ライフサイエンスコーパス: megabase

1 1 megabases of the total genome size of 61.1 megabases).

2 ng fragments ranging from 5 kilobases to > 1 megabase.

3 th a median of 0.35 non-silent mutations per megabase.

4 human genome with Hi-C at a resolution of 1 megabase.

5 overgos contained three to nine overgos per megabase.

6 per megabase to greater than 20 overgos per megabase.

7 ed enhancer-enhancer hubs spanning up to one megabase.

8 pha-satellite DNA, which spans up to several megabases.

9 stance scales, ranging from tens of bases to megabases.

10 tion control is apparently lost over several megabases.

11 el transcriptional interaction spanning 14.3 megabases.

12 lted in a final genome error rate of 1 in 10 megabases.

13 r of its six chromosomes, each spanning many megabases.

14 y 96 loci from a genome of approximately 400 megabases.

15 arthritis severity at a resolution of a few megabases.

16 o be caused by a deletion of approximately 2 megabases.

17 been impractical for regions beyond tens of megabases.

18 D7S3314, corresponding to a distance of 27.2 megabases.

19 corresponding to a physical distance of 9.5 megabases.

20 uced no false positives in analysis of three megabases.

21 generate extended haplotypes on the order of megabases.

22 e into 625 contigs with an N50 length of 2.4 megabases.

23 ordination of NL contacts, even over tens of megabases.

24 ow mutational burden (number of mutation per megabase, 0.8 and 4, respectively).

25 ng or adjacent gains or losses, covering 360 megabases (12% of the genome) were identified in these p

26 ished dosage of the genes deleted in the 1.5-megabase 22q11 minimal critical deleted region in a mous

27 esis, and progress toward assembly of a 3.97-megabase, 57-codon Escherichia coli genome in which all

28 of the hypermutated phenotype (>12 mutations/megabase); 6 had mutation frequencies >200/megabase, and

29 y, 0.02 and 0.07 nonsynonymous mutations per megabase, a dramatically lower average mutational freque

30 e characterization of haplotypes that extend megabases along the human genome using high molecular we

31 lele-specific chromatin analysis of over 100 megabases along the maternally or paternally duplicated

32 f CENP-A and histone H3.1 binding within the megabase, alpha-satellite repeat-containing centromeres

33 ogies, which has led to a decreased cost per megabase and an increase in the number and diversity of

34 exonic somatic mutation rate of 12.0 events/megabase and identified the majority of genes previously

35 we produced high-quality sequence data of 59 megabases and assembled ~200,000 reads into 19,501 conti

36 py-number alterations, of which 21 span <0.5 megabases and contain a median of five genes.

37 ocrustacean Daphnia pulex, which is only 200 megabases and contains at least 30,907 genes.

38 nal centromeres span several kilobases up to megabases and do not seem to have DNA sequence specifici

39 ntotheonella' with genomes of greater than 9 megabases and multiple, distinct biosynthetic gene clust

40 nome-wide array data to identify ROHs (>1 megabase) and conducted global burden and locus-specific

41 ates even in heavily treated CRPCs (2.00 per megabase) and confirmed the monoclonal origin of lethal

42 had relatively few SNVs (average of 5.9 per megabase) and only a single SV.

43 behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest

44 ic mutation rate (0.31 non-silent events per megabase) and wide mutational diversity.

45 s/megabase); 6 had mutation frequencies >200/megabase, and 5 of these had somatic mutations in POLE,

46 somatic mutation rate was 1.2 mutations per megabase, and there was a median of 230 somatic rearrang

47 The LBA111 genome is 1.23 megabases, and it is closely related to that of Megaviru

48 identified, including two that are only 1.7 megabases apart on chromosome 17.

49 ty, from simple "point" centromeres to multi-megabase arrays of DNA satellites, has defied explanatio

50 raveling from the origin to the terminus (>2 megabases) at rates >50 kilobases per minute.

51 utionary distance and frequently are located megabases away from target developmental genes.

52 he effects of noncoding SNPs both nearby and megabases away.

53 example, FOXO1, AZI2) often situated several megabases away; and finally, regions associated with dif

54 At 99 megabases, B. antarctica has the smallest insect genome

55 mes in pools, we assembled a sequence of 774 megabases carrying 5326 protein-coding genes, 1938 pseud

56 IR induces rapid modification of megabase chromatin domains surrounding DSBs via poly-ADP

57 rs rapidly after DSB formation, spreads over megabase chromatin domains, and is required for stable a

58 n centromeres are positioned within specific megabase chromosomal regions containing alpha-satellite

59 map length (P), measured in centimorgans per megabase (cM/Mb).

