ライフサイエンスコーパス: mediate

1 ells (MCs) in the MOB where 5-HT2A receptors mediate a direct excitatory action.

2 auditory synapses demonstrate that CP-AMPARs mediate a major component of glutamatergic transmission.

3 ntigen polypeptide (HBcAg/p21) synthesis, it mediates a dramatic increase in viral capsid production

4 provide an amended model of processive VASP-mediated actin assembly in clustered arrays.

5 , we established a kinetic model of Ena/VASP-mediated actin filament elongation.

6 of IL-36gamma and highlight that cathepsin S-mediated activation of IL-36gamma may be important in th

7 annel expression, but not changes in Ca(2+) -mediated activation of SK channels, contributes to exace

8 Integrin-mediated adhesion is a central feature of cellular adhes

9 s have been discovered, but the factors that mediate alpharetroviral avian leukosis virus (ALV) integ

10 ac1 guanine nucleotide exchange factor Tiam1 mediates an OGD-induced increase in Rac1 activity in hip

11 gs provide evidence for EAF2 as a key factor mediating androgen protection of DNA damage via Ku70/Ku8

12 wth through a novel SOCE/Ca(2+)/beta-catenin-mediated anti-proliferation of GC cells, which is differ

13 ntly, radiation therapy (RT) was believed to mediate antineoplastic activity mostly (if not only) as

14 hypothesis that PNE would aggravate the SLCF-mediated apnea and bradycardia via up-regulating TRPV1 e

15 The TRAIL pathway can mediate apoptosis of hepatic stellate cells to promote t

16 Furthermore, LMP1 blocks IRF5-mediated apoptosis in EBV-infected cells.

17 several insights, including in sphingolipid-mediated apoptosis, inflammation and energy storage/usag

18 ough the surface-initiated electrochemically mediated atom transfer radical polymerization (SI-eATRP)

19 ed no effect of retinoschisin on Na/K-ATPase-mediated ATP hydrolysis and ion transport.

20 rey matter (GM) in auditory cortex partially mediates auditory delay, suggesting less efficient local

21 sthenia gravis (MG) is a prototypical B cell-mediated autoimmune disease affecting 20-50 people per 1

22 set that suppresses follicular helper T cell-mediated B cell responses in the germinal center reactio

23 s a crucial role of inflammation in cytokine-mediated beta-cell dysfunction and death in type 1 diabe

24 ly defective strain that fails to remove Pxr-mediated blockage of development and reintroduced variab

25 1r plays an important role in murine asthma, mediating both AHR and mucus secretion after HDM exposur

26 ter controller of Wnt/beta-catenin signaling-mediated breast cancer tumorigenesis, metastasis, and ca

27 e signaling and pathophysiological functions mediated by 20-HETE in hypertension and cardiovascular d

28 Cancer cell invasion from primary tumors is mediated by a complex interplay between cellular adhesio

29 requires homotypic membrane fusion, which is mediated by a family of Dynamin-like Atlastin GTPase pro

30 ic reticulum or the periplasm of bacteria is mediated by a highly conserved heterotrimeric membrane p

31 idues in ABD1, we find that this activity is mediated by a positively charged surface that is partial

32 Fast excitatory neurotransmission is mediated by AMPA-subtype ionotropic glutamate receptors

33 vergeneralization in anxiety patients may be mediated by an inability to recruit the dlPFC, which med

34 This effect is likely mediated by changes in host vitellogenin, insulin signal

35 as in late pregnancy, energy availability is mediated by coordinated muscle-placenta metabolic adjust

36 ndependent mechanism of G protein activation mediated by cytoplasmic factors.

37 s to increased addiction risk which could be mediated by enhanced excitatory synaptic strength in ven

38 espiratory abnormalities caused by LT-IH are mediated by epigenetic re-programming of the redox state

39 activation of alternative signaling pathways mediated by factors secreted by BM stromal cells and inv

40 Cell division is mediated by filaments of FtsZ and FtsA (FtsAZ) that recr

41 rther breakdown of amino acids in the liver, mediated by increased glucagon, without preventing muscl

42 Mitochondrial targeting of Vms1 is mediated by its conserved mitochondrial targeting domain

43 y to injury after preterm birth.Inflammation mediated by microglia plays a key role in brain injury a

44 rmine whether itch induced by SP can also be mediated by Mrgprs.

