ライフサイエンスコーパス: medial temporal lobe

1 d to the hippocampus or large lesions of the medial temporal lobe.

2 ty between these regions as well as with the medial temporal lobe.

3 on between these regions as well as with the medial temporal lobe.

4 pital cortex, posterior parietal cortex, and medial temporal lobe.

5 orbital frontal cortex, temporal cortex, and medial temporal lobe.

6 interference resolution throughout the human medial temporal lobe.

7 be, cingulate cortex, fusiform, putamen, and medial temporal lobe.

8 osis, are localized to neocortex rather than medial temporal lobe.

9 ories, and less sparse than elsewhere in the medial temporal lobe.

10 on-carriers, with trend-level effects in the medial temporal lobe.

11 vulnerable to the AD process, including the medial temporal lobe.

12 fimbria-fornix in regions located within the medial temporal lobe.

13 scan times and does not show laminae in the medial temporal lobe.

14 ently associated with imaging changes in the medial temporal lobe.

15 ward pathway are dopaminergic targets in the medial temporal lobe.

16 ad appeared primarily in the hippocampus and medial temporal lobe.

17 ssociated with increased (18)F-AV1451 in the medial temporal lobe.

18 executive networks, and striatum) and/or the medial temporal lobe.

19 y engage the two information pathways in the medial temporal lobes.

20 likely draws on neural resources outside the medial temporal lobes.

21 The seizure focus lies in the medial temporal lobes.

22 al cortex, angular gyrus, posterior MTG, and medial temporal lobes.

23 interconnected with memory structures in the medial temporal lobe [4].

24 elatively less pronounced involvement of the medial temporal lobe, abnormal cerebrospinal fluid amylo

25 compared with incorrect retrieval, with the medial temporal lobe acting as a hub for these interacti

26 onkeys with neonatal ablations of either the medial temporal lobe (AH) or the inferior temporal corte

27 s its major source in the bilateral anterior medial temporal lobe (AMTL) whereas it is suggested that

28 iduals with notably focal involvement of the medial temporal lobe and a slow steady progression, like

29 r binding that was confined primarily to the medial temporal lobe and adjacent neocortical regions.

30 haviour relationships (i.e. episodic memory: medial temporal lobe and angular gyrus; semantic memory:

31 tions between rather than within the visual, medial temporal lobe and default mode networks, whereas

32 is work with emphasis on the neuroanatomy of medial temporal lobe and diencephalic structures importa

33 Therefore, medial temporal lobe and dorsal striatum structures appe

34 ion were correlated with BOLD signals in the medial temporal lobe and frontal cortex.

35 Medial temporal lobe and hippocampal subfields were quan

36 usually from medial prefrontal cortex to the medial temporal lobe and hippocampus.

37 ween hippocampal area CA1 and regions of the medial temporal lobe and midbrain during extended blocks

38 sociations of olfactory tract integrity with medial temporal lobe and posterior cortical structures.

39 ight the importance of phase coding in human medial temporal lobe and suggest that different brain re

40 with localised volume loss in the thalamus, medial temporal lobe and temporal neocortex.

41 inal cortex sits at the boundary between the medial temporal lobe and the ventral visual pathway.

42 case of bilateral, symmetrical damage to the medial temporal lobe and well-documented memory impairme

43 icits across studies, suggesting multi-focal medial temporal lobe and/or prefrontal cortex dysfunctio

44 r's disease, there is focal tauopathy in the medial temporal lobes and adjacent cortices.

45 dependent on the engagement of the posterior medial temporal lobes and eloquent cortex.

46 FC as part of a memory network including the medial temporal lobes and hippocampus.

47 es that several brain regions, including the medial temporal lobes and prefrontal cortex (PFC), are i

48 Based on evidence that the medial temporal lobes and prefrontal cortex represent co

49 eflected through increased activation in the medial temporal lobes and prefrontal cortex, and more co

50 n regions, including the thalamus, bilateral medial temporal lobe, and cerebellum.

51 he midbrain, basal ganglia, basal forebrain, medial temporal lobe, and discrete cortical regions.

