ライフサイエンスコーパス: meibomian gland

1 progesterone modulate gene expression in the meibomian gland.

2 progesterone regulate gene expression in the meibomian gland.

3 he expression of numerous genes in the mouse meibomian gland.

4 ression of more than 1590 genes in the mouse meibomian gland.

5 n of IGF-1 action in epithelial cells of the meibomian gland.

6 in the sex-related differences of the mouse meibomian gland.

7 r role in the sex-related differences of the meibomian gland.

8 significant impact on gene expression in the meibomian gland.

9 ression of more than a thousand genes in the meibomian gland.

10 mine whether neurotransmitters influence the meibomian gland.

11 expression of almost 400 genes in the human meibomian gland.

12 y multiple changes in gene expression in the meibomian gland.

13 ctopic row of hair follicles in place of the Meibomian glands.

14 r and ectopic cilia formed at the expense of Meibomian glands.

15 dant in the eyelid, which contains wax-laden meibomian glands.

16 ant second row of eyelashes arising from the meibomian glands.

17 me; and (2) trophic effects on sebaceous and Meibomian glands.

18 n managing OSD arising from disorders of the meibomian glands.

19 ed to the basement membranes of acini of the meibomian glands.

20 ing TH, CGRP, and SP were more sparse in the meibomian glands.

21 ent of OSD that arises from disorders of the meibomian glands.

22 ands and contributes to the formation of the meibomian glands.

23 erior segment of the eye, and the absence of meibomian glands.

24 anterior segment defects and the absence of meibomian glands.

25 d bulbar conjunctiva, corneal epithelium and meibomian glands.

26 terations in the lipid content of the rabbit meibomian gland; 19-nortestosterone treatment modulated

27 that 1) as previously reported, mice lacked meibomian glands; 2) >80% developed corneal lesions such

28 Numerous nerve fibers near the meibomian gland acini were immunoreactive for NPY and VI

29 Secretions that are produced by meibomian glands (also known as meibum) are a major sour

30 Immortalized human meibomian gland and conjunctival epithelial cells were c

31 ting stress showed hyperproliferation of the meibomian gland and ductal dilation suggesting a marked

32 he expression of numerous genes in the mouse meibomian gland and that many of these genes are involve

33 ment and the commonest was an anomaly of the meibomian glands and lacrimal drainage system defects.

34 The meibomian glands and other structures within the lid mar

35 o impaired vitamin A metabolism, loss of the meibomian glands and recurrent eyelid trauma.

36 nic eyelid closure as well in development of meibomian glands and the anterior segment of the eye.

37 exists in the epithelial cell nuclei of rat meibomian glands and, in addition, whether androgen defi

38 nance of primary epithelial cells from human meibomian glands and, second, to immortalize these cells

39 anterior eye segment defects, absence of the meibomian glands, and defects in the semilunar cardiac v

40 al and neutral lipid fractions of the rabbit meibomian gland; and androgens did not appear to influen

41 within acinar epithelial cell nuclei of rat meibomian glands; androgen deficiency was associated wit

42 ontent, and fatty acid profile of the rabbit meibomian gland, as well as the appearance of the tear f

43 essenger RNA is also present in lacrimal and meibomian glands, as well as in a number of other tissue

44 lopment and maturation of both sebaceous and meibomian glands, as well as in the formation and compos

45 B presenting over seventeen months including meibomian gland assessment using a recognized classifica

46 Meibography grading of meibomian gland atrophy and acini appearance, and slit-l

47 Aged heterozygotes also showed meibomian gland atrophy.

48 redness, tear volume, anterior blepharitis, meibomian gland capping) and tear inflammatory cytokine

49 The findings also show that the human meibomian gland contains several highly expressed genes

50 rmore, corneal stroma neovascularization and meibomian gland degeneration were examined by immunohist

51 Murine lacrimal, harderian and meibomian glands develop from the prospective conjunctiv

52 ents with dry eye who had rosacea-associated meibomian gland disease (MGD) or Sjogren's syndrome (SS)

53 Study groups included meibomian gland disease (MGD), aqueous tear deficiency (

54 hology, causes, and ocular surface impact of meibomian gland disease (MGD), as well as its relationsh

55 5 patients with DE, including subgroups with meibomian gland disease (MGD), Sjogren's syndrome (SS) a

56 ormal and 33 subjects with tear dysfunction (meibomian gland disease [n = 11], aqueous tear deficienc

57 ffective treatment for OSD that results from meibomian gland disease.

