ライフサイエンスコーパス: melanocortin-1 receptor

1 uction of beta-defensin 3, an antagonist for melanocortin 1 receptor.

2 strated a hydrophobic binding pocket for the melanocortin 1 receptor.

3 alpha-melanocyte-stimulating hormone through melanocortin 1 receptor.

4 of human skin pigmentation via action at the melanocortin-1 receptor.

5 te human skin pigmentation via action at the melanocortin-1 receptor.

6 examined for their ability to stimulate the melanocortin-1 receptor.

7 lating hormone (alpha-MSH) to the alpha-MSH-(Melanocortin-1) receptor.

8 UV-tanning pathway include sunscreen agents, melanocortin 1 receptor activators, adenylate cyclase ac

9 A la-Arg-Lys-Leu peptide resulted in a 60 nM melanocortin-1 receptor agonist that is 100-fold selecti

10 line variants in MC1R, the gene encoding the melanocortin-1 receptor, and sun exposure increase risk

11 The melanocortin-1 receptor binding affinities of the peptid

12 The melanocortin-1 receptor-binding affinity of DOTA-Nle-Cyc

13 he interleukin-1 receptor antagonist and the melanocortin-1 receptor, further adding to the picture.

14 The melanocortin 1 receptor gene (MC1R) is responsible for n

15 We examined self-reported phenotypes and melanocortin 1 receptor gene (MC1R) variants in relation

16 The melanocortin 1 receptor gene is a main determinant of hu

17 variants in a low-penetrance gene, MC1R, the melanocortin 1 receptor gene, increase melanoma risk to

18 odel, with a focus on indoor tanning and the melanocortin 1 receptor gene, MC1R.

19 utional DNA for nine common polymorphisms in melanocortin-1 receptor gene (MC1R).

20 n genes and discovered four mutations in the melanocortin-1-receptor gene, Mc1r, that seem to be resp

21 Common genetic variants in the MC1R (melanocortin 1 receptor) gene, which determines skin and

22 test experimentally the association between melanocortin 1 receptor genotype and melanoma susceptibi

23 hlight the molecular mechanisms by which the melanocortin 1 receptor genotype controls genomic stabil

24 al response to ultraviolet radiation and the melanocortin 1 receptor genotype.

25 ivity and receptor selectivity for the human melanocortin 1 receptor (hMC1R) (IC(50) = 17 nM).

26 ng chimeric receptor constructs of the human melanocortin-1 receptor (hMC1R), a receptor that is not

27 ple for the use of phage displaying multiple melanocortin-1 receptor-homing peptides for the pretarge

28 The melanocortin 1 receptor is a key genetic determinant of

29 The melanocortin-1 receptor is expressed only on melanocytes

30 alpha-MSH signals by binding to the melanocortin-1 receptor (MC-1R) and elevating cyclic AMP

31 in human skin and the effect of POMC on the melanocortin-1 receptor (MC-1R) and melanocyte regulatio

32 The melanocortin-1 receptor (MC-1R) is a G-protein-coupled r

33 The melanocortin 1 receptor (MC1-R) is expressed by monocyte

34 ulating hormone (alpha-MSH) that function as melanocortin 1 receptor (MC1R) agonists.

35 timulating hormone (MSH), which binds to the melanocortin 1 receptor (Mc1r) and induces an activation

36 s based on the affinity between cell surface melanocortin 1 receptor (MC1R) antigen and anti-MC1R ant

37 tely 6.6-kb region located upstream from the melanocortin 1 receptor (MC1R) gene and containing its p

38 an association between variants in the human melanocortin 1 receptor (MC1R) gene and red hair and fai

39 Variants of the melanocortin 1 receptor (MC1R) gene are common in indivi

40 Mutations in the Melanocortin 1 receptor (Mc1r) gene contribute to pigmen

41 available data suggest that variants of the melanocortin 1 receptor (MC1R) gene may predict greater

42 Melanocortin 1 receptor (MC1R) gene variants alter pigme

43 Here, we show that the human melanocortin 1 receptor (MC1R) gene, a critical componen

44 product of inactivating polymorphisms in the melanocortin 1 receptor (MC1R) gene.

45 n are disruptive variants (R alleles) in the melanocortin 1 receptor (MC1R) gene.

