ライフサイエンスコーパス: meiotic recombination

1 rDNA) array, however, undergoes little or no meiotic recombination.

2 in how it mediates homologous DNA pairing in meiotic recombination.

3 hat creates double-strand breaks to initiate meiotic recombination.

4 e sibling diversity approaching that seen in meiotic recombination.

5 ch undergoes copy-number changes mediated by meiotic recombination.

6 M activity of Rad51 is fully dispensable for meiotic recombination.

7 tion of plant genomes through the control of meiotic recombination.

8 t this interplay may be a general feature of meiotic recombination.

9 the pairing of homologous chromosomes during meiotic recombination.

10 hromosomes in pachytene cells, which undergo meiotic recombination.

11 Dmc1's JM activity alone is responsible for meiotic recombination.

12 explain other, seemingly complex features of meiotic recombination.

13 ired telomeric repeats and were dependent on meiotic recombination.

14 much progress has been made in understanding meiotic recombination.

15 e segregation, and repression of pericentric meiotic recombination.

16 s are introduced into the genome to initiate meiotic recombination.

17 e opposing arm's centromere during zebrafish meiotic recombination.

18 endogenous DNA damage, and also occur during meiotic recombination.

19 an 25 years, has only been identified during meiotic recombination.

20 subtelomeric regions, it locally influences meiotic recombination.

21 t tenfold lower levels (per DSB) than during meiotic recombination.

22 isms for the regulation of transcription and meiotic recombination.

23 some arms, coincident with zones of elevated meiotic recombination.

24 rge regions of the genome with low levels of meiotic recombination.

25 replication forks, telomere dysfunction, and meiotic recombination.

26 d by Ctp1, which plays an additional role in meiotic recombination.

27 in many aspects of DNA metabolism including meiotic recombination.

28 the DNA double-strands breaks that initiate meiotic recombination.

29 g, genetic requirements, and relationship to meiotic recombination.

30 s are similarly important during mitotic and meiotic recombination.

31 s and, thus, its absence causes a failure in meiotic recombination.

32 tic DNA double-strand break (DSB) repair and meiotic recombination.

33 hat is required for chromosomal synapsis and meiotic recombination.

34 yielded significant statistical support for meiotic recombination.

35 ts suggest a possible late role of RAD51C in meiotic recombination.

36 double mutants revealed a role for AtNBS1 in meiotic recombination.

37 he HOP2 and MND1 genes are indispensable for meiotic recombination.

38 osome synapsis and an early-stage failure in meiotic recombination.

39 two separate and critical steps in mammalian meiotic recombination.

40 In this study, our phenotype of interest is meiotic recombination.

41 , so we used one of these mutations to assay meiotic recombination.

42 known homeostatic mechanisms that act during meiotic recombination.

43 ures governing successive steps in mammalian meiotic recombination.

44 nd annealing, break-induced replication, and meiotic recombination.

45 velope, facilitating chromosomal pairing and meiotic recombination.

46 have important implications in understanding meiotic recombination.

47 equires crossover-fated events formed during meiotic recombination.

48 other axis-associated protein with a role in meiotic recombination.

49 vel role for UNC-84 in DNA damage repair and meiotic recombination.

50 y and establish a role for the centrosome in meiotic recombination.

51 xt of the Sgs1-Top3-Rmi1 complex to regulate meiotic recombination.

52 in the regulation of gene transcription and meiotic recombination.

53 en found to link changes in SC dynamics with meiotic recombination.

54 ying homolog polymorphism patterns can shape meiotic recombination.

55 romeric regions that are virtually devoid of meiotic recombination.

56 provide new information on the mechanism of meiotic recombination.

57 mplex functions with the DMC1 recombinase in meiotic recombination.

58 mosome revealed partitioning correlated with meiotic recombination.

59 licated in double strand break repair during meiotic recombination.

