratio) is associated with a loss of mechanosensitivity.

7 common sequence 'signature' that identifies mechanosensitivity.

8 coincides developmentally with the onset of mechanosensitivity.

9 ter) might exert their effect by influencing mechanosensitivity.

10 cted against either region result in loss of mechanosensitivity.

11 lope stiffness at the heart of its region of mechanosensitivity.

12 s to hypotheses on the nature of the channel mechanosensitivity.

13 teria differ in kinetics and their degree of mechanosensitivity.

14 ts native mechanosensitivity or even acquire mechanosensitivity.

15 d or substituted, affect channel kinetics or mechanosensitivity.

16 irculating level and is able to modulate GVA mechanosensitivity.

17 erexcitability of A-fibre axons and enhanced mechanosensitivity.

18 during development: exactly at the onset of mechanosensitivity.

19 ircadian variation in stomach content or GVA mechanosensitivity.

20 se to electrical pacing, suggesting impaired mechanosensitivity.

21 ghts into how viscoelastic properties affect mechanosensitivity.

22 s a rapid noninvasive whole-cell reporter of mechanosensitivity.

23 expressed just before or after maturation of mechanosensitivity.

24 needed to "really swim," i.e., achieve high mechanosensitivity.

25 clarify their physiological role in bladder mechanosensitivity.

26 broadly classified into two groups based on mechanosensitivity.

27 ve E4 stiffness, highlighting cell-intrinsic mechanosensitivity.

28 er they exhibit circadian variation in their mechanosensitivity.

29 s require kinocilia and kinocilial links for mechanosensitivity.

30 ed lidocaine analog (QX-314) failed to block mechanosensitivity.

31 mily members do not directly affect cellular mechanosensitivity; 2) there are residual manifestations

32 develop a self-consistent physical model for mechanosensitivity, a process by which a cell detects th

33 hat were mechanically insensitive and gained mechanosensitivity after IS exposure were rare.

34 onse (P = 0.92, n = 14), and maintained this mechanosensitivity after luminal anaesthesia.

35 We map mechanosensitivity along the lateral line using imaging

36 reveals a biophysical explanation for TRAAK mechanosensitivity--an expansion in cross-sectional area

37 ol recordings but differ in terms of reduced mechanosensitivity and adaptation to sustained stimulati

38 sensor, and Coulter counter assays to study mechanosensitivity and adhesion of E and R cells.

39 tor (Lepr) signaling in determining the bone mechanosensitivity and also evaluated whether difference

40 sensitization of afferent pathways mediating mechanosensitivity and chemosensitivity.

41 5A-syntrophin gamma 2 interaction determines mechanosensitivity and current availability.

42 Therefore, Piezo2 is critical to EC cell mechanosensitivity and downstream physiological effects.

43 reate planarizable push-pull probes with the mechanosensitivity and fluorescence lifetime needed for

44 bout how membrane lipids may influence their mechanosensitivity and function.

45 tivity filter that may have implications for mechanosensitivity and gating of TRAAK channels.

46 adigms emerging for bilayer-mediated channel mechanosensitivity and how this molecular detail may pro

47 amined the role of P2X(3) receptors in colon mechanosensitivity and intracolonic zymosan-produced hyp

48 These results show how the mechanosensitivity and mechanics of single cells can be

49 ract in response to stretch, suggesting that mechanosensitivity and mechanotransduction can occur at

50 genes of Caenorhabditis elegans involved in mechanosensitivity and neuronal degeneration.

51 vity by dampening stretch-sensitive afferent mechanosensitivity and normalizing afferent sensitizatio

52 each recurved bristle are essential for its mechanosensitivity and the kicking behavior.

53 r evidence of Ca2+ influx and determined its mechanosensitivity and voltage dependence.

54 Hair bundles mediate mechanosensitivity, and their highly organized structure

55 adian fluctuations in gastric vagal afferent mechanosensitivity are lost.

56 of cells, but the mechanisms underlying the mechanosensitivity are not clearly understood.

57 onship between action potential duration and mechanosensitivity as has been observed in vivo.

58 ata indicate for the first time that myocyte mechanosensitivity as indicated by the MLP ratio is regu

59 We find that HCT-8 cells lose mechanosensitivity as they undergo E-to-R transition.

60 Myocyte mechanosensitivity, as indicated by the muscle LIM prote

61 alysis revealed that R616Q channels maintain mechanosensitivity but have greater constitutive activit

62 roduced NO in cultured DRG neurons decreases mechanosensitivity by inhibiting voltage-gated Na(+) and

63 The block of Na(V)1.5 mechanosensitivity by ranolazine does not utilize the es

64 Block of Na(V)1.5 mechanosensitivity by ranolazine was not due to the know

65 etically, we show both cellular rigidity and mechanosensitivity can be restored in Atat1 deficient se

66 To examine how mechanosensitivity changes during the transition to hear

67 development, a switch to correctly polarized mechanosensitivity coincides with the formation of tip l

68 n sensory neurons, and show that Merkel-cell mechanosensitivity completely depends on Piezo2.

