ライフサイエンスコーパス: mediator of inflammation

1 ide (NO) has been recognized as an important mediator of inflammation.

2 ereas bradykinin is a potent vasodilator and mediator of inflammation.

3 mediator of antiviral defenses, it is also a mediator of inflammation.

4 the myelomonocytic lineage and an important mediator of inflammation.

5 e the CTpr level, which is a potential toxic mediator of inflammation.

6 rse physiological actions, particularly as a mediator of inflammation.

7 We concluded that endogenous NO acts as a mediator of inflammation.

8 cell types such as cardiomyocytes; and as a mediator of inflammation.

9 kinetic factor to an activated and efficient mediator of inflammation.

10 Nuclear factor kappa B (NF-kappaB) is a key mediator of inflammation.

11 ly active IL-1beta, IL-18, and other soluble mediators of inflammation.

12 40 gene and the genes encoding several other mediators of inflammation.

13 amines and a reduction in canonical cytokine mediators of inflammation.

14 such as periodontitis, with a focus on lipid mediators of inflammation.

15 initiating the biosynthesis of lipid-derived mediators of inflammation.

16 nes with a prominent increase in markers and mediators of inflammation.

17 to release peptides in response to trauma or mediators of inflammation.

18 precursor (CTpr) levels are both markers and mediators of inflammation.

19 eukin (IL-1)alpha and IL-1beta are important mediators of inflammation.

20 ing peptides, which are proposed to be major mediators of inflammation.

21 gamma(+/+) cells appear to involve different mediators of inflammation.

22 r enhanced synthesis of paracrine eicosanoid mediators of inflammation.

23 rostaglandins and glucocorticoids are potent mediators of inflammation.

24 on and tissue injury could thus be important mediators of inflammation.

25 is (RA), and can secrete cytokines and other mediators of inflammation.

26 ed metabolites mapping to pathways for lipid mediators of inflammation.

27 genase (COX)-derived oxylipins are important mediators of inflammation.

28 lly similar, but functionally distinct lipid mediators of inflammation.

29 osynthesis to the production of proresolving mediators of inflammation.

30 mily of cytokines comprises a set of pivotal mediators of inflammation.

31 act as upstream facilitators and downstream mediators of inflammation.

32 erleukin-1 beta and -18, which are important mediators of inflammation.

33 oxygenase pathways are known to be important mediators of inflammation.

34 h mobility group box 1 are critical cytokine mediators of inflammation.

35 rging evidence that specialized proresolving mediators of inflammation accelerate wound healing by pr

36 nt studies have implicated HMGB1 as an early mediator of inflammation after HS/R and organ ischemia/r

37 Herein, we describe LPA as an important mediator of inflammation after spinal cord injury (SCI)

38 ls of expression of messenger RNA (mRNA) for mediators of inflammation, aggrecanases, MMPs, and their

39 noids and platelet-activating factor, potent mediators of inflammation, allergy, apoptosis, and tumor

40 These results suggest that on stimulation by mediators of inflammation, although the basal transcript

41 Interleukin-1 beta (IL-1beta) is a major mediator of inflammation and a growth promoter for many

42 sed by Egr-1, suggesting that Egr-1 is a key mediator of inflammation and apoptosis in vascular cells

43 The CD40 pathway is a key mediator of inflammation and autoimmunity.

44 Moreover, NO is also a critical mediator of inflammation and carcinogenesis.

45 Interleukin (IL)-1 is an important mediator of inflammation and cardiovascular disease.

46 rachidonic acid, a omega-6 PUFA, is a potent mediator of inflammation and cell proliferation.

47 TNF-alpha is a central mediator of inflammation and critical for host response

48 Nitric oxide (NO) is a ubiquitous mediator of inflammation and immunity, involved in the p

49 Much evidence implicates IL-8 as a major mediator of inflammation and joint destruction in rheuma

50 These results suggest that fibrin is a mediator of inflammation and may impede the reparative p

51 results indicate that LOX-1 is an important mediator of inflammation and neutrophil dysfunction in s

52 The TAK1 (MAP3K7) is a key mediator of inflammation and non-canonical TGF-beta sign

53 in contrast to the role of HMGB1 as an early mediator of inflammation and organ damage in hepatic I/R

54 flammation of sepsis, HMGB1 acts as an early mediator of inflammation and organ damage in hepatic isc

55 E(2) (PGE(2)) is a prevalent and established mediator of inflammation and pain in numerous tissues an

56 IL-13 is an important mediator of inflammation and remodeling.

57 hat epithelial-derived MMP-9 is an important mediator of inflammation and tissue damage in colitis.

