ライフサイエンスコーパス: melanosomal

1 The melanosomal accumulation of CDDP remarkably modulates me

2 se microscopy, which allows visualization of melanosomal aggregates and individual melanosomes.

3 unction suggesting a role for pi-stacking in melanosomal amyloid assembly.

4 tify the critical PMEL domain that forms the melanosomal amyloid core (CAF).

5 f the CAF and provides insights into how the melanosomal amyloid core forms.

6 Thus, a melanosomal anion channel that requires OCA2 is essentia

7 ntaining a CD8 T-cell epitope derived from a melanosomal antigen (Trp2(180-188)) elicited antigen-spe

8 Melanosomal antigen expression is governed by MITF, PAX3

9 ells in lymphangioleiomyomatosis may process melanosomal antigens different from melanocytic cells.

10 the percentage of LAM cells expressing these melanosomal antigens is limited.

11 a patients previously immunized with defined melanosomal antigens.

12 ing lymphocytes are frequently reactive with melanosomal antigens.

13 n factors-master regulators of lysosomal and melanosomal biogenesis and autophagy-control mTORC1 lyso

14 As a key factor in melanosomal biogenesis, understanding intracellular traf

15 LOC-3 complexes in delivery and recycling of melanosomal biogenetic components, supplying directional

16 -pore channel 2 (TPC2) as the first reported melanosomal cation conductance by directly patch-clampin

17 ow that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative c

18 not only determines sorting to the endocytic/melanosomal compartment, but also controls export from t

19 s a component of a postulated premelanosomal/melanosomal complex of membrane-bound melanogenic oxidor

20 from Pmel17 only forms fibrils under acidic melanosomal conditions.

21 olycystic kidney disease (PKD) domain into a melanosomal core matrix.

22 osomes, and subsequent illumination leads to melanosomal damage shown by electron microscopy.

23 Melanosomal defects along with ocular immune abnormaliti

24 ink-eyed dilution) and human P genes lead to melanosomal defects and ocular developmental abnormaliti

25 osinase, which also engages AP-3 for optimal melanosomal delivery, both AP-1- and AP-3-favoring OCA2

26 man melanocytes and suggest that the altered melanosomal distribution in skin after sun exposure is d

27 Only the cytoplasmic (extra-melanosomal) domain of tyrosinase, which contains two se

28 Tyrosinase-related protein 2 (TRP2) is a melanosomal enzyme expressed in most mammalian melanocyt

29 ears to stabilize the catalytic functions of melanosomal enzymes and allows melanin biosynthesis to b

30 he NTR controls the hierarchical assembly of melanosomal fibrils.

31 ase in unpigmented or hypopigmented immature melanosomal forms, leading to the hypopigmented coat col

32 osamine; it was located predominantly in the melanosomal fraction of cell homogenates; the activity w

33 hat is controlled by two autosomal loci: the melanosomal gene, SILV, and a modifier gene, harlequin (

34 -reactive T cells to aberrant transcripts of melanosomal genes.

35 Melanosomal glycoproteins are transported to melanosomes

36 more extensively glycosylated than endocytic/melanosomal gp75, containing trans-Golgi processed sugar

37 In contrast, tyrosinase exhibited a melanosomal (i.e., perinuclear and dendritic) pattern in

38 Although genes encoding putative melanosomal ion transporters have been identified as key

39 Steady-state melanosomal localization requires a conserved consensus

40 re defined by antiserum directed against the melanosomal marker tyrosinase related protein 1.

41 co-segregates with exogenously expressed pre-melanosomal markers OA1 and fibrillar PMEL, following ea

42 ng organelles confirmed its coresidence with melanosomal markers.

43 he RPE-specific genes Mitf and Wnt13 and the melanosomal matrix protein MMP115.

44 D12S53E encodes a melanosomal matrix protein whose expression is closely c

45 rated that the p protein is localized to the melanosomal membrane and does not function as a tyrosine

46 PI(3,5)P2 modulates TPC2 activity to control melanosomal membrane potential, pH, and regulate pigment

47 d of tyrosinase-related protein 1 (Tyrp1), a melanosomal membrane protein previously thought to traff

48 e membrane; and (3) this membrane lacked the melanosomal membrane protein tyrosinase-related protein

49 smic tail of gp75 (TRP-1), the most abundant melanosomal membrane protein, we performed yeast two-hyb

50 ace depends on the presence of this resident melanosomal membrane protein.