69 We further show that this mechanosensitivity enhances the firing frequency of indi

70 We find that organoid hair cells acquire mechanosensitivity equivalent to functionally mature hai

71 We contrasted their mechanosensitivity, excitability and chemosensitivity in

72 However, the regulation of this mechanosensitivity has yet to be further explored.

73 Understanding mechanosensitivity (i.e., how cells sense the stiffness

74 s study demonstrates the use of AFM to study mechanosensitivity in a cell system that responds at fas

75 Furthermore, Runx1 is required to establish mechanosensitivity in C-LTMRs, by controlling the expres

76 ity; 2) there are residual manifestations of mechanosensitivity in hair cells of mouse Tmc1:Tmc2 doub

77 nship between cell mechanical properties and mechanosensitivity in live cells of the dinoflagellate P

78 In contrast, mechanosensitivity in non-vagal afferents was modulated

79 mall-fiber sensory neurons and produces less mechanosensitivity in oocytes.

80 olecular determinant contributing to dynamic mechanosensitivity in proprioceptors.

81 oocytes and found that they possess similar mechanosensitivity in response to hypo-osmolar stress.

82 Finally, whereas the mechanosensitivity in the glomerular layer was observed

83 Mechanosensitivity in the intestine requires an intact c

84 dbcAMP also induced mechanosensitivity in the majority of MIA units (6/9, 67

85 e saw an age-associated decrease in afferent mechanosensitivity in the mouse colon affecting HT units

86 ated with attenuated high-threshold afferent mechanosensitivity in the murine colon, and associated l

87 rant urothelial function, increased afferent mechanosensitivity, increased smooth muscle contractilit

88 s (e.g. mitosis and apoptosis), may increase mechanosensitivity independently of the intrinsic proper

89 We establish that this broad loss of mechanosensitivity is dependent upon the acetyltransfera

90 s of baroreceptor activity each suggest that mechanosensitivity is diminished in ASIC2 null mice.

91 echanosensor region demonstrate that filamin mechanosensitivity is important for the maturation of ac

92 lls, but it has yet to be tested whether the mechanosensitivity is important for their function in in

93 have obliquely oriented tip links, and their mechanosensitivity is mediated exclusively by "top-to-to

94 The absence of mechanosensitivity is not due to the vitelline membrane,

95 We show that gene mechanosensitivity is preserved after LINC disruption, b

96 The demonstrated mechanosensitivity is quantitatively consistent with mem

97 ecular mechanism of TRAAK channel gating and mechanosensitivity is unknown.

98 However, the molecular mechanism driving BFM mechanosensitivity is unknown.

99 Our results suggest that mechanosensitivity may be a general feature in olfactory

100 Ranolazine block of Na(V)1.5 mechanosensitivity may be relevant in disorders of mecha

101 al activation of TRPV4 restored aberrant TEC mechanosensitivity, migration and normalized abnormal an

102 ned and condensed the nucleus, and increased mechanosensitivity more rapidly than soluble factors.

103 Altered mechanosensitivity occurred in the absence of any change

104 ogical and pathological conditions may alter mechanosensitivity of a cell independently of the intrin

105 layer can be harnessed to control gating and mechanosensitivity of a eukaryotic ion channel.

106 pport these predictions, suggesting that the mechanosensitivity of adhesions is an emergent property

107 contains a genetic locus that modulates the mechanosensitivity of bone tissue.

108 To date, there are very few reports on mechanosensitivity of Ca2+ channels, particularly neuron

109 Our findings provide in vivo evidence for mechanosensitivity of cell-cell junctions and imply that

110 h ellipsoid packing models revealed that the mechanosensitivity of chromosomes was correlated with th

111 that natural variations in TRP-4 reduce the mechanosensitivity of dopaminergic neurons.

112 Our data suggests that icilin modulates the mechanosensitivity of dorsal horn neurones.

113 ty and affected the spontaneous activity and mechanosensitivity of gastrointestinal sensory nerves.

114 Although mechanosensitivity of heart rhythm has been described in

115 Herein we leveraged the mechanosensitivity of hESCs and employed, to our knowled

116 ly imaging the structure of hair bundles and mechanosensitivity of individual lateral-line hair cells

117 skin nerve preparation studies show that the mechanosensitivity of low-threshold mechanoreceptors str

118 hannel, providing insights into the basis of mechanosensitivity of mechanotransduction channels.

119 ere used to test changes in the activity and mechanosensitivity of meningeal nociceptors in response

120 romoted a delayed and robust increase in the mechanosensitivity of meningeal nociceptors, with a time

121 ted currents in vitro is responsible for the mechanosensitivity of most low-threshold mechanoreceptor

122 To understand better the mechanosensitivity of Muller cells and its association w

123 The effect of ranolazine on mechanosensitivity of Na(V)1.5 was approximated by lidoc

124 Mechanosensitivity of Na(V)1.5 was tested in voltage-cla

125 Ranolazine effectively inhibits mechanosensitivity of Na(V)1.5.

126 Together, these data demonstrate the mechanosensitivity of neovascular networks and highlight

127 tivation thereby specifically increasing the mechanosensitivity of neurons.