45 perates under cholinergic constraint that is mediated by muscarinic receptor-dependent regulation of

46 cts of inflammation that had been considered mediated by neurokinin-1 receptor (NK-1R), we sought to

47 ring is promoted through chromosome movement mediated by nuclear envelope proteins, microtubules, and

48 These cardiovascular effects appear to be mediated by paracrine FGF control of kidney FGFR1 and su

49 lying the observed changes in cBLI signal is mediated by rearrangement of the actin cytoskeleton, a p

50 ermatitis (ACD), it is not known if they are mediated by shared or distinct signaling pathways.

51 n dynamics and species persistence are often mediated by species traits.

52 lytic asymmetric cyclopropanation of allene, mediated by the dirhodium catalyst Rh2 (S-TBPTTL)4 , and

53 l cells, and the antitumor effects of P4 are mediated by the endometrial stroma.

54 autoinhibition is induced by TGFbeta and is mediated by the inhibitory SMAD, SMAD7.

55 still show changes in perceptual sensitivity mediated by the intact cortical circuits.

56 This selectivity is primarily mediated by the interaction between a peripheral element

57 etical studies of the C-H amination reaction mediated by the iron dipyrrinato complex ((Ad) L)FeCl(OE

58 Chemoreception, mediated by the odorant receptors on the membrane of olf

59 thane plume show that oxidation is primarily mediated by the reduction of iron and manganese oxides.

60 possessing high level vancomycin resistance mediated by the reprogramming of peptidoglycan biosynthe

61 In bacteria various tactic responses are mediated by the same cellular pathway, but sensing of ph

62 phagosomal membrane; however, its removal is mediated by the same protease.

63 We propose that deficits in IP3-mediated Ca(2+) signaling represent a convergent hub fun

64 itotic defects that likely contribute to HPV-mediated cancer progression.

65 ies-Ltn1p-dependent ubiquitination and Rqc2p-mediated Carboxy-terminal Alanine and Threonine (CAT) ta

66 vo, AAV9 (adeno-associated virus serotype 9)-mediated cardiac overexpression of Qki5 prevented cardia

67 ed molecular dynamics simulations of vacancy-mediated cation diffusion in Gd2Ti2O7 pyrochlore and rep

68 Antibody-mediated CD4(+) T-cell depletion in HF mice (starting 4

69 ly facilitates and later antagonizes TGFbeta-mediated cell cycle arrest, yet remains critical for the

70 proteins, triggering constitutive caspase-8-mediated cell death dependent on FADD but independent of

71 acid inducible gene I (RIG-I) initiates ZBP1-mediated cell death via the RIG-I-MAVS-IFN-beta signalin

72 nt and release progeny virions in a membrane-mediated cell-to-cell manner.

73 ed with mER isoforms were used to detect EDC-mediated changes in endogenous ER target gene expression

74 ine how the doxycycline-inducible lentiviral-mediated ChR2 expression may affect cell viability and e

75 Likewise, MtMATE67-mediated citrate transport into the symbiosome space wou

76 ycan (GAG)-bound CXCL10, resulting in target-mediated clearance, which was corroborated using CXCL10-

77 lls lacking these factors revealed that Ire1-mediated cleavage of ER-associated mRNAs results in ribo

78 reby HIV infection impedes successful T cell-mediated control of M. tuberculosis have not been well d

79 yte attraction, together with dendritic cell-mediated cross-priming, are the key elements.

80 ament calcium sensitivity and alters calpain-mediated cTnI proteolysis.

81 ts against the development of UV irradiation-mediated cutaneous squamous cell carcinoma in mice.

82 lograft injury in a model of severe antibody-mediated damage in highly sensitized recipients.