60 he smallest sequenced eukaryotic genome, 2.9 megabases coding for 1997 proteins.

61 h hierarchy of structural layers, from multi-megabase compartments to sub-megabase topologically asso

62 including medium size (from 1 kilobase to 1 megabase) deletions and duplications, and balanced inver

63 that interacts in cis with PTHLH over a 24.4-megabase distance and in trans with the sex-determining

64 es within FTO are functionally connected, at megabase distances, with the homeobox gene IRX3.

65 rrelated with the protein-coding genome over megabase distances.

66 regulates an imprinted gene cluster nearly a megabase distant from IGF2.

67 ssing structural variation across contiguous megabase DNA regions.

68 tive compartments, and partitioning into sub-megabase domains (TADs).

69 Loading of nascent CENP-A on the megabase domains of replicated centromere DNA is shown t

70 ganization of individual chromatin polymers, megabase domains, and mitotic chromosomes.

71 eport the sequence and annotation of the 458-megabase draft genome of Lucilia cuprina.

72 from 10-20 kb (enhancers/repressors) to many megabases during intra- and inter-chromosomal interactio

73 ene is duplicated in Yaa mice because of a 4-Megabase expansion of the pseudoautosomal region.

74 gous end-joining using kilobase, rather than megabase, fragments of DNA, which we refer to as "stitch

75 ts can be located at distances up to several megabases from their target genes.

76 The 26-megabase genome contains 9068 predicted genes, including

77 This enormous, 3.9-megabase genome contains six genome equivalents of forei

78 The 37-megabase genome of C. cinerea was sequenced and assemble

79 We sequenced and assembled >94% of the 640-megabase genome of Eucalyptus grandis.

80 hanisms of adaptation, we sequenced the 13.7-megabase genome of G. sulphuraria.

81 The 23-megabase genome of Plasmodium falciparum, the causative

82 sis of a high-quality assembly from the 1180-megabase genome of Symbiodinium kawagutii.

83 of the highly polymorphic approximately 520-megabase genome of the Florida lancelet Branchiostoma fl

84 Here we show the complete 29.4-megabase genome sequence of the clinical isolate Af293,

85 se about two-thirds of the approximately 160-megabase genome, reflecting a recent massive expansion o

86 We have sequenced its approximately 20-megabase genome, which contains approximately 6500 intro

87 ic mutations and yield an estimated 17.7 per megabase genome-wide somatic mutation rate.

88 The 115- to 141-megabase genomes offer insights into the evolution of pa

89 ave sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin st

90 yndrome (22q11DS), the result of a 1.5- to 3-megabase hemizygous deletion on human chromosome 22, res

91 he human genome assembly correspond to multi-megabase heterochromatic regions composed primarily of t

92 Over megabases, homoplasy rates fluctuate 1.9-fold, peaking t

93 size from 125 bp (budding yeast) to several megabases (human).

94 ctivation of distinct regions within the one megabase IgH locus.

95 The 3-megabase Igkappa locus undergoes differentially controll

96 arget activity within loops spanning up to 2 megabases implies involvement of linear tracking.

97 liar are deletions at the breakpoints, up to megabases in extent.

98 te inversions ranging from 200 kb to several megabases in length.

99 he level of large chromosomal domains (0.5-5 megabases in mammals) within which replicons are activat

100 Gains and losses of hundreds of megabases in many chromosomes are typical of the changes

101 er the primary linkage peak (approximately 4 megabases in size).

102 romosome is estimated to be at least several megabases in size.

103 altered in 27 of 50 recurrent CNA regions <5 megabases in size.

104 ng from single modified DNA bases to several megabases in the case of heterochromatic histone modific

105 lay high haplotype homozygosity over several megabases in the Dw3 region, but most markers linked to

106 at an intermediate scale (10 kilobases to 4 megabases), including 64 insertions affecting 58 genes.

