ライフサイエンスコーパス: medicinal

1 ly applied to the expedient synthesis of the medicinal agent haloperidol.

2 he model probe fluorescein-maleimide and the medicinal agent paclitaxel (PTX) into cells.

3 ility has been exploited in order to develop medicinal agents that are intended to treat bones which

4 pene lactones represent a prolific source of medicinal agents with several derivatives in human clini

5 eir rapidly growing uses and applications in medicinal and agrochemical arenas prompt the researchers

6 , have been intensely investigated from both medicinal and chemical-synthesis perspectives for decade

7 s a prebiotic ingredient in food, as well as medicinal and pharmaceutical products.

8 nt public attention and concern both for its medicinal and recreational use.

9 e-containing beverage with immense economic, medicinal, and cultural importance.

10 ed mushroom and widely used for nutritional, medicinal, and industrial applications.

11 e elucidation and verification in synthetic, medicinal, and natural product chemistry.

12 eview on the history, taxonomy, ecology, and medicinal application of different Nicotiana species gro

13 nately, progress in developing chelators for medicinal applications has been hindered by a limited un

14 arbon-metal bond are described, and selected medicinal applications of such conjugates are discussed.

15 has potential for synthetic, biological, and medicinal applications.

16 e and rate is crucial for its pharmaceutical/medicinal applications.

17 complex plant natural products with numerous medicinal applications.

18 actions; and NDI intercalations with DNA for medicinal applications.

19 are being studied intensively for a range of medicinal applications.

20 stem was demonstrated for the first time for medicinal aromatic plants by sgRNAs transcribed from bot

21 in serum, informing future research into the medicinal behaviours and dosing of this living antibacte

22 y perception and exerts a range of potential medicinal benefits.

23 , causes euphoria and exerts a wide range of medicinal benefits.

24 oundation for the therapeutic development of medicinal cannabidiol to address the current opioid abus

25 Emerging clinical studies show that 'medicinal' cannabis or cannabinoid-based medications rel

26 -based (19)F NMR offers opportunities to the medicinal chemist for characterizing and ultimately disc

27 r appear to be of particular interest to the medicinal chemist for other reasons.

28 Correction for 'The medicinal chemist's toolbox for late stage functionaliza

29 ave focused on unraveling the content of the medicinal chemist's toolbox.

30 of ever-expanding synthetic methodologies, a medicinal chemist's toolkit continues to swell.

31 g blocks with better potency: selection by a medicinal chemist, manual modeling, docking followed by

32 From the perspective of the medicinal chemist, the GRI is also important as a genera

33 alysis of chemical reactions used in current medicinal chemistry (2014), three decades ago (1984), an

34 the training of chemistry undergraduates in medicinal chemistry (as practiced in industry) in two mo

35 tically probing one of its exit vectors is a medicinal chemistry activity that can benefit from molec

36 ides are increasingly important molecules in medicinal chemistry and agrochemistry, but their prepara

37 ues are also valuable as building blocks for medicinal chemistry and as tools for chemical biology.

38 teractions, and they have a broad utility in medicinal chemistry and drug discovery.

39 luorinated building blocks of high value for medicinal chemistry and drug discovery.

40 or organic synthesis, for pharmaceutical and medicinal chemistry and for material science.

41 sicochemical properties as a stable motif in medicinal chemistry and its propensity to undergo ring-o

42 p and transition metal chemistry, catalysis, medicinal chemistry and materials science.

43 , classes of compounds that are important to medicinal chemistry and natural product synthesis.

44 as immediate applications in drug discovery, medicinal chemistry and other commercial areas of chemic

45 te a new approach that fuses the concepts of medicinal chemistry and protein design, and paves the wa

46 etween trifluoromethylation in materials and medicinal chemistry and structural biology and biotechno

47 evalence of drug ring combinations in modern medicinal chemistry and to identify areas of under-repre

48 as a significant and novel emerging area for medicinal chemistry and we provide an overview of one of

49 The potential utility of these methods in medicinal chemistry applications is highlighted.

50 derivatives appearing in recent patents for medicinal chemistry applications.

51 are made freely available as a resource for medicinal chemistry applications.

52 Here, starting with a medicinal chemistry approach, Baker et al. generate an i

53 accine candidate that was identified using a medicinal chemistry approach.

54 Over the past years, medicinal chemistry approaches from a kinetic perspectiv

55 Examples of the use of oxetanes in medicinal chemistry are reported, including a collation

56 acids Phe, Tyr, Trp, and His within peptide medicinal chemistry are showcased herein with examples o

57 lysis of the data set, we have carried out a medicinal chemistry campaign in order to define the stru

58 a more practical fashion, thus empowering a medicinal chemistry campaign that is not wedded to semi-

59 A key challenge encountered in the medicinal chemistry campaign was maintaining a balance b

60 analog of levetiracetam, was identified in a medicinal chemistry campaign with the objective of disco

61 still not available to the computational and medicinal chemistry communities.

62 It is well understood in the medicinal chemistry community that potency measured with

63 ce for both FBDD practitioners and the wider medicinal chemistry community.

64 Here we use medicinal chemistry concepts to assemble a panel of mole

65 Our current medicinal chemistry data also revealed that the RNase H

66 er of observations of each transformation in medicinal chemistry databases.

67 rogen bonding is discussed in the context of medicinal chemistry design.

68 to facilitate the synthesis of analogues and medicinal chemistry development efforts in a time- and r

69 This medicinal chemistry effort culminated in the identificat

70 The medicinal chemistry effort featured the judicious placem

71 n this perspective, we comment on and review medicinal chemistry efforts aimed at the prevention or t

72 sent paper, we report for the first time the medicinal chemistry efforts conducted around the pharmac

73 Medicinal chemistry efforts have resulted in more than 1

74 Initial medicinal chemistry efforts identified key elements for

75 elopment for ASD and the state-of-the-art of medicinal chemistry efforts in related areas.

76 those privileged scaffolds that have guided medicinal chemistry efforts yielding molecules that have

77 e latent electrophiles not typically used in medicinal chemistry efforts, until one reacts with a pro

78 NS4B has thus been the object of impressive medicinal chemistry efforts, which led to the identifica

79 esents the current end-point of an extensive medicinal chemistry endeavor that spans almost three dec

80 al chemistry programs on the assumption that medicinal chemistry expertise will be acquired on the jo

81 Through medicinal chemistry exploration, we established a robust

82 etabolic pathways is now a major strategy in medicinal chemistry for targeting cancers.

83 Moreover, the broad utility of halogens in medicinal chemistry has motivated the use of hybrid quan

84 Recent advances in medicinal chemistry have led to the development of ligan

85 Organometallic medicinal chemistry is a relatively young field that exp

86 cinal chemistry knowledge in the training of medicinal chemistry is discussed.

87 Lead optimization (LO) in medicinal chemistry is largely driven by hypotheses and

88 ally the role of a corpus of robustly tested medicinal chemistry knowledge in the training of medicin

89 ng structure-based drug design, and parallel medicinal chemistry led to the identification of pyridin

90 de the continued extraction of data from the medicinal chemistry literature, new sources of bioactivi

91 This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence th

92 We examined the medicinal chemistry of the selenosemicarbazone, 2-acetyl

93 d also be able to provide an overview of the medicinal chemistry of these closely related infectious

94 Computational medicinal chemistry offers viable strategies for finding

95 Further medicinal chemistry on the compounds' basic scaffold cou

96 pathological conditions, opens a plethora of medicinal chemistry opportunities to develop receptor mo

97 A pre-requisite to medicinal chemistry optimisation programmes required to

98 e synthesis of 65 new analogues arising from medicinal chemistry optimization at different sites on t

99 mall-molecule compounds discovered following medicinal chemistry optimization for the potential treat

100 We report the discovery and medicinal chemistry optimization of a novel series of py

101 n be a useful approach to guide this type of medicinal chemistry optimization once it has been valida

102 Medicinal chemistry optimization resulted in 83, an oral

103 dentified from high-throughput screening and medicinal chemistry optimization such as olesoxime (11),

104 Medicinal chemistry optimization that paid particular at

105 Herein we report the structure-based design, medicinal chemistry optimization, and unique ADME assays

106 ternative class of CA inhibitor, wherein the medicinal chemistry pedigree of primary sulfonamides has

107 derived metabolites can represent innovative medicinal chemistry possibilities toward the identificat

108 A medicinal chemistry program allowed delivery of compound

109 The compounds generated during this medicinal chemistry program and others from the GSK coll

110 Here we describe a medicinal chemistry program starting from amicarbalide t

111 The medicinal chemistry program that led to PFI-3 from an in

112 We report here the results of a medicinal chemistry programme focused on an imidazopyrid

113 activities in assays often propagate through medicinal chemistry programs and compromise their outcom

114 receptor (CB2R), raised the interest of many medicinal chemistry programs for its therapeutic relevan

115 graduates over candidates with degrees from medicinal chemistry programs on the assumption that medi

116 is a key metric that is often used to drive medicinal chemistry programs.

117 several design-synthesize-test iterations on medicinal chemistry projects where they carry out the de

118 l methods are becoming a feasible reality in medicinal chemistry research due to improved computation

119 ive RNA ligands, including: 1) Compliance to medicinal chemistry rules, 2) distinctive structural fea

120 A medicinal chemistry strategy based on modifications of t

121 ential structure-based virtual screening and medicinal chemistry strategy, we identified Cmpd-43 and

122 identified by high-throughput screening and medicinal chemistry structure optimization.

123 lpha-substituted piperazines for early stage medicinal chemistry studies, a simple, general synthetic

124 intermediates with KDM5B, which is a current medicinal chemistry target for cancer.

125 cribe the strategies chosen by the different medicinal chemistry teams in academia and the pharmaceut

126 tumor regression studies, and the inorganic medicinal chemistry that led to clinical implementation

127 s with great potential in areas ranging from medicinal chemistry to biomaterial science.

128 ting immense interest in epigenetic-focused, medicinal chemistry to develop structurally guided chemi

129 ngineering" promises to extend principles of medicinal chemistry to proteins.

130 In the absence of a well-defined medicinal chemistry tool-kit focused on PMTs, most curre

131 This work thus provides the first medicinal chemistry toolbox (experimental procedures and

132 y equally well be described as "the arc of a medicinal chemistry triumph".

133 Medicinal chemistry was used to develop an analog, terme

134 Here, high-throughput compound screening and medicinal chemistry were employed to develop compounds t

135 icle entitled "Chromone: A Valid Scaffold in Medicinal Chemistry" and is mainly focused on chromones

136 tors and ligands without the complexities of medicinal chemistry, and also challenge the biophysical

137 cations of this method in organic synthesis, medicinal chemistry, and chemical biology.

138 have wide applications in organic synthesis, medicinal chemistry, and material science; however, litt

139 mpounds are vital to research in organic and medicinal chemistry, and there are several chiral cataly

140 presents one of the privileged structures in medicinal chemistry, and there have been an increasing n

141 Scaffolds are a core concept in medicinal chemistry, and they can be the focus of multip

142 the basics of GPCR allosteric pharmacology, medicinal chemistry, drug metabolism, and validated appr

143 Intensive medicinal chemistry, guided by potency, selectivity, and

144 d-like scaffolds as privileged structures in medicinal chemistry, in this paper we describe a small l

145 pplications in many different areas, such as medicinal chemistry, polymer synthesis, organocatalysis,

146 thin organic synthesis, natural product, and medicinal chemistry, reports on chiral beta-ketoester mo

147 d during the past 10 years in the Journal of Medicinal Chemistry, the leading journal in the field of

148 emistry, the leading journal in the field of medicinal chemistry, to provide a picture of the changin

149 Furthermore, using computational and medicinal chemistry, we identified a GBA analog, referre

150 Accordingly, we look to medicinal chemistry, which emphasizes biological functio

151 one of the most employed reactions in modern medicinal chemistry.

152 pen new windows for asymmetric catalysis and medicinal chemistry.

153 Indazoles represent a privileged scaffold in medicinal chemistry.

154 eas of pharmacology, pharmacy, oncology, and medicinal chemistry.

155 ds are fundamental building blocks of modern medicinal chemistry.

156 latform for their further optimisation using medicinal chemistry.

157 ic chiral scaffolds are privileged motifs in medicinal chemistry.

158 for late stage functionalization in parallel medicinal chemistry.

159 articular relevance for chemical biology and medicinal chemistry.

160 r (bio)-isostere, is a classical strategy in medicinal chemistry.

161 th emphasis on recent developments impacting medicinal chemistry.

162 nucleosides display a broad applicability in medicinal chemistry.

163 ess useful building blocks for synthetic and medicinal chemistry.

164 o accelerate the exploitation of halogens in medicinal chemistry.

165 e potency of drugs is now fairly standard in medicinal chemistry.

166 The scaffold concept is widely applied in medicinal chemistry.

167 of hydrogen bond acceptor types relevant to medicinal chemistry.

168 anding the evolution that is taking place in medicinal chemistry.

169 mpounds, which are applicable in material to medicinal chemistry.

170 ral products, ingredients, and inhibitors in medicinal chemistry.

171 ients continues to be a challenging goal for medicinal chemistry.

172 njugation strategies used in oligonucleotide medicinal chemistry.

173 providing novel leads and pharmacophores for medicinal chemistry.

174 thus appearing as valuable new scaffolds for medicinal chemistry.

175 lecting their increasingly important role in medicinal chemistry.

176 y yielding access to motifs commonly used in medicinal chemistry.

177 ctures, which is a topic of high interest in medicinal chemistry.

178 ssays are the linchpin of drug discovery and medicinal chemistry.

179 ment, mode of action studies, and eventually medicinal chemistry.

180 sis, biological processes, and materials and medicinal chemistry.

181 on of fluorine is of paramount importance in medicinal chemistry.

182 discovery, thereby increasing innovation in medicinal chemistry.

183 ucture-based drug design approaches can help medicinal chemists a long way toward discovering better

184 anic molecules are of particular interest to medicinal chemists and materials scientists.

185 ew of current applications will be useful to medicinal chemists and other investigators interested in

186 olically robust and therefore widely used by medicinal chemists and radiochemists alike.

187 To optimize drug candidates, modern medicinal chemists are increasingly turning to an unconv

188 Medicinal chemists are often guided by the physicochemic

189 the boundaries of unexplored chemical space, medicinal chemists are routinely turning to unusual stra

190 derable change in large pharma including how medicinal chemists are trained.

191 Graduate and postgraduate training of medicinal chemists at GSK is also briefly described.

192 will be a useful and valuable tool for those medicinal chemists dealing with research programs focuse

193 Medicinal chemists do not yet completely understand the

194 rom their nascency and remain perplexing for medicinal chemists due to their poor drug-like nature.

195 aim of this Perspective is to illustrate how medicinal chemists have elegantly employed the gem-dimet

196 Over the past two decades, medicinal chemists have identified a number of chemical

197 Inspired by this time-tested moiety, medicinal chemists have widely explored its use in devel

198 e a resource for both FBDD practitioners and medicinal chemists in general.

199 ant drug design and development challenge to medicinal chemists to achieve acceptable oral pharmacoki

200 -H functionalization chemistries has enabled medicinal chemists to consider a synthetic strategy, lat

201 in the above-mentioned disorders and to help medicinal chemists to design novel dynamin ligands, whic

202 ng xenobiotics is also due to the attempt of medicinal chemists to stabilize candidates toward cytoch

203 ual guide within the binding site, directing medicinal chemists where to grow the molecule and alerti

204 modulate its druglike properties, providing medicinal chemists with an unconventional strategy for r

205 ith a discussion on what might lie ahead for medicinal chemists, biologists, and physicians as they t

206 ilico ADME-PK should serve as a resource for medicinal chemists, computational chemists, and DMPK sci

207 the ingenuity, experience, and intuition of medicinal chemists, focusing on the key question of whic

208 small molecule HCV therapeutics, designed by medicinal chemists, has been hailed as "the arc of a med

209 otential interest for structural biologists, medicinal chemists, molecular modellers and teachers.

210 ew fluorine-containing chemical entities for medicinal chemists.

211 optimized to address the needs of practicing medicinal chemists.

212 are close to becoming a mainstream tool for medicinal chemists.

213 s is complicated by natural variation in the medicinal components of diets and their covariance with

214 organic chemists around the world synthesize medicinal compounds or extract multiple compounds from p

215 s a more difficult challenge for traditional medicinal development, and there have, therefore, been f

216 , TAAR1 is considered a promising target for medicinal development.

217 logical research on channel function and for medicinal development.

218 is of highly functionalized amide-containing medicinal drugs, such as O-Me-alibendol and -buclosamide

219 terest due to their wide applications in the medicinal field.

220 uses by BaYaka fall into three main domains: medicinal, foraging, and social norms/beliefs; (2) most

221 Turmeric has been used as a medicinal herb for thousands of years for treatment of v

222 odi, an endangered and endemic high-altitude medicinal herb of northwestern Himalayas.

223 Honokiol is a key component of a medicinal herb, Magnolia bark.

224 Several herbal remedies, but not Chinese medicinal herbs, were associated with an overall decreas

225 (SM) Bunge is one of the widely-used Chinese medicinal herbs.

226 causes cytotoxicity, although the potential medicinal impact of this effect has not been fully estab

227 been reported despite heavy biosynthetic and medicinal interest.

228 trials of curcumin and other polyphenols of medicinal interest.

229 d families, facilitating the transmission of medicinal knowledge and its fitness implications.

230 sis were obtained directly on ganglia of the medicinal leech (Hirudo medicinalis) without in-gel dige

231 n previous studies using Hirudo verbana (the medicinal leech), endocannabinoids were found to depress

232 olumes of serial EM data from ganglia of the medicinal leech.

233 this system to the segmental ganglia of the medicinal leech.

234 The medicinal macrofungus Inonotus obliquus widely utilized

235 Importance: Medicinal marijuana use is currently legal in 23 states

236 erpillar fungus Ophiocordyceps sinensis is a medicinal mushroom increasingly used as a dietary supple

237 Well-known edible and medicinal mushroom species as well as uncommon or unknow

238 Ganoderma lucidum is a well-known medicinal mushroom.

239 and antioxidant activities and assessment of medicinal/nutritional uses of the essential oils are sub

240 as a boon in several fields like industrial, medicinal or agriculture; some of them have been also va

241 et rare antioxidants from many herbs of food/medicinal origins.

242 Despite numerous industrial and medicinal/pharmaceutical applications of its antioxidati

243 aside I and bacopaside II, isolated from the medicinal plant Bacopa monnieri Screening was conducted

244 scovery of iridoid biosynthetic genes in the medicinal plant Catharanthus roseus has provided insight

245 the oxygenated diterpenoids from the Chinese medicinal plant Danshen (Salvia miltiorrhiza).

246 ected endophytes isolated from the Brazilian medicinal plant Lychnophora ericoides by pairwise inter-

247 novel natural antioxidant isolated from the medicinal plant Panax ginseng C.A. Mey.

248 escin, a predominant steroidal lactone, from medicinal plant Physalis pubescens L., commonly named as

249 s are major bioactive compounds found in the medicinal plant Scutellaria baicalensis Georgi.

250 e characterize CYP716 enzymes from different medicinal plant species by heterologous expression in en

251 ) is an important traditional Chinese herbal medicinal plant species for its haemostatic effects.

252 key ingredient from the traditional Chinese medicinal plant thunder god vine, which has been used to

253 activity compared to standardised methods of medicinal plant use classification.

254 or bioactivity, and phylogenetic patterns in medicinal plant uses have suggested that phylogeny can b

255 Here we show that medicinal plant uses interpreted from a perspective of a

256 However, the common practice of grouping medicinal plant uses into standardised categories may re

257 Our interpretation of medicinal plant uses may therefore allow for a more targ

258 is an important traditional Tibetan medicinal plant with pharmacological properties effectiv

259 ium wilfordii, which has long been used as a medicinal plant, exhibits impressive and effective anti-

260 differential AQP1 modulators isolated from a medicinal plant.

261 ation for further research on this important medicinal plant.

262 Due to the great importance of medicinal plants for health, we need to find new and sus

263 foraging, and social norms/beliefs; (2) most medicinal plants have known bioactive properties, and so

264 that their use is adaptive; (3) knowledge of medicinal plants is mainly shared between spouses and bi

265 ne-derived phenolic natural product found in medicinal plants under the Rhodiola genus.

266 (EDB) Sambucus nigra L. is one of the oldest medicinal plants which is useful for therapeutic and nut

267 oils and flavoured olive oils with aromatic/medicinal plants, was established using liquid-liquid mi

268 iated mechanism of action for anti-infective medicinal plants.

269 d two varieties of Manuka honey derived from medicinal plants.

270 ed were edible, but also included nonedible, medicinal, poisonous and toxic specimens.

271 to its intriguing chemical structure and the medicinal potential of phorbol esters.

272 required for manufacture of advanced therapy medicinal products (ATMPs).

273 methods for the determination of veterinary medicinal products from egg albumen are needed.

274 tion system in the European Advanced Therapy Medicinal Products regulation, providing a pragmatic and

275 t also hopefully help assign newly developed medicinal products to those patients who will have the b

276 extract and salidroside have also displayed medicinal properties as anti-cardiovascular diseases and

277 g new ways for discovering and utilizing the medicinal properties of plants.

278 from Curcuma longa plant, long known for its medicinal properties, inhibited NTHi-induced CXCL5 expre

279 has attained much attention renowned for its medicinal properties.

280 plant tea used in the Amazon for ritual and medicinal purposes, and by interested individuals worldw

281 iophysical character, better suitability for medicinal purposes, and comparable pharmacology against

282 molecules, are currently being evaluated for medicinal purposes, separately and in combination.

283 uent Geniposide, is widely used in China for medicinal purposes.

284 ially and legally, for both recreational and medicinal purposes.

285 Despite their numerous medicinal qualities, very few anthraquinone biosynthetic

286 tifs (e.g., CF3, CHF2, OCF3, SCF3, OCHF2) of medicinal relevance onto (hetero)arenes.

287 sis of terpenoid ring systems of interest in medicinal research, particularly those that have been hi

288 e fascinating fields of synthetic chemistry, medicinal science, biochemistry, pharmacology, material

289 This study describes the design, medicinal synthesis, and discovery of small-molecule LIM

290 Medicinal targeting of heterodimer thermodynamics repres

291 ng the successful cases, Traditional Chinese Medicinal (TCM) formulae can achieve synergistic effects

292 suggest that Si3N4 might provide unique new medicinal therapies and effective remedies for various b

293 However, DTCs also have recognized medicinal use in the treatment of heavy metal poisonings

294 Worldwide medicinal use of cannabis is rapidly escalating, despite

295 build a sound scientific basis for increased medicinal use of CBD.

296 As the medicinal use of cobalt has waned and measures to reduce

297 ch as psilocybin, have an ancient history of medicinal use.

298 ophysical properties severely complicate its medicinal use.

299 Medicinal uses of plants were proposed as proxy for bioa

300 extensively, owing to their nutritional and medicinal value, for thousands of years.