ライフサイエンスコーパス: mechanotransduction

1 partners to filamentous actin, facilitating mechanotransduction.

2 nics that are likely sensed through cellular mechanotransduction.

3 naling, clathrin-independent endocytosis and mechanotransduction.

4 present an important mechanism for mediating mechanotransduction.

5 also inducing it de novo in a process termed mechanotransduction.

6 he classical neurotransmitter in endothelial mechanotransduction.

7 the extracellular milieu in a process called mechanotransduction.

8 ements, one of the main features of auditory mechanotransduction.

9 edical therapy and understanding complicated mechanotransduction.

10 oteolysis can act as a mechanism of cellular mechanotransduction.

11 o mechanical load through a process known as mechanotransduction.

12 cadherin, which may facilitate intercellular mechanotransduction.

13 logical significance of flow-induced ciliary mechanotransduction.

14 leoskeleton, and the progression of cellular mechanotransduction.

15 driven actomyosin contractility and cellular mechanotransduction.

16 ctrosensing and provide a role in lipid raft mechanotransduction.

17 r augment scar deposition through fibroblast mechanotransduction.

18 enotypic switch in prostate cancer cells via mechanotransduction.

19 which are rapidly transforming the study of mechanotransduction.

20 s essential for mechanistic understanding of mechanotransduction.

21 forces, auxeticity could be a key element in mechanotransduction.

22 o advances our fundamental knowledge of bone mechanotransduction.

23 CXXC oxidized state may be essential for TCR mechanotransduction.

24 ells, suggesting that PilY1 mediates surface mechanotransduction.

25 g that a Pcdh15a-Tmc complex is critical for mechanotransduction.

26 4-MAPK module as a regulator of pathological mechanotransduction.

27 late complexes that are proposed to underlie mechanotransduction.

28 ia and AC6 in a novel mechanism of osteocyte mechanotransduction.

29 ndian hedgehog (Ihh), a critical mediator of mechanotransduction.

30 on of cell patterning, force generation, and mechanotransduction.

31 cellular activities, a phenomenon defined as mechanotransduction.

32 in in osteocyte-polarized mechanosensing and mechanotransduction.

33 unction with, a direct stress-sensing due to mechanotransduction.

34 is, locomotion, molecular sequestration, and mechanotransduction.

35 physical mechanisms of FAK activation during mechanotransduction.

36 ) important for myofibrillar development and mechanotransduction.

37 pecialized subtype of skin cells involved in mechanotransduction.

38 d play a fundamental role in skeletal muscle mechanotransduction.

39 l bowel and that it is important for EC cell mechanotransduction.

40 n, and is an important component of cellular mechanotransduction.

41 geneous gene variants pertaining to cellular mechanotransduction.

42 of planar cell polarity (PCP) necessary for mechanotransduction.

43 r functions such as cell matrix adhesion and mechanotransduction.

44 s with FM4-64, which was used as a proxy for mechanotransduction.

45 ike organelle with an important role in bone mechanotransduction.

46 re variants in genes with a role in cellular mechanotransduction.

47 al viral macropinocytosis, phagocytosis, and mechanotransduction.

48 mation of the tripartite complex and disrupt mechanotransduction.

49 t cytoskeletal proteins that are involved in mechanotransduction.

50 ed on changes in cell adhesion, cytoskeletal mechanotransduction [5], and/or proteolysis [6], most li

51 lmonary vascular stiffness and YAP-dependent mechanotransduction altered glutaminolysis, pulmonary va

52 oding: skin displacement at touch receptors, mechanotransduction and action-potential initiation.

53 Aberrant mechanotransduction and dysregulated-microRNA pathways a

54 biological atherogenic processes, including mechanotransduction and inflammatory processes in endoth

55 Mechanotransduction and its downstream effects function

56 stereocilia and microvilli are essential for mechanotransduction and maintaining their organization.

57 d, revealing the interdependence of podocyte mechanotransduction and maintenance of their physiologic

58 covered specific protein complexes linked to mechanotransduction and mechanotransmission within the s

59 ) signalling is central to the endothelium's mechanotransduction and networked activity.

