ライフサイエンスコーパス: mechanosensor

1 esponse to a mechanical stimulus are called "mechanosensors".

2 er of putative binding domains, may act as a mechanosensor.

3 indicated that it might be a part of such a mechanosensor.

4 egans, may be components of the baroreceptor mechanosensor.

5 ed receptor superfamily, also functions as a mechanosensor.

6 hich has a domain homologous to a eukaryotic mechanosensor.

7 esponse to stretch, indicating that APJ is a mechanosensor.

8 A acts as an autoinhibited force-activatable mechanosensor.

9 investigated whether polycystin-1 is a bone mechanosensor.

10 drite anchor may have evolved into part of a mechanosensor.

11 ignalling and suggest Spectrins as potential mechanosensors.

12 ins that have been independently proposed as mechanosensors.

13 ls and innervating afferents act together as mechanosensors.

14 arge conductance, is one of the best studied mechanosensors.

15 pears that stators themselves act as dynamic mechanosensors.

16 teractions, may be common to other candidate mechanosensors.

17 hair cell development and their function as mechanosensors.

18 ss the evidence supporting these proteins as mechanosensors.

19 pted by force seem more likely than singular mechanosensors.

20 s, and fungi are primary chemo-, thermo-, or mechanosensors.

21 gle-headed myosin I molecule is an exquisite mechanosensor, able to sense strain over a very small fo

22 rthermore, it is currently impossible to use mechanosensor activity to drive gene expression.

23 k has been done to develop assays to monitor mechanosensor activity.

24 , our data imply the existence of sequential mechanosensor alphabetaTCR repertoire tuning via the pre

25 f families are now candidates for eukaryotic mechanosensors and proprioception, as well as cardiovasc

26 ovide important clues to the location of the mechanosensors and the kinds of mechanical forces they c

27 al and functional evidence that filamins are mechanosensors and/or mechanotransducers playing essenti

28 The EC cell is a specialized mechanosensor, and it is well known that it releases 5-H

29 Myosin II and cortexillin I form the core mechanosensor, and mechanotransduction is mediated by IQ

30 Whether animal ion channels functioning as mechanosensors are directly activated by stretch force o

31 Mechanosensors are important for many life functions, in

32 have to be in a sensory capacity, perhaps as mechanosensors as hypothesised in two-cilia physical mod

33 ions, insects rely on feedback from antennal mechanosensors but it is not clear how these inputs comb

34 mains has been proposed to act as a cellular mechanosensor, but so far evidence linking their mechani

35 addition, the polar flagellum functions as a mechanosensor controlling lateral gene expression.

36 dings suggest that the TCR is an anisotropic mechanosensor, converting mechanical energy into a bioch

37 model that accounts for the feedback between mechanosensors, cyclic-di-GMP signaling, and production

38 hypothesis that polycystin-1 could act as a mechanosensor, detecting changes in fluid flow in the ki

39 been suggested to function as an anisotropic mechanosensor during immune surveillance, converting mec

40 sulfate proteoglycan glypican-1 is a primary mechanosensor for shear-induced NO production.

41 air cells of the mammalian inner ear are the mechanosensors for the detection of sound and head movem

42 Hair cells are mechanosensors for the perception of sound, acceleration

43 Hair cells of the cochlea are mechanosensors for the perception of sound.

44 , an ion channel in a family that includes a mechanosensor from C. elegans, is shown by Lu et al. in

45 se components have been speculated to be the mechanosensor (FUSE) and effectors (FBP/FIR) of a real-t

46 The identity of the mechanosensor has not been established.

47 Our analysis demonstrates that this mechanosensor has three critical elements: the myosin mo

48 This Ca(2+)-responsive mechanosensor hypothesis for primary cilia has been invo

49 of force application between pre-TCR and TCR mechanosensors, impacting signal initiation.

50 nnel conductance of the vertebrate hair-cell mechanosensor, implicating them directly in inner ear me

51 ed receptor-like protein that functions as a mechanosensor in a variety of cell types and is present

52 in is an actin cross-linker and may act as a mechanosensor in adhesion sites.

53 hat NOTCH1 is atheroprotective and acts as a mechanosensor in adult arteries, where it integrates res

54 ve multiple functions, including acting as a mechanosensor in bone (re)modeling.

55 Integrins are considered to be an important mechanosensor in cardiac myocytes.

56 ' sensor in Salmonella typhimurium, and as a mechanosensor in other bacteria.

57 ponse suggests that the CRD is not a generic mechanosensor in this kinase family.

58 cytes have been hypothesized to be the major mechanosensors in bone.

59 rings that have the potential to function as mechanosensors in cells and as building blocks in spring

60 h as talin, vinculin and filamin function as mechanosensors in cells, but it has yet to be tested whe

61 sensing ion channel 3 (ASIC3) are peripheral mechanosensors in colon afferent neuronal fibers that me

62 anobiological processes, but also act as key mechanosensors in diverse functions including intracellu

63 been repurposed in eukaryotes to function as mechanosensors in multiple developmental and environment

64 a result, they have developed highly robust mechanosensors in the form of bacterial mechanosensitive

65 ity and selectivity, synchronization between mechanosensors in the mosquito arises from entrainment t

66 and polycystin-2 function as flow-sensitive mechanosensors in the same signal-transduction pathway.

