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1 1 malignant FNA, 5 oncocytic/Hurthle cell, 2 medullary, 1 follicular, and 4 metastases from underlyin
2 ced V-ATPase apical membrane accumulation in medullary A-ICs but not in cortical A-ICs or other IC su
5 nsepithelial resistance, and defective renal medullary accumulation of sodium and other osmolytes.
6 -pituitary-adrenal axis, sympathetic adrenal-medullary activation and catecholamine levels, the infla
9 progression, was associated with aggressive medullary and anaplastic carcinomas, and its expression
10 other, more rare subtypes of thyroid cancer-medullary and anaplastic-are ideally treated by physicia
12 tic disorders, cyst-dependent obstruction of medullary and cortical tubules initiates a process culmi
14 n of SLAMF7-CAR T cells led to resolution of medullary and extramedullary myeloma manifestations in a
15 eatment options for patients with hereditary medullary and nonmedullary thyroid cancers related to mu
17 rons in the medial aspect of the superficial medullary and spinal dorsal horn from the trigeminal sub
19 -expressing NK cells, including conventional medullary and thymic NK cells, whereas TRAIL(+) Eomes(-)
20 llular scaffolds with vascular, cortical and medullary architecture, a collecting system and ureters.
22 CR7, how other T cell subsets gain access to medullary areas during their normal development is not c
23 eses that in conditions of MeCP2 deficiency, medullary astrocytes are unable to produce/release appro
24 (ii) MeCP2 deficiency impairs the ability of medullary astrocytes to sense changes in PCO2/[H(+) ].
25 tude of CO2 -induced [Ca(2+) ]i responses in medullary astrocytes was markedly reduced in conditions
26 ice with normal angiopoietin-Tie2 signaling, medullary AVR exhibited an unusual hybrid endothelial ph
27 adrenal cortex, and the sympathetic-adrenal-medullary axis, which controls stress-induced catecholam
28 some also prevented the secondary decline in medullary blood flow and ischemia that develops 2 hours
29 ctive role in renal IR injury by maintaining medullary blood flow and that a genetic deficiency in th
32 ning REM sleep is located in the pontine and medullary brainstem and includes ascending and descendin
33 c databases revealed ANTXR1 amplification in medullary breast carcinoma and overexpression in estroge
36 nce of Wnt7b signaling, the periureteric bud medullary capillaries displayed narrower lumens lined wi
38 ndocrine glands-like C cells of the thyroid (medullary carcinoma), the parasympathetic and sympatheti
39 we test whether these rostral ventrolateral medullary catecholaminergic (RVLM-CA) neurons use glutam
42 st PSB-0739 in primary cultures of rat inner medullary CD cells potentiated the expression of AQP2 an
44 ine release was measured from bovine adrenal medullary chromaffin cell (CC) cultures maintained over
45 ine and norepinephrine released from adrenal medullary chromaffin cells and norepinephrine released l
47 n regulates NO production in the renal inner medullary collecting duct (IMCD), the segment with the g
48 3D cell culture model that uses mouse inner-medullary collecting duct (mIMCD3) cells to generate epi
49 hibition of p38MAPK activity in murine inner medullary collecting duct 3 (mIMCD3) cells decreased exp
50 (PI3K-C2alpha) in renal tubule-derived inner medullary collecting duct 3 cells and show that PI3K-C2a
51 ar to cells lacking PC2, NEK8-depleted inner medullary collecting duct cells exhibited a defective re
52 genetic knockdown of TRIP13 in murine inner medullary collecting duct cells in the presence of hydro
55 ely integrated into the aquaporin 2-positive medullary collecting duct when microinjected into the ki
57 ubule and decreased slightly in the cortical/medullary collecting duct, whereas BK channel abundance
60 n vitro microperfusion of cortical and outer medullary collecting ducts, was unaffected in mutant mic
61 de use of primarily cultured rat renal inner medullary collecting-duct cells and microarray analysis
62 artment kidney phantom (70% cortical and 30% medullary compartment), a sphere, and an ellipsoid of eq