60 instability is a failure to up-regulate the meiotic recombination 11 (Mre11) nuclease in S phase, wh

61 ed and recruited by the MRN protein complex [meiotic recombination 11 (Mre11)/DNA repair protein Rad5

62 Meiotic recombination 11 homolog (MRE11) is downregulate

63 h homologous recombination (HR) by requiring meiotic recombination 11 homolog A (Mre11) nuclease acti

64 During meiotic recombination, a subset of programmed DNA double

65 plays a key role in establishing domains of meiotic recombination along chromosomes.

66 man enhancer of invasion-10 (Hei10) mediates meiotic recombination and also plays roles in cell proli

67 r results suggest that MEIOB is required for meiotic recombination and chromosomal synapsis.

68 Meiotic recombination and chromosome assortment events d

69 Meiotic recombination and de novo mutation are the two m

70 ations identify a novel function of CUL4A in meiotic recombination and demonstrate an essential role

71 lay similar roles in wild-type fission yeast meiotic recombination and in the repair of spontaneous a

72 that associate with female fertility, female meiotic recombination and neurological disease.

73 fic endonuclease that has been implicated in meiotic recombination and processing of damaged replicat

74 luding chorion proteins, proteins regulating meiotic recombination and segregation, gustatory and olf

75 onary forces that can lead to a cessation of meiotic recombination and the accumulation of structural

76 erein it must possess the ability to undergo meiotic recombination and the capacity to differentiate

77 provide new insights into the regulation of meiotic recombination and the impact of meiotic recombin

78 e very useful insights into the mechanism of meiotic recombination and the process of genome evolutio

79 + family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoin

80 eview, we focus on advances in understanding meiotic recombination and then summarize the attempts to

81 omplex may allow the chromosomes to regulate meiotic recombination, and a stable complex may be requi

82 nctions in double-strand break (DSB) repair, meiotic recombination, and DNA damage checkpoint pathway

83 aintenance, cell cycle checkpoint signaling, meiotic recombination, and DNA double-stranded break (DS

84 rast, BRCA1 plays a relatively minor role in meiotic recombination, and female Brca1 mutants are fert

85 as a profound effect on the FOA dynamics and meiotic recombination, and it implicates an RT-dependent

86 play an important role in the progression of meiotic recombination, and maintain ribosomal DNA stabil

87 ell as the most plastic, aspects of meiosis, meiotic recombination, and related parasexual processes.

88 ted steps, including germ cell self-renewal, meiotic recombination, and terminal differentiation into

89 preprogrammed double-strand breaks initiate meiotic recombination, and the checkpoints that govern t

90 rring in the p53(-) germline were incited by meiotic recombination, and transcripts produced from the

91 Gene conversions resulting from meiotic recombination are critical in shaping genome div

92 Two known types of meiotic recombination are crossovers and gene conversion

93 ed double-strand breaks (DSBs) that initiate meiotic recombination are dangerous lesions that can dis

94 NA double-strand breaks (DSBs) that initiate meiotic recombination are directed to a subset of genomi

95 DNA double-strand breaks that initiate meiotic recombination are exonucleolytically processed.

96 Crossovers (COs) generated through meiotic recombination are important for the correct segr

97 Rates of meiotic recombination are widely variable both within an

98 n, we established that germline Sxl controls meiotic recombination as well as cystocyte proliferation

99 this end, we report the local stimulation of meiotic recombination at a number of chromosomal sites b

100 late numerous stress responses, and activate meiotic recombination at hotspots like ade6-M26.

101 on the Spo11 (Rec12)-dependent initiation of meiotic recombination at hotspots?

102 rid to investigate genome-wide variation and meiotic recombination at nucleotide resolution.

103 omologues, as well as direct comparison with meiotic recombination at the same locus.