52 n the posterior cingulate gyrus, lateral and medial temporal lobe, and occipital lobe as well as caud

53 receive inputs from extrastriate cortex, the medial temporal lobe, and three subcortical structures (

54 during deep sleep and that the thalamus and medial temporal lobe are involved in establishing the mn

55 Although the pivotal role of the medial temporal lobe as a whole for memory formation is

56 words and faces in the ipsilateral anterior medial temporal lobe as strongest predictors for postope

57 n the medial prefrontal, medial parietal and medial temporal lobes as well as activated regions in th

58 rment highlights aberrant development in the medial temporal lobe associated with the occurrence of p

59 Associations between cognition, medial temporal lobe atrophy (MTA), lesion volumes, and

60 g (n = 35) by using the Scheltens' scale for medial temporal lobe atrophy (MTA), the Koedam's scale f

61 mpal atrophy (RR=2.59, 95% CI=1.95 to 3.44), medial temporal lobe atrophy (RR=2.11, 95% CI=1.70 to 2.

62 nes have also recommended the application of medial temporal lobe atrophy rating.

63 , bicaudate index, global cortical (GCA) and medial temporal lobe atrophy scores and single voxel (ba

64 on4, abnormal CSF tau level, hippocampal and medial temporal lobe atrophy, entorhinal atrophy, depres

65 INTERPRETATION: Medial temporal lobe AV-1451 uptake distinguishes AD dem

66 Medial temporal lobe AV-1451 uptake distinguishes AD dem

67 ntified regions in the prefrontal cortex and medial temporal lobe believed to be important for each o

68 r gray matter reductions over 6 years in the medial temporal lobes bilaterally.

69 boratory settings, the hippocampus and other medial temporal lobe brain structures have been shown to

70 diversity of spatial coding across the human medial temporal lobe by recording neuronal activity duri

71 mical changes in the hippocampus and related medial temporal lobe circuitry-brain areas that are impo

72 structure and connectivity exist within the medial temporal lobe circuits that contribute to learnin

73 ng experiences, typical neurons in the human medial temporal lobe code for a considerable range of ob

74 me and greater glucose hypometabolism in the medial temporal lobe compared with the other CN groups.

75 Stimulations in the medial temporal lobe components of the DN evoked relativ

76 differences in the salience network and the medial temporal lobe contribute to memory impairment in

77 mal rejection of a single-process account of medial temporal lobe contributions to recognition memory

78 tive activation in the ipsilateral posterior medial temporal lobe correlated with worse postoperative

79 ecise contributions of the subregions in the medial temporal lobe cortex (MTLC), most notably the per

80 rior work has implicated the hippocampus and medial temporal lobe cortex in memory for temporal infor

81 pecific to the hippocampus, and not found in medial temporal lobe cortex, category-selective areas of

82 dic memory propose a division of labor among medial temporal lobe cortices comprising the parahippoca

83 (DG), and the subiculum as well as adjacent medial temporal lobe cortices in healthy carriers and no

84 s implicated the hippocampus and surrounding medial temporal lobe cortices in support of recognition

85 However, the nature of contributions of medial temporal lobe cortices to downstream hippocampal

86 xed recognition signaling distributed across medial temporal lobe cortices.

87 Yet memory-impaired patients with medial temporal lobe damage are sometimes impaired at re

88 estigations have reported that patients with medial temporal lobe damage exhibit an abnormally large

89 of impaired discrimination performance after medial temporal lobe damage may reflect impaired learnin

90 ork and was predicted by a common profile of medial temporal lobe downregulation involving the anteri

91 memory function to the ipsilateral posterior medial temporal lobe due to the underlying disease, sugg

92 erved patterns of neural activity across the medial temporal lobe during an associative learning task

93 dean distance to the goal are encoded by the medial temporal lobe during navigation.

94 ion in an a priori region of interest in the medial temporal lobe during verbal encoding and recognit

95 ea that such changes are merely secondary to medial temporal lobe dysfunctions is challenged.

96 We studied 33 patients with unilateral medial temporal lobe epilepsy (16 left) before, 3 and 12

97 We studied 36 patients with unilateral medial temporal lobe epilepsy (19 right) before and 3 an

98 We studied 46 patients with unilateral medial temporal lobe epilepsy (25/26 left hippocampal sc

99 We studied 72 patients with unilateral medial temporal lobe epilepsy (41 left) and 20 healthy c

100 Medial temporal lobe epilepsy (MTLE) is associated with

101 e induced neuronal loss and axonal damage in medial temporal lobe epilepsy (MTLE) may lead to the dev

102 gs establish further parallels between human medial temporal lobe epilepsy and a naturally occurring

103 Humans with medial temporal lobe epilepsy present with white matter

104 vity dynamics before spontaneous seizures in medial temporal lobe epilepsy.

