ライフサイエンスコーパス: megakaryocyte progenitor

1 mbocytosis with increased megakaryocytes and megakaryocyte progenitors.

2 fects in erythroid cells and an expansion of megakaryocyte progenitors.

3 nt cells, including GATA-1s-expressing fetal megakaryocyte progenitors.

4 l embryos harbor definitive erythroid or any megakaryocyte progenitors.

5 initive waves, each containing erythroid and megakaryocyte progenitors.

6 ect on erythroid, granulocyte-macrophage, or megakaryocyte progenitors.

7 ell cycling in BaF3/Mpl cells and in primary megakaryocyte progenitors.

8 FU-MK, we developed a new protocol to purify megakaryocyte progenitors.

9 e a pure population of primary CD41-positive megakaryocyte progenitors.

10 cripts and a maturation of SL-MkPs and other megakaryocyte progenitors.

11 y, we demonstrate that bipotential erythroid-megakaryocyte progenitor and CD150(+)CD9(hi)endoglin(lo)

12 ion environment with subsequent expansion of megakaryocyte progenitors and immature megakaryoblasts,

13 (Mpl) support survival and proliferation in megakaryocyte progenitors and in BaF3 cells engineered t

14 growth factor which causes proliferation of megakaryocyte progenitors as well as induces megakaryocy

15 At this time, the number of megakaryocyte progenitors begins to decline in the yolk

16 pulations: "Pre-MEP," enriched for erythroid/megakaryocyte progenitors but with residual myeloid diff

17 e that survivin is necessary for survival of megakaryocyte progenitors, but is not required for polyp

18 critical role in commitment of the erythroid-megakaryocyte progenitor by modulating the level of the

19 ripotent stem cells to generate immortalized megakaryocyte progenitor cell lines that can be cryopres

20 erate (approximately sevenfold) expansion of megakaryocyte progenitor cells (colony-forming unit-mega

21 ulate the growth, development, and ploidy of megakaryocyte progenitor cells and platelet production i

22 Marrow megakaryocyte progenitor cells averaged 3.3 (range, 0.4

23 353 +/- 255 x 10(6)/kg; P = .04); (3) marrow megakaryocyte progenitor cells fourfold (from a mean of

24 SDF-1alpha on migration and proliferation of megakaryocyte progenitor cells in vitro.

25 ntegrity and stability of mRNAs derived from megakaryocyte progenitor cells remain poorly quantified

26 product of megakaryocyte number and volume), megakaryocyte progenitor cells, circulating levels of en

27 through stimulation of the proliferation of megakaryocyte progenitor cells, to support of the matura

28 ciencies in the numbers of megakaryocytes or megakaryocyte progenitor cells.

29 nificantly greater number of IL-3-responsive megakaryocyte progenitors CFU (CFU-MK) and an increase i

30 asia, we investigated the effect of SDF-1 on megakaryocyte progenitors (colony-forming units-megakary

31 mine the expression of the CXCR4 receptor on megakaryocyte progenitors (colony-forming units-megakary

32 counting for the increased cell death in the megakaryocyte progenitor compartment.

33 CD41(+) megakaryocyte progenitors derived from these cells expre

34 cription factors preferentially expressed in megakaryocyte progenitors (Gata2 and Zfpm1) and decrease

35 P1 knock-in megakaryocyte progenitors have reduced proliferative cap

36 KO mice show significantly increased megakaryocyte progenitors in the BM by FACS analysis and

37 ng that survivin is required for survival of megakaryocyte progenitors in vivo.

38 rders that selectively affect fetal/neonatal megakaryocyte progenitors, including the thrombocytopeni

39 n of both the lympho-myeloid and the erythro-megakaryocyte progenitors is dependent on Ikaros and its

40 We found that SDF-1alpha potently induced megakaryocyte progenitor migration and significantly enh

41 ion profile closely resemble that of primary megakaryocyte progenitors (MkPs) and they further differ

42 The embryonic megakaryocyte progenitors (MKPs) in the E11.5 FL were id

43 s, Abcg4 was highly expressed in bone marrow megakaryocyte progenitors (MkPs).

44 l embryos had normal primitive erythroid and megakaryocyte progenitor numbers and kinetics between em

45 ceivable that the affected patients harbor a megakaryocyte progenitor pool whose apoptotic activity i

46 We define a bipotential erythroid-megakaryocyte progenitor population, the CD150(+)CD9(lo)

47 TP-RO mRNA sequences significantly inhibited megakaryocyte progenitor proliferation.

48 and/or TPO hastened myeloid, erythroid, and megakaryocyte progenitor recovery compared to vehicle co

49 Surprisingly, fetal NF-E2-deficient megakaryocyte progenitors showed reduced proliferation p

50 Mature megakaryocytes, but not megakaryocyte progenitors, specifically bound fibrinogen

51 We conclude that in BaF3/Mpl cells and megakaryocyte progenitors, thrombopoietin-induced phosph

52 -4 (VLA-4)-mediated localization of CXCR4(+) megakaryocyte progenitors to the vascular niche, promoti

53 n and LY294002 were blocked in G(1), whereas megakaryocyte progenitors treated with thrombopoietin an

54 Megakaryocyte progenitors were elevated, especially in t

55 ABCG4 is highly expressed in megakaryocyte progenitors, where it promotes cholesterol

56 lopment of leukocytes, with the exception of megakaryocyte progenitors, which are significantly reduc

57 In contrast, reduced numbers of megakaryocyte progenitors with restricted proliferative

58 port that chemokine-mediated interactions of megakaryocyte progenitors with sinusoidal bone marrow en