83 lts reveal the intracellular mechanisms that mediate DAT endocytic recycling following constitutive a

84 uplications intersecting with a TAD boundary mediate de novo formation of a 3D contact domain compris

85 1 regulates activation of Rab5 and endosomal-mediated degradation of mitochondria, suggesting cross-t

86 vents PD-L1 from being targeted for lysosome-mediated degradation.

87 Cell-biological mechanisms mediating delamination are, however, poorly understood.

88 te the molecular consequences of CRISPR/Cas9-mediated deletions at 17 sites in four loci of the mouse

89 es of ULK1-mediated phosphorylation and PP2A-mediated dephosphorylation provide a phospho-switch that

90 e (XBP1-conditional knockout), with antibody-mediated depletion of CD4+ T cells.

91 ition occurs by interferon-gamma (IFN-gamma)-mediated depletion of intracellular tryptophan, and some

92 Furthermore, antibody-mediated depletion of T cells prevented nasopharyngeal i

93 ny orally acquired pathogens, and antibiotic-mediated depletion of the microbiota reduces host resist

94 yD88, promoted MyD88-dependent signaling and mediates dermatosis in Ptpn6(spin) mice.

95 s Ubp2 for degradation thereby inducing Rsp5-mediated desaturation of fatty acids.

96 y disease of the CNS characterised by immune-mediated destruction of myelin and progressive neuroaxon

97 Arterial stiffness, flow-mediated dilation (FMD), nitroglycerin-mediated dilation

98 flow-mediated dilation (FMD), nitroglycerin-mediated dilation (GMD), urinary nitric oxide (NO), and

99 , part of which was attributable to cysteine-mediated dimer formation.

100 physiologic cascade that produces sputum and mediates disease severity.

101 al mechanism that could contribute to immune-mediated diseases.

102 Celiac disease (CD) is an immune-mediated disorder characterized by an accumulation of im

103 How cells respond to pathogen-mediated disruption of gene expression to nevertheless i

104 lational modification coincides with the ATM-mediated DNA damage response that occurs on functional t

105 We reveal that defective ATM-mediated DNA repair is a consequence of P62 accumulation

106 DNA damage is concomitant with defective ATM-mediated DNA repair signaling and accumulation of protei

107 f alternative splicing, which bypasses miRNA-mediated down-regulation under drought stress.

108 he IFNgamma receptor, a protein complex that mediates downstream signaling events.

109 semble efficiently at centromeres during G1, mediate early events in centromere establishment at an e

110 gammaRIII, resulting in enhanced FcgammaRIII-mediated effector functions.

111 Inhibition of KLK5-mediated effects may offer potential as a therapeutic ap

112 or independent ( approximately 70%) of Twist-mediated EMT.

113 ight HOTAIR as a crucial player in the Snail-mediated EMT.

114 logous end-joining (NHEJ), and microhomology-mediated end-joining (MMEJ).

115 The robustness of processes like clathrin-mediated endocytosis (CME) across a diverse range of org

116 During clathrin-mediated endocytosis (CME), endocytic-site maturation ca

117 Clathrin- and actin-mediated endocytosis is essential in eukaryotic cells.

118 ed LGR5 internalization by blocking clathrin-mediated endocytosis.

119 MRN-mediated endonucleolytic cleavage of DNA at sites of pro

120 RTN3-mediated ER-phagy requires conventional autophagy compon

121 atus, where those complexes trigger Galphai3-mediated ERK signaling.

122 present exclusively in the Vbeta8.1 segment mediated essential interactions with the GAP5040-48 pept

123 repellents to combinatorially increase Mical-mediated F-actin disassembly, cellular remodeling, and r

124 lso synapse with GABAergic interneurons that mediate feed-forward inhibition onto GCs.

125 This TCR-mediated feedback is a global effect on the intercellula

126 anonical role in protein recycling, REs also mediate forward secretory trafficking in neuronal dendri

127 c base leads us to propose an atypical water-mediated fucosylation mechanism facilitated by an H-bond

128 nd growth is apparent, indicating telomerase-mediated G-strand extension.