105 ory systems in the parahippocampal gyrus and medial temporal lobe, especially involving the perirhina

106 Beyond the medial temporal lobe, event-specific reactivation was fo

107 tive activation in the ipsilateral posterior medial temporal lobe for encoding words correlated with

108 tes the amygdala, which in turn prepares the medial temporal lobe for memory formation.

109 s, and additional activity in the insula and medial temporal lobe for positively valent shots recalle

110 howed increased functional coupling with the medial-temporal lobe, for remembered objects only.

111 ngs indicate that the PACAP system modulates medial temporal lobe function in humans.

112 en single-process and dual-process models of medial temporal lobe function.

113 memory system with a particular emphasis on medial temporal lobe function.

114 al ganglia (g = 0.39; 95% CI, 0.09-0.70) and medial temporal lobe (g = 0.32; 95% CI, 0.12-0.52).

115 Though memory dependent on the medial temporal lobes has been shown to drive attention,

116 In contrast, the cerebellum and medial temporal lobes have levels of aerobic glycolysis

117 Reorganization within the medial temporal lobe, however, is an efficient process.

118 even for a task that reliably activates the medial temporal lobes (i.e., autobiographical recall).

119 of the functional organization of the human medial temporal lobes in which the PRC and PHC are assoc

120 ce for functional differentiation within the medial temporal lobe, in that we show the hippocampus co

121 refrontal cortex, the fusiform gyrus and the medial temporal lobe including both perirhinal and parah

122 , sensorimotor cortex, the striatum, and the medial temporal lobe, including the amygdala.

123 The medial temporal lobe, including the hippocampus, has bee

124 ns between objects supported by the anterior medial temporal lobes, including the perirhinal cortex,

125 umed that incipient protein pathology in the medial temporal lobe instigates the loss of episodic mem

126 The basal ganglia and medial temporal lobe interact competitively or cooperati

127 found that amyloid-beta accumulation in the medial temporal lobe is associated with accumulation in

128 In mammals, the medial temporal lobe is crucial for this rapid form of l

129 The medial temporal lobe is implicated as a key brain region

130 Binding errors support the view that the medial temporal lobe is involved in linking together dif

131 Some prominent studies have claimed that the medial temporal lobe is not involved in retention of inf

132 esolved question in our understanding of the medial temporal lobes is how functional differences betw

133 studies of path integration in patients with medial temporal lobe lesions and rats with hippocampal l

134 The patient with large medial temporal lobe lesions had intact remote memory, m

135 eficit and the type of error associated with medial temporal lobe lesions remains to be fully establi

136 e assessed the ability of four patients with medial temporal lobe lesions to maintain varying numbers

137 ippocampal damage and one patient with large medial temporal lobe lesions were tested for their abili

138 prising theoretical modeling, the effects of medial temporal lobe lesions, and electrophysiological s

139 ent in the early-onset group, and more focal medial temporal lobe loss in the late-onset group.

140 ignificantly lower gray matter volume in the medial temporal lobe (maximum z score = 5.2 and cluster

141 ese findings suggest that dysfunction in the medial temporal lobe may represent a very early sign of

142 unction in specific brain systems, notably a medial temporal lobe memory system and a frontostriatal

143 Here we show that a key part of the medial temporal lobe memory system previously reported t

144 tures that are considered to be part of the "medial temporal lobe memory system" could play a role in

145 perirhinal cortex, two key components of the medial temporal lobe memory system, provide qualitativel

146 Declarative memory is known to depend on the medial temporal lobe memory system.

147 inciple for studying higher-level vision and medial temporal lobe memory.