107 essive zones (range, 0.35 approximately 5.98 megabases), including a 14-gene cluster located on 16p11

108 Here we have localized Ph1 to a 2.5-megabase interstitial region of wheat chromosome 5B cont

109 Cdcs1 was positioned within a minimum 7-megabase interval containing nuclear factor-kappaB p50.

110 ve; we found that allelic variation in a 0.3-megabase interval in the class I D locus confers substan

111 nt to localize the effect of Ctrq-3 to a 1.2-megabase interval of genomic DNA that contains Irgb10 an

112 ltered vertical eye movements linked to a 11-megabase interval on 1p32.

113 yndromic uterine fibroids, we explored a two-megabase interval spanning FH in the NIEHS Uterine fibro

114 ond, we examined genetic variation in the 15-megabase interval surrounding the QTL in small and giant

115 E pumps three-quarters of the chromosome (>3 megabases) into one of the two daughter cells.

116 incidence of approximately three lesions per megabase is preferentially repaired in the transcribed s

117 At intervals of more than three megabases it is nearly identical to a map built in Europ

118 At the sub-megabase level, we observed stochastic clusters of conta

119 y correlated with rates of recombination per megabase, levels of sequence polymorphisms do not fully

120 Xi exhibits extremely large loops, up to 77 megabases long, called "superloops." DXZ4 lies at the an

121 locus, human chromosome 17q21.31, contains a megabase-long inversion polymorphism, many uncharacteriz

122 Using a 7-megabase-long region of the Drosophila melanogaster chro

123 of mammals and birds can be partitioned into megabase-long regions, termed isochores, with consistent

124 vidual chromosomes, and specific segments at megabase (Mb) and kilobase (kb) resolutions of single av

125 We have sequenced the approximately 90 megabase (Mb) genome of the human filarial parasite Brug

126 1(env), was determined by comparing the 1.94-megabase (Mb) genome sequence of the isolate with that r

127 (HSY) and its X counterpart, yielding an 8.1-megabase (Mb) HSY pseudomolecule, and a 3.5-Mb sequence

128 irless skin of the extremities (3 and 14 per megabase (Mb) of genome), intermediate in those originat

129 d that targeted deletion in mice of the 0.11 megabase (mb)-long minimal deleted region (MDR) encompas

130 hundreds of tandem duplications of up to 10 megabases (Mb) in size.

131 ransfer of bacterial genomes as large as 1.8 megabases (Mb) into yeast under conditions that promote

132 infestans genome, which at approximately 240 megabases (Mb) is by far the largest and most complex ge

133 re than 1,000 somatic mutations found in 274 megabases (Mb) of DNA corresponding to the coding exons

134 in the biosphere: 5.3 x 1031 (+/-3.6 x 1031) megabases (Mb) of DNA.

135 Analysis of approximately 3.7 megabases (Mb) of genomic sequence, including 0.87 Mb of

136 are being produced, going from the initial 1 Megabases (Mb) resolution to the current 10 Kilobases (K

137 ggested that Bxs6 lies between 59.7 and 74.8 megabases (Mb), although the interval of 0.6 Mb between

138 These MCRs possess a median size of 2.7 megabases (Mb), with 21 (33%) MCRs spanning 1 Mb or less

139 omosome sequence generated here comprises 30 megabases (Mb).

140 p to 1421 genes with a total coverage of 5.5 Megabases (Mb).

141 complex phenotypes can be linked to long (>1-megabase [Mb]) runs of homozygosity (ROHs) detectable by

142 e polymorphism (SNP) arrays, we mapped a 1.3 megabase minimally deleted region including only the rep

143 Within the 2.7-megabase mouse Igh locus, V(D)J recombination is regulat

144 We sequenced the approximately 120-megabase nuclear genome of Chlamydomonas and performed c

145 Here we present analysis of the 363 megabase nuclear genome of the blood fluke.

146 Using a multiple alignment of more than a megabase of contiguous sequence from eight mammalian spe

147 that the observed skew of GNGNAGGG within 1 megabase of dif occurred by chance in E. coli is 1.7 x 1

148 Laboratory mice with over half a megabase of DNA upstream of their Myc gene removed still

149 ble to predict >90% of target genes within 1 megabase of eQTLs.

150 genes expected based on number of genes per megabase of genome explains the observed density suggest

151 9.4% of the euchromatic DNA and includes one megabase of heterochromatic sequence within the pericent

152 Analysis of approximately 1 megabase of sequence from each library showed that despi

153 We assess >1 megabase of sequence in the vicinity of two essential tr

154 cer-trapping strategy in mice to scan a half-megabase of the 8q24 gene desert encompassing the prosta

155 ize (Zea mays) B chromosome contains several megabases of a B-specific repeat (ZmBs), a 156-bp satell

156 M activation is not amplified by H2AX across megabases of chromatin to induce global signaling and re

157 tion of rare and common variants in over 300 megabases of coding sequence.