60 es (SFK) are known to play critical roles in mechanotransduction and other crucial cell functions.

61 adhesive complexes participating in cellular mechanotransduction and regulation of the Rho GTPase pat

62 first phase, the actin cytoskeleton promotes mechanotransduction and serves as a dynamic scaffold for

63 close localization, as well as their role in mechanotransduction and signaling, we hypothesized that

64 ich protein 3, is thought to mediate cardiac mechanotransduction and stress responses, whereas the mi

65 to rows of increasing height is critical for mechanotransduction and the sense of hearing.

66 or with PDZ-binding motif (TAZ) in mediating mechanotransduction and vascular homeostasis.

67 have been identified, such as cell polarity, mechanotransduction, and G-protein-coupled receptor (GPC

68 iscuss important work on integrin signaling, mechanotransduction, and lessons learned about integrin

69 rse functions including nuclear positioning, mechanotransduction, and meiotic chromosome movements.

70 Some components of the mechanotransduction apparatus have been identified, most

71 useful for exploiting ultrasound-stimulated mechanotransduction applications in the future.

72 mal rootlets, but hair bundle morphology and mechanotransduction are affected before the onset of hea

73 Although the mechanisms underlying mechanotransduction are far from being fully elucidated,

74 The mechanism(s) of chondrocyte mechanotransduction are not fully understood, but could

75 er developments in stem cell engineering and mechanotransduction are poised to have substantial impli

76 However, the mechanisms that control such mechanotransduction are poorly understood.

77 a HER2 pathway-targeted therapeutic via the mechanotransduction arm of the Hippo pathway.

78 r cell (NSPC) fate is strongly influenced by mechanotransduction as modulation of substrate stiffness

79 ctin-mediated regulation is conserved during mechanotransduction, as substrate compliance increased Y

80 Impaired mechanosensation and mechanotransduction associated with the changes in stret

81 we show that Sca4 reduces vinculin-dependent mechanotransduction at cell-cell junctions.

82 Mechanotransduction at E-cadherin junctions has been pos

83 an indispensable player in cadherin-specific mechanotransduction at intercellular junctions.

84 iple for the conducting airway tree in which mechanotransduction at the level of cells is driven to o

85 the potential for using this method to probe mechanotransduction at the single cell level.

86 ot play a role in the bundle's key function, mechanotransduction, at least until after two months of

87 vide better insights into mechanisms driving mechanotransduction-based diseases.

88 such as stiffness, and so the mathematics of mechanotransduction becomes important to understand.

89 ational testing and hypothesis generation on mechanotransduction biological relevance and involvement

90 We here present a molecular map of mechanotransduction, built in CellDesigner to warrant th

91 These are all features of hair cell mechanotransduction, but the underlying biophysical mech

92 Intercellular junctions are crucial for mechanotransduction, but whether tight junctions contrib

93 an unexpected function in the regulation of mechanotransduction by hair cells.

94 We sought to deconstruct chondrocyte mechanotransduction by identifying mechanosensitive ion

95 membrane tension exerts upstream control in mechanotransduction by periodically compressing and rela

96 Thus, mechanotransduction by primary cilia in TM cells is impl

97 that clarin-1 is functionally important for mechanotransduction channel activity and for proper loca

98 ults indicate that Piezo2 is the Merkel-cell mechanotransduction channel and provide the first line o

99 transient receptor potential (TRP) family, a mechanotransduction channel for Drosophila touch sensati

100 potential (TRP) family of ion channels, as a mechanotransduction channel for gentle touch.

101 as recently been identified as the principal mechanotransduction channel for proprioception.

102 norhabditis eleganssenses gentle touch via a mechanotransduction channel formed from the DEG/ENaC pro

103 Although prior candidates for the mechanotransduction channel have been proposed, each has

104 d, mTOMT binds to putative components of the mechanotransduction channel in hair cells and is essenti

105 Current findings indicate that the mechanotransduction channel in hair cells is a complex m

106 The mechanotransduction channel PIEZO in class IV neurons is

107 The molecular composition of the mechanotransduction channel underlying auditory percepti

108 sion of TRP-4, the pore-forming subunit of a mechanotransduction channel, sensitizes neurons to ultra

109 ng that NOMPC is a pore-forming subunit of a mechanotransduction channel.