148 onal specialization of structures within the medial temporal lobe "memory system," as well as the ind

149 In concert with other spatial cells in the medial temporal lobe (MTL) [3-6], they provide a represe

150 studies accordingly have reported increased medial temporal lobe (MTL) activation during exemplar ge

151 two experiments, patients with damage to the medial temporal lobe (MTL) and healthy controls produced

152 nial electroencephalography across the human medial temporal lobe (MTL) and neocortex during sleep an

153 eval processes, which may depend on specific medial temporal lobe (MTL) and prefrontal cortex (PFC) s

154 critical question for memory research is how medial temporal lobe (MTL) and prefrontal cortex (PFC),

155 ns of the brain, including subregions of the medial temporal lobe (MTL) and the posterior parietal co

156 iking responses of individual neurons in the medial temporal lobe (MTL) are attenuated, delayed, and

157 It remains an intriguing question why the medial temporal lobe (MTL) can display either attenuatio

158 The medial temporal lobe (MTL) can represent information fro

159 Increased cSFS-medial temporal lobe (MTL) connectivity was associated w

160 The medial temporal lobe (MTL) contains "concept cells" that

161 Patients with medial temporal lobe (MTL) damage are sometimes impaired

162 However, in humans, the impact of bilateral medial temporal lobe (MTL) damage on a large-scale neura

163 AKT1 controls important processes in medial temporal lobe (MTL) development and plasticity, b

164 generated from representational accounts of medial temporal lobe (MTL) function, that the major whit

165 Recordings in the human medial temporal lobe (MTL) have demonstrated the existen

166 Given the critical role of the medial temporal lobe (MTL) in episodic memory, age-relat

167 The medial temporal lobe (MTL) is an early site of tau accum

168 The medial temporal lobe (MTL) is believed to support episod

169 Neural circuitry in the medial temporal lobe (MTL) is critically involved in men

170 The medial temporal lobe (MTL) is generally thought to be cr

171 The medial temporal lobe (MTL) is the first brain area to su

172 By contrast, one patient with large medial temporal lobe (MTL) lesions performed poorly over

173 tients with hippocampal lesions (H) or large medial temporal lobe (MTL) lesions, including patients w

174 The medial temporal lobe (MTL) makes critical contributions

175 yloid-beta on age-related changes within the medial temporal lobe (MTL) memory system is less clear.

176 Left medial temporal lobe (MTL) NAA/Cho but not NAA/Cr was de

177 During learning we recorded from medial temporal lobe (MTL) neurons that responded to at

178 We show that among medial temporal lobe (MTL) neurons, certain populations

179 n4 allele have been reported to have greater medial temporal lobe (MTL) pathology and poorer memory t

180 hat chronic seizures disrupting the anterior medial temporal lobe (MTL) preserve anterior and posteri

181 Several models have proposed that different medial temporal lobe (MTL) regions represent different k

182 d with activations in frontal, parietal, and medial temporal lobe (MTL) regions.

183 es and study how single neurons in the human medial temporal lobe (MTL) respond to the same images el

184 levated dopamine function and alterations in medial temporal lobe (MTL) structure and function are tw

185 y also demonstrated functional impairment of medial temporal lobe (MTL) structures by systemic inflam

186 loid (Abeta) and tau proteins and atrophy of medial temporal lobe (MTL) structures crucial to memory

187 Intense debate surrounds the role of medial temporal lobe (MTL) structures in recognition mem

188 Medial temporal lobe (MTL) structures may constitute a r

189 There has been interest in the idea that medial temporal lobe (MTL) structures might be especiall

190 y depend upon the hippocampus and associated medial temporal lobe (MTL) structures.

191 tocol to delineate the alERC/pmERC and other medial temporal lobe (MTL) subregions.

192 f memory concerns whether there are distinct medial temporal lobe (MTL) substrates of recollection an

193 verage on the functional properties of human medial temporal lobe (MTL) substructures.

194 egulate the activity of their neurons in the medial temporal lobe (MTL) to alter the outcome of the c

195 ogical data indicate that tau tangles in the medial temporal lobe (MTL) underlie episodic-memory impa

196 enual anterior cingulate cortex (ACC) to the medial temporal lobe (MTL) with diffusion tensor imaging

197 And if so, how is this accomplished by the medial temporal lobe (MTL), a brain region intimately li

198 was associated with impaired functioning of medial temporal lobe (MTL), a brain region that is cruci

199 Neurons in the medial temporal lobe (MTL), a critical area for declarat

200 ently results in reduced activity within the medial temporal lobe (MTL), and this response is believe