46 g mechanism remains elusive, but the role of melanocortin 1 receptor (MC1R) has been implicated and w

47 The melanocortin 1 receptor (MC1R) is a regulator of eu- and

48 Variation at the melanocortin 1 receptor (MC1R) is very common in most no

49 Reduced function alleles of the melanocortin 1 receptor (MC1R) lead to red hair, freckli

50 hypertrophic scarring (HTS) are unknown, and melanocortin 1 receptor (MC1R) loss-of-function leads to

51 The melanocortin 1 receptor (MC1R) mediates the tanning resp

52 The melanocortin 1 receptor (MC1R), a G(s) protein-coupled r

53 the yellow/red tail color that maps close to melanocortin 1 receptor (mc1r), a gene involved in pigme

54 Loss-of-function in melanocortin 1 receptor (MC1R), a GS protein-coupled rec

55 The melanocortin 1 receptor (MC1R), a GS-coupled receptor th

56 n studied to date, two key genes, Agouti and Melanocortin 1 receptor (Mc1r), encode a ligand-receptor

57 most vertebrates, two key genes, Agouti and Melanocortin 1 receptor (Mc1r), encode a ligand-receptor

58 Skin pigmentation, which is regulated by the melanocortin 1 receptor (MC1R), is an effective protecti

59 olor mutations, only one gene in humans, the melanocortin 1 receptor (MC1R), is known to account for

60 show that a loss-of-function mutation in the melanocortin 1 receptor (Mc1r), recognized as a Mendelia

61 the melanocortin 4 receptor, but not to the melanocortin 1 receptor (MC1R), whereas ASIP binds with

62 multiple copies of a specific ligand for the melanocortin 1 receptor (MC1R), which has been evaluated

63 The melanocortin 1 receptor (MC1R), which signals through cA

64 und that McSCs migrate to the epidermis in a melanocortin 1 receptor (Mc1r)-dependent manner and diff

65 of whom contain functional disruption of the melanocortin 1 receptor (MC1R).

66 des were observed in mice with nonfunctional melanocortin 1 receptors (MC1R), ruling out the possibil

67 he identification of a novel peripheral skin melanocortin-1 receptor (MC1R) antagonist.

68 indicated that SHU9119 is an agonist at the melanocortin-1 receptor (MC1R) but an antagonist at the

69 atural variation in the coding region of the melanocortin-1 receptor (MC1R) gene is associated with c

70 Sequence variation in the melanocortin-1 receptor (MC1R) gene is associated with r

71 en somatic BRAF-mutant melanoma and germline melanocortin-1 receptor (MC1R) gene status.

72 mone receptor (MSHR), the protein product of melanocortin-1 receptor (MC1R) gene, leads to the synthe

73 a region of chromosome 11 that includes the Melanocortin-1 receptor (MC1R) gene, which regulates col

74 s perfectly associated with variation in the melanocortin-1 receptor (MC1R) gene.

75 , charge-changing amino acid mutation in the melanocortin-1 receptor (Mc1r) in beach mice, which decr

76 The melanocortin-1 receptor (MC1R) is a key regulator of pig

77 The melanocortin-1 receptor (MC1R) is a seven-transmembrane

78 Aiming at the design of specific melanocortin-1 receptor (MC1R) targeted imaging probes,

79 We sequenced the melanocortin-1 receptor (Mc1r) to study the genetic basi

80 The individuals carrying melanocortin-1 receptor (MC1R) variants, especially thos

81 The melanocortin-1 receptor (MC1R), a G-protein-coupled rece

82 didate gene for this color difference is the melanocortin-1 receptor (MC1R), a key regulator of melan

83 y cAMP-dependent signaling downstream of the melanocortin-1 receptor (MC1R).

84 gmentary within the normal population is the melanocortin-1 receptor (MC1R).

85 chimerical receptor constructs of the human melanocortin-1 receptor (MC1R; a receptor that is not in

86 have been identified, but only one gene, the melanocortin 1 receptor (MCR1), has so far been identifi

87 tation process may not necessarily involve a melanocortin-1 receptor-mediated mechanism.

88 Melanocortin 1 receptor polymorphisms correlate with ski

89 a paracrine-acting, transient antagonist of melanocortin 1 receptors that specifies the subapical ba

90 ily, examining their potential as ligands of melanocortin-1 receptor, through selection based on thei

91 majority of redheads sequenced (89%) had two melanocortin 1 receptor variants previously found to be

92 cyte cultures naturally expressing different melanocortin 1 receptor variants to alpha-melanocortin a

93 whom were also screened for the presence of melanocortin 1 receptor variants.

94 ine efficacy have been attributed in part to melanocortin-1 receptor variants.

95 -talk between the mu-opiate receptor and the melanocortin-1 receptor, we conclude that the beta-endor

96 identified several new potential ligands of melanocortin-1 receptor, which may have implications for

97 ng via cell-surface signaling by binding the melanocortin 1 receptor with the antagonist agouti-signa