58 phospholipase A2alpha (cPLA2alpha)] is a key mediator of inflammation and tumorigenesis.

59 as the immune-suppressive function of lipid mediators of inflammation and alarmins, are just some ex

60 thesis of leukotrienes, potent extracellular mediators of inflammation and allergic disorders.

61 of arachidonic acid to leukotrienes, potent mediators of inflammation and allergy.

62 hesis of eicosanoids and other lipid-derived mediators of inflammation and allergy.

63 CD4+ T helper 1 (TH1) cells are important mediators of inflammation and are regulated by numerous

64 T cells are critical mediators of inflammation and as such, their migration t

65 pro-HGF in vitro raises the possibility that mediators of inflammation and blood coagulation may also

66 ransfusion requirements, and levels of serum mediators of inflammation and cardiac troponin I were si

67 These elevated gene products are molecular mediators of inflammation and collagen degradation in ac

68 ern recognition receptors that are essential mediators of inflammation and host defense in the gastro

69 Genes encoding mediators of inflammation and host defense, including CD

70 Cytokines are critical mediators of inflammation and host defenses.

71 e derived from arachidonic acid and serve as mediators of inflammation and immediate hypersensitivity

72 A (dsRNA)-activated genes, including several mediators of inflammation and immune cell recruitment.

73 Statins have diverse effects on the cellular mediators of inflammation and immunity that may be parti

74 t of direct interactions between the soluble mediators of inflammation and infectious agents.

75 thelial cells were cultured and assessed for mediators of inflammation and injury, such as ICAM-1, AP

76 airways quantitatively with respect to known mediators of inflammation and intercellular communicatio

77 synovial intimal lining of the joint are key mediators of inflammation and joint destruction in rheum

78 Prostaglandins and NO. are important mediators of inflammation and other physiological and pa

79 expression with indices of disease severity, mediators of inflammation and outcome indicates a key ro

80 the synthesis of leukotrienes LTB4 and LTC4, mediators of inflammation and pain, were found in the UT

81 that this was, in part, due to the effect of mediators of inflammation and predicted that greater cha

82 ood pressure (BP), heart rate, cortisol, and mediators of inflammation and reductions in heart rate v

83 NOS; NOS-2) and cyclooxygenase-2 (COX-2) are mediators of inflammation and regulators of epithelial c

84 sis of eicosanoids and other bioactive lipid mediators of inflammation and resolution underlying dise

85 LPG's inhibitory activity for several mediators of inflammation and the persistence of signifi

86 Eicosanoids are potent mediators of inflammation and tightly associated with mo

87 ophil cationic protein (ECP), are well-known mediators of inflammation and tissue damage in asthma.

88 ctivation and mRNA stabilization of numerous mediators of inflammation and tissue repair.

89 ) and prostaglandin E(2) (PGE(2)), important mediators of inflammation and tumor promotion.

90 xygenase-2), which is an important enzymatic mediator of inflammation, and a target of aspirin.

91 Nitric oxide (NO.), an important mediator of inflammation, and beta-catenin, a component

92 e, CO blocked expression of Egr-1, a central mediator of inflammation, and decreased tissue damage; i

93 rosis factor alpha (TNF-alpha) is a critical mediator of inflammation, and its production is tightly

94 ONOOCO(2)(-)), a macrophage-derived chemical mediator of inflammation, and the classical one-electron

95 Monocytes are major mediators of inflammation, and apoptosis provides a mech

96 Inflammasomes are mediators of inflammation, and constitutively activated

97 Expression is modulated by serum factors, mediators of inflammation, and kinase activators and inh

98 ritic inflammation and inhibited the defined mediators of inflammation, angiogenesis, cell survival,

99 sis factor alpha (TNF-alpha) is an important mediator of inflammation, apoptosis, and the development

100 Accordingly, these mediators of inflammation are the targets of several ant

101 Both of these mediators of inflammation are thought to contribute to t

102 to generate arachidonate-derived eicosanoid mediators of inflammation are uncertain.