201 lateral parietal and posteromedial cortices, medial temporal lobe (MTL), hippocampus, and ventral pre

202 sing source reconstruction we found that the medial temporal lobe (MTL), in a location compatible wit

203 It is debated whether subregions within the medial temporal lobe (MTL), in particular the hippocampu

204 nctional divisions between structures in the medial temporal lobe (MTL), in particular the perirhinal

205 sed HFA in the left hemisphere including the medial temporal lobe (MTL), left inferior frontal gyrus,

206 emonstrate functional segregation within the medial temporal lobe (MTL), showing domain specificity i

207 er MDMA, and this was localized to the right medial temporal lobe (MTL), thalamus, inferior visual co

208 The idea that the medial temporal lobe (MTL), traditionally viewed as an e

209 ns is thought to depend on structures in the medial temporal lobe (MTL), whereas associations learned

210 How is such demand met by neurons in the medial temporal lobe (MTL), which plays a fundamental ro

211 ated recent proposals that structures in the medial temporal lobe (MTL)--in particular, perirhinal co

212 The medial temporal lobe (MTL)-hippocampus and surrounding p

213 he activity of neuronal ensembles within the medial temporal lobe (MTL).

214 al substrates in the striatum and not on the medial temporal lobe (MTL).

215 een the RSC and memory structures within the medial temporal lobe (MTL).

216 is critically dependent on structures of the medial temporal lobe (MTL).

217 with reduced glucose metabolism of the left medial temporal lobe (MTL; r(2) = 0.38) and correlated w

218 The medial temporal lobes (MTL) are known to play a crucial

219 upports the central involvement of the human medial temporal lobes (MTL) in storing and retrieving me

220 linked to differential contributions of the medial temporal lobes (MTL) to episode-specific memory a

221 racted course of development relative to the medial temporal lobes (MTL).

222 for the lateral prefrontal cortex (PFC) and medial temporal lobes (MTL).

223 We find that suppression in a medial temporal lobe network changes trial-by-trial in p

224 We recorded medial temporal lobe neuronal activity as epilepsy patie

225 Closed-loop experimental testing of single medial temporal lobe neurons in humans reveals top-down

226 dings with cell-type-specific imaging in the medial temporal lobe of cognitively assessed, aged rhesu

227 nal magnetic resonance imaging (fMRI) in the medial temporal lobes of monkeys and humans, respectivel

228 (fMRI) studies of recognition memory and the medial temporal lobe often suggest qualitative differenc

229 fully characterize the effects of DBS in the medial temporal lobe on human memory.

230 bilateral anterior cingulate, frontal pole, medial temporal lobe, opercular cortex and right orbitof

231 y reflect subtle structural pathology in the medial temporal lobes or the effects of the propagation

232 a nigra and ventral tegmental area (SN/VTA), medial temporal lobe, or subsequent memory performance.

233 tal, lateral parietal, lateral temporal, and medial temporal lobes (P < .05, familywise error correct

234 In anterior cingulate cortex, insula, medial temporal lobe, parahippocampal gyrus, striatum, a

235 The medial temporal lobes play an important role in episodic

236 Lower glucose metabolism in the left medial temporal lobe predicted by HOMA-IR was significan

237 The medial temporal lobes, prefrontal cortex and parts of pa

238 d-beta] in AD, which typically begins in the medial temporal lobe progressing along the cortical defa

239 ssociation was especially robust in the left medial temporal lobe (R2 = 0.178).

240 and conduct detailed 3D measurements in the medial temporal lobe region.

241 ng than in other hippocampal (e.g., CA3) and medial temporal lobe regions (e.g., entorhinal cortex).

242 ivity of the posterior cingulate cortex with medial temporal lobe regions (mean [SD] parameter estima

243 ral alterations in the hippocampus and other medial temporal lobe regions have been observed in schiz

244 g memories from awareness not only modulates medial temporal lobe regions involved in explicit retent

245 nctional connectivity between these distinct medial temporal lobe regions with the ventral tegmental

246 MCI) with evidence of early hyperactivity in medial temporal lobe regions, followed by failure of hip

247 the pathophysiology of schizophrenia in key medial temporal lobe regions.

