ライフサイエンスコーパス: melanocortin-4 receptor

1 ium spiny neurons owing to activation of the melanocortin 4 receptor.

2 -acetyl alpha-MSH successfully activated the melanocortin 4 receptor.

3 in the search for novel ligands of the human melanocortin 4 receptor.

4 -alpha-MSH to cells overexpressing the human melanocortin-4 receptor.

5 for the melanocortin-3 receptor than for the melanocortin-4 receptor.

6 AGRP are functional antagonists of the human melanocortin-4 receptor.

7 tagonists of the melanocortin-3 receptor and melanocortin-4 receptor.

8 esting there is allosteric modulation of the melanocortin-4 receptor.

9 sequent activation of central nervous system melanocortin 4 receptors.

10 binding affinity for both melanocortin-3 and melanocortin-4 receptors.

11 A potent and selective antagonist of the melanocortin-4 receptor, 1-[2-[(1S)-(3-dimethylaminoprop

12 In 293T cells expressing the melanocortin 4 receptor, Act-alphaMSH is far more potent

13 lanocyte-stimulating hormone (alphaMSH) is a melanocortin 4 receptor agonist, and its potency in redu

14 iency were treated with setmelanotide, a new melanocortin-4 receptor agonist.

15 tion of body weight: PVN neurons express the melanocortin 4 receptor and appear to be physiological t

16 2) is an adaptor protein that contributes to melanocortin-4 receptor and prokineticin receptor 1 sign

17 hrough the modulation of the activity of the melanocortin-4 receptor and prokineticin receptors.

18 The melanocortin pathway, specifically the melanocortin-4 receptor and the cognate endogenous agoni

19 Furthermore, the melanocortin-4 receptor antagonist SHU9119 partially inh

20 tions in the coding region of the serpentine Melanocortin 4 receptor are the most common genetic caus

21 se can prevent the genetic predisposition of melanocortin-4 receptor-associated obesity and diabetes.

22 inity to the melanocortin 3 receptor and the melanocortin 4 receptor, but not to the melanocortin 1 r

23 e consider the structure and function of the melanocortin-4 receptor circuitry and its role in energy

24 Furthermore, the obesity induced by melanocortin 4 receptor deficiency also constricted the

25 not significantly altered in the ob, db, or melanocortin 4 receptor-deficient mouse model of obesity

26 hypothalamus; the MSH normally then binds to melanocortin-4 receptor expressing neurons and inhibits

27 Heterozygous coding mutations in the melanocortin 4 receptor gene (MC4R) are the most common

28 Mutations in the melanocortin-4 receptor gene (MC4R) represent the common

29 The genetic variants near the Melanocortin-4 receptor gene (MC4R), a key protein regul

30 tively low affinity for binding at the human melanocortin 4 receptor (hMC4R), were prepared by solid

31 ed to introduce selectivity toward the human melanocortin 4 receptor (hMC4R).

32 Mutations of the human melanocortin-4 receptor (hMC4R) have been previously ide

33 This fusion protein bound to the human melanocortin-4 receptor (hMC4R) with an affinity similar

34 Specific interactions of human melanocortin-4 receptor (hMC4R) with its nonpeptide and

35 or the interaction of ligands with the human melanocortin-4 receptor (hMC4R), agonist structure-activ

36 ossibly acting upstream or downstream of the melanocortin 4 receptor in the PVN, is responsible for s

37 egulation of signaling by melanocortin 3 and melanocortin 4 receptors in the CNS is controlled via ne

38 t a role for the melanocortin system and the melanocortin-4 receptor in the ring dove feeding behavio

39 The melanocortin 4 receptor is involved in the control of th

40 In this regard, the melanocortin-4 receptor is a critical coordinator of mam

41 derived peptides were optimized for in vitro melanocortin-4 receptor (MC-4R) binding affinity, agonis

42 one (alpha-MSH) at melanocortin-3 (MC-3) and melanocortin-4 receptors (MC-4).

43 the interaction between leptin, insulin, and melanocortin-4 receptors (MC-4Rs) in the control of rena

44 The centrally located melanocortin-3 and melanocortin-4 receptors (MC3R, MC4R) are involved in th

45 that intraventricular administration of the melanocortin 4 receptor (MC4-R) agonist MT II and antago

46 The melanocortin 4 receptor (MC4-R) plays a pivotal role in

47 Stimulation of the hypothalamic melanocortin 4 receptor (MC4-R) produces relative anorex

48 Activation of melanocortin 4 receptors (MC4-Rs) in brain nuclei associ

49 In this study, we characterize the rat melanocortin-4 receptor (MC4-R) and demonstrate that thi

50 The melanocortin-4 receptor (MC4-R) appears to be an importa

51 t genetic or pharmacological blockade of the melanocortin-4 receptor (MC4-R) attenuates uremia-associ

52 Inactivation of the melanocortin-4 receptor (MC4-R) by gene-targeting result

53 ays inverse agonism at constitutively active melanocortin-4 receptor (MC4-R) expressed on transfected

54 The melanocortin-4 receptor (MC4-R) is a G protein-coupled,

55 The melanocortin-4 receptor (MC4-R) is an important mediator

56 The melanocortin-4 receptor (MC4-R) is an important regulato

57 satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-indu

58 fluorescent protein under the control of the melanocortin-4 receptor (MC4-R) promoter, we observed Y1

59 de is also an antagonist of the hypothalamic melanocortin-4 receptor (MC4-R).