129 entral fovea of BCM patients to consider AAV-mediated gene augmentation therapy.

130 eficient cells had a reduced capacity for HR-mediated gene conversion both spontaneously and in respo

131 RNAi-mediated gene silencing of il17a in fibrotic mice arrest

132 We used viral-mediated gene transfer to block the transcription functi

133 between L1 and Reelin as well as the Reelin-mediated generation of L1-80 contribute to brain develop

134 l progenitors that were engineered by CRISPR-mediated genome editing to controllably release GLP-1 (g

135 9-specific CD8(+) cells without CD4(+) cells mediated glomerular injury when MPO was planted in glome

136 Mice with single-minded 1-mediated Glp1r knockdown had reduced hypothalamic-pituit

137 ortico-basal ganglia circuits are thought to mediate goal-directed learning by a process of outcome e

138 ine a specific requirement for primary cilia-mediated GPCR signaling in interneuronal connectivity an

139 vels of polycomb repressive complex 2 (PRC2)-mediated H3K27 trimethylation (H3K27me3), and this is hy

140 le acid accumulation that contributes to AhR-mediated hepatotoxicity.

141 B formation, Mer2 is required for pairing by mediating homolog spatial juxtaposition, with implicatio

142 gnificant impact on research related to MPYS-mediated human diseases and medicine.

143 Here, we obtain cavity mediated hybridization of GaAs and J-aggregate excitons

144 Development of severe IgE-mediated hypovolemia and shock required VE-restricted AB

145 which may act as the bridging molecule that mediates IL-37 binding to the TGF-beta receptor complex.

146 iants that escape cellular and antibody (Ab)-mediated immune pressure, yet possess contemporary fitne

147 f osteoclast (OC) cell fusion, as well as DC-mediated immune regulation.

148 Central to CD8(+) T cell-mediated immunity is the recognition of peptide-major hi

149 -induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca(2+)]c to trigger the PYK2/M

150 h tissues can enable control of infection or mediate inflammatory damage.

151 tential benefit of gene replacement in RPE65-mediated inherited retinal dystrophy.

152 ivated by thrombin or FXa also enhanced TFPI-mediated inhibition of FXa approximately 12-fold in the

153 ed to an activity-dependent switch from GABA-mediated inhibition to excitation.

154 3-HIB and FGF21 might be involved in protein-mediated insulin resistance in humans.

155 Talin, a cytoskeletal protein essential in mediating integrin activation, has been previously shown

156 ults implicated a novel mechanism of exosome-mediated intercellular communication in the activation o

157 RNA-mediated interference has been one major approach for se

158 ion of esophageal cancer cells through Orai1-mediated intracellular Ca(2+) oscillations and reveal a

159 tal-transporter-1 (DMT-1), indicating PrP(C)-mediated iron uptake through DMT-1.

160 How these different activities are mediated is not known.

161 Loop-mediated isothermal amplification (LAMP) is a DNA amplif

162 ct and identify a disinhibitory circuit that mediates it.

163 conserved region in the Ulp2 C terminus that mediates its specificity for rDNA-associated proteins an

164 Pdcd1 (PD-1) disruption augmented CAR T cell mediated killing of tumor cells in vitro and enhanced cl

165 An siRNA-mediated knockdown of Mule or TRIM26 leads to stabilisat

166 ysteine, suggesting that Y10 phosphorylation-mediated LDHA activity promotes cancer cell invasion and

167 ting that MLL1 is dispensable for MLL-fusion-mediated leukemogenesis.

168 ulator of adipose triglyceride lipase (ATGL)-mediated lipolysis that plays important roles in metabol

169 phage/monocyte-like cells in the cochlea can mediate local autoinflammation via activation of the NLR

170 al signaling and bioenergetics pathways that mediate lymphocyte exit from quiescence.

171 ively, which suggests that their actions are mediated mainly by modulation of KCNQ1 pore function.