158 quencing) technologies, we examined over 100 megabases of DNA from amplified extracts, revealing unbi

159 n of the ancestral human genome, we identify megabases of DNA lost in different human lineages and pi

160 somatic mutations across approximately 1,800 megabases of DNA representing 1,507 coding genes from 44

161 oligonucleotides encoding approximately 2.5 megabases of DNA, which is at least 50 times larger than

162 ed computational and manual annotation of 24 megabases of heterochromatic sequence in the Release 5 D

163 Plant and animal centromeres comprise megabases of highly repeated satellite sequences, yet ce

164 to fully mature centromeres that accumulate megabases of homogeneous satellite arrays.

165 Human centromeres are defined by megabases of homogenous alpha-satellite DNA arrays that

166 ancers interconnected in some instances over megabases of linear chromatin.

167 r targets, and therefore 'searching' through megabases of non-target DNA.

168 We detect 4 megabases of novel sequence, encoding 11 new transcripts

169 he genetic interactions are located within 5 megabases of regions of known physical chromosome intera

170 ch to map the genomic locations of almost 20 megabases of sequence unlocalized or missing from the cu

171 Most animals and plants have megabases of tandem repeats at their centromeres, unlike

172 gregate, we recovered 1.34 gigabases and 303 megabases of the Neandertal and Denisovan genome, respec

173 enome reduced in size by nearly 8%, with 1.1 megabases of the synthetic genome deleted, inserted, or

174 with alleles that are highly divergent (15.1 megabases of the total genome size of 61.1 megabases).

175 ds with random errors, we assembled 99% (244 megabases) of the Oropetium genome into 625 contigs with

176 , DNA content increased by approximately 250 megabases, often representing a substantial fraction of

177 ysis, we mapped the Tsk2 gene mutation to <3 megabases on chromosome 1.

178 omosome is a vast region of approximately 15 megabases on distal 8p that appears to have a strikingly

179 repeat satellite III (SAT III), which spans megabases on the X chromosome of Drosophila melanogaster

180 ost significant linkage to a single locus (8 megabases) on chromosome 4 (logarithm of the odds [LOD]

181 omarkers Associated to Structural Ensembles (MEGABASE), on odd-numbered chromosomes, we predict the s

182 These 177 high-confidence CNVRs cover 28.1 megabases or approximately 1.07% of the genome.

183 Our method identified events of 10 megabases or greater occurring in as little as 16% of th

184 umina exon and RNA sequencing revealed a 1.2-megabase pair deletion encompassing the 27- and 50-kD ga

185 asts and erythroblasts the folding of 10-160-megabase pair engineered chromosome regions consisting o

186 ected indels ranging from 10 base pairs to 1 megabase pair that are difficult to detect via a single

187 GCRs, including balanced translocations and megabase-pair inversions.

188 ter than the reference genome and that 420.2 megabase pairs of common repeats and 99.1% of validated

189 re typically arranged in an array that spans megabase pairs of DNA.

190 cal length over the distal first euchromatic megabase pairs of the X chromosome, our data suggest tha

191 cted human genomic regions comprising 1% (30 megabase pairs) of the human genome.

192 ing control region is the promoter for a one megabase paternal transcript encoding the ubiquitous pro

193 mutations averaged two to six mutations per megabase per cell, similar to that seen in many cancers,

194 e estimate a genomic duplication rate of 4-5 megabases per million years since divergence.

195 ire ETV1 locus (7p21) is rearranged to a 1.5-megabase prostate-specific region at 14q13.3-14q21.1 in

196 The large megabase receptor loci undergo 3D changes in their struc

197 The disease gene mapped to a less than 2-megabase recessive locus at 12q21.33 with a logarithm of

198 A several megabase region at the "distal" end of the mouse IgH loc

199 usted multivariate linear analyses in the 40-megabase region encompassing the linkage peak were condu

200 ; unaffected, n=44) for fine mapping of a 23-megabase region in 13q14.2-q22.2.

201 lti into N. vitripennis and mapped to an 0.9 megabase region of chromosome 1.