63 TECs and in addition affects the size of the medullary compartment, TEC-specific HIPK2 deletion only
67 at yellow fluorescent protein(+) ASCs in the medullary cords migrated along myelomonocytic cells and
68 s sensed higher concentrations of S1P in the medullary cords than in the T cell zone and that the S1P
70 omplete SCI, we created bilaterally complete medullary corticospinal tract lesions in adult mice, eli
71 utosomal dominant polycystic kidney disease, medullary cystic kidney disease, diabetic nephropathy, o
72 These findings demonstrate that cortical and medullary DCs play specialized roles in their respective
73 he immune defense against pyelonephritis, as medullary DCs were less CX3CR1 dependent than cortical D
74 contrast, Foxp3(+) nTreg cell development is medullary dependent, with mTECs fostering the generation
77 tricted to interneurons in lamina IIi of the medullary dorsal horn, where they constitute 1/3 of tota
80 microscopy to demonstrate that CCR4 promotes medullary entry of the earliest post-positive selection
81 vation with 5-thioglucose stimulated adrenal medullary epinephrine (Epi) release (3,153%) and feeding
82 fluenced the ability of Aire to regulate the medullary epithelial cell transcriptome and so was cruci
84 with increased frequencies of AIRE-positive medullary epithelial cells and CD11c-positive dendritic
85 expression of a large set of genes in thymic medullary epithelial cells, thereby controlling the repe
86 d CD40-CD40L pathways is required for normal medullary epithelium and for maintenance of self-toleran
87 -) and that transitioned into a multilaminar medullary epithelium forming neurotubules with adluminal
93 was significant correlation between eGFR and medullary FA (r = 0.65, P < .001), cortical ADC (r = 0.4
104 e mice, an effect accompanied by a hypotonic medullary interstitium and impaired countercurrent multi
106 al reabsorption of water into the hypertonic medullary interstitium mediated by collecting ducts.
107 rapid accumulation of fluid and cysts in the medullary interstitium, loss of medullary vascular bundl
108 s canonical Wnt signaling in the surrounding medullary interstitium, where the capillaries reside.
111 ormally induces clearance of the renal outer medullary K(+) channel (ROMK) from the cell surface.
112 ne-independent activation of the renal outer medullary K(+) channel and ENaC, to which angiotensin II
113 iets induced upregulation of the renal outer medullary K(+) channel in AS(-/-) mice, whereas upregula
114 +) and NeuN(+) cells within the multilayered medullary layer approximate expression patterns similar
118 s to positions adjacent to both cortical and medullary lymphatic sinuses where the T cells exhibited
119 ered a program of PGE that is common between medullary (m) and cortical TEC, further elaborated in mT
120 vant MF59 localizes in subcapsular sinus and medullary macrophage compartments of mouse draining LNs,
122 the development and functional importance of medullary microenvironments during self-tolerant T-cell
123 thymus, interactions with both cortical and medullary microenvironments regulate the development of
124 of thymocyte precursors through cortical and medullary microenvironments, enabling specialized stroma
126 indicate that a functional compromise of the medullary mTEC(high) compartment may link alloimmunity t
127 chromophobe (n = 5), papillary (n = 5), and medullary (n = 2) RCC and unclassified RCC (uRCC, n = 23
128 mmunoblotting revealed downregulation of the medullary Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in these
129 ation between chronic hyperaldosteronism and medullary nephrocalcinosis has rarely been made, with on
131 increased risk of kidney stone formation or medullary nephrocalcinosis, namely 46% compared with 6%
133 identification of a discrete JAG1(+) thymic medullary niche enriched for DC-lineage cells expressing
137 to mammalian water balance and depends on a medullary osmotic gradient generated by a countercurrent
139 3 to 36.3 +/- 3.5 mm Hg (p < 0.001), whereas medullary oxygenation decreased from 29.6 +/- 4.7 to 13.