172 These results demonstrate an lncRNA-mediated mechanism by which a transcriptional factor con

173 pecific (1) O2 generation and subsequent ROS mediated mechanism.

174 nistration of naloxone, suggesting an opioid-mediated mechanism; pharmacological and genetic data sug

175 It is well suited for understanding hypoxia-mediated mechanisms in cancer disease and other biologic

176 more effective than WQ in blocking HIV-1 Env-mediated membrane fusion and had higher levels of bindin

177 l roles in engaging the host receptor and in mediating membrane fusion, respectively.

178 Combining alkali-metal-mediated metalation (AMMM) and N-heterocyclic carbene (N

179 ausal roles for CADM1, SPHK1, and YAP/TAZ in mediating metastatic phenotypes in vitro and in vivo Not

180 tiple effector subsets, including ThCTL that mediate MHC class II-restricted cytotoxicity.

181 Antibiotic-mediated microbiota destruction and the consequent loss

182 lization with tubulin is enhanced upon Taxol-mediated microtubule stabilization, which, together with

183 important role in mitochondrial dynamics by mediating mitochondrial fission.

184 Although the mother centriole mediates most centrosome-dependent processes, the role o

185 r positioning through recruitment of Akap450-mediated MT nucleation activity to the NE.

186 y C ATP-binding cassette (ABCC) transporters mediate multidrug resistance and ion conductance regulat

187 ibiting Calcineurin activity attenuated FoxO-mediated murf1 expression and protected sarcomeres from

188 Our results demonstrate that AAV-mediated muscle-specific gene editing has significant po

189 e review on the latest development of folate-mediated nanomedicines and nanoprobes for chemotherapy a

190 The requirement of autophagy in Mincle-mediated NET formation was further supported by exogenou

191 Chd1 depletion robustly enhances TDP-43-mediated neurodegeneration and promotes the formation of

192 Type I IFN-mediated neutrophil activation and NET formation may con

193 sphorylation of DNA-PKcs after DNA damage to mediate NHEJ.

194 that the 65 kDa protein encoded by CPSF30-L mediates nitrate signaling in part by regulating NRT1.1

195 ealed that Skp2 regulates CRPC through Twist-mediated oncogenic functions including epithelial-mesenc

196 However, whether this attenuation is mediated only through PR-ER interaction remains unknown.

197 s an essential signal for axon guidance that mediates opposing effects on growth cone motility.

198 or activator of nuclear factor-kappaB ligand-mediated osteoclastogenesis.

199 malaria, CD36 plays several roles, including mediating parasite sequestration to host organs, phagocy

200 evidence for glucagon-like peptide 1 (GLP-1)-mediated paraventricular hypothalamic circuit coordinati

201 e transport and that inhibiting the caveolae-mediated pathway significantly reduced cellular uptake o

202 Both in G protein-mediated pathways and in beta-arrestin 2 recruitment, no

203 ole of neutrophils and the IL-17A pathway in mediating pediatric severe therapy-resistant asthma (STR

204 c PSS sequences that were also sufficient to mediate PGBD5-induced DNA rearrangements in rhabdoid tum

205 analicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion.

206 propose that the opposing activities of ULK1-mediated phosphorylation and PP2A-mediated dephosphoryla

207 ing ERK, mTOR, and Akt signaling, via PTPN13-mediated phosphorylation.

208 ovide first insight into the key step of MSP-mediated phosphotransfer in a eukaryotic system, the pho

209 A copper-mediated picolinamide directed regioselective cross-coup

210 e groups (both p < 0.001); (2) the mean cone-mediated PLR was reduced significantly in the moderate-s

211 mparisons indicated: (1) the mean melanopsin-mediated PLR was significantly reduced in the mild and m

212 electively reduces BMPR-II transcription and mediates post-translational BMPR-II cleavage via the she

213 nd PKA that creates a mechanism whereby cAMP mediates PP2A disinhibition.

214 nhancing both transcription and Drosha/DGCR8-mediated primary miRNA (pri-miRNA) processing.