202 ssociation mapping across an approximately 4 megabase region of the xMHC using a validated panel of s

203 Hemizygous deletion of a 1.5- to 3-megabase region on chromosome 22 causes 22q11.2 deletion

204 We identified a 3-megabase region on human chromosome 21 containing 6 cand

205 ygous deletion of mouse chromosome 11B3, a 4-megabase region syntenic to human 17p13.1, produces a gr

206 gments, and 4 J(H) segments within a several megabase region.

207 f ICF1-iPSC methylomes also identifies large megabase regions of CG hypomethylation typically localiz

208 kaemia (ALL) with recurrent amplification of megabase regions of chromosome 21 (iAMP21).

209 ng hybridization-based purification of multi-megabase regions with sequencing on the Illumina Genome

210 to high quality and spans approximately 132 megabases, representing approximately 4.5% of the human

211 organization of chromatin in the nucleus at megabase resolution.

212 ome sequences within the linkage region (4.8 megabases) revealed missense mutation c.591C>A p.Glu197A

213 n studies indicate that the LDD test, at the megabase scale used, effectively distinguishes selection

214 fferent epigenetic states at the kilobase-to-megabase scale, a length scale that is directly relevant

215 omosomes maintain domain organization at the megabase scale, but show variable cell-to-cell chromosom

216 At the megabase scale, the chromatin conformation is consistent

217 methylated regions from the kilobase to the megabase scale.

218 gineering genomes from the nucleotide to the megabase scale.

219 How Xist spreads silencing on a 150-megabases scale is unclear.

220 Our results suggest that multiple-megabase-scale ancestral haplotypes persist in outbred h

221 Analysis of SNP variation revealed megabase-scale blocks of sequence divergence among curre

222 ers of genes that promote reprogramming, and megabase-scale chromatin domains spanned by H3K9me3, inc

223 We report locus-specific disintegration of megabase-scale chromosomal conformations in brain after

224 th scales, ranging from single base pairs to megabase-scale chromosomal domains, and discuss the emer

225 abilistic 3D folding states for a contiguous megabase-scale chromosomal region, supporting the divers

226 proach that allows for reliable detection of megabase-scale CNVs in single somatic cells.

227 Megabase-scale copy number variants (CNVs) can have prof

228 that 13 to 41% of neurons have at least one megabase-scale de novo CNV, that deletions are twice as

229 iPSCs share megabase-scale differentially methylated regions proxima

230 y genetic polymorphisms that act in cis upon megabase-scale DNA segments.

231 e or repressed chromatin states, up to multi-megabase-scale domains associated with nuclear positioni

232 revealed that chromosomes are organized into megabase-scale domains that demarcate active and inactiv

233 ated across cancer types are concentrated in megabase-scale domains that occur near the telomeres and

234 that alignment can be reestablished after a megabase-scale gap in sequence homology.

235 (1) Megabase-scale genomic domains rich in ZIC2 peaks and ge

236 y, we assign genetic aberrations to specific megabase-scale haplotypes generated from whole-genome se

237 ing from thousands of single base changes to megabase-scale path reorganizations, gap closures, and l

238 We report results of a megabase-scale phylogenomic analysis of the Reptilia, th

239 spects of genome instability-specifically, a megabase-scale rearrangement underlying two genomic diso

240 indings reveal considerable variation in the megabase-scale recombination landscape among recently di

241 expression of clusters of genes embedded in megabase-scale regions marked with H3K36me2 and that con

242 by MeCP2, but also enriched within extended megabase-scale regions surrounding MeCP2-repressed genes

243 estimated haplotypes to characterize mosaic megabase-scale structural mutations in 31,100 GWA study

244 Mammalian genomes are organized into megabase-scale topologically associated domains (TADs).

245 akpoint subdivision of the X chromosome with megabase-scale X segments borne on Y chromosomes.

246 We found strong agreement at megabase scales between estimates from our method applie

247 associated with gene expression variation at megabase scales.

248 enetically identical with the Y, harboring a megabase segment that is missing from the X.

249 nt than existing browsers when viewing multi-megabase segments of chromosomes.

250 overy by allowing fine mapping to only a few megabases, significantly decreasing the number of potent

251 y used to assemble genetic constructs in the megabase size range, and has previously been used to tra

252 an chromosomes, centromeric regions comprise megabase-size arrays of 171 bp alpha-satellite DNA monom

253 A in a single cell and to randomly partition megabase-size DNA strands into multiple nanoliter compar

254 n sample groups, and uncover the presence of megabase-size placenta hypomethylated domains.