60 ceptors, melanocortin-3-receptor (MC3-R) and melanocortin-4-receptor (MC4-R), are expressed in many d

61 C) at the melanocortin 3 receptor (MC3R) and melanocortin 4 receptor (MC4R) and has been proposed to

62 Humans with functional variants in the melanocortin 4 receptor (MC4R) are obese, hyperphagic, a

63 ons in the coding sequence of the serpentine melanocortin 4 receptor (MC4R) are the most frequent gen

64 es between patients with SIM1 deficiency and melanocortin 4 receptor (MC4R) deficiency suggest that s

65 agouti peptide is a potent antagonist of the melanocortin 4 receptor (MC4R) expressed in neurons, and

66 oding mutations in conserved residues of the melanocortin 4 receptor (MC4R) gene, contributing to the

67 This locus, near the melanocortin 4 receptor (MC4R) gene, overlaps a region p

68 rosses the blood-brain barrier, binds to the melanocortin 4 receptor (MC4R) in the paraventricular an

69 The melanocortin 4 receptor (MC4R) is a G-protein-coupled re

70 rease in hypothalamic oxytocin (Oxt) and PVN melanocortin 4 receptor (Mc4r) mRNA.

71 The melanocortin 4 receptor (MC4R) plays an important role i

72 Melanocortin 4 receptor (MC4R) plays an important role i

73 eavage and polyadenylation in the intronless melanocortin 4 receptor (MC4R) pre-mRNA.

74 dependent BMI-associated signals in BDNF and melanocortin 4 receptor (MC4R) regions.

75 Melanocortin 4 receptor (MC4R) regulates energy homeosta

76 Loss of function of the melanocortin 4 receptor (MC4R) results in hyperphagia, o

77 Melanocortin 4 receptor (MC4R) signaling mediates divers

78 Mrap2 interacts directly with melanocortin 4 receptor (Mc4r), a protein previously imp

79 ed genetic deletion of the gene encoding the melanocortin 4 receptor (MC4R), as well as pharmacologic

80 and anatomical approaches, we show that the melanocortin 4 receptor (MC4R), implicated in the contro

81 Signalling though the melanocortin 4 receptor (MC4R), which is widely expresse

82 e was tested in a cell line expressing human melanocortin 4 receptor (MC4R).

83 icosities in close apposition to a subset of melanocortin-4 receptor (MC4R(PVH)) cells, which are als

84 yte stimulating hormones (alpha-MSH) and the melanocortin-4 receptor (Mc4r) all lead to obesity in ma

85 Recent studies have demonstrated that melanocortin-4 receptor (MC4R) antagonists can prevent w

86 Loss-of-function mutations in the human melanocortin-4 receptor (MC4R) are associated with obesi

87 ings suggest that the proximal region of the melanocortin-4 receptor (MC4R) C terminus is crucial not

88 Features of melanocortin-4 receptor (MC4R) deficiency have been obse

89 In the current study, we investigated melanocortin-4 receptor (MC4R) expression in the nodose

90 Melanocortin-4 receptor (MC4R) has an important regulato

91 The melanocortin-4 receptor (MC4R) has been broadly investig

92 The melanocortin-4 receptor (MC4R) has been studied extensiv

93 ly significant heterozygous mutations in the Melanocortin-4 receptor (MC4R) have been implicated in 2

94 We show here that absence of the melanocortin-4 receptor (MC4R) in mice causes dilated ca

95 The melanocortin-4 receptor (MC4R) in the hypothalamus is th

96 ological studies have defined a role for the melanocortin-4 receptor (Mc4r) in the regulation of ener

97 Melanocortin-4 receptor (MC4R) is a G protein-coupled re

98 Melanocortin-4 receptor (MC4R) is a G protein-coupled re

99 Melanocortin-4 receptor (MC4R) is a G protein-coupled re

100 The melanocortin-4 receptor (MC4R) is a G-protein coupled re

101 Melanocortin-4 receptor (MC4R) is a G-protein-coupled re

102 Melanocortin-4 receptor (MC4R) is a G-protein-coupled re

103 The melanocortin-4 receptor (MC4R) is a G-protein-coupled re

104 Melanocortin-4 receptor (MC4R) is critical for energy ho

105 The melanocortin-4 receptor (MC4R) is critically involved in

106 The melanocortin-4 receptor (MC4R) is essential for control

107 The melanocortin-4 receptor (MC4R) is involved in energy hom

108 The melanocortin-4 receptor (MC4R) is involved in regulating

109 The melanocortin-4 receptor (MC4R) is well recognized as an

110 Melanocortin-4 receptor (MC4R) ligands are known to modu

111 een the antagonist AGRP amino acids with the melanocortin-4 receptor (MC4R) may be important for the