215 aempferol significantly attenuated TGF-beta1-mediated profibrotic pathways in vitro and in vivo, whil

216 g that Nlrp3 suppression is required for aPC-mediated protection from IRI.

217 Critically, our understanding of ROS-mediated PTP oxidation is not yet sufficient to predict

218 ing the iris sphincter and ciliary muscle to mediate pupillary constriction and lens accommodation, r

219 -(18)F, Si-(18)F, Al-(18)F, and iodine (III)-mediated radiofluorination via the spirocyclic iodonium

220 logical inhibition of PPP canceled the UCHL1-mediated radioresistance.

221 lly general mechanism whereby climate change-mediated range shifts can reduce phylogenetic diversity

222 and leads to desensitization of mice to IgE-mediated reactions.

223 onsible for the appropriate long-range AMPAR-mediated recruitment of neurogliaform cells.

224 yzed proton-coupled electron transfer (PCET) mediated regioselective ortho-specific nitration of arom

225 branes, and this property is central to PITP-mediated regulation of lipid signaling.

226 mingly paradoxical result was linked to NEMO-mediated regulation of NFkappaB and IL6 secretion, incre

227 However, the extent of CMV-mediated regulation of nucleolar biology is not well est

228 Antibody-mediated rejection (AMR) is an increasingly recognized f

229 r antibodies results in accelerated antibody-mediated rejection (AMR), complement activation, and gra

230 patients and a better prediction of antibody-mediated rejection.

231 Immune-checkpoint-blockade (ICB)-mediated rejuvenation of exhausted T cells has emerged a

232 data suggest H3-G34R slows resolution of HR-mediated repair and that unresolved replication intermed

233 ether our results reveal modulation of miRNA-mediated repression by characteristics and features of t

234 , the mcr-1 gene was identified as a plasmid-mediated resistance mechanism in human and animal Entero

235 st cells are activated via a non-FcepsilonRI mediated response following silver nanoparticle (Ag NP)

236 ) no significant differences in the mean rod-mediated responses.

237 mother cells, suggesting that TEX1- and TAS3-mediated restriction of ARF3 expression limits excessive

238 TRIM23 was critical for autophagy-mediated restriction of multiple viruses, and this activ

239 Here, we reveal that dynein-Snapin-mediated retrograde transport regulates BACE1 traffickin

240 he formation of death signaling complexes by mediating RIP1 dissociation from TNF receptor 1.

241 bility and could accommodate the alphaLbeta2-mediated rolling adhesion of leukocytes.

242 Although CML38 was essential for AtRALF1-mediated root inhibition, it appeared not to have an eff

243 Taken together, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an impo

244 sphorylated by CDK1, and blocking basal CDK1-mediated S81 phosphorylation markedly suppresses AR acti

245 Thus, it is proposed that SlCBL10 mediates salt tolerance by regulating Na(+) and Ca(2+) f

246 In the absence of antibiotic-mediated selection, sensitive bacteria are expected to d

247 (VEGF) secretion for this pathway of hypoxia-mediated self-renewal.

248 creased ATZ levels in vivo by reducing c-Jun-mediated SERPINA1 gene expression.

249 ssential protein has also been implicated in mediating several forms of use-dependent plasticity, but

250 By comparing relative bias for MOR-mediated signaling in each pathway, we demonstrate a str

251 ion, revealing a previously unrecognized P2X-mediated signaling.

252 The PI3K/Akt/mTOR pathway mediates signals from multiple receptors including insul

253 ny cell signaling pathways that were able to mediate significant decreases in aggregate levels.

254 but not the sequence, restored strong miR159-mediated silencing.

255 Because Mrgprs mediate some aspects of inflammation that had been consi

256 In particular, SRp55-mediated splicing changes modulate the function of the p

257 activated by intracellular Ca(2+) sparks and mediated spontaneous transient outward currents in devel

258 te differentiation into polarized MPhis that mediate stellate cell activation via TGF-beta.

259 lyoxylate shunt, isocitrate lyase (ICL), may mediate survival of Mtb during the acute and chronic pha

260 known ingestion with typical rapid onset IgE-mediated symptoms.