58 ibum from normal donors (Mn) and donors with meibomian gland dysfunction (Md) by (1)H-NMR spectroscop

59 )H-NMR spectra of meibum from 39 donors with meibomian gland dysfunction (Md) were compared to meibum

60 is less ordered than meibum from donors with meibomian gland dysfunction (Md).

61 rading of clinical variables associated with meibomian gland dysfunction (MGD) in real-time examinati

62 It has been generally accepted that meibomian gland dysfunction (MGD) is a leading cause of

63 Meibomian gland dysfunction (MGD) is a primary cause of

64 Meibomian gland dysfunction (MGD) is the major cause of

65 Meibomian gland dysfunction (MGD) may be the leading cau

66 lated to be necessary for the development of meibomian gland dysfunction (MGD), a common form of chro

67 Twelve patients also had noninflamed meibomian gland dysfunction (MGD).

68 ure changes in human meibum composition with meibomian gland dysfunction (MGD).

69 ned from 41 normal donors and 51 donors with meibomian gland dysfunction (MGD).

70 investigating the linkage of lid changes and meibomian gland dysfunction may shed new lights on the p

71 Meibum lipid compositional changes with meibomian gland dysfunction reflect changes in hydrocarb

72 time, Oxford Schema, Schirmer's test I, and meibomian gland dysfunction testing.

73 time, corneal and conjunctival staining, and meibomian gland dysfunction, all in both eyes, and a com

74 its associated lacrimal gland inflammation, meibomian gland dysfunction, and severe dry eye.

75 igating ocular surface pathologies involving meibomian gland dysfunction, blepharitis, corneal or con

76 s, accompanied by tear hyperosmolarity, mild meibomian gland dysfunction, reduced BUT, mucus filament

77 Restasis) may also have a positive effect on meibomian gland dysfunction, the other main form of dry

78 e pathology of the ocular surface resembling Meibomian gland dysfunction.

79 luorescein corneal stain, and assessment for meibomian glands dysfunction (MGD) were carried out.

80 Immortalized human meibomian gland epithelial (SLHMG) cells were examined f

81 g), and promoted lipid accumulation in human meibomian gland epithelial cells (about 2-fold increase

82 port the hypothesis that IGF-1 acts on human meibomian gland epithelial cells and may explain why tre

83 It was possible to isolate viable human meibomian gland epithelial cells and to culture them in

84 Meibomian gland epithelial cells are essential in mainta

85 The results show that human meibomian gland epithelial cells may be isolated, cultur

86 demonstrate that EGF and BPE stimulate human meibomian gland epithelial cells to proliferate.

87 N, SETTING, AND MATERIAL: Immortalized human meibomian gland epithelial cells were cultured in the pr

88 To test our hypotheses, immortalized human meibomian gland epithelial cells were cultured with or w

89 ication of IGF-1 and growth hormone to human meibomian gland epithelial cells.

90 tiation (e.g., lipid accumulation), of human meibomian gland epithelial cells.

91 its a pronounced lipid accumulation in human meibomian gland epithelial cells.

92 ammatory mediator and protease expression in meibomian gland epithelial cells.

93 , keratinization, and inflammation, in human meibomian gland epithelial cells.

94 icant, time-dependent proliferation of human meibomian gland epithelial cells.

95 d attenuates cell survival pathways in human meibomian gland epithelial cells.