255 the conservation of coordinately replicated megabase-sized "replication domains" punctuated by origi

256 ome organization, including segregation into megabase-sized active and inactive compartments, and par

257 eres of Arabidopsis thaliana are composed of megabase-sized arrays of a 178-bp satellite repeat.

258 yotes, centromeres are typically composed of megabase-sized arrays of satellite repeats that evolve r

259 present the sequence and analysis of the 11 megabase-sized chromosomes of Trypanosoma brucei.

260 ariation of the genome involves kilobase- to megabase-sized deletions, duplications, insertions, inve

261 most widely used for preparing high-quality megabase-sized DNA from divergent organisms.

262 ve successfully used to prepare high-quality megabase-sized DNA from hundreds of plant, animal, fish,

263 Megabase-sized DNA is crucial to modern genomics researc

264 f-renewing cells by inducing derepression of megabase-sized gene domains harboring downstream effecto

265 We identify large, megabase-sized local chromatin interaction domains, whic

266 though re-formation rates vary greatly, many megabase-sized loops recovered in under an hour, consist

267 g (GIPS) to selectively capture and sequence megabase-sized portions of a mutant genome.

268 iate for aligning many, but by no means all, megabase-sized regions of multiple mammalian genomes.

269 CISMR (CRISPR-mediated isolation of specific megabase-sized regions of the genome), which enables us

270 f regulatory genes, stable gene deserts, and megabase-sized regions rich in moderately conserved nonc

271 Cen2, Cen3, Cen5, Cen7, and Cen8) contained megabase-sized satellite repeat arrays that are unique t

272 to perform targeted isolation of contiguous megabase-sized segments of the genome.

273 es of transposable elements covary in large, megabase-sized segments.

274 o establish regulatory fine structure within megabase-sized topologically associated domains.

275 Megabase-sized, complex, repetitive regions of genomes a

276 an initial analysis of the approximately 730-megabase Sorghum bicolor (L.) Moench genome, placing app

277 essive mutations within the approximately 50 megabases spanned by Rw.

278 Y chromosomes of Drosophila contain multi-megabase stretches of satellite DNA repeats and a handfu

279 cleotide variants (SNVs; average of 11.2 per megabase), structural variants (SVs; average of 46), or

280 esults in reduced DCC binding across several megabases surrounded by topologically associating domain

281 an adjacent 'gene desert' of approximately 2 megabases that contains the long non-coding RNA gene PVT

282 xpectedly, UCYN-A has a reduced genome (1.44 megabases) that is structurally similar to many chloropl

283 in the genome of these lymphomas was one per megabase, there were a tremendous number of copy number

284 nsus region was narrowed down by more than a megabase to 2.2 Mb at chromosome 22q12.3 flanked by D22S

285 density ranged from less than one overgo per megabase to greater than 20 overgos per megabase.

286 rearrangements ranging in size from several megabases to a few hundred base pairs can be generated b

287 that, for genomes spanning approximately 100 megabases to approximately 10 gigabases, errors become i

288 As genome size changes from megabases to gigabases, we predict that regularity of RO

289 from nearly the entire Wolbachia genome (>1 megabase) to short (<500 base pairs) insertions.

290 ers, from multi-megabase compartments to sub-megabase topologically associating domains (TADs) and su

291 conformation capture (Hi-C) has revealed sub-megabase topologically associating domains (TADs), which

292 associated regulatory elements, can exceed a megabase, transgenic complementation in mice has, in spe

293 ion in recombination rates (centimorgans per megabase) was observed along the X chromosome, ranging f

294 th eve enhancers across distances of several megabases, when the communication is mediated by Homie.

295 At the intermediate scale of kilobases to megabases, which encompasses the sizes of genes, gene cl

296 In most species, we identify striking megabase-wide regions, where nucleotide diversity is les

297 NPs) nominally associated with EEM in the 40-megabase window encompassing the linkage peak.

298 ersonii, which consists of approximately 830 megabases with an N50 of 44,303 bp anchored to 12 chromo

299 of regions ranging from tens of kilobases to megabases with the same basic protocol.

300 adscale recombination rate (centimorgans per megabase) within M. musculus.