67 r results suggest that podosomes are dynamic mechanosensors in which interactions of myosin tension a

68 ells (ECs) lining blood vessels express many mechanosensors, including platelet endothelial cell adhe

69 nction for neutral sphingomyelinase as a new mechanosensor initiating the ERK cascade and possibly ot

70 However, the molecular identity of the mechanosensor is not known, nor is it clear whether mult

71 and whether podosomes can function as direct mechanosensors, like focal adhesions [6-9].

72 uplex and i-motif structures, along with the mechanosensor mechanism for control of gene expression,

73 nally induced superhelicity in maintaining a mechanosensor mechanism for controlling the firing rate

74 e a model for how information from different mechanosensors might be integrated to govern remodeling.

75 on identified nociceptors and low-threshold mechanosensors (non-nociceptors) isolated from rats.

76 sed by most large DRG neurons (low-threshold mechanosensors not involved in acid-induced nociception)

77 ng that the nucleus may also act as a direct mechanosensor of substratum topography.

78 formation, i.e. the flagellum is acting as a mechanosensor of surfaces.

79 They have been proposed to function as mechanosensors of cell wall stress induced by wall remod

80 Integrins are mechanosensors of shear stress in endothelial cells, and

81 Exposure to intense sound can damage the mechanosensors of the inner ear and their afferent inner

82 y from membrane to channel as in prokaryotic mechanosensors or are they mediated through macromolecul

83 of cell adhesion-related genes including the mechanosensor p66Shc.

84 ally, short interfering RNA-knockdown of the mechanosensor PECAM-1 reverses frequency-dependent regul

85 FN fibril assembly that was dependent on the mechanosensor PECAM.

86 inhibits Epac1-mediated sensitization of the mechanosensor Piezo2 and that Piezo2 contributes to infl

87 lar protein redistribution, we show that the mechanosensor protein, vinculin, is necessary and suffic

88 oncept of the thick filament as a regulatory mechanosensor provides a novel explanation for the dynam

89 /30) that are rapidly adapting low threshold mechanosensors (RAR-like fibres).

90 e suggests that polycystin-1 (PC1) acts as a mechanosensor, receiving signals from the primary cilia,

91 that require more or less force to open the mechanosensor region demonstrate that filamin mechanosen

92 odel in which the opening and closing of the mechanosensor region regulates filamin binding to cellul

93 Under shear flow, it acts as a mechanosensor responding with a size-dependent globule-s

94 e we identify the B. subtilis flagellum as a mechanosensor that activates the DegS-DegU regulatory pa

95 system, evidence supports the AT1 R being a mechanosensor that contributes to arteriolar myogenic co

96 II and cortexillin I define a cellular-scale mechanosensor that controls cell shape during cytokinesi

97 gether, these data implicate YAP1 as a fluid mechanosensor that functions to regulate genes that prom

98 These stimuli are detected by a mechanosensor that initiates a variety of signaling syst

99 animals CONCLUSION: PC-1 is a cardiomyocyte mechanosensor that is required for cardiac hypertrophy t

100 II and cortexillin I define a cellular-scale mechanosensor that monitors and corrects shape defects,

101 the actin cross-linker cortexillin I form a mechanosensor that responds to mechanical stress, which

102 MscL is a bacterial mechanosensor that serves as a biological emergency rele

103 as aeruginosa has been implicated as a novel mechanosensor that stimulates virulence in response to s

104 ical strain and the identity of the cellular mechanosensor that triggers subsequent responses.

105 s manner, neutrophils use focal adhesions as mechanosensors that convert shear stress-mediated tensil

106 aganglionic laminar endings (IGLEs; putative mechanosensors that coordinate peristalsis) and intramus

107 identity of microvascular endothelial (MVE) mechanosensors that sense blood flow in response to mech

108 We speculate that platelet integrins are mechanosensors that test their ligands across the platel

109 Hair cells of the inner ear are mechanosensors that transduce mechanical forces arising

110 of the vertebrate inner ear are specialized mechanosensors that transduce mechanical forces arising

111 As a specialized mechanosensor, the EC cell releases this serotonin in re

112 as ion channels and focal adhesions as local mechanosensors, the investigation of how mechanical pert

113 They are mechanosensors through which cells exert actin cytoskele

114 nosensitive channel MscL is the best-studied mechanosensor, thus serving as a paradigm of how a prote

115 a indicate that the cilium can function as a mechanosensor to detect fluid flow through the lumen of

116 al activation of cardiac nNOS by acting as a mechanosensor to regulate AMPK activity, and that pharma

117 ted muscle, harbors factors that function as mechanosensors to ensure coordinated contractile activit

118 from nociceptors to their SONs, but not from mechanosensors to the same SONs, which suggests striking

119 tyrosine kinases and integrins can serve as mechanosensors to transduce mechanical stimuli into chem

120 Type IV pili (TFP) function as mechanosensors to trigger acute virulence programs in Ps

121 f a role of lipidated signaling molecules as mechanosensors, transducing mechanical stimuli to chemic

122 Like the alphabetaTCR, the pre-TCR is a mechanosensor undergoing force-based structural transiti

123 turnover of the IAC component Talin, a known mechanosensor, was analyzed using fluorescence recovery

124 this study implicate filamin-A as a tunable mechanosensor, where its sensitivity can be modulated by

125 vitro, we discovered that formin Cdc12 is a mechanosensor, whereby myosin pulling on formin-bound ac

126 MyoII acts as a mechanosensor, which directs its force-induced recruitme