ライフサイエンスコーパス: mechlorethamine

1 usly the crosslinking of formal C-C pairs by mechlorethamine).

2 ks by nitrogen mustards, e.g., melphalan and mechlorethamine.

3 formal mismatch pairs can be crosslinked by mechlorethamine.

4 l comparing mechlorethamine, 0.02%, gel with mechlorethamine, 0.02%, compounded ointment.

5 The use of a novel mechlorethamine, 0.02%, gel in the treatment of patients

6 bserver-blinded, multicenter trial comparing mechlorethamine, 0.02%, gel with mechlorethamine, 0.02%,

7 vity yeast pso2Delta mutants display towards mechlorethamine, an ICL-inducing compound.

8 the C-C cross-link is pH dependent for both mechlorethamine and chlorambucil.

9 Mechlorethamine and melphalan are used as model systems

10 A detailed analysis of energy profiles of mechlorethamine and melphalan binding to guanine and ade

11 cross-linking by two nitrogen mustard drugs, mechlorethamine and melphalan.

12 the monofunctionally bound intermediates of mechlorethamine and phosphoramide mustard assumed thermo

13 Mechlorethamine and phosphoramide mustard induced intras

14 thylenemelamine, and short-lived response to mechlorethamine and prednisone.

15 thecin, aphidicolin, hydroxyurea, cisplatin, mechlorethamine and x-rays) on key nuclear and cytoplasm

16 involved in the repair of nitrogen mustard (mechlorethamine)- and cisplatin-induced DNA ICLs, but th

17 zine, and prednisone (MOPP) or procarbazine, mechlorethamine, and vinblastine (PAVe) in S studies; MO

18 ealed that curcumin inhibited camptothecin-, mechlorethamine-, and doxorubicin-induced apoptosis of M

19 he face of treatment with alkylating agents (mechlorethamine), anthracylines (doxorubicin), and micro

20 For the mustards mechlorethamine, chlorambucil, and melphalan, both sites

21 Here, we report the formation of a new mechlorethamine cross-link with the d[GXC].d[GYC] fragme

22 Mechlorethamine cross-links this fragment preferentially

23 (10)-C(29) and C(13)-C(26), we show that two mechlorethamine crosslinks form between C(13) and C(29)

24 rgic contact dermatitis to topically applied mechlorethamine decreased with advancing stage of diseas

25 Cisplatin and mechlorethamine, DNA crosslinking agents, caused dose- a

26 uced dose of bleomycin compared with VBM) or mechlorethamine, doxorubicin, vinblastine, vincristine,

27 in, vinblastine, and dacarbazine (ABVD) with mechlorethamine, doxorubicin, vincristine, bleomycin, vi

28 itor, SD-282, suppressed MKP-1 activation by mechlorethamine, enhanced active JNK levels, and increas

29 esponse analyses demonstrated superiority of mechlorethamine gel to ointment (P< .01).

30 Response rates for mechlorethamine gel vs ointment were 58.5% vs 47.7% by t

31 Combination treatment with doxorubicin and mechlorethamine had similar effects, and the enhanced ef

32 Nitrogen mustards such as mechlorethamine have previously been shown to covalently

33 ethyl-N'-nitro-N-nitrosoguanidine (MNNG) and mechlorethamine HCl (HN2), oxidizing agents, such as hyd

34 ically used nitrogen mustard antitumour drug mechlorethamine (HN2), were quantitated at the level of

35 est that the C-C mismatch is cross-linked by mechlorethamine in the minor groove.

36 ated with triplet repeat expansion diseases, mechlorethamine may serve as a useful probe for these st

37 chemotherapeutic nitrogen mustards (namely, mechlorethamine, melphalan, and chlorambucil), at least

38 ed responses in 52% of patients treated with mechlorethamine (nitrogen mustard), vincristine, and pro

39 in the aprt gene was treated with melphalan, mechlorethamine or phosphoramide mustard.

40 on of a reactive intermediate in the case of mechlorethamine, our model predicts a significant prefer

41 sity of pretransplantation chemotherapy with mechlorethamine (relative risks [RRs] = 2.0 and 4.3 for

42 doxorubicin, cyclophosphamide, and etoposide/mechlorethamine, vincristine, procarbazine, and predniso

43 curs after frontline chemotherapy with MOPP (mechlorethamine, vincristine, procarbazine, and predniso

44 A randomized trial designed to compare mechlorethamine, vincristine, procarbazine, and predniso

45 Primary chemotherapy was mechlorethamine, vincristine, procarbazine, and predniso

46 cin, vinblastine, and dacarbazine (ABVD) and mechlorethamine, vincristine, procarbazine, prednisone,

47 Mechlorethamine was applied once daily for up to 12 mont

48 rmation of corresponding aziridinium ion for mechlorethamine, while the formation of the aziridinium

49 A mycosis fungoides who had not used topical mechlorethamine within 2 years and were naive to prior u