248 n a sample of human patients with unilateral medial temporal lobe resection that included the amygdal

249 Adults with right (n = 13) or left (n = 5) medial temporal lobe resections were compared with demog

250 these results show that many neurons in the medial temporal lobe signal the subjects' perceptual dec

251 ve of accumulation of early tauopathy in the medial temporal lobe, specifically in the entorhinal cor

252 The amygdala is a medial temporal lobe structure implicated in social and

253 In contrast, medial temporal lobe structures (perirhinal cortex, amyg

254 after damage to the hippocampus and related medial temporal lobe structures and that damage to these

255 iderable evidence now supports the view that medial temporal lobe structures are involved in nonmnemo

256 observation has raised the possibility that medial temporal lobe structures are sometimes critical f

257 on to ipsilateral posterior or contralateral medial temporal lobe structures does not underpin better

258 Our results demonstrate the importance of medial temporal lobe structures for memory and raise dou

259 The hippocampus and other medial temporal lobe structures have been linked to both

260 related Review from Baxter, "Involvement of Medial Temporal Lobe Structures in Memory and Perception

261 cortex (POR) are heavily interconnected with medial temporal lobe structures involved in learning and

262 hanced synchronous activity within and among medial temporal lobe structures is correlated with incre

263 miliarity, and the question of how different medial temporal lobe structures may contribute different

264 We tested the hypothesis that although medial temporal lobe structures may support reactivation

265 tive differences in how measured activity in medial temporal lobe structures varies with memory stren

266 predominantly focus on the contributions of medial temporal lobe structures, based on extensive lesi

267 y following a bilateral surgical ablation of medial temporal lobe structures, including the hippocamp

268 y others there was activation in lateral and medial temporal lobe structures, posterior cingulate cor

269 , in part, from declines in the integrity of medial temporal lobe structures, such as the hippocampus

270 arietal cortex, the posterior cingulate, and medial temporal lobe structures, with responses in the h

271 l cortex (RSP) is highly interconnected with medial temporal lobe structures, yet relatively little i

272 pends on associative mechanisms supported by medial temporal lobe structures.

273 s independent of the hippocampus and related medial temporal lobe structures.

274 cortex, the head of the caudate nucleus, and medial temporal lobe structures.

275 findings have implications for roles of the medial temporal lobe sub-regions for successful formatio

276 e entorhinal region, subiculum, and adjacent medial temporal lobe subfields.

277 amily history risks on cortical thickness in medial temporal lobe subregions among volunteers without

278 In contrast, a medial temporal lobe subsystem becomes engaged when deci

279 ization of memory representations within the medial temporal lobe system.

280 The medial temporal-lobe system is essential for the formati

281 ), recordings of single neurons in the human medial temporal lobe, taken as subjects' discriminated o

282 o Alzheimer disease pathology, including the medial temporal lobe, temporal-parietal association cort

283 ealed bilaterally symmetrical lesions of the medial temporal lobe that eliminated the temporal pole,

284 ce of a map-like representation in the human medial temporal lobe that encodes the coordinates of fam

285 eview is focused on specific circuits of the medial temporal lobe that have become better understood

286 prefrontal, parietal, and motor cortex), the medial temporal lobe, the basal ganglia, and midbrain do

287 ting widespread brain regions, including the medial temporal lobe, thereby allowing a progressive sta

288 Within the medial temporal lobe, this reactivation was observed in

289 uptake in key regions implicated in memory (medial temporal lobes), visuospatial function (occipital

290 In ventral/medial temporal lobe (VMTL) structures, incidental react

291 stage 2 + 3 participants had greater loss of medial temporal lobe volume and greater glucose hypometa

292 Hippocampal and medial temporal lobe volumes are larger in higher-fit ad

293 s subgroup, [(11)C]flumazenil DeltaVT in the medial temporal lobe was correlated with positive sympto

294 Volumetric reduction in the medial temporal lobe was correlated with PS symptom seve

295 ms, and baseline [(11)C]flumazenil VT in the medial temporal lobe was negatively correlated with visu

296 c schizophrenia, whereas elevated Glx in the medial temporal lobe was seen with chronic schizophrenia

297 had greater activation in the left posterior medial temporal lobe when successfully encoding words po

298 mporal gyrus cortices) are components of the medial temporal lobe, which is critical for long-term me

299 increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic mem

300 urons in the human medial frontal cortex and medial temporal lobe while subjects held up to three ite