104 CDK-S is also essential for initiation of meiotic recombination because it phosphorylates Ser30 of

105 Meiotic recombination begins with the induction of progr

106 Meiotic recombination between highly similar duplicated

107 Meiotic recombination between homologous chromosomes ens

108 chromosome segregation and fertility require meiotic recombination between homologous chromosomes rat

109 The rate of meiotic recombination between markers located in euchrom

110 ly clustering deleted genomic segments using meiotic recombination between the bacterial genomes harb

111 olog, Sgs1, plays an integral role in normal meiotic recombination, beyond its documented activity li

112 and BLM homolog, have substantially reduced meiotic recombination, both gene conversions and crossov

113 Meiotic recombination breaks down linkage disequilibrium

114 ion and frequency of Spo11 (Rec12)-initiated meiotic recombination, but paradoxically they are suicid

115 rtant for repairing mismatches formed during meiotic recombination, but play only a relatively minor

116 Initiation of meiotic recombination by DNA double-strand break formati

117 ission yeast Rec12 (Spo11 homolog) initiates meiotic recombination by forming developmentally program

118 ts demonstrate that the outcome of mammalian meiotic recombination can be biased, that this bias can

119 hat such rearrangement-mediated reduction of meiotic recombination can lead to genetically isolated h

120 Therefore, activation of the meiotic recombination checkpoint, which arrests meiotic

121 t is due to unrepaired breaks triggering the meiotic recombination checkpoint.

122 we show that the MRN complex is required for meiotic recombination, chromatin remodeling at the ade6-

123 These results demonstrate how meiotic recombination combines with an ancient, preserve

124 SNP and indel markers to analyze patterns of meiotic recombination, confirming a high rate of crossov

125 About 40% of the hotspots for meiotic recombination contain the degenerate consensus s

126 ethods will facilitate genetic dissection of meiotic recombination control.

127 light on the mechanism of action of Hed1 in meiotic recombination control.

128 Meiotic recombination creates genetic diversity and ensu

129 Meiotic recombination, crucial for proper chromosome seg

130 Using a meiotic recombination dataset, we show that ssG is more

131 bination "jungles"; these preferred sites of meiotic recombination differ greatly among individuals.

132 allow us to accelerate crop breeding, where meiotic recombination distributions can be limiting.

133 During meiotic recombination, double-strand breaks (DSBs) are f

134 Meiotic recombination drives eukaryotic sexual reproduct

135 ed double-strand breaks (DSBs) that initiate meiotic recombination (e.g., hundreds per meiocyte in mi

136 Meiotic recombination enables the reciprocal exchange of

137 p53 and POLiota also act together to promote meiotic recombination enzyme 11 (MRE11)-dependent accumu

138 In eukaryotes, meiotic recombination events are distributed nonrandomly

139 The results show that the vast majority of meiotic recombination events are localized to narrow DNA

140 assessing effects of micronutrient status on meiotic recombination events in human sperm.

141 higher levels of interaction when in cis to meiotic recombination events in the budding yeast Saccha

142 at in a variety of organisms the majority of meiotic recombination events occur at a relatively small

143 heterogeneities in the average frequency of meiotic recombination events that occur along the physic

144 f Cre-mediated loxP recombination events and meiotic recombination events when the two occurred at li

145 anisms implicates a role for BLM helicase in meiotic recombination events, prompting us to explore th

146 nt source of germline mutations, as sites of meiotic recombination experience recurrent double-strand

147 The Y chromosome, inherited without meiotic recombination from father to son, carries relati

148 that, to the contrary, Top3-Rmi1 acts in all meiotic recombination functions previously associated wi

149 Meiotic recombination generates crossovers between homol

150 in determining sequence-specific hotspots of meiotic recombination genome wide.