110 NOMPC fulfils all the criteria that apply to mechanotransduction channels and has 29 ankyrin repeats,

111 In fly campaniform mechanoreceptors, the mechanotransduction channels are gated by compressive fo

112 In hair cells, mechanotransduction channels are located in the membrane

113 ICANCE STATEMENT Tip links transmit force to mechanotransduction channels at the tip of hair bundles

114 Mechanotransduction channels in hair cells are gated by

115 How force gates mechanotransduction channels is a central question in th

116 How metazoan mechanotransduction channels sense mechanical stimuli is

117 Auditory hair cells contain mechanotransduction channels that rapidly open in respon

118 parts in the adult fly, use some of the same mechanotransduction channels to detect sound waves and m

119 ss two molecularly and functionally distinct mechanotransduction channels with different subcellular

120 ound, acceleration and touch are mediated by mechanotransduction channels, which convert mechanical s

121 ce, acceleration, hearing and pain relies on mechanotransduction channels, which convert mechanical s

122 ghts into the basis of mechanosensitivity of mechanotransduction channels.

123 hair cells contain two molecularly distinct mechanotransduction channels.

124 n of selectin catch-bonds, revealing a novel mechanotransduction circuit that rapidly converts extend

125 in 15 (PCDH15) is a central component of the mechanotransduction complex in auditory and vestibular h

126 onstrate that the CR plays a key role in the mechanotransduction complex in hair cells.

127 he six touch receptor neurons (TRNs) using a mechanotransduction complex that contains the pore-formi

128 n 2 binds to the components of the hair cell mechanotransduction complex, TMC1 and TMC2, and these in

129 e been shown to interact with members of the mechanotransduction complex.

130 f water motion by the lateral line relies on mechanotransduction complexes at stereocilia tips.

131 e development, and that mTOR is an essential mechanotransduction component modulated by Shp2 in the c

132 AMP sensor) potentiation of Piezo2-mediated mechanotransduction contributes to mechanical allodynia.

133 mic control of stereocilia morphology by the mechanotransduction current.

134 on of stereocilia bundles and a reduction in mechanotransduction currents and sensitivity in cochlear

135 cal defects as the mutant mice age and while mechanotransduction currents can be evoked in early post

136 Merkel cells display fast, touch-evoked mechanotransduction currents.

137 at the observed phenotype is likely due to a mechanotransduction defect.

138 dues 315-494, which correspond to a putative mechanotransduction domain that binds vinculin in verteb

139 xidase 2 (Nox2) function as key mediators of mechanotransduction during both physiological adaptation

140 stigating the role of hemodynamic forces and mechanotransduction during morphogenesis.

141 e the role of the lipid membrane in auditory mechanotransduction, especially in generating nonlinear

142 oach provides a toolset to better understand mechanotransduction events fundamental to cell biology.

143 ted availability of tools to study molecular mechanotransduction events in live cells.

144 he mechanisms by which these finely balanced mechanotransduction events occur, however, are not well

145 In addition to biochemical mechanotransduction, evidence exists for a myosin-depend

146 ser-cut EHTs are a viable platform for novel mechanotransduction experiments and characterizing the b

147 Adaptation is a hallmark of hair cell mechanotransduction, extending the sensory hair bundle d

148 of therapeutically targeting TRPV4-mediated mechanotransduction for the treatment of diseases such a

149 During mechanotransduction, force allosterically alters the fun

150 Mechanotransduction from pulsed focused ultrasound (pFUS

151 ggest an interconnected physical pathway for mechanotransduction, from the extracellular milieu to th

152 Mechanotransduction has been divided into mechanotransmi

153 Studies of cellular mechanotransduction have converged upon the idea that ce

154 d in more detail, and detailed mechanisms of mechanotransduction have started to emerge.

