ライフサイエンスコーパス: meibomian

1 in conjunctiva of the eyelid and in cells of Meibomian and preputial (sebaceous) glands.

2 lts correlated with the number of obstructed meibomian ducts (P = 0.005) and a pathologic meibomian g

3 film breakup time (TBUT), corneal staining, meibomian dysfunction assessment, and conjunctival stain

4 the Oxford and van Bijsterveld indexes, and Meibomian dysfunction grading.

5 elial sodium channel (ENaC) subunits exhibit meibomian gland (MG) dysfunction.

6 Meibomian gland (MG) formation is employed as a model wh

7 esence of corneal subepithelial fibrosis and meibomian gland (MG) orifice metaplasia were recorded.

8 Numerous nerve fibers near the meibomian gland acini were immunoreactive for NPY and VI

9 Immortalized human meibomian gland and conjunctival epithelial cells were c

10 ting stress showed hyperproliferation of the meibomian gland and ductal dilation suggesting a marked

11 he expression of numerous genes in the mouse meibomian gland and that many of these genes are involve

12 B presenting over seventeen months including meibomian gland assessment using a recognized classifica

13 Meibography grading of meibomian gland atrophy and acini appearance, and slit-l

14 Aged heterozygotes also showed meibomian gland atrophy.

15 redness, tear volume, anterior blepharitis, meibomian gland capping) and tear inflammatory cytokine

16 The findings also show that the human meibomian gland contains several highly expressed genes

17 rmore, corneal stroma neovascularization and meibomian gland degeneration were examined by immunohist

18 ents with dry eye who had rosacea-associated meibomian gland disease (MGD) or Sjogren's syndrome (SS)

19 Study groups included meibomian gland disease (MGD), aqueous tear deficiency (

20 hology, causes, and ocular surface impact of meibomian gland disease (MGD), as well as its relationsh

21 5 patients with DE, including subgroups with meibomian gland disease (MGD), Sjogren's syndrome (SS) a

22 ormal and 33 subjects with tear dysfunction (meibomian gland disease [n = 11], aqueous tear deficienc

23 ffective treatment for OSD that results from meibomian gland disease.

24 ibum from normal donors (Mn) and donors with meibomian gland dysfunction (Md) by (1)H-NMR spectroscop

25 )H-NMR spectra of meibum from 39 donors with meibomian gland dysfunction (Md) were compared to meibum

26 is less ordered than meibum from donors with meibomian gland dysfunction (Md).

27 rading of clinical variables associated with meibomian gland dysfunction (MGD) in real-time examinati

28 It has been generally accepted that meibomian gland dysfunction (MGD) is a leading cause of

29 Meibomian gland dysfunction (MGD) is a primary cause of

30 Meibomian gland dysfunction (MGD) is the major cause of

31 Meibomian gland dysfunction (MGD) may be the leading cau

32 lated to be necessary for the development of meibomian gland dysfunction (MGD), a common form of chro

33 Twelve patients also had noninflamed meibomian gland dysfunction (MGD).

34 ure changes in human meibum composition with meibomian gland dysfunction (MGD).

35 ned from 41 normal donors and 51 donors with meibomian gland dysfunction (MGD).

36 investigating the linkage of lid changes and meibomian gland dysfunction may shed new lights on the p

37 Meibum lipid compositional changes with meibomian gland dysfunction reflect changes in hydrocarb

38 time, Oxford Schema, Schirmer's test I, and meibomian gland dysfunction testing.

39 time, corneal and conjunctival staining, and meibomian gland dysfunction, all in both eyes, and a com

40 its associated lacrimal gland inflammation, meibomian gland dysfunction, and severe dry eye.

41 igating ocular surface pathologies involving meibomian gland dysfunction, blepharitis, corneal or con

42 s, accompanied by tear hyperosmolarity, mild meibomian gland dysfunction, reduced BUT, mucus filament

43 Restasis) may also have a positive effect on meibomian gland dysfunction, the other main form of dry

44 e pathology of the ocular surface resembling Meibomian gland dysfunction.

45 Immortalized human meibomian gland epithelial (SLHMG) cells were examined f

46 g), and promoted lipid accumulation in human meibomian gland epithelial cells (about 2-fold increase

47 port the hypothesis that IGF-1 acts on human meibomian gland epithelial cells and may explain why tre

48 It was possible to isolate viable human meibomian gland epithelial cells and to culture them in

49 Meibomian gland epithelial cells are essential in mainta

50 The results show that human meibomian gland epithelial cells may be isolated, cultur

51 demonstrate that EGF and BPE stimulate human meibomian gland epithelial cells to proliferate.