140 though sleep-active GABAergic neurons in the medullary parafacial zone (PZ) are needed for normal SWS
142 perfusion was not significantly changed, but medullary perfusion decreased (671 BPU [500-900 BPU] to
145 mic accumulation of mature thymocytes within medullary perivascular spaces and reduced numbers of rec
147 ition of the potassium-excretory renal outer medullary potassium (ROMK) channel have also been implic
148 me is caused by mutations in the renal outer medullary potassium (ROMK) channel, but the molecular me
149 elial sodium channel (ENaC), the renal outer medullary potassium channel (ROMK), and other transport
152 epithelial sodium channel-alpha, renal outer medullary potassium channel, and Na(+), K(+)-ATPase in t
154 at changes in the electrical excitability of medullary pre-sympathetic neurones are the main causal m
155 tability of respiratory rhythm recorded from medullary preparations decreased with age but was higher
156 on of both AQP2 and pAQP2 in the renal inner medullary principal cells appeared more dispersed, and t
157 cement of electrodes less than 5 mm from the medullary pyramids resulted in treatment effect arcing i
160 ional tissue hypoxia rather than cortical or medullary R2* values used to assess renal BOLD MR imagin
162 ons of ATP or a P2-receptor blocker into the medullary raphe had no effect on cardiorespiratory activ
163 lamic nucleus [PaMP]) and autonomic (rostral medullary raphe pallidus [RPa]) responses were targeted
164 if CO2/H(+)-sensitive neurons in the NTS and medullary raphe respond to ATP, and whether purinergic s
165 inase drivers targeted different portions of medullary raphe serotonergic, tryptophan hydroxylase 2 (
169 g in the pre-Botzinger complex (pre-BotC), a medullary region generating the inspiratory phase of bre
173 ) has previously been identified as an extra-medullary reservoir for normal hematopoietic stem cells
174 nimals with MeCP2 removed from specific pons medullary respiratory circuits, we performed whole-body
176 esults indicate that MeCP2 expression in the medullary respiratory network is sufficient for normal r
177 e from lumbar locomotor CPG circuitry to the medullary respiratory networks that is able to depolariz
178 lterations in the electrical excitability of medullary respiratory neurones and their central modulat
179 eir spinal projections, several parts of the medullary reticular formation as well as the spinally pr
183 lox) kidneys showed more cell death in outer medullary S3 segments at 2 hours but less tubular damage
184 ressive increase of neuronal excitability in medullary slices containing the pre-BotC produces mixed-
185 nd hypoglossal (XII) nerve motor activity in medullary slices from neonatal mice in conditions where
188 providing evidence for an independence from medullary support by the earliest stages after positive
189 ein, we evaluated the involvement of ventral medullary sympatho-excitatory catecholaminergic C1 neuro
190 heart rate variability (sympathetic adrenal medullary system), EEG event-related potentials (nocicep
191 s of p53 primarily disrupts the integrity of medullary TEC (mTEC) niche, a defect that spreads to the
193 ression of thymotropic chemokines, decreased medullary TEC to cortical TEC ratios, and altered thymic
195 adult mice, we found that both cortical and medullary TECs (cTECs and mTECs) proliferated more activ
196 el antigen specifically expressed in Aire(+) medullary TECs (mTECs) induced efficient deletion via di
197 antigens or presenting a neo-self-antigen by medullary TECs, displaying decreased negative selection-
198 The proximal convoluted tubule (PCT) and the medullary thick ascending limb (mTAL) in the kidney cons
200 (2+)]i oscillations were markedly reduced in medullary thick ascending limbs isolated from P2Y2 recep
202 tical role in T cell tolerance by regulating medullary thymic epithelial cell (mTEC) development.