103 are members of the specialized pro-resolving mediators of inflammation, are produced.

104 exists between vascular cellular hypoxia and mediators of inflammation associated with aortic aneurys

105 We hypothesized that mediators of inflammation associated with atherosclerosi

106 Nitric oxide is believed to be a prominent mediator of inflammation based in part on the correlativ

107 TGF-beta1 is an important suppressive mediator of inflammation, but it can also drive fibrosis

108 COX2 activity is an important mediator of inflammation, but it is not known whether CO

109 ensitivity is differentially associated with mediators of inflammation by studying 2 chronic inflamma

110 onstitutive decay of instable mRNAs encoding mediators of inflammation by various experimental approa

111 ults of these studies indicate that a common mediator of inflammation can lead to the induction of SS

112 ntation abolished the expression of mRNA for mediators of inflammation (cyclooxygenase 2, 5-lipoxygen

113 Resolvin E1 (RvE1) is a potent proresolving mediator of inflammation derived from omega-3 eicosapent

114 ienes (cys-LTs) are a family of potent lipid mediators of inflammation derived from arachidonic acid.

115 Leukotrienes (LTs) are potent mediators of inflammation derived from the 5-lipoxygenas

116 for the first time that ONOO(-) is a potent mediator of inflammation-derived hyperalgesia operating

117 Specialized proresolving mediators of inflammation drive macrophage efferocytosis

118 though TNF-alpha is believed to be a central mediator of inflammation-driven atherosclerosis, genetic

119 eased by many cell types and is an important mediator of inflammation during infection.

120 ents of microorganisms and are critical host mediators of inflammation during infection.

121 Mediators of inflammation, fibrosis, and regeneration we

122 iator of lethality in sepsis and as an early mediator of inflammation following injury.

123 tivating factor (PAF), a potent phospholipid mediator of inflammation, for its ability to activate CR

124 Leukotriene B(4) (LTB(4)) is a potent lipid mediator of inflammation formed by the 5-lipoxygenase (5

125 Leukotrienes (LTs) are lipid mediators of inflammation formed by enzymatic oxidation

126 The leukotrienes are potent lipid mediators of inflammation formed by the 5-lipoxygenase-c

127 se), the expression of which is regulated by mediators of inflammation, had a strong, positive associ

128 ucible nitric-oxide synthase (iNOS), a major mediator of inflammation, has been implicated in beta-ce

129 Inducible nitric-oxide synthase (iNOS), a mediator of inflammation, has been implicated in many hu

130 ur data support the hypothesis that cellular mediators of inflammation have a role in atherogenesis a

131 Neutrophils and macrophages, as key mediators of inflammation, have defined functionally imp

132 or necrosis factor (TNF) alpha is a critical mediator of inflammation; however, TNFalpha is rarely re

133 Although PAF plays a key role as a mediator of inflammation in acute pancreatitis, the site

134 rP was induced in glia by TNF-alpha, a known mediator of inflammation in brain and of PTHrP induction

135 valuated whether prostacyclin is a necessary mediator of inflammation in graded bacteremia or is suff

136 Thus, TNF-alpha appears to be an important mediator of inflammation in patients with poor viral con

137 by antibody to cyclophilin A (CyPA), a known mediator of inflammation in peripheral tissues, and by c

138 Tumor necrosis factor (TNF) is a powerful mediator of inflammation in rheumatoid arthritis (RA).

139 ypothesis that osteopontin may be a critical mediator of inflammation in specific disease and injury

140 rt the conclusion that MCP-1 is an important mediator of inflammation in the CNS.

141 Originally identified as a potential mediator of inflammation in the skin, we recently report

142 ogenesis of bacterial meningitis as a potent mediator of inflammation in the subarachnoid space.

143 Therefore, PDE3 is a novel mediator of inflammation in VSMCs.

144 Recent work indicates T cells are important mediators of inflammation in a mouse model of T2D.

145 e cyclooxygenase (COX) enzymes are important mediators of inflammation in arthritis.

146 arachidonyl-phosphatidyl choline (PAPC), are mediators of inflammation in endothelial cells (ECs) and

147 staglandin E2 (PGE2) have been implicated as mediators of inflammation in OA.