151 he double-strand breaks (DSBs) that initiate meiotic recombination greatly outnumber eventual COs, th

152 Meiotic recombination has a profound effect on patterns

153 ur understanding of the details of mammalian meiotic recombination has recently advanced significantl

154 ven unfavorable chromosome interactions when meiotic recombination has to proceed in genotoxic enviro

155 me-wide analyses have suggested thousands of meiotic recombination hot spots across mammalian genomes

156 9 (PRDM9) protein is a major determinant of meiotic recombination hot spots and acts through sequenc

157 en identified as a likely trans regulator of meiotic recombination hot spots in humans and mice.

158 s for histone acetylation marks at mammalian meiotic recombination hot spots.

159 observed in the locations and activities of meiotic recombination hot spots.

160 fic KRAB-ZFPs, including genomic imprinting, meiotic recombination hotspot choice, and placental grow

161 PRDM9 plays a key role in specifying meiotic recombination hotspot locations in humans and mi

162 histone H3 methyltransferase that specifies meiotic recombination hotspots during gametogenesis.

163 tein PRDM9 has a critical role in specifying meiotic recombination hotspots in mice and apes, but it

164 t mutations, copy number variations, and the meiotic recombination hotspots utilized by males and fem

165 PRDM9 is a major specifier of human meiotic recombination hotspots, probably via binding of

166 tially the osmotic stress response (OSA) and meiotic recombination (HRA, HRR).

167 found that hDNA often goes unrepaired during meiotic recombination in an Msh6 mutant, leading to high

168 urther evidence for at least two pathways of meiotic recombination in Arabidopsis and indicate that A

169 Meiotic recombination in budding yeast requires two RecA

170 op2-Mnd1 specifically stimulates Dmc1 during meiotic recombination in budding yeast.

171 of joint molecule intermediates (JMs) during meiotic recombination in budding yeast.

172 g data, suggest that DNA methylation affects meiotic recombination in cis.

173 To examine hDNA in meiotic recombination in Drosophila melanogaster, we sou

174 double-strand break repair model applies to meiotic recombination in Drosophila.

175 covers the repressive role of methylation on meiotic recombination in euchromatic regions and suggest

176 of function may trigger changes that enhance meiotic recombination in euchromatin regions but are not

177 r regions, they are drastically depleted for meiotic recombination in heterozygotes.

178 he double-strand breaks (DSBs) that initiate meiotic recombination in mice and humans.

179 tion of crossovers (COs) between homologs by meiotic recombination in most species.

180 Here, when analyzing meiotic recombination in mutant plants with hypomethylat

181 Last, we pay special attention to the meiotic recombination in polyploidy, which is a common g

182 5-Sae3 is a mediator of Dmc1 assembly during meiotic recombination in S. cerevisiae.

183 both crossover and noncrossover pathways of meiotic recombination in Saccharomyces cerevisiae.

184 n pericentromeric regions-the cold spots for meiotic recombination in soybean-showed significantly lo

185 e genomic region, we found that interhomolog meiotic recombination in the array is reduced compared t

186 pe of chromosomal recombination, we analyzed meiotic recombination in the decreased DNA methylation 1

187 e reexamined the effects of these factors on meiotic recombination in the nematode Caenorhabditis ele

188 uminate broad similarities in the control of meiotic recombination in these diverse species but also

189 ts of a single meiosis and may indicate that meiotic recombination in this nematode has novel feature

190 ombination events, which are consistent with meiotic recombination in this primarily haploid organism

191 d an orthologue of dmc1, a gene specific for meiotic recombination in yeast, in 3 species of Pneumocy

192 required for all known functions of Sgs1 in meiotic recombination, including channeling JMs into phy

193 Meiotic recombination, including crossovers (COs) and ge

194 The nonrandom distribution of meiotic recombination influences patterns of inheritance

195 ndings reveal that the process of initiating meiotic recombination inherently selects against nuclei

196 Meiotic recombination initiated by programmed double-str

197 Meiotic recombination initiates following the formation

198 budding yeast genome contains regions where meiotic recombination initiates more frequently than in

199 Meiotic recombination initiates via programmed double-st

200 Meiotic recombination initiates with formation of develo

201 Two high-resolution maps of meiotic recombination initiation sites across the genome

202 g to centromeres prior to and independent of meiotic recombination initiation.