155 are of functional importance in chondrocyte mechanotransduction; however, direct evidence of mechani

156 ment as an adhesion-independent mechanism of mechanotransduction in 3D culture, and highlight stress

157 ted stiffening hydrogels to investigate cell mechanotransduction in a disease-relevant system.

158 nitial adhesions on fibronectin, but impairs mechanotransduction in a subsequent step, preventing adh

159 provide insights into the molecular basis of mechanotransduction in a tactile-specialist vertebrate.

160 strate that loss of TRPV4-mediated cartilage mechanotransduction in adulthood reduces the severity of

161 y distinct roles of TRPV4-mediated cartilage mechanotransduction in age-related and post-traumatic OA

162 , and show that both are deaf and exhibit no mechanotransduction in auditory hair cells, despite the

163 Mechanotransduction in Caenorhabditis elegans touch rece

164 eful information about the important role of mechanotransduction in cancer, and how circulating tumor

165 the potential of pharmacologically targeting mechanotransduction in cancer.

166 the present study provide new insights into mechanotransduction in cardiac myocytes.

167 t our methods as a resource for the study of mechanotransduction in cell-cell adhesions [corrected].

168 approach with which to systematically study mechanotransduction in confined environments.

169 M is therefore a simple method for assessing mechanotransduction in hair cells and permits an increas

170 x rigidity in fibrotic livers would activate mechanotransduction in hepatocytes and lead to inhibitio

171 llular perturbation of nuclear mechanics and mechanotransduction in live cells.

172 which along with TMC1 has been implicated in mechanotransduction in mammalian hair cells.

173 nels that are hypothesized to play a role in mechanotransduction in mammals.

174 Together, this study elucidates the mechanotransduction in MSCs fate commitments and display

175 al control of axonal sorting and the role of mechanotransduction in myelination are largely unknown.

176 (Asic3(f/f)) and probe the role of ASIC3 in mechanotransduction in neurite-bearing Pv+ DRG neurons t

177 ibrotic levels of matrix stiffness activated mechanotransduction in primary hepatocytes through focal

178 t sensitivity to dynamic stimuli and impairs mechanotransduction in Pv+ DRG neurons because of substr

179 C disease xerocytosis, implicating a role of mechanotransduction in RBC volume regulation.

180 ruction of the bundle is required for proper mechanotransduction in response to external forces and t

181 Protocadherin 15 (PCDH15) is required for mechanotransduction in sensory hair cells as a component

182 Piezo1 ion channels are mediators of mechanotransduction in several cell types including the

183 otubules increase cytoskeletal stiffness and mechanotransduction in striated muscle and that targetin

184 Mechanotransduction in the auditory and vestibular syste

185 av3 protein can modify integrin function and mechanotransduction in the CM and intact heart.

186 ereocilia and a kinocilium, is essential for mechanotransduction in the ear.

187 he cells to paclitaxel, suggesting a role of mechanotransduction in the evolution of drug resistance.

188 mechanism is still not fully understood for mechanotransduction in the hair bundle of auditory senso

189 protrusions with graded heights that mediate mechanotransduction in the inner ear.

190 the surface of eukaryotic cells that mediate mechanotransduction in the kidney, brain, and bone.

191 Mechanotransduction in the mammalian auditory system dep

192 ur data also underscore the role of impaired mechanotransduction in the pathology of this hereditary

193 ke 2b (Tmc2b) is differentially required for mechanotransduction in the zebrafish lateral line.

194 ownstream bioeffects such as cell injury and mechanotransduction in ultrasound therapy, the fundament

195 mary cilium-dependent mechanism of osteocyte mechanotransduction in vitro.

196 er the Pcdh15-Tmc interaction is relevant to mechanotransduction in vivo, we overexpressed N-terminal

197 main distortion as a bona fide mechanism for mechanotransduction in vivo.

198 ghts into different biomechanical states for mechanotransduction, including the first estimate of the

199 RK, and Wnt were found to be involved in the mechanotransduction-induced phenotypic switching of pros

200 How mechanotransduction intersects with chemical and transcr

201 MKs adapt to extracellular stiffness through mechanotransduction involving actomyosin-based modulatio

202 ient murine hair cells start to develop, but mechanotransduction is affected and stereocilia deterior

203 ption, but its possible role in neurosensory mechanotransduction is disputed.