128 These data suggest that the selective mechanosensitivity of NR2B can significantly impact neur

129 Moreover, the mechanosensitivity of parvalbumin-expressing neurons tha

130 s a mechanistic feedback system based on the mechanosensitivity of periosteal progenitor cells, which

131 The ability of GsMTx4 to target the mechanosensitivity of Piezo1 supports the use of this ch

132 us these myosins, especially 2B, have marked mechanosensitivity of product release.

133 ysiological recordings demonstrated that the mechanosensitivity of recurved bristles requires Nanchun

134 , we used a recombinant system to assess the mechanosensitivity of specific subtypes and demonstrate

135 provides durability and rigidity for normal mechanosensitivity of stereocilia and may contribute to

136 erapeutic gene restores the architecture and mechanosensitivity of stereociliary bundles, improves he

137 in mediating changes in the dynamic range of mechanosensitivity of TFs.

138 For adaptation to set the position of mechanosensitivity of the bundle accurately, the free Ca

139 a major role in both the open dwell time and mechanosensitivity of the channel.

140 gthened instead of weakened by force) drives mechanosensitivity of the flagellar motor complex.

141 to the Kir3.4 subunit, which reproduced the mechanosensitivity of the heteromeric channel when expre

142 Mechanosensitivity of the nerve endings was quantified u

143 nic tone consistent with previous reports of mechanosensitivity of this G protein-coupled receptor.

144 stin via membrane bending, demonstrating the mechanosensitivity of this unique membrane motor protein

145 essential for NOMPC mechanogating in vitro, mechanosensitivity of touch receptor neurons in vivo, an

146 Mechanosensitivity of TRAAK is mediated directly through

147 Mechanosensitivity of TRPV4 provides the simplest explan

148 Leptin potentiated mucosal receptor mechanosensitivity only in SLD mice and with reduced pot

149 ther a decrease or an increase in its native mechanosensitivity or even acquire mechanosensitivity.

150 This shows that the loss mechanosensitivity plays an important role during the tr

151 en shown to exhibit circadian fluctuation in mechanosensitivity, potentially allowing for time of day

152 n be used to elucidate the genes involved in mechanosensitivity regulation.

153 ults provide an explanation for TREK channel mechanosensitivity, regulation by diverse stimuli, and p

154 The mechanosensitivity response is selective.

155 asts of C3H (the mouse strain with poor bone mechanosensitivity) restored) their anabolic responses t

156 f different types of lipids on MscS and MscL mechanosensitivity simultaneously using the patch-clamp

157 Moreover, the superior mechanosensitivity, SM 3.4 VPa(-1) of the FTNG enables

158 Although integrin alpha subunit determines mechanosensitivity, the ligation between alpha subunit a

159 In the periphery, ATP mediates nociception, mechanosensitivity, thermal sensitivity and O2 chemosens

160 ing new insights into the basis of hair-cell mechanosensitivity; this enterprise has been joined by l

161 owel syndrome, yet the molecules that confer mechanosensitivity to colon sensory neurons and their co

162 In contrast, mechanosensitivity to distension and the secondary respo

163 SNS-gp130(-/-) mice revealed reduced mechanosensitivity to high mechanical forces in the von

164 his F-actin network is also found to provide mechanosensitivity to the Cav1.3 channels when varying i

165 ive voltage-gated potassium channels confers mechanosensitivity to the chimeric channels.

166 am product of phospholipase A(2), relegating mechanosensitivity to the enzymes or their regulators.

167 e (ARPKD) is poorly understood, but impaired mechanosensitivity to tubular flow and dysfunctional cal

168 Mechanosensitivity toward the extracellular matrix was i

169 function, which is correlated with aberrant mechanosensitivity towards extracellular matrix stiffnes

170 The mechanisms of mechanosensitivity underlying the response of the human

171 including nociceptors have strongly reduced mechanosensitivity upon Atat1 deletion, and that consequ

172 Chemosensitivity but not mechanosensitivity was correlated with reflux symptoms a

173 Mechanosensitivity was evaluated with a barostat using u

174 steoblasts, indicating that the differential mechanosensitivity was intrinsic to osteoblasts.

175 Furthermore, NR2B mechanosensitivity was regulated by PKC activity, becaus

176 Na(v)1.5 was expressed in HEK 293 cells and mechanosensitivity was studied in cell-attached patches.

177 orectal distension, and colon afferent fiber mechanosensitivity were assessed in control (C57BL/6) mi

178 me points, both tension and mucosal receptor mechanosensitivity were the lowest and highest, respecti

179 156 out of 465 neurons tested (34%) showed mechanosensitivity while 55 out of 118 neurons (47%) wer

180 res that suggest an exaggerated intracranial mechanosensitivity (worsening of the pain by coughing, b