51 Melanosomal membrane proteins are frequently recognized

52 Thus, these endocytic/melanosomal membrane proteins can be processed to abunda

53 nase-related proteins (TRPs) are a family of melanosomal membrane proteins involved in mammalian pigm

54 , localizes exclusively to endolysosomal and melanosomal membranes unlike most G protein-coupled rece

55 larly pertinent due to their high content in melanosomal membranes.

56 itical for the refolding of GP100 within the melanosomal milieu, and subsequent reorganization of amo

57 Aberrant melanosomal morphology may potentially have consequences

58 conserved among eukaryotes, as the mammalian melanosomal MVB cargo MART-1 is modified by K63Ub chains

59 s that have down-regulated components of the melanosomal pathway, but constitutively express HLA-DR*0

60 TRP-1 displayed a typical melanosomal pattern in both normal and HPS-2 melanocytes

61 near the Golgi, in contrast to its punctate melanosomal pattern in wild-type melanocytes.

62 ant role in the generation or maintenance of melanosomal pH.

63 Mutations in two melanosomal protein genes (Tyrp1(b) and Gpnmb(R150X)) ar

64 indicate that pigment production and mutant melanosomal protein genes may contribute to human pigmen

65 However, analysis of a melanosomal protein has uncovered an alternative pathway

66 We show that the melanosomal protein Pmel17 is sorted into ILVs by a mech

67 We conclude that GPNMB is a melanosomal protein that is released by proteolytic ecto

68 a mutation of the gene encoding the integral melanosomal protein tyrosinase, resulting in aberrant me

69 BLOC-1-deficient melanocytes accumulate the melanosomal protein tyrosinase-related protein-1 (Tyrp1)

70 In BLOC-2-deficient melanocytes, the melanosomal protein TYRP1 was largely depleted from pigm

71 d and sorted in a manner distinct from other melanosomal proteins (such as tyrosinase, Tyrp1 and Dct)

72 n normal melanocytes Rab33A colocalizes with melanosomal proteins and that a constitutively active GT

73 r distribution is quite similar to the other melanosomal proteins and usually correlates with melanin

74 In contrast to other melanosomal proteins such as TYR and TYRP1, the processi

75 ne response to tumor antigens represented by melanosomal proteins such as tyrosinase, gp100, and MART

76 All three enzymes are membrane-bound melanosomal proteins with similar structural features an

77 ase-related protein-1 (Tyrp1), but not other melanosomal proteins, in endosomal vacuoles and the cell

78 melanocytes to melanosomes, and, like other melanosomal proteins, localizes to lysosomes when expres

79 Whereas the functions of other melanosomal proteins, such as tyrosinase, tyrosinase-rel

80 lutely required for melanogenesis, but other melanosomal proteins, such as TYRP1, DCT, and gp100, als

81 characterized the processing of two distinct melanosomal proteins, tyrosinase (TYR) and Pmel17, to el

82 ult from mutations in related genes encoding melanosomal proteins.

83 In contrast, a mutation in another melanosomal regulatory gene, Hps1, minimally affects mel

84 data provide the first direct evidence that melanosomal regulatory genes influence drug sensitivity

85 Preventing melanosomal sequestration of cytotoxic drugs by inhibiti

86 Absence of the melanosomal structural protein gp100/Pmel17 causes incre

87 n that shows high homology with a well-known melanosomal structural protein, Pmel17/gp100.

88 t, S91 mouse melanoma cells exhibit aberrant melanosomal trafficking, in accordance with the known de

89 pecific expression pattern likely related to melanosomal transport and docking.

90 inesin in microtubule-associated anterograde melanosomal transport in human melanocyte dendrites.

91 ytoplasmic dynein participates in retrograde melanosomal transport in human melanocytes and suggest t

92 nsported to melanosomes by a dileucine-based melanosomal transport signal (MTS).

93 To determine whether kinesin participates in melanosomal transport, cultured melanocytes were treated

94 cts in three genes involved in intracellular melanosomal transport, previously described in mammals,

95 3-favoring OCA2 variants required BLOC-1 for melanosomal transport.

96 e with the known defect in myosin-V mediated melanosomal transport.

97 tion phenotypes; of those, only one putative melanosomal transporter (SLC45A2) has known function in

98 Melanosomal tyrosine transport was saturable, with an ap