52 N, SETTING, AND MATERIAL: Immortalized human meibomian gland epithelial cells were cultured in the pr

53 To test our hypotheses, immortalized human meibomian gland epithelial cells were cultured with or w

54 eir agonists influence the function of human meibomian gland epithelial cells.

55 ication of IGF-1 and growth hormone to human meibomian gland epithelial cells.

56 tiation (e.g., lipid accumulation), of human meibomian gland epithelial cells.

57 its a pronounced lipid accumulation in human meibomian gland epithelial cells.

58 ammatory mediator and protease expression in meibomian gland epithelial cells.

59 , keratinization, and inflammation, in human meibomian gland epithelial cells.

60 icant, time-dependent proliferation of human meibomian gland epithelial cells.

61 d attenuates cell survival pathways in human meibomian gland epithelial cells.

62 chirmer test results without anesthesia, and meibomian gland examination.

63 esis in the study was that androgens control meibomian gland function, regulate the quality and/or qu

64 This study was conducted to identify meibomian gland genes that may promote the development a

65 Therapeutically, anti-inflammatory therapy, meibomian gland heating and expression, and scleral cont

66 ilm osmolarity, inflammatory biomarkers, and meibomian gland imaging.

67 hypothesis that the androgen control of the meibomian gland involves the regulation of gene expressi

68 The findings show that the meibomian gland is an androgen target organ and that and

69 In prior work, it has been found that the meibomian gland is an androgen target organ, that androg

70 A striking characteristic of the human meibomian gland is its rich sensory, sympathetic, and pa

71 al abnormalities are not solely dependent on meibomian gland lipid secretion.

72 Neither specific aqueous nor meibomian gland measurements were significantly correlat

73 Meibomian gland obstruction and meibocyte depletion are

74 on between symptoms and global, aqueous, and meibomian gland parameters.

75 eal staining, tear breakup time, Schirmer's, meibomian gland quality, orifice plugging, lid vasculari

76 meibomian ducts (P = 0.005) and a pathologic meibomian gland secretion (P = 0.001).

77 These findings also suggest that meibomian gland secretion is under the control of divers

78 e Disease Index, tear film breakup time, and meibomian gland secretion quality.

79 Human meibomian gland secretions (meibum) were analyzed by ele

80 lar components of the lipids in normal human meibomian gland secretions (meibum).

81 tty acids and the fatty acid amides in human meibomian gland secretions by using electrospray mass sp

82 he production, secretion, and/or delivery of meibomian gland secretions to the ocular surface, the go

83 The response of the meibomian gland to desiccating stress also suggest that

84 ontent, and fatty acid profile of the rabbit meibomian gland, as well as the appearance of the tear f

85 thetic preganglionic neurons that project to meibomian gland-innervating ganglion cells are located i

86 d in the search documented an improvement in meibomian gland-related OSD after treatment with these a

87 expression of almost 400 genes in the human meibomian gland.

88 y multiple changes in gene expression in the meibomian gland.

89 progesterone modulate gene expression in the meibomian gland.

90 progesterone regulate gene expression in the meibomian gland.

91 he expression of numerous genes in the mouse meibomian gland.

92 ression of more than 1590 genes in the mouse meibomian gland.

93 n of IGF-1 action in epithelial cells of the meibomian gland.

94 in the sex-related differences of the mouse meibomian gland.

95 r role in the sex-related differences of the meibomian gland.

96 significant impact on gene expression in the meibomian gland.

97 ression of more than a thousand genes in the meibomian gland.

98 mine whether neurotransmitters influence the meibomian gland.

99 terations in the lipid content of the rabbit meibomian gland; 19-nortestosterone treatment modulated

100 al and neutral lipid fractions of the rabbit meibomian gland; and androgens did not appear to influen

101 Secretions that are produced by meibomian glands (also known as meibum) are a major sour

102 ment and the commonest was an anomaly of the meibomian glands and lacrimal drainage system defects.

103 The meibomian glands and other structures within the lid mar

104 o impaired vitamin A metabolism, loss of the meibomian glands and recurrent eyelid trauma.

105 nic eyelid closure as well in development of meibomian glands and the anterior segment of the eye.

106 exists in the epithelial cell nuclei of rat meibomian glands and, in addition, whether androgen defi

107 nance of primary epithelial cells from human meibomian glands and, second, to immortalize these cells

108 Murine lacrimal, harderian and meibomian glands develop from the prospective conjunctiv

109 luorescein corneal stain, and assessment for meibomian glands dysfunction (MGD) were carried out.

110 Meibomian glands from intact, androgen- and/or placebo-t

111 ty has no obvious effect on the histology of meibomian glands in male or female mice.

