1 Gly-NH(2)) and key pharmacophore elements of melanotropins.

2                            A number of alpha-melanotropin (alpha-MSH) analogues have been designed de

3                      A number of novel alpha-melanotropin (alpha-MSH) analogues have been designed, s

4 timulates the synthesis and release of alpha-melanotropin (alpha-MSH) and adrenocorticotropic hormone

5 tropic cells [corticotropin (ACTH) and alpha-melanotropin (alpha-MSH)], and with somatolactin endocri

6                Beads with a disulfide-linked melanotropin analog served as a direct control.

7                              A new series of melanotropin analogues with His or Arg residues in the c

8 ticotropic hormone, alpha-, beta-, and gamma-melanotropin, beta-endorphin, and beta-lipotropin.

9  It has been shown by extensive studies that melanotropin bioactivities are critically dependent on t

10 ding interactions between melanoma cells and melanotropin-bound beads also could be abolished by prio

11                               Binding of the melanotropin conjugates was not restricted to any one ph

12 2), compound 1, a cyclic derivative of alpha-melanotropin, is a nonselective high affinity antagonist

13 sent the first examples of a class of cyclic melanotropin ligands with high selectivity and defined b

14  Examination of conformationally constrained melanotropin peptide (Ac-Nle4-c[Asp5-His-Phe7-Arg-Trp9-A

15 longed (residual) biological activity of the melanotropin peptides alpha-MSH (alpha-melanocyte-stimul

16 nal 16 kDa fragment, also known as pro-gamma-melanotropin (pro-gamma-MSH), is required, releasing sho

17 is-Phe7-Arg-Trp9-Ala-Lys]-NH2) on four human melanotropin receptors (hMC1R, hMC3R, hMC4R, and hMC5R)

18 and keratinocytes were also shown to express melanotropin receptors by the same criteria established

19                     Topographically modified melanotropin side chain pharmacophore residues Phe7 and

20                        These newly developed melanotropins will serve as critical biochemical tools f