ライフサイエンスコーパス: meibum

1 les with little hysteresis observed (1.9 J/G meibum).

2 in normal human meibomian gland secretions (meibum).

3 teresis increased many fold compared to pure meibum.

4 uch higher rigidity and hysteresis than pure meibum.

5 phase transitions in bulk samples of bovine meibum.

6 better understand lipid composition in human meibum.

7 pecies as the major amphiphilic component of meibum.

8 ich made them the largest group of lipids in meibum.

9 glycerides, and cholesteryl esters in human meibum.

10 ns of a set of training NMR spectra of human meibum.

11 f the levels of cholesteryl esters in infant meibum and Md suggests that the relative amounts of thes

12 As Cer and FC can be elevated in meibum and the tear film because of certain pathologic p

13 ydrogel contact lenses and, potentially, the meibum and/or tear film.

14 nation and collision-induced dissociation of meibum, and lipid standards were used to identify lipid

15 We studied meibum architecture and its relation to bulk and interfa

16 Wax esters (WE) of human meibum are one of the largest group of meibomian lipids.

17 produced by meibomian glands (also known as meibum) are a major source of lipids for the ocular surf

18 viscosity and elasticity has implications in meibum behavior in the tear film.

19 re, the purpose of this study was to compare meibum collected from humans and three typical laborator

20 spectra of human meibum indicate that human meibum collected from normal donors (Mn) is less ordered

21 on-induced dissociation of this species from meibum, compared with an oleamide standard, confirmed it

22 suggests that the relative amounts of these meibum components alone are unlikely to be responsible f

23 In this study, the changes in meibum composition were measured in search of markers of

24 is tool was used to measure changes in human meibum composition with meibomian gland dysfunction (MGD

25 Their meibum contains less CH(3) and C horizontal lineC groups

26 side comparison of the rabbit and the human meibum demonstrated their vast differences.

27 Composed primarily of a mixture of lipids, meibum exhibits a range of melt temperatures.

28 presence of micron-scale inhomogeneities in meibum films at higher temperatures.

29 mian gland dysfunction (Md) were compared to meibum from 33 normal donors (Mn).

30 (1)H-NMR spectra of meibum from 39 donors with meibomian gland dysfunction (

31 Compared with meibum from adolescents and adults, meibum from infants

32 from normal donors (Mn) is less ordered than meibum from donors with meibomian gland dysfunction (Md)

33 w the mechanical properties and structure of meibum from healthy subjects depend on temperature.

34 red with meibum from adolescents and adults, meibum from infants and children contains less CH(3) and

35 ion of possible compositional differences in meibum from normal donors (Mn) and donors with meibomian

36 progressively higher amounts of CER or FC to meibum had a strong impact on the rigidity, stability, a

37 Mass analysis of meibum in an acidic chloroform-methanol solution in posi

38 ved between three-dimensional melting of dry meibum in bulk and the two-dimensional melting in MLF at

39 ponent analyses of infrared spectra of human meibum indicate that human meibum collected from normal

40 sruption occurs, the quality and quantity of meibum is altered, with a negative impact on the ocular

41 interfacial rheology measurements show that meibum is extremely viscous and highly elastic.

42 to detect differences in the composition of meibum, it is promising that NMR can be used as a diagno

43 waxes, cholesteryl esters, and glycerides in meibum lipid (ML).

44 It may be that a change in the normal meibum lipid composition and conformation causes this ab

45 Meibum lipid compositional changes with meibomian gland

46 ad to these effects is strong aggregation of meibum lipids with FC or Cer that leads to the formation

47 4% and 40 +/- 2%, respectively, of the total meibum lipids.

48 Bulk meibum melted in a narrower temperature range and showed

49 h disease may alter the temperature at which meibum melts.

50 MGD leads to changes in meibum quality and quantity that can cause evaporative d

51 A set of WE and CE standards was spiked in meibum samples for ionization efficiency determination a

52 (mumol/mg) for each of 51 WEs and 31 CEs in meibum samples was determined.

53 Meibum samples were collected by using a soft-squeezing

54 Intact lipids in meibum samples were detected by direct infusion electros

55 Major neutral lipid classes in meibum samples were quantitatively profiled by ESI-MS an

56 The meibum samples were studied by direct infusion electrosp

57 ss of the terpenoids could be deleterious to meibum since they exhibit a plethora of mostly positive

58 ads to the formation of smaller particles of meibum surrounded by a thinner layer of FC or Cer.

59 saturation could be the critical feature in meibum that stabilizes tears in infants.

60 he production, secretion, and/or delivery of meibum to the ocular surface.

61 If the melt temperature of meibum was altered significantly from disease-induced co

62 Meibum was obtained from 41 normal donors and 51 donors

63 Meibum was obtained from healthy volunteers.

64 ative levels of cholesteryl esters in infant meibum were comparable to those in Md.

65 Interfacial films of meibum were highly viscoelastic at 17 degrees C, but as

66 Human meibomian gland secretions (meibum) were analyzed by electrospray quadrupole time-of

67 primary amide, is a predominant component of meibum when examined by electrospray mass spectrometry.

68 were shown to comprise 41 +/- 8% (wt/wt) of meibum, which made them the largest group of lipids in m

69 obed by small angle x-ray scattering of bulk meibum, which showed evidence of a majority crystalline

70 A series of mixtures of meibum with Cer or FC (mixed MLF) taken in different rat

71 The analysis of intact lipids in meibum with direct infusion ESI-MS/MS analysis has the a