203 rosophila, we discovered that the process of meiotic recombination instigates programmed activation o

204 To analyze another product of meiotic recombination, interhomolog noncrossovers (NCOs)

205 acking both enzymes have profound defects in meiotic recombination intermediate metabolism and crosso

206 ome stability complex, we observe persistent meiotic recombination intermediates (DNA joint molecules

207 S312, and ERCC1 form a complex that resolves meiotic recombination intermediates into crossovers.

208 ions in male germ cells to promote repair of meiotic recombination intermediates, thereby improving t

209 A key step in meiotic recombination involves the nucleolytic resolutio

210 Meiotic recombination is a critical step in gametogenesi

211 Meiotic recombination is a fundamental cellular mechanis

212 Meiotic recombination is a fundamental process in all eu

213 Meiotic recombination is a major driver of genetic diver

214 Meiotic recombination is an essential feature of sexual

215 Since meiotic recombination is coupled with synaptonemal compl

216 pecies have revealed two mechanisms by which meiotic recombination is directed to the genome-through

217 Meiotic recombination is essential for fertility in most

218 In Saccharomyces cerevisiae (budding yeast), meiotic recombination is increased in the absence of the

219 Meiotic recombination is initiated by programmed DNA dou

220 Meiotic recombination is initiated by programmed DNA dou

221 Meiotic recombination is initiated by programmed double

222 In fission yeast, meiotic recombination is initiated by Rec12 (Spo11 homol

223 Meiotic recombination is initiated by the formation of D

224 Meiotic recombination is initiated by the programmed ind

225 many organisms, including yeasts and humans, meiotic recombination is initiated preferentially at a l

226 affect chromosome structure, their impact on meiotic recombination is not well understood.

227 Therefore, elucidating how meiotic recombination is positioned is of fundamental an

228 The basis by which centromeric meiotic recombination is repressed has been largely unkn

229 Meiotic recombination is required for the segregation of

230 Meiotic recombination is the foundation for genetic vari

231 Meiotic recombination is the fundamental process that pr

232 Meiotic recombination is tightly regulated by cis- and t

233 ecies such as barley (Hordeum vulgare) where meiotic recombination is very heavily skewed to the ends

234 They provide compelling evidence that most meiotic recombination is, like transcription, regulated

235 and repeat-associated DNA methylation on the meiotic recombination landscape of an Arabidopsis mappin

236 In addition, Cep63 loss severely impairs meiotic recombination, leading to profound male infertil

237 gh cohesin is required for the completion of meiotic recombination, little is known about how cohesin

238 males and fem-3 worms is a substrate for the meiotic recombination machinery and repair of the result

239 Fine scale meiotic recombination maps have uncovered a large amount

240 fied by successive megachunk integration and meiotic recombination-mediated assembly, producing a fun

241 Hop2-Mnd1 is a meiotic recombination mediator that stimulates DNA stran

242 NA breaks that are the initiating events for meiotic recombination, most organisms make very few cros

243 Female infertility caused by a meiotic recombination mutation or irradiation was revers

244 Extensive variation in the frequency of meiotic recombination occurs along chromosomes and is ty

245 In mammals, meiotic recombination occurs at 1- to 2-kb genomic regio

246 nd other data in support of a model in which meiotic recombination occurs in two phases-one specializ

247 In many organisms, meiotic recombination occurs preferentially at a limited

248 n of meiotic recombination and the impact of meiotic recombination on genome function.

249 Meiotic recombination, one of the central biological pro

250 ructure, meiosis-specific telomere behavior, meiotic recombination, pairing, synapsis, and installati

251 Trans-acting factors involved in the early meiotic recombination pathway play a major role in promo

252 o profile hotspots at different steps of the meiotic recombination pathway that have been used in dif

253 dence that mcm5 plays a critical role in the meiotic recombination pathway.