204 One of the earliest events in cellular mechanotransduction is often an increase in intracellula

205 However, the molecular mechanism of EC cell mechanotransduction is unknown.

206 till debated, and the molecular mechanism of mechanotransduction is unknown.

207 Yet, the characterization of mechanotransduction lacks some of the most basic tools a

208 eolin-1/ERK and Wnt/beta-catenin pathways in mechanotransduction leading to osteocyte survival.

209 re mTOMT is critical for the assembly of the mechanotransduction machinery of hair cells.

210 is an essential component of the hair cell's mechanotransduction machinery that functionally couples

211 oth thought to be integral components of the mechanotransduction machinery.

212 We suggest that cellular mechanotransduction may be an important mechanism underl

213 Such a fluctuation-driven mechanotransduction mechanism is mediated by motor prote

214 However, the EC cell mechanotransduction mechanism is unknown.

215 roperties and biological structure, cellular mechanotransduction mechanisms also exist.

216 ease genes, including PPAP2B, participate in mechanotransduction mechanisms by which vascular endothe

217 rials and a better understanding of cellular mechanotransduction mechanisms may support the translati

218 stenotic kidney function, likely in part by mechanotransduction-mediated expression of angiogenic fa

219 Importantly, such a mechanotransduction-mediated phenotypic switch in prosta

220 We show that functional, mechanotransduction-mediating tip links have at least tw

221 d vestibular phenotypes are due to a lack of mechanotransduction (MET) in Tomt-deficient hair cells.

222 und perception requires functional hair cell mechanotransduction (MET) machinery, including the MET c

223 nence and overactive bladder due to abnormal mechanotransduction; more broadly, our findings indicate

224 ify a number of cellular functions including mechanotransduction, nuclear localization, chromatin pos

225 es in situ are highly polarized cells, where mechanotransduction occurs at substrate attachment sites

226 ar shaping, cytoskeletal remodeling, and the mechanotransduction of external forces into biochemical

227 Implications for mechanotransduction of hemodynamic forces are discussed.

228 It is well known that mechanotransduction of hemodynamic forces mediates cellu

229 itis by attenuating Piezo-mediated cartilage mechanotransduction of injurious strains.

230 artilage, as well as the differentiation and mechanotransduction of mesenchymal stem cells, osteoblas

231 promoter in human cutaneous SCC and acts via mechanotransduction of signals to beta-catenin.

232 tle is known regarding the protein's role in mechanotransduction or as a modulator of RhoA signaling.

233 In striated muscle, X-ROS is the mechanotransduction pathway by which mechanical stress t

234 to therapeutically target the TRPV4-mediated mechanotransduction pathway for the treatment of aging-a

235 This study identifies components of the mechanotransduction pathway in the oligodendrocyte linea

236 d ex vivo and in vivo approaches to define a mechanotransduction pathway involving Rho/Rho kinase (Rh

237 One reported mechanotransduction pathway of increased endothelial cel

238 Here, we have identified a mechanotransduction pathway that translates laminar flow

239 Pharmacologic disruption of this mechanotransduction pathway with the ROCK inhibitor fasu

240 To uncover a new mechanotransduction pathway, we study the frequency-depe

241 ects may arise due to subtle defects in this mechanotransduction pathway.

242 detail the key signaling components of such mechanotransduction pathways and extracellular matrix co

243 le for examining BM stiffness and underlying mechanotransduction pathways as therapeutic targets for

244 Mechanotransduction pathways convert forces that stress

245 Then we specially focus on mechanotransduction pathways in cancer progression and d

246 water content, particularly associated with mechanotransduction pathways, have revealed novel mechan

247 genes showed that collagen gels desensitise mechanotransduction pathways.

248 ing reported recently, and mediates distinct mechanotransduction pathways.