96 eir agonists influence the function of human meibomian gland epithelial cells.

97 chirmer test results without anesthesia, and meibomian gland examination.

98 Meibomian glands from intact, androgen- and/or placebo-t

99 esis in the study was that androgens control meibomian gland function, regulate the quality and/or qu

100 This study was conducted to identify meibomian gland genes that may promote the development a

101 Therapeutically, anti-inflammatory therapy, meibomian gland heating and expression, and scleral cont

102 ilm osmolarity, inflammatory biomarkers, and meibomian gland imaging.

103 ty has no obvious effect on the histology of meibomian glands in male or female mice.

104 eous glands (SGs) or in free SGs such as the Meibomian glands in the eyelids.

105 thetic preganglionic neurons that project to meibomian gland-innervating ganglion cells are located i

106 hypothesis that the androgen control of the meibomian gland involves the regulation of gene expressi

107 The findings show that the meibomian gland is an androgen target organ and that and

108 In prior work, it has been found that the meibomian gland is an androgen target organ, that androg

109 A striking characteristic of the human meibomian gland is its rich sensory, sympathetic, and pa

110 al abnormalities are not solely dependent on meibomian gland lipid secretion.

111 glands were significantly enlarged, and the meibomian glands malformed.

112 Neither specific aqueous nor meibomian gland measurements were significantly correlat

113 elial sodium channel (ENaC) subunits exhibit meibomian gland (MG) dysfunction.

114 Meibomian gland (MG) formation is employed as a model wh

115 esence of corneal subepithelial fibrosis and meibomian gland (MG) orifice metaplasia were recorded.

116 Meibomian gland obstruction and meibocyte depletion are

117 The meibomian glands of rhesus and cynomolgous monkeys are r

118 scosity could alter secretion of lipids from meibomian glands, or tear-film stabilization properties

119 on between symptoms and global, aqueous, and meibomian gland parameters.

120 lities in the fur texture and the absence of meibomian glands prompted us to evaluate other epidermal

121 eal staining, tear breakup time, Schirmer's, meibomian gland quality, orifice plugging, lid vasculari

122 Many pathologies can disrupt function of meibomian glands, ranging from congenital to acquired ca

123 d in the search documented an improvement in meibomian gland-related OSD after treatment with these a

124 expression in cutaneous sebaceous vs eyelid Meibomian glands remain to be established.

125 meibomian ducts (P = 0.005) and a pathologic meibomian gland secretion (P = 0.001).

126 These findings also suggest that meibomian gland secretion is under the control of divers

127 e Disease Index, tear film breakup time, and meibomian gland secretion quality.

128 Human meibomian gland secretions (meibum) were analyzed by ele

129 lar components of the lipids in normal human meibomian gland secretions (meibum).

130 tty acids and the fatty acid amides in human meibomian gland secretions by using electrospray mass sp

131 he production, secretion, and/or delivery of meibomian gland secretions to the ocular surface, the go

132 eral corneal, or bulbar conjunctival stroma; meibomian glands; skin; retina-choroid; or episcleral re

133 mal development of both sebaceous glands and meibomian glands, specialized sebaceous glands of the ey

134 The response of the meibomian gland to desiccating stress also suggest that

135 sebaceous carcinomas apparently derived from Meibomian glands were also negative (n = 12).

136 Meibomian glands were isolated and processed for RNA ext

137 Meibomian glands were obtained from adult, age-matched w

138 Meibomian glands were obtained from orchiectomized mice

139 Meibomian glands were obtained from young adult, ovariec

140 Human meibomian glands were removed from lid segments after su

141 ring a transgene for the Eda-A1 isoform, but meibomian glands were restored little if at all.

142 In the eyelid, Meibomian glands were uniformly negative for 15-lipoxyge

143 airs arising inappropriately from the eyelid meibomian glands-which is evident from birth.

144 lts indicate that aging mice show dropout of meibomian glands with loss of gland volume and a forward