112 Melanocortin-4 receptor (MC4R) plays critical roles in r

113 e resulted in the discovery of over 70 human melanocortin-4 receptor (MC4R) polymorphisms observed as

114 The Melanocortin-4 receptor (MC4R) regulates food intake, en

115 Haploinsufficiency of the melanocortin-4 receptor (MC4R) results in melanocortin o

116 Melanocortin-4 receptor (MC4R) SNPs have been associated

117 in (AGRP) is an endogenous antagonist of the melanocortin-4 receptor (MC4R) that functions in the hyp

118 tribution of extracytoplasmic domains of the melanocortin-4 receptor (MC4R) to AGRP binding by making

119 actors that mediate their action through the melanocortin-4 receptor (MC4R) whereas AGRP is an opposi

120 The melanocortin-4 receptor (MC4R), a centrally expressed G

121 The hypothalamic melanocortin-4 receptor (MC4R), a seven transmembrane G-

122 ct of exogenous alpha-MSH is mediated by the melanocortin-4 receptor (MC4R), and what thermoeffector

123 f AgRP are not limited to its actions at the melanocortin-4 receptor (MC4R), because MC4R-deficient (

124 to play an important role downstream of the melanocortin-4 receptor (MC4R), but this hypothesis has

125 hypothalamus (PVN) were shown to contain the melanocortin-4 receptor (MC4R), concentrated in the vent

126 Melanocortin-4 receptor (Mc4r)-expressing neurons in the

127 erge with GABAergic ARC(AgRP) projections on melanocortin-4 receptor (MC4R)-expressing satiety neuron

128 Melanocortin-4 receptor (Mc4r)-null mice exhibit late-on

129 ulates body energy homeostasis including the melanocortin-4 receptor (MC4R).

130 the G93A SOD1 mutation that also lacked the melanocortin-4 receptor (MC4R).

131 ssess single nucleotide polymorphisms in the melanocortin-4 receptor (MC4R).

132 d as potent and selective antagonists of the melanocortin-4 receptor (MC4R).

133 Both peptides bind with high affinity to the melanocortin-4 receptor (MC4R); existing data show that

134 Melanocortin-4 receptors (MC4R) have weight-independent

135 ing and satiety are coordinated centrally by melanocortin-4 receptors (MC4R) in neurons of the hypoth

136 istic actions of these ligands at downstream melanocortin-4 receptors (MC4R) in the paraventricular n

137 Melanocortin-4-receptor (MC4R) haploinsufficiency is the

138 Defects in melanocortin-4-receptor (MC4R) signalling result in hype

139 Melanocortin-4-receptor (MC4R)-expressing neurons modula

140 ake in rodents, presumably via activation of melanocortin-4-receptor (MC4R).

141 Whether melanocortin 4 receptors (MC4Rs) in extra-hypothalamic n

142 Melanocortin 4 receptors (MC4Rs) in the central nervous

143 Activation of brain melanocortin 4 receptors (MC4Rs) leads to reduced food i

144 Further, we found that deletion of melanocortin 4 receptors (MC4Rs), a downstream target of

145 Melanocortin-4 receptors (MC4Rs) are expressed by vagal

146 n supraoptic oxytocin neurons, and alpha-MSH melanocortin-4 receptors (MC4Rs) are highly expressed in

147 Activation of melanocortin-4 receptors (MC4Rs) restrains feeding and p

148 To a greater degree, they also contain melanocortin-4 receptors (MC4Rs), implying that leptin c

149 Activation of melanocortin-4-receptors (MC4Rs) reduces body fat stores

150 ral despair, are prevented by blocking these melanocortin 4 receptor-mediated synaptic changes in viv

151 -3 receptor (mMC3R) antagonists and nM mouse melanocortin-4 receptor (mMC4R) agonists.

152 In vitro mutagenesis of the mouse melanocortin-4 receptor (mMC4R) has been performed, base

153 x 10(-6)) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the lea

154 does not suppress the obese phenotype of the melanocortin-4-receptor null allele or those of the mono

155 to moderately increased dietary fat content, melanocortin-4 receptor-null mutant (MC4R-/-) mice exhib

156 es not alter hypothalamic mRNA expression of melanocortin 4 receptor or adiponectin serum and mRNA ex

157 2) = 5.9) is also an antagonist at the brain melanocortin-4 receptor (pA(2) = 6.9), with no observabl

158 Binding data demonstrate that melanocortin 4 receptor responds to all chimeras and is

159 downstream of hypothalamic and/or brainstem melanocortin 4 receptors, that project via the autonomic

160 Haploinsufficiency of the melanocortin-4 receptor, the most common monogenetic obe

161 hingosine 1-phosphate receptor-3 (S1P3), the melanocortin-4 receptor, the Smoothened receptor, formyl

162 showed that potency of binding to the human melanocortin 4 receptor was not diminished for linker-li

163 POMC neurons and subsequent activation of melanocortin 4 receptors were critical for nicotinic-ind

164 of protease-activated receptors-1 and -2 and melanocortin-4 receptors yields agonists and/or antagoni