ライフサイエンスコーパス: melastatin

1 this leads to closure of the TRPM1 channel (melastatin).

2 arity to several vertebrate genes, including melastatin.

3 icroRNA (miR-211) hosted within an intron of melastatin.

4 hannel, subfamily M, member 1, also known as melastatin.

5 cascade and the transient receptor potential melastatin 1 (TRPM1) cation channel.

6 metabotropic glutamate receptor 6 to the TRP melastatin 1 (TRPM1) channel to transmit signals from ph

7 aining G(alphao), and the cation channel TRP melastatin 1 (TRPM1).

8 Go , closure of transient receptor potential melastatin 1 channels and hyperpolarization of these cel

9 ressed from the transient receptor potential melastatin 1 intronic region, regulates oxidative phosph

10 Transient receptor potential melastatin-1 (TRPM1) is essential for the light-induced

11 try (SOCE), the transient receptor potential melastatin 2 (TRPM2) channel contributes to Ca(2+) relea

12 try through the transient receptor potential melastatin 2 (TRPM2) channel in macrophages.

13 Transient receptor potential melastatin 2 (TRPM2) channel is known to be a cellular r

14 neurons express transient receptor potential melastatin 2 (TRPM2) channels that underlie NMDA-induced

15 variant of the transient receptor potential melastatin 2 (TRPM2) gene may confer susceptibility to t

16 cation channel transient receptor potential melastatin 2 (TRPM2) in a murine model of kidney ischemi

17 Transient receptor potential melastatin 2 (TRPM2) ion channel has an essential functi

18 Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channe

19 Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channe

20 Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca(2+)-permeable channel gated

21 cation channel transient receptor potential melastatin 2 (TRPM2) plays a key role in pathogen-evoked

22 The transient potential receptor melastatin-2 (TRPM2) channel has emerged as an important

23 DP ribose opens transient receptor potential melastatin-2 (TRPM2) channels in endothelial cells leadi

24 TIONALE: TRPM2 (transient receptor potential melastatin-2) expressed in endothelial cells (ECs) is a

25 (MFA), that the Transient Receptor Potential Melastatin 3 (TRPM3) channel promotes the growth of clea

26 Transient receptor potential melastatin 3 (TRPM3) channels are activated by heat, and

27 Transient receptor potential melastatin 3 (TRPM3) is a calcium-permeable nonselective

28 Transient receptor potential melastatin 3 ion channel (TRPM3) belongs to the TRP fami

29 stimulation of transient receptor potential melastatin-3 (TRPM3) channels.

30 e non-selective Transient Receptor Potential Melastatin 4 (TRPM4) cation channel is abundantly expres

31 x through transient receptor potential (TRP) melastatin 4 (TRPM4) channels to cause membrane depolari

32 Transient receptor potential (TRP) melastatin 4 (TRPM4) is a widely expressed cation channe

33 dently enhances transient receptor potential melastatin 4 (TRPM4), a Ca2+-activated nonselective (CAN

34 bly of Sur1 and transient receptor potential melastatin 4 (Trpm4).

35 a-gustducin and transient receptor potential melastatin 5.

36 (2+) conducting transient receptor potential melastatin 7 (TRPM7) channel-enzyme (chanzyme) has been

37 Transient receptor potential melastatin 7 (TRPM7) channels are novel Ca(2+)-permeable

38 Transient receptor potential melastatin 7 (TRPM7) channels represent the major magnes

39 Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containin

40 Transient receptor potential melastatin 7 (TRPM7) is a broadly expressed, non-selecti

41 Transient receptor potential melastatin 7 (TRPM7) is a divalent ion channel with a C-

42 Transient receptor potential melastatin 7 (TRPM7) is a newly found gene essential to

43 ABSTRACT: The transient receptor potential melastatin 7 (TRPM7) is a protein that combines an ion c

44 Transient receptor potential melastatin 7 (TRPM7) is a ubiquitously expressed Mg(2+)-

45 r inhibition of transient receptor potential melastatin 7 (TRPM7) reduces store-operated calcium entr

46 re we show that Transient Receptor Potential Melastatin 7 (TRPM7), a divalent-permeant channel-kinase

47 e find that the transient receptor potential melastatin 7 (TRPM7)-associated Mg2+ -inhibited cation (

48 of MSCs through Transient receptor potential melastatin 7 (TRPM7)-Osterix axis.