254 omes, that is, heterozygosity, can influence meiotic recombination pathways in cis and trans.

255 tent cells and their derivatives, as well as meiotic recombination patterns.

256 Meiotic recombination predominantly occurs at discrete g

257 matic cells, less is known about its role in meiotic recombination primarily because of the embryonic

258 oted mcm5(A7)) that specifically impairs the meiotic recombination process.

259 , but also for the regulation of mitotic and meiotic recombination processes.

260 Meiotic recombination promotes genetic diversification a

261 Meiotic recombination promotes genetic variation by mixi

262 ataxia telangiectasia mutated gene 1 (ATM), meiotic recombination protein 11 (MRE-11), and others].

263 election is a key determinant for organizing meiotic recombination, providing evidence that genome-wi

264 chromatin, increased gene density, elevated meiotic recombination rates and in the proximity of repe

265 dditionally, there was a correlation between meiotic recombination rates and targeting frequencies at

266 Meiotic recombination rates can vary widely across genom

267 ent to the existing procedures of estimating meiotic recombination rates from population genetic data

268 It is generally considered that meiotic recombination rates increase with temperature, d

269 meiosis and various evolutionary processes, meiotic recombination rates sometimes vary within specie

270 Meiotic recombination rates vary greatly along the chrom

271 that for this region in the genome, enhanced meiotic recombination rates, as well as other as-of-yet

272 st syntenic blocks occur in regions with low meiotic recombination rates, no transposable elements, a

273 ere generated and analyzed by sequencing for meiotic recombination, representing the first tetrad ana

274 Meiotic recombination results in the formation of cytolo

275 y is caused by sexually dimorphic defects in meiotic recombination, revealing its two distinct functi

276 The nonrandom distribution of meiotic recombination shapes heredity and genetic divers

277 Meiotic recombination shapes the genetic diversity trans

278 al deletions significantly reduce or abolish meiotic recombination similarly to c(3)G null homozygote

279 Our results show that meiotic recombination sites are localized away from PRDM

280 PRDM9 binding localizes almost all meiotic recombination sites in humans and mice.

281 Physical mapping methods independent of meiotic recombination, such as radiation hybrid (RH) map

282 igh intrachromosomal recombination is due to meiotic recombination, suggesting frequent outcrossing i

283 ce motifs that predict consistent, localized meiotic recombination suppression around a subset of PRD

284 and ubiquitin have antagonistic roles during meiotic recombination that are balanced to effect differ

285 In contrast to meiotic recombination, the mitotic recombination frequen

286 ate that BRCA2 also plays a critical role in meiotic recombination, this time through direct interact

287 We propose a model linking rates of meiotic recombination to the probability of recombinatio

288 at Sgs1 and Mus81/Mms4 collaborate to direct meiotic recombination toward interhomolog interactions t

289 rge-scale variation in GC-content, caused by meiotic recombination, via the non-adaptive process of G

290 PRDM9 binding and its role in fertility and meiotic recombination, we humanized the DNA-binding doma

291 s for genes that encode proteins involved in meiotic recombination were altered, which suggested that

292 an integral part of a new regulatory step of meiotic recombination, which has implications to prevent

293 with quantitative traits, or fine mapping of meiotic recombination, which is a key determinant of gen

294 itability and genome stability are shaped by meiotic recombination, which is initiated via hundreds o

295 Mammalian meiotic recombination, which preferentially occurs at sp

296 ) formed by the SPO11 transesterase initiate meiotic recombination, which promotes pairing and segreg

297 Our work reveals that condensin coordinates meiotic recombination with chromosome segregation at the

298 l, our findings further our understanding of meiotic recombination with implications for both basic a

299 ly constrained by the low rates of effective meiotic recombination, with clear public health implicat

300 We observe several instances of meiotic recombination within copy number variants associ