249 in vivo, we altered brain stiffness, blocked mechanotransduction pharmacologically and knocked down t

250 However, whether this mechanotransduction phenomenon holds for in situ osteocy

251 To directly evaluate whether mechanotransduction plays a role in glial cell different

252 Integrin-mediated mechanotransduction plays important roles in development

253 es in which aberrant integrin activation and mechanotransduction precipitate changes in cell spreadin

254 way that is upstream of previously described mechanotransduction processes and demonstrate that P2Y2

255 hannel families that have been implicated in mechanotransduction processes and evaluate the qualifica

256 lacking endogenous MA channels to assay the mechanotransduction properties of various proteins.

257 Integrins are adhesive, signaling, and mechanotransduction proteins.

258 Inhibition of mechanotransduction provides a novel locus of action of

259 identify a new pathway by which endothelial mechanotransduction regulates FN assembly and flow-media

260 The study of mechanotransduction relies on tools that are capable of

261 However, the mechanisms of mechanotransduction remain elusive.

262 ter cell fate, yet the mechanisms underlying mechanotransduction remain obscure because of a lack of

263 owever, the cytoplasmic components mediating mechanotransduction remain unclear.

264 far, no arterial-specific mediators of this mechanotransduction response have been identified.

265 Our results suggest that filamin-FilGAP mechanotransduction response is best explained by a band

266 In mechanotransduction, sensory receptors convert force int

267 Agrin may act as a mechanotransduction signal in the extracellular matrix (

268 Previous work has identified several mechanotransduction signaling processes that are involve

269 iliary base may be an essential regulator of mechanotransduction signaling.

270 igurations predicted that the arrangement of mechanotransduction sites at heminodes is a key structur

271 une synapse formation, actin foci formation, mechanotransduction, T cell transendothelial migration,

272 They may mediate mechanotransduction, the conversion of external mechanic

273 Mechanotransduction, the conversion of physical forces i

274 Mechanotransduction, the pathway by which mechanical for

275 Mechanotransduction--the ability to output a biochemical

276 olecular and systems-level understandings of mechanotransduction through a multiscale model linking t

277 tretch-induced division orientation required mechanotransduction through E-cadherin cell-cell adhesio

278 esult suggests that Shp2 is an antagonist of mechanotransduction through inhibition of mTOR activity.

279 ron differentiation by altering cytoskeletal mechanotransduction through the Hippo/YAP/Smad pathway.

280 Thus, endothelial flow mechanotransduction through the junctional complex is me

281 tional effectors of the Hippo pathway and of mechanotransduction to myelin formation in Schwann cells

282 ad manipulate host intercellular tension and mechanotransduction to promote spread.

283 spect ratio, and size) and study the nuclear mechanotransduction to regulate gene expression.

284 in response to shear stress, linking Piezo1 mechanotransduction to regulation of cell morphology.

285 nd architecture influence gene localization, mechanotransduction, transcription, and cell function.

286 reproduces the main properties of hair-cell mechanotransduction using only realistic parameters cons

287 ulation may enable the cell to fine tune its mechanotransduction via membrane receptors.

288 educed in mutant hair cells, indicating that mechanotransduction was also compromised.

289 tic leukemia 1 (MKL1), a well-known actor in mechanotransduction, was found to be preferentially relo

290 Using a 3D model for mechanotransduction we find that perturbations in the sh

291 metabolism, microenvironment, immunity, and mechanotransduction were discussed.

292 aa) and sputnik (cad23) that lack functional mechanotransduction were resistant to cisplatin-induced

293 establish a fast, non-tension mechanism for mechanotransduction where disruption of ordered lipids i

294 Here, we design and analyze a model of mechanotransduction where each tip link attaches to two

295 However, the process of mechanotransduction whereby a mechanical stimulus gives

296 l line, we found that chemical inhibition of mechanotransduction with quinine and EGTA protected agai

297 mparisons of gene expression, cell shape and mechanotransduction, with an in vivo reference, have not

298 suggests how they may function in inner-ear mechanotransduction, with implications for other cadheri

299 MP (cAMP) production, which is important for mechanotransduction within the inner ear, is catalyzed b

300 rway stretch sensor and that Piezo2-mediated mechanotransduction within various airway-innervating se