ライフサイエンスコーパス: melanocytic nevi

1 alyzed the difference between DNs and common melanocytic nevi.

2 2% of primary melanomas were associated with melanocytic nevi.

3 valence and morphologic features of perianal melanocytic nevi.

4 nomas (primary and metastatic) compared with melanocytic nevi.

5 melanomas compared with primary melanoma and melanocytic nevi.

6 melanomas are derived directly from benign, melanocytic nevi.

7 nonsquamous (1 pingueculum, 1 dermolipoma, 2 melanocytic nevi, 1 melanoma).

8 from 100 biopsy-proven lesions, including 55 melanocytic nevi, 20 melanomas, 15 basal cell carcinomas

9 Melanocytic nevi also demonstrated catK expression, but

10 ations of NRAS and BRAF were found in benign melanocytic nevi and cutaneous melanomas.

11 to better understand the characteristics of melanocytic nevi and define pathways of melanocytic tumo

12 These results show that although melanocytic nevi and dysplastic nevi harbor stable genom

13 haracterized by the sudden onset of numerous melanocytic nevi and have been traditionally described i

14 owed abundant expression of MAP-2 protein in melanocytic nevi and in the in situ and invasive compone

15 In this study, melanocytic nevi and malignant melanomas were examined b

16 ptosis inhibitor Survivin to be expressed in melanocytic nevi and melanoma but not in normal melanocy

17 ce in growth arrest and tumor suppression in melanocytic nevi and melanoma.

18 ns of chromosomal aberrations between benign melanocytic nevi and melanoma.

19 BRAF mutations occur at a high frequency in melanocytic nevi and metastatic lesions, but recent data

20 aberration in melanoma that is distinct from melanocytic nevi and should be further evaluated as a di

21 molecular differences between DNs and common melanocytic nevi are not completely understood.

22 Melanocytic nevi are the most potent risk factors for me

23 icroscope to image in vivo and noninvasively melanocytic nevi at three different stages: common nevi

24 arcinomas, actinic keratoses, atypical nevi, melanocytic nevi, blue nevi, and seborrheic keratoses.

25 confirmatory, showing a strong signal in the melanocytic nevi but progressive signal attenuation with

26 loss abrogates growth arrest of Braf(V600E) melanocytic nevi, but is insufficient for complete progr

27 and -mRNA was characterized in melanomas and melanocytic nevi by immunocytochemistry and in situ reve

28 discriminative genes between DNs and common melanocytic nevi by three independent statistical approa

29 typical moles, are distinguished from common melanocytic nevi by variegation in pigmentation and clin

30 Melanoma and benign melanocytic nevi can overlap significantly in their hist

31 Congenital melanocytic nevi (CMN) and infantile hemangiomas are com

32 Large congenital melanocytic nevi (CMN) are at an increased risk of devel

33 Congenital melanocytic nevi (CMN) are pigmented birthmarks that aff

34 Congenital melanocytic nevi (CMN) can be associated with neurologic

35 les (PNs) and melanoma arising in congenital melanocytic nevi (CMN) is crucial, as patients with PNs

36 15 Expression was significantly increased in melanocytic nevi compared with melanomas (mean H scores,

37 A high melanocytic nevi count is the strongest known risk facto

38 Most melanocytic nevi develop on sun-exposed skin during chil

39 d molecular bases of acquired and congenital melanocytic nevi during childhood.

40 prone to developing large, markedly atypical melanocytic nevi (EB nevi), which may mimic melanoma cli

41 Eruptive melanocytic nevi (EMN) are characterized by the sudden o

42 Melanocytic nevi frequently harbor oncogenic BRAF mutati

43 alogous genotypic profiles for epidermal and melanocytic nevi from recent studies.

44 While melanocytic nevi have been associated with genetic facto

45 in the primary melanomas than in the benign melanocytic nevi, however, only p53 over-expression was

46 opathologic examination revealed remnants of melanocytic nevi in 103 melanomas (54.2%).

47 pproach to small- or medium-sized congenital melanocytic nevi in black children must be different bec

48 Numbers and distribution of melanocytic nevi in childhood are major indicators of th

49 the natural history and clinical spectrum of melanocytic nevi in children as well as potentially worr

50 atypical mole phenotype, development of new melanocytic nevi in older individuals is uncommon and co

51 ed to prevalence and morphologic features of melanocytic nevi in the perianal area.

52 adigm for understanding the growth arrest of melanocytic nevi in vivo termed stable clonal expansion.

53 tential of the method to distinguish between melanocytic nevi in vivo.

54 nevi) from melanoma, we sequenced exomes of melanocytic nevi including dysplastic nevi (n = 19), fol

55 Additionally, melanocytic nevi including dysplastic nevi showed a sign

56 to determine the discriminatory profiles of melanocytic nevi (including dysplastic nevi) from melano

57 t approximately 50% of the existing acquired melanocytic nevi involuted, while the remaining nevi did

58 Importance: The presence of numerous melanocytic nevi is a significant melanoma risk factor,

59 A large number of melanocytic nevi is the strongest known risk factor for

60 expression of PEDF in common and dysplastic melanocytic nevi, melanoma in situ, invasive melanoma, a

61 A survey of benign melanocytic nevi (moles), suspected precursors or marker

62 d gene panel (785 genes) characterization of melanocytic nevi (n = 46) and primary melanomas (n = 42)

63 diatricians to discuss treatment options for melanocytic nevi, nevus sebaceus, port-wine stains, and

64 epts of the risks associated with congenital melanocytic nevi of different sizes and strategies for t

65 utaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggestin

66 es were preferentially represented in benign melanocytic nevi over melanomas and selectively mapped t

67 which growth arrest can be overcome and how melanocytic nevi relate to melanoma are also considered.

68 nome-wide association study on the number of melanocytic nevi reported by 9136 individuals of Europea

69 The density of acquired melanocytic nevi represents an important risk factor for

70 F1, RAC1, and PTEN, were not found among any melanocytic nevi sequenced.

71 melanoma is the presence of large numbers of melanocytic nevi so that genes controlling nevus phenoty

72 y role for Wnt signaling in the formation of melanocytic nevi, suggesting that activated Wnt signalin

73 This review summarizes the types of melanocytic nevi that are commonly observed in children,

74 the first to characterize certain pigmented melanocytic nevi that may also fit this paradigm.

75 Spitz nevi are benign melanocytic nevi that overlap histopathologically with m

76 pe characterized by the presence of multiple melanocytic nevi: the atypical mole syndrome.

77 ith dermoscopy are associated with enlarging melanocytic nevi, their actual growth dynamics remain un

78 differentiating dysplastic nevi from common melanocytic nevi through a molecular lens.

79 in clinical melanoma tissues, compared with melanocytic nevi tissues.

80 stages of malignant progression from common melanocytic nevi to metastatic melanomas and examine the

81 udinal tracking of microscopic structures in melanocytic nevi using RCM is feasible.

82 ions between primary cutaneous melanomas and melanocytic nevi vary widely between 4% and 72%.

83 f BRAF oncogenic mutations was identified in melanocytic nevi, VGP, metastatic melanomas, and melanom

84 Phenotypical data on melanocytic nevi were collected from a random sample of

85 sions and Relevance: In this study, perianal melanocytic nevi were common and were associated with pr

86 Despite this, the vast majority of melanocytic nevi, which typically form as a result of BR

87 ry oncogenes, which typically lead to benign melanocytic nevi with characteristic histologic features

88 MN) syndrome is the association of pigmented melanocytic nevi with extra-cutaneous features, classica