112 eous glands (SGs) or in free SGs such as the Meibomian glands in the eyelids.

113 glands were significantly enlarged, and the meibomian glands malformed.

114 The meibomian glands of rhesus and cynomolgous monkeys are r

115 lities in the fur texture and the absence of meibomian glands prompted us to evaluate other epidermal

116 expression in cutaneous sebaceous vs eyelid Meibomian glands remain to be established.

117 sebaceous carcinomas apparently derived from Meibomian glands were also negative (n = 12).

118 Meibomian glands were isolated and processed for RNA ext

119 Meibomian glands were obtained from adult, age-matched w

120 Meibomian glands were obtained from orchiectomized mice

121 Meibomian glands were obtained from young adult, ovariec

122 Human meibomian glands were removed from lid segments after su

123 ring a transgene for the Eda-A1 isoform, but meibomian glands were restored little if at all.

124 In the eyelid, Meibomian glands were uniformly negative for 15-lipoxyge

125 lts indicate that aging mice show dropout of meibomian glands with loss of gland volume and a forward

126 anterior eye segment defects, absence of the meibomian glands, and defects in the semilunar cardiac v

127 essenger RNA is also present in lacrimal and meibomian glands, as well as in a number of other tissue

128 lopment and maturation of both sebaceous and meibomian glands, as well as in the formation and compos

129 scosity could alter secretion of lipids from meibomian glands, or tear-film stabilization properties

130 Many pathologies can disrupt function of meibomian glands, ranging from congenital to acquired ca

131 mal development of both sebaceous glands and meibomian glands, specialized sebaceous glands of the ey

132 airs arising inappropriately from the eyelid meibomian glands-which is evident from birth.

133 ctopic row of hair follicles in place of the Meibomian glands.

134 r and ectopic cilia formed at the expense of Meibomian glands.

135 n managing OSD arising from disorders of the meibomian glands.

136 dant in the eyelid, which contains wax-laden meibomian glands.

137 ant second row of eyelashes arising from the meibomian glands.

138 me; and (2) trophic effects on sebaceous and Meibomian glands.

139 ed to the basement membranes of acini of the meibomian glands.

140 ing TH, CGRP, and SP were more sparse in the meibomian glands.

141 ent of OSD that arises from disorders of the meibomian glands.

142 ands and contributes to the formation of the meibomian glands.

143 erior segment of the eye, and the absence of meibomian glands.

144 anterior segment defects and the absence of meibomian glands.

145 d bulbar conjunctiva, corneal epithelium and meibomian glands.

146 that 1) as previously reported, mice lacked meibomian glands; 2) >80% developed corneal lesions such

147 within acinar epithelial cell nuclei of rat meibomian glands; androgen deficiency was associated wit

148 eral corneal, or bulbar conjunctival stroma; meibomian glands; skin; retina-choroid; or episcleral re

149 e (TBUT), corneal and conjunctival staining, meibomian grading, and Ocular Surface Disease Index and

150 imals, canines, mice, and rabbits, for their meibomian lipid composition in order to determine which

151 determine the biophysical parameters of thin meibomian lipid film (MLF): the lift-off area, collapse

152 ceramide (Cer) and free cholesterol (FC) on meibomian lipid films (MLF) using a Langmuir trough (LT)

153 The rabbit meibomian lipidome, on the other hand, was vastly differ

154 he closest match to humans in terms of their meibomian lipidomes, while canines were the second close

155 animal species have been evaluated for their meibomian lipidomes.

156 Meibomian lipids are the primary component of the lipid

157 Bovine and human meibomian lipids exhibit similar physical properties.

158 barrier is disrupted, creating potential for meibomian lipids to adhere more strongly.

159 nd structural properties of human and bovine meibomian lipids to provide insight into the physical be

160 Bulk rheological properties of pooled meibomian lipids were measured by a commercial stress-co

161 erfacial viscoelasticity of spread layers of meibomian lipids.

162 human meibum are one of the largest group of meibomian lipids.

163 ds and ocular [lacrimal, harderian (HG), and meibomian (MG)] glands and is necessary for normal ocula

164 sing Schirmer information, lid plugging, and meibomian quality to define objective DES, 176 patients

165 staining (r(2) = 0.43), OSDI (r(2) = 0.41), meibomian score (r(2) = 0.37), TBUT (r(2) = 0.30), and S

166 appear to influence the gross morphology of meibomian tissue or to exert a demonstrable effect on th

167 analyze more than 100 individual species of meibomian WE, which were shown to comprise 41 +/- 8% (wt

168 al information on previously uncharacterized meibomian WE.