203 o-step terminal differentiation model of the medullary thymic epithelial cell (mTEC) lineage from imm
204 hough the molecular mediators that stimulate medullary thymic epithelial cell (mTEC) maturation are p
205 sting of a branching structure that contains medullary thymic epithelial cell (mTEC) networks to supp
206 reduction of autoimmune receptor-expressing medullary thymic epithelial cells (Aire1 mTEC) and a dec
207 ism, we have previously reported that mature medullary thymic epithelial cells (mTEC(high)) expressin
208 eral self-antigens (TRA), which is in mature medullary thymic epithelial cells (mTEC(high)) partly co
209 ize the developmental pathways that generate medullary thymic epithelial cells (mTEC) from their imma
211 in developing T cells is highly dependent on medullary thymic epithelial cells (mTEC), and mTEC devel
212 CD70 was expressed on Aire(-) and Aire(+) medullary thymic epithelial cells (mTECs) and on dendrit
213 ulate transcription of a battery of genes in medullary thymic epithelial cells (mTECs) and, consequen
217 of tissue-restricted self antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential f
218 roles for bone marrow (BM)-derived APCs and medullary thymic epithelial cells (mTECs) on the convent
220 plethora of tissue-restricted Ags (TRAs) by medullary thymic epithelial cells (mTECs) plays an essen
222 neages--cortical thymic epithelial cells and medullary thymic epithelial cells (mTECs)--are yet to be
225 (+) T cells preferentially damaged recipient medullary thymic epithelial cells and impaired negative
227 on is enriched, particularly in neonates, in medullary thymic epithelial cells expressing the autoimm
228 lls that colocalize with dendritic cells and medullary thymic epithelial cells in the thymic medulla.
230 ng T cells and autoimmune regulator-positive medullary thymic epithelial cells, a key process for cen
231 nity by promoting self-antigen expression in medullary thymic epithelial cells, such that developing
233 ngly autoimmune regulator-expressing, mature medullary thymic epithelial cells, which play a pivotal
239 n of Bim during early/cortical, but not late/medullary, thymic development controls the agonist selec
241 ative selection and functional maturation of medullary thymocytes as well as the production of regula
242 ytes exhibit a stochastic migration, whereas medullary thymocytes show confined migratory behavior.
246 ity of nonendocrine manifestations preceding medullary thyroid cancer (MTC) for early diagnosis of mu
248 tory differentiated thyroid cancer (DTC) and medullary thyroid cancer (MTC) in the past 10 years.
249 oring the prospects of a cure for persistent medullary thyroid cancer (MTC) stratified by basal calci
256 ycaemia, pancreatitis, pancreatic cancer, or medullary thyroid cancer reported between GLP-1 receptor
258 ment and treatment of patients with advanced medullary thyroid cancer with emphasis on current target
259 s cabozantinib (FDA-approved for progressive medullary thyroid cancer) and PF-04217903 block their ac
260 from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patie
266 nts that are approved for differentiated and medullary thyroid cancers have prolonged progression-fre
267 t breast cancers, non-Hodgkin lymphomas, and medullary thyroid cancers represent novel indications fo
269 t frequently mutated malignant subtypes were medullary thyroid carcinoma (9/12, 75%) and PTC (14/30,
270 nase, are associated with the development of medullary thyroid carcinoma (MTC) and pathogenesis of mu
277 explain the increased expression of CAIX in medullary thyroid carcinoma and provide a rationale for
278 ilar expression pattern was recapitulated in medullary thyroid carcinoma cells in vivo, consistent wi
281 ce of acute pancreatitis, pancreatic cancer, medullary thyroid carcinoma, and serious adverse events
284 ic carcinomas, and its expression pattern in medullary thyroid carcinomas suggested contribution of b
285 ressed in various human cancers (e.g., lung, medullary thyroid, pancreatic, colon, and gastrointestin
287 normal sheep, resting levels of cortical and medullary tissue PO2 were 29.5 +/- 4.4 and 29.1 +/- 4.3
288 In one model, approximately one-third of medullary Tph2(+) neurons are silenced by postnatal (P)
289 in the other, approximately three-fourths of medullary Tph2(+) neurons, also with some Tph2(low or ne
290 the mechanisms underlying the modulation of medullary trigeminovascular (Sp5C) neurons have not been
293 cysts in the medullary interstitium, loss of medullary vascular bundles, and decreased urine concentr
294 exity of the tidal volume signal (related to medullary ventilatory command), (3) autonomic function,
296 ogenous adrenal gland hormones (cortical and medullary) was associated with 3- to 10-fold higher conc
297 ation of the prohemocytes located within the medullary zone and the secondary lobes of the lymph glan
299 ich normally consists of an immature center (medullary zone) where cells remain undifferentiated, and
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