148 The mediators of inflammation in spondyloarthropathies have

149 anscription factor that is activated by many mediators of inflammation including IL-1, IL-6, and bact

150 ern diet, are precursors for a number of key mediators of inflammation including the 2-series of pros

151 ve target for inhibiting Ca(2+) responses to mediators of inflammation, including C5a, UDP, PAF, and

152 tion of SCW-induced arthritis and changes in mediators of inflammation, including T cell subsets, pro

153 peralgesia and interacts with many different mediators of inflammation, including the MAPK signaling

154 oleamine 2,3-dioxygenase (IDO), is a pivotal mediator of inflammation-induced depression, its mechani

155 However, the specific mediators of inflammation-induced injury remain unclear.

156 st invading pathogens but are also important mediators of inflammation-induced injury.

157 mis, are the sites for the expression of two mediators of inflammation, inducible nitric oxide syntha

158 As an established mediator of inflammation, interleukin-6 (IL-6) is implic

159 Insight into pathogenic mediators of inflammation is essential for targeted and

160 r necrosis factor-alpha (TNF-alpha), a major mediator of inflammation, is chronically produced in the

161 COX-2, a key mediator of inflammation, is upregulated in activated mo

162 e synthesis of prostanoids, which are potent mediators of inflammation, is dramatically increased.

163 Although originally identified as mediators of inflammation, it is now apparent that chemo

164 ammation and cancer, and it is believed that mediators of inflammation may be responsible for this ph

165 The reduction in the mediators of inflammation may thus be responsible for th

166 n vivo may represent previously unrecognized mediators of inflammation-mediated protein modification

167 and c) changes in the inflammatory cells and mediators of inflammation of the respiratory secretions

168 essed the effect of myeloperoxidase (MPO), a mediator of inflammation, on nitrosation observed during

169 Circulating mediators of inflammation participate in the mechanisms

170 s recent developments in the role of soluble mediators of inflammation, particularly arachidonic acid

171 Information on mediators of inflammation permeated many sessions, havin

172 )-irradiated keratinocytes secrete the lipid mediator of inflammation, platelet-activating factor (PA

173 Because the lipid mediator of inflammation, platelet-activating factor (PA

174 ucible nitric-oxide synthase (iNOS), a major mediator of inflammation, plays an important role in obe

175 ust is compartmentalized, involving specific mediators of inflammation released by macrophages, neutr

176 Lipid mediators of inflammation resolution, e.g., resolvin D2,

177 Platelet-activating factor (PAF) is a mediator of inflammation shown to orchestrate inflammato

178 and APCs, are major producers of the central mediator of inflammation, soluble TNF-alpha (sTNF).

179 The biliary epithelium is exposed to mediators of inflammation such as bacterial endotoxin or

180 Important mediators of inflammation such as the cytokine tumor nec

181 nd its expression is markedly upregulated by mediators of inflammation such as tumor necrosis factor

182 AS1 is a transcription factor that activates mediators of inflammation, such as tumor necrosis factor

183 Prostaglandin E(2) is a potent lipid mediator of inflammation that effects changes in cell fu

184 The anaphylatoxin C5a is a potent mediator of inflammation that exerts a broad range of ac

185 CD95 is a mediator of inflammation that has also been proposed as

186 These findings identify TGR5 as a negative mediator of inflammation that may serve as an attractive

187 lso possess a repertoire of potent preformed mediators of inflammation that are released on activatio

188 s suggest that the production of pleiotropic mediators of inflammation that influence cartilage homeo

189 elet-activating factor (PAF) is an important mediator of inflammation, the action of which in endothe

190 s an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocat

191 ism is key to the control of essential early mediators of inflammation, TNF, CXCL1, and CXCL2, as wel

192 y throughout the lung, caused by blood-borne mediators of inflammation, voluminous aspiration, or inh

193 KLF4 was an epithelial-specific mediator of inflammation; we developed a new mouse model

194 ation of hepatic stellate cells, but hepatic mediators of inflammation were not significantly differe

195 latelet-activating factor (PAF), both potent mediators of inflammation, were used as triggers for gen

196 uce the aggregation of HMGB1 protein, a late mediator of inflammation, which subsequently stimulates

197 products of arachidonic acid metabolism are mediators of inflammation with an important role in the

198 Prostaglandins (PGs) are mediators of inflammation with pronociceptive actions wi