261 Lipin-2 regulates MAPK activation, which mediates synthesis of pro-IL-1beta during inflammasome p

262 ne macrocycles with ODNs, which were used to mediate the assembly of gold nanoparticles.

263 Pannexin-1 (Panx1) channels mediate the efflux of ATP and AMP from cancer cells in r

264 at Gi/o and phosphoinositide 3-kinase (PI3K) mediate the increase independently of epidermal growth f

265 interactions in vivo would permit lncRNAs to mediate the juxtaposition of two or more DNA regions on

266 type ionotropic glutamate receptors (AMPARs) mediate the majority of excitatory synaptic transmission

267 neurons in the ventral tegmental area (VTA) mediate the positive reinforcing effects of nicotine.

268 ood and activity monitoring and goal setting mediated the effect of LOW vs CONTROL (50%).

269 Although specific cell populations mediated the effects of age and sex on gene expression,

270 cetyltransferase 8 (KAT8, also known as MOF) mediates the acetylation of histone H4 at lysine 16 (H4K

271 the interaction with PTPdelta, but IL1RAPL1 mediates the activity of IL-1beta on dendrite morphology

272 by an inability to recruit the dlPFC, which mediates the cognitive control needed to overcome anxiet

273 response, to be the ubiquitin E3 ligase that mediates the degradation of Plk3.

274 ro and in vivo These data indicate that Gab2 mediates the pathologic progression of HCC by integratin

275 demonstrate that the polo-like kinase PLK-1 mediates the repulsive coupling between MEX-5 and POS-1

276 o experiments highlighted potential residues mediating the AP-1/Arf1 interaction and the unlocking of

277 , we now show that NMDARs have a key role in mediating the effect of leptin to modulate beta-cell ele

278 ory function of phosphoinositide 3-kinase in mediating the metabolic action of glucocorticoids.

279 n to ER degradation (CUE) domain in SMARCAD1 mediate their direct interaction.

280 these rare non-coding variants are likely to mediate their effects on lipid traits by regulating gene

281 ode of action of T6SS effector proteins that mediate this protective effect remain poorly defined.

282 val: -0.12, -0.02) than the indirect effects mediated through later poverty at age 7-14 years (beta =

283 The inhibitory effect of F4 was not mediated through the inhibition of MAPKs and NF-kappaB a

284 on of MAPKs and NF-kappaB activation but was mediated through the suppression of c-Fos/AP-1 activity

285 RNA sequencing confirmed that Hh-mediated transcription is increased in B-lineage cells f

286 responses in vitro and in vivo require ETS1-mediated transduction of VEGF signaling to release pause

287 eg formation via neonatal Fc receptor (FcRn)-mediated transfer and uptake of allergen-containing IgG

288 we demonstrate that eIF4E regulates HAV IRES-mediated translation by two distinct mechanisms.

289 motic challenges and thereby activated TRPV4-mediated transmembrane currents.

290 sm has served as the predominant model of GR-mediated transrepression of inflammatory genes.

291 erlin knockdown significantly decreased IL-6-mediated tumor cell migration, tumorsphere formation and

292 age genes, and reveals unexpected mechanisms mediating tumor viability and invasion, including potass

293 igidity and cell motility/contractility help mediate tumour progression.

294 We show that Ubp2 also counteracts Mdm30-mediated turnover of the yeast mitofusin Fzo1 and that M

295 R and OAS1 play important roles in the ISG15-mediated type I IFN sensitivity of HEV.

296 y shown that IRF4 is activated through c-Src-mediated tyrosine phosphorylation in virus-transformed c

297 PCGF3/5-PRC1-mediated ubiquitylation of histone H2A signals recruitme

298 ys an essential role in adaptive immunity by mediating V(D)J recombination in developing lymphocytes.

299 requires cleavage by host cell proteases to mediate virus-cell and cell-cell fusion.

300 rostructure in the optic radiation partially mediates visual delay, suggesting increased transmission