49 ermeable TRPM7 (transient receptor potential melastatin 7) channels.

50 TRPM7 (transient-receptor-potential melastatin 7) is an ion channel with alpha-kinase functi

51 enthol receptor transient receptor potential melastatin 8 (TRPM8) and compared its behavior with that

52 Transient receptor potential melastatin 8 (TRPM8) and transient receptor potential va

53 l ganglion, the transient receptor potential melastatin 8 (TRPM8) channel is a Ca(2+)-permeable catio

54 nthol-activated transient receptor potential melastatin 8 (TRPM8) channels are thought to be regulate

55 nthol-activated transient receptor potential melastatin 8 (TRPM8) channels diminishes over time in th

56 nthol-activated transient receptor potential melastatin 8 (TRPM8) channels.

57 The transient receptor potential melastatin 8 (TRPM8) ion channel is a major sensor of en

58 The transient receptor potential melastatin 8 (TRPM8) ion channel is a major sensor of en

59 interacts with transient receptor potential melastatin 8 (TRPM8) ion channels in cold-sensitive sens

60 Transient receptor potential melastatin 8 (TRPM8) is a nonselective cation channel ex

61 One such channel--TRP melastatin 8 (TRPM8) or cold and menthol receptor 1 (CMR

62 is detected by transient receptor potential melastatin 8 (TRPM8), a nonselective cation channel expr

63 nthol activates transient receptor potential melastatin 8 (TRPM8), an ion channel also activated by c

64 enthol receptor transient receptor potential melastatin 8 (TRPM8).

65 receptor TRPM8 (transient receptor potential melastatin 8) has been suggested to play a role in cold

66 pport a role of transient receptor potential melastatin 8-mediated facilitation of synaptic strength

67 sitive channel transient receptor potential (melastatin)-8 (TRPM8), heterologously expressed in Chine

68 port that human transient receptor potential melastatin-8 (TRPM8) and an N-terminally truncated TRPM8

69 In the same experimental setup, blocking the melastatin-8 (TRPM8) channel with AMG2850 (30 mg/kg) att

70 imation via the transient receptor potential melastatin-8 (TRPM8) channel without evoking nociceptive

71 tagonist of the transient receptor potential melastatin-8 (TRPM8) channel.

72 Transient Receptor Potential Melastatin-8 (TRPM8), a recently identified member of th

73 diesel exhaust PM > crystalline silica; TRP melastatin-8 is also robustly activated by CFA1, whereas

74 man melanomas characterized by low levels of melastatin and miR-211.

75 further divided into TRPC (canonical), TRPM (melastatin), and TRPV (vanilloid) subfamilies.

76 umor suppressive activity is not mediated by melastatin but instead by a microRNA (miR-211) hosted wi

77 human primary cutaneous melanomas examined, melastatin expression appeared to correlate inversely wi

78 ssion pattern observed suggests that loss of melastatin expression is an indicator of melanoma aggres

79 n, whereas primary melanomas showed variable melastatin expression.

80 dermal transient receptor potential channel, melastatin family (TRPM) channel GTL-2 and IP(3)R-stimul

81 The melastatin-family transient receptor potential 2 (TRPM2)

82 The mouse melastatin gene contains 27 exons and spans at least 58

83 a member of the Transient-Receptor-Potential Melastatin ion channel family.

84 Melastatin is greatly downregulated in metastatic melano

85 lcium-permeable channel, transient potential melastatin-like 2 (TRPM2), via stimulation of poly-ADP-r

86 We found that transient receptor potential-melastatin-like 7 (TRPM7) channel expression regulated E

87 The gene transient receptor potential-melastatin-like 7 (Trpm7) encodes a protein that functio

88 l disruption of transient receptor potential-melastatin-like 7 (Trpm7) in mice results in embryonic l

89 Transient receptor potential melastatin-like 7 (TRPM7) is a channel protein that also

90 Transient receptor potential melastatin-like 7 channel (TRPM7) is a ubiquitous, const

91 lected against via suppression of the entire melastatin locus during human melanoma progression.

92 ate was 90% +/- 7%, whereas in patients with melastatin loss, the disease-free survival rate was 51%

93 A was 100%, whereas in stage I patients with melastatin loss, the disease-free survival rate was 77%

94 sion criterion, TRP polycystic (P)3, and TPR melastatin (M)8 were found to be uniquely adipospecific.

95 The transient receptor potential melastatin member 7 (TRPM7) and member 6 (TRPM6) are div

96 amily includes the putative tumor suppressor melastatin (MLSN) and is a poorly characterized group of

97 Melastatin (MLSN-1), a novel melanocyte-specific gene re

98 Uniform melastatin mRNA expression in the primary tumor was corr

99 erformed to assess the prognostic utility of melastatin mRNA expression while adjusting for other pro

100 udied the relationship between expression of melastatin mRNA in the primary cutaneous tumor and progn

101 Downregulation of melastatin mRNA in the primary cutaneous tumor is a prog

102 I patients whose tumors diffusely expressed melastatin mRNA was 100%, whereas in stage I patients wi

103 Melastatin mRNA was evaluated by in situ hybridization i

104 II disease whose tumors diffusely expressed melastatin mRNA, the 8-year disease-free survival rate w

105 the mouse are consistent with involvement of melastatin mutations in the mouse ruby-eye-2 defect, con

106 Increasing expression of miR-211 but not melastatin reduced migration and invasion of malignant a

107 that the transient receptor potential (TRP) melastatin related 7 (TRPM7) is the molecular basis of t

108 a member of the transient receptor potential melastatin-related (TRPM) family of cation channels, whi

109 The transient receptor potential melastatin-related channel 2 (TRPM2) is a nonselective c

110 cation channel that belongs to the family of melastatin-related transient receptor potential (TRPM) c

111 ium (Ca(2+))-permeable cation channel of the melastatin-related transient receptor potential (TRPM) i

112 TRPM6 and TRPM7 are members of the melastatin-related transient receptor potential (TRPM) s

113 The melastatin-related transient receptor potential channel

114 Melastatin-related transient receptor potential channel

115 Used in combination, melastatin status and tumor thickness allow for the iden

116 Multivariate analysis revealed that melastatin status, mitotic rate, and tumor thickness inf

117 The melastatin subfamily (TRPM) channels have N-terminal dom

118 , inhibitors of transient receptor potential melastatin subfamily 4 (TRPM4), intracellular introducti

119 rent carried by transient receptor potential melastatin subfamily 4 channels via type 2 inositol 1,4,

120 mate receptor 6/transient receptor potential melastatin subfamily M member 1-signaling (mGluR6/TRPM1-

121 nsient receptor potential ion channel of the melastatin subfamily, TRPM8, is a major cold receptor in

122 his analysis identified a novel gene, termed melastatin, that is expressed at high levels in poorly m

123 Melastatin transcripts were not detected in melanoma met

124 cation channel transient receptor potential melastatin (TRPM) 4 is involved in the control of Ca(2+)

125 lycosylation of transient receptor potential melastatin (Trpm) 4b, a membrane glycoprotein that regul

126 Transient receptor potential melastatin (TRPM) cation channels are polymodal sensors

127 The TRP-melastatin (TRPM) subfamily includes the putative tumor

128 amilies: classical (TRPC), vanilloid (TRPV), melastatin (TRPM), muclopins (TRPML), polycystin (TRPP),

129 The transient receptor potential melastatin (TRPM)-3 channel is critