ライフサイエンスコーパス: medicinal chemistry

1 nucleosides display a broad applicability in medicinal chemistry.

2 ess useful building blocks for synthetic and medicinal chemistry.

3 o accelerate the exploitation of halogens in medicinal chemistry.

4 e potency of drugs is now fairly standard in medicinal chemistry.

5 The scaffold concept is widely applied in medicinal chemistry.

6 of hydrogen bond acceptor types relevant to medicinal chemistry.

7 anding the evolution that is taking place in medicinal chemistry.

8 mpounds, which are applicable in material to medicinal chemistry.

9 ral products, ingredients, and inhibitors in medicinal chemistry.

10 ients continues to be a challenging goal for medicinal chemistry.

11 njugation strategies used in oligonucleotide medicinal chemistry.

12 providing novel leads and pharmacophores for medicinal chemistry.

13 thus appearing as valuable new scaffolds for medicinal chemistry.

14 lecting their increasingly important role in medicinal chemistry.

15 yrrolidin-3-ol, a valuable building block in medicinal chemistry.

16 pplications of carbamates in drug design and medicinal chemistry.

17 y yielding access to motifs commonly used in medicinal chemistry.

18 s have triggered major interest in inorganic medicinal chemistry.

19 ctures, which is a topic of high interest in medicinal chemistry.

20 ns is a great challenge for both organic and medicinal chemistry.

21 in asymmetric synthesis, crop protection and medicinal chemistry.

22 ssays are the linchpin of drug discovery and medicinal chemistry.

23 ) ligands provides a formidable challenge in medicinal chemistry.

24 t building blocks for biological studies and medicinal chemistry.

25 piperidines was prepared as novel cores for medicinal chemistry.

26 19)F NMR, suggesting their use in probes and medicinal chemistry.

27 hting their potential as building blocks for medicinal chemistry.

28 a number of implications for the practice of medicinal chemistry.

29 ommon task in computer-aided drug design and medicinal chemistry.

30 ined piperazines, key scaffold components in medicinal chemistry.

31 ons in molecular biology, biotechnology, and medicinal chemistry.

32 fold for developing improved activators with medicinal chemistry.

33 ivity cliff concept is of high relevance for medicinal chemistry.

34 monomers, is currently still a challenge in medicinal chemistry.

35 ons in molecular biology, biotechnology, and medicinal chemistry.

36 d applications of directed C-H activation in medicinal chemistry.

37 erefore it represents an attractive tool for medicinal chemistry.

38 variety of scientific disciplines, including medicinal chemistry.

39 n of a series of heterocycles of interest in medicinal chemistry.

40 s can yield results that are very useful for medicinal chemistry.

41 otential of NOD inhibitors is a key topic in medicinal chemistry.

42 st misunderstood computational approaches in medicinal chemistry.

43 ta-2-en-1-ols, important building blocks for medicinal chemistry.

44 ned to explore activity cliff progression in medicinal chemistry.

45 yridines as a starting point for hit-to-lead medicinal chemistry.

46 of the major computational tools employed in medicinal chemistry.

47 likely to be a key challenge to 21st century medicinal chemistry.

48 gnificant opportunities for further study in medicinal chemistry.

49 ment, mode of action studies, and eventually medicinal chemistry.

50 sis, biological processes, and materials and medicinal chemistry.

51 on of fluorine is of paramount importance in medicinal chemistry.

52 discovery, thereby increasing innovation in medicinal chemistry.

53 one of the most employed reactions in modern medicinal chemistry.

54 pen new windows for asymmetric catalysis and medicinal chemistry.

55 Indazoles represent a privileged scaffold in medicinal chemistry.

56 eas of pharmacology, pharmacy, oncology, and medicinal chemistry.

57 ds are fundamental building blocks of modern medicinal chemistry.

58 latform for their further optimisation using medicinal chemistry.

59 ic chiral scaffolds are privileged motifs in medicinal chemistry.

60 for late stage functionalization in parallel medicinal chemistry.

61 articular relevance for chemical biology and medicinal chemistry.

62 r (bio)-isostere, is a classical strategy in medicinal chemistry.

63 th emphasis on recent developments impacting medicinal chemistry.

64 alysis of chemical reactions used in current medicinal chemistry (2014), three decades ago (1984), an

65 tically probing one of its exit vectors is a medicinal chemistry activity that can benefit from molec

66 A systematic study of medicinal chemistry aimed at identifying a new generatio

67 ides are increasingly important molecules in medicinal chemistry and agrochemistry, but their prepara

68 rable physiochemical properties required for medicinal chemistry and agrochemistry.

69 ues are also valuable as building blocks for medicinal chemistry and as tools for chemical biology.

70 Medicinal chemistry and biophysical evaluations focused

71 luorinated building blocks of high value for medicinal chemistry and drug discovery.

72 teractions, and they have a broad utility in medicinal chemistry and drug discovery.

73 or organic synthesis, for pharmaceutical and medicinal chemistry and for material science.

74 e amides, a class of privileged scaffolds in medicinal chemistry and important synthetic intermediate

75 Extensive medicinal chemistry and iterative structure-activity rel

76 sicochemical properties as a stable motif in medicinal chemistry and its propensity to undergo ring-o

77 There is an increasing use of carbamates in medicinal chemistry and many derivatives are specificall

78 Despite their potential applications in both medicinal chemistry and materials science, there have be

79 p and transition metal chemistry, catalysis, medicinal chemistry and materials science.

80 class of compounds with applications in both medicinal chemistry and materials science.

81 , classes of compounds that are important to medicinal chemistry and natural product synthesis.

82 -unsaturated esters, useful intermediates in medicinal chemistry and natural products synthesis, is r

83 as immediate applications in drug discovery, medicinal chemistry and other commercial areas of chemic

84 The medicinal chemistry and preclinical biology of imidazopy

85 te a new approach that fuses the concepts of medicinal chemistry and protein design, and paves the wa

86 etween trifluoromethylation in materials and medicinal chemistry and structural biology and biotechno

87 evalence of drug ring combinations in modern medicinal chemistry and to identify areas of under-repre

88 as a significant and novel emerging area for medicinal chemistry and we provide an overview of one of

89 s is expected to benefit molecular design in medicinal chemistry and, more broadly, in life as well a

90 icle entitled "Chromone: A Valid Scaffold in Medicinal Chemistry" and is mainly focused on chromones

91 tors and ligands without the complexities of medicinal chemistry, and also challenge the biophysical

92 cations of this method in organic synthesis, medicinal chemistry, and chemical biology.

93 have wide applications in organic synthesis, medicinal chemistry, and material science; however, litt

94 mpounds are vital to research in organic and medicinal chemistry, and there are several chiral cataly

95 presents one of the privileged structures in medicinal chemistry, and there have been an increasing n

96 Scaffolds are a core concept in medicinal chemistry, and they can be the focus of multip

97 The potential utility of these methods in medicinal chemistry applications is highlighted.

98 For medicinal chemistry applications, a key question becomes

99 are made freely available as a resource for medicinal chemistry applications.

100 3 character and may prove useful in multiple medicinal chemistry applications.

101 that exhibit properties of high interest for medicinal chemistry applications.

102 derivatives appearing in recent patents for medicinal chemistry applications.

103 Here, starting with a medicinal chemistry approach, Baker et al. generate an i

104 accine candidate that was identified using a medicinal chemistry approach.

105 Over the past years, medicinal chemistry approaches from a kinetic perspectiv

106 Using structural information, classical medicinal chemistry approaches, and M2-specific biologic

107 sized on the basis of other computational or medicinal chemistry approaches.

108 utility of this strategy and its benefit to medicinal chemistry are demonstrated by the direct trifl

109 The progress and evolution in medicinal chemistry are discussed, specifically focusing

110 Examples of the use of oxetanes in medicinal chemistry are reported, including a collation

111 acids Phe, Tyr, Trp, and His within peptide medicinal chemistry are showcased herein with examples o

112 the training of chemistry undergraduates in medicinal chemistry (as practiced in industry) in two mo

113 o provide the history and perspective of the medicinal chemistry behind the discovery and development

114 lysis of the data set, we have carried out a medicinal chemistry campaign in order to define the stru

115 a more practical fashion, thus empowering a medicinal chemistry campaign that is not wedded to semi-

116 The present study describes the medicinal chemistry campaign that led to the development

117 A medicinal chemistry campaign that was conducted to addre

118 A key challenge encountered in the medicinal chemistry campaign was maintaining a balance b

119 analog of levetiracetam, was identified in a medicinal chemistry campaign with the objective of disco

120 properties of P7C3 were optimized through a medicinal chemistry campaign, providing analogues for de

121 BR127 (2) was used as a starting point for a medicinal chemistry campaign, which yielded NIBR189 (4m)

122 ccupy a privileged position in synthetic and medicinal chemistry, chemical biology, and materials sci

123 still not available to the computational and medicinal chemistry communities.

124 It is well understood in the medicinal chemistry community that potency measured with

125 ction, appears to be underappreciated by the medicinal chemistry community.

126 ce for both FBDD practitioners and the wider medicinal chemistry community.

127 Here we use medicinal chemistry concepts to assemble a panel of mole

128 Our current medicinal chemistry data also revealed that the RNase H

129 er of observations of each transformation in medicinal chemistry databases.

130 A rational medicinal chemistry design strategy to deliver CNS penet

131 rogen bonding is discussed in the context of medicinal chemistry design.

132 to facilitate the synthesis of analogues and medicinal chemistry development efforts in a time- and r

133 the basics of GPCR allosteric pharmacology, medicinal chemistry, drug metabolism, and validated appr

134 This medicinal chemistry effort culminated in the identificat

135 A focused medicinal chemistry effort delivered several 6-alkyl-2,4

136 The medicinal chemistry effort featured the judicious placem

137 This medicinal chemistry effort led to the identification of

138 Here we summarize the extensive medicinal chemistry effort to develop novel P2 cyclopent

139 starting point for initiating a hit-to-lead medicinal chemistry effort.

140 n this perspective, we comment on and review medicinal chemistry efforts aimed at the prevention or t

141 sent paper, we report for the first time the medicinal chemistry efforts conducted around the pharmac

142 Medicinal chemistry efforts have resulted in more than 1

143 Initial medicinal chemistry efforts identified key elements for

144 , and may have a profound impact upon future medicinal chemistry efforts in oncology.

145 elopment for ASD and the state-of-the-art of medicinal chemistry efforts in related areas.

146 In this Perspective, we summarize published medicinal chemistry efforts in the context of the availa

147 n preceding communications we summarized our medicinal chemistry efforts leading to the identificatio

148 Our findings have implications for further medicinal chemistry efforts of ZL006, IC87201 and analog

149 dulating AP-1 associated signaling pathways, medicinal chemistry efforts remain an urgent need to yie

150 potent cruzain inhibitors in guiding further medicinal chemistry efforts to develop drug candidates f

151 ively, these observations will inform future medicinal chemistry efforts to improve the selectivity o

152 s review, we outline current drug design and medicinal chemistry efforts toward the development of ne

153 those privileged scaffolds that have guided medicinal chemistry efforts yielding molecules that have

154 e latent electrophiles not typically used in medicinal chemistry efforts, until one reacts with a pro

155 NS4B has thus been the object of impressive medicinal chemistry efforts, which led to the identifica

156 rotein binding assessments as they relate to medicinal chemistry efforts.

157 gability" of each interface informing future medicinal chemistry efforts.

158 ation of pharmacological liabilities through medicinal chemistry efforts.

159 esents the current end-point of an extensive medicinal chemistry endeavor that spans almost three dec

160 pproach employs a combination of a five-step medicinal chemistry evaluation and a two-step biological

161 al chemistry programs on the assumption that medicinal chemistry expertise will be acquired on the jo

162 In a systematic medicinal chemistry exploration, we demonstrated chemica

163 Through medicinal chemistry exploration, we established a robust

164 etabolic pathways is now a major strategy in medicinal chemistry for targeting cancers.

165 nation chemistry, to fundamental entities in medicinal chemistry, guanidines are amongst the most int

166 Intensive medicinal chemistry, guided by potency, selectivity, and

167 Moreover, the broad utility of halogens in medicinal chemistry has motivated the use of hybrid quan

168 Recent advances in medicinal chemistry have led to the development of ligan

169 rus as a significant, new emerging topic for medicinal chemistry, highlighting the key viral target p

170 ive for fields such as organic synthesis and medicinal chemistry; however, there have been relatively

171 d-like scaffolds as privileged structures in medicinal chemistry, in this paper we describe a small l

172 cal insights into the drug class of ARBs and medicinal chemistry insights for future drug development

173 Organometallic medicinal chemistry is a relatively young field that exp

174 densely substituted homochiral compounds in medicinal chemistry is briefly described.

175 cinal chemistry knowledge in the training of medicinal chemistry is discussed.

176 Lead optimization (LO) in medicinal chemistry is largely driven by hypotheses and

177 din-4-ol, a highly prized building block for medicinal chemistry, is reported.

178 s of novel ligands bound to an ER construct, medicinal chemistry iterations led to (E)-3-(3,5-difluor

179 ally the role of a corpus of robustly tested medicinal chemistry knowledge in the training of medicin

180 Through medicinal chemistry lead optimization studies focused on

181 composition of matter patentability of a new medicinal chemistry lead.

182 Portoghese Medicinal Chemistry Lectureship, several vignettes of dr

183 ng structure-based drug design, and parallel medicinal chemistry led to the identification of pyridin

184 ng natural products and their derivatives in medicinal chemistry led us to discover four novel series

185 nds acting in the 0.1 to 10 muM range in the medicinal chemistry literature are at least 85% similar

186 The aim of this article is to review the medicinal chemistry literature around small molecule app

187 de the continued extraction of data from the medicinal chemistry literature, new sources of bioactivi

188 from multiple sources, including the primary medicinal chemistry literature.

189 We have summarized the current status of the medicinal chemistry of 5-HT6R antagonists and the encour

190 represents a complete picture of the current medicinal chemistry of chikungunya, supporting the devel

191 This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence th

192 We examined the medicinal chemistry of the selenosemicarbazone, 2-acetyl

193 This review details the medicinal chemistry of these agonists, highlights their

194 d also be able to provide an overview of the medicinal chemistry of these closely related infectious

195 of this template, we have here explored the medicinal chemistry of truncated analogues that have onl

196 Computational medicinal chemistry offers viable strategies for finding

197 Further medicinal chemistry on the compounds' basic scaffold cou

198 pathological conditions, opens a plethora of medicinal chemistry opportunities to develop receptor mo

199 A pre-requisite to medicinal chemistry optimisation programmes required to

200 e synthesis of 65 new analogues arising from medicinal chemistry optimization at different sites on t

201 Hit to lead medicinal chemistry optimization established the SAR aro

202 mall-molecule compounds discovered following medicinal chemistry optimization for the potential treat

203 es a successful example of hypothesis-driven medicinal chemistry optimization from a singleton hit ag

204 Starting with hit compound 1a, medicinal chemistry optimization led to compound 31.

205 We present the discovery and medicinal chemistry optimization of 2-pyridinyl-N-(4-ary

206 Herein, we report the identification and medicinal chemistry optimization of a 4-((2-hydroxy-3-me

207 We report the discovery and medicinal chemistry optimization of a novel series of py

208 t screen of >400000 compounds and subsequent medicinal chemistry optimization of small molecules that

209 the original screening library, facilitated medicinal chemistry optimization of the antimalarial lea

210 Medicinal chemistry optimization of the potency against

211 n be a useful approach to guide this type of medicinal chemistry optimization once it has been valida

212 In medicinal chemistry optimization programs it is relative

213 Medicinal chemistry optimization resulted in 83, an oral

214 dentified from high-throughput screening and medicinal chemistry optimization such as olesoxime (11),

215 Medicinal chemistry optimization that paid particular at

216 Medicinal chemistry optimization to maintain this twiste

217 Herein we report the structure-based design, medicinal chemistry optimization, and unique ADME assays

218 h-throughput screening campaign, followed by medicinal chemistry optimization, to yield a selective m

219 entified a number of promising compounds for medicinal chemistry optimization.

220 over viable new starting point scaffolds for medicinal chemistry optimization.

221 ternative class of CA inhibitor, wherein the medicinal chemistry pedigree of primary sulfonamides has

222 action, scientific rationale, binding mode, medicinal chemistry, pharmacokinetic and pharmacodynamic

223 mechanisms of action, scientific rationale, medicinal chemistry, pharmacokinetic properties, and hum

224 e mechanism of action, scientific rationale, medicinal chemistry, pharmacokinetic properties, and hum

225 Our medicinal chemistry plan focused on identifying a molecu

226 This discovery is the result of a medicinal chemistry plan focused on improving the develo

227 is to present the concept of the RoI from a medicinal chemistry point of view and to highlight the e

228 pplications in many different areas, such as medicinal chemistry, polymer synthesis, organocatalysis,

229 idates the effectiveness and usefulness of a medicinal chemistry/polypharmacology approach to obtain

230 derived metabolites can represent innovative medicinal chemistry possibilities toward the identificat

231 uscript summarizes the scientific rationale, medicinal chemistry, preclinical, and early development

232 We report the continuation of a focused medicinal chemistry program aimed to further optimize a

233 A medicinal chemistry program allowed delivery of compound

234 The compounds generated during this medicinal chemistry program and others from the GSK coll

235 Here we describe a medicinal chemistry program starting from amicarbalide t

236 The medicinal chemistry program that led to PFI-3 from an in

237 Evolution of our medicinal chemistry program, structure activity, and pro

238 The evolution of our medicinal chemistry program, structure-activity relation

239 We report here the results of a medicinal chemistry programme focused on an imidazopyrid

240 , may serve as a suitable starting point for medicinal chemistry programs aided by MD simulations aim

241 on metabolic diseases and summarizes recent medicinal chemistry programs aimed at delivering small m

242 ts to integrate activity trends from diverse medicinal chemistry programs and apply them to problems

243 activities in assays often propagate through medicinal chemistry programs and compromise their outcom

244 receptor (CB2R), raised the interest of many medicinal chemistry programs for its therapeutic relevan

245 graduates over candidates with degrees from medicinal chemistry programs on the assumption that medi

246 This mini-review focuses on medicinal chemistry programs that have synthesized biolo

247 is a key metric that is often used to drive medicinal chemistry programs.

248 several design-synthesize-test iterations on medicinal chemistry projects where they carry out the de

249 nd experimental simplicity in the context of medicinal chemistry projects.

250 ange of protein targets at various stages of medicinal-chemistry projects.

251 discovered through live virus inhibition or medicinal chemistry rather than M2-targeted high-through

252 The medical need, medicinal chemistry rationale, preclinical data, and pha

253 thin organic synthesis, natural product, and medicinal chemistry, reports on chiral beta-ketoester mo

254 l methods are becoming a feasible reality in medicinal chemistry research due to improved computation

255 resource in the fields of drug discovery and medicinal chemistry research.

256 ive RNA ligands, including: 1) Compliance to medicinal chemistry rules, 2) distinctive structural fea

257 ded cinnamic acid derivative, two privileged medicinal chemistry scaffolds.

258 s Perspective, we will provide insights into medicinal chemistry strategies for the development of ch

259 ters of CNS drugs as well as their impact on medicinal chemistry strategies toward molecules with opt

260 A medicinal chemistry strategy based on modifications of t

261 The successful medicinal chemistry strategy confirms that a conserved m

262 ential structure-based virtual screening and medicinal chemistry strategy, we identified Cmpd-43 and

263 identified by high-throughput screening and medicinal chemistry structure optimization.

264 Numerous medicinal chemistry studies are currently aimed at the d

265 ioxanes, thereby facilitating biological and medicinal chemistry studies of peroxy natural products.

266 In this Perspective, we summarize the medicinal chemistry studies that led to the discovery of

267 lpha-substituted piperazines for early stage medicinal chemistry studies, a simple, general synthetic

268 rough high-throughput screening experiments, medicinal chemistry studies, chemical biology research a

269 intermediates with KDM5B, which is a current medicinal chemistry target for cancer.

270 cribe the strategies chosen by the different medicinal chemistry teams in academia and the pharmaceut

271 property-driven design coupled with parallel medicinal chemistry techniques to arrive at a novel seri

272 tumor regression studies, and the inorganic medicinal chemistry that led to clinical implementation

273 Here, we describe medicinal chemistry that was accelerated by a diversity-

274 d during the past 10 years in the Journal of Medicinal Chemistry, the leading journal in the field of

275 There are two branches in boron medicinal chemistry: the first focuses on single boron a

276 Given their use in medicinal chemistry, there are surprisingly few substant

277 s with great potential in areas ranging from medicinal chemistry to biomaterial science.

278 ting immense interest in epigenetic-focused, medicinal chemistry to develop structurally guided chemi

279 se materials, with applications ranging from medicinal chemistry to electronic materials.

280 strategy employed NMR, X-ray, modeling, and medicinal chemistry to expose the critical role that bio

281 re used extensively in molecular biology and medicinal chemistry to modulate gene expression at the R

282 cules are of interest in fields ranging from medicinal chemistry to polymer science.

283 ngineering" promises to extend principles of medicinal chemistry to proteins.

284 This scaffold evolved via medicinal chemistry to yield orally bioavailable leads w

285 and structural characterization, along with medicinal chemistry, to identify and characterize small

286 emistry, the leading journal in the field of medicinal chemistry, to provide a picture of the changin

287 In the absence of a well-defined medicinal chemistry tool-kit focused on PMTs, most curre

288 This work thus provides the first medicinal chemistry toolbox (experimental procedures and

289 umber of important research areas, including medicinal chemistry, total synthesis and materials scien

290 ntly, there has been significant interest in medicinal chemistry toward the discovery and design of l

291 y equally well be described as "the arc of a medicinal chemistry triumph".

292 Medicinal chemistry was used to develop an analog, terme

293 pin-2-one nucleus, a privileged structure in medicinal chemistry, we have synthesized a novel class o

294 Furthermore, using computational and medicinal chemistry, we identified a GBA analog, referre

295 Here, high-throughput compound screening and medicinal chemistry were employed to develop compounds t

296 -ClPh is traced back to historical models of medicinal chemistry where para-substituted regioisomers

297 are versatile building blocks, especially in medicinal chemistry, where they serve as bioisosteres of

298 Accordingly, we look to medicinal chemistry, which emphasizes biological functio

299 ept, and lay a strong foundation for further medicinal chemistry work in developing organic CO prodru

300 Subsequent medicinal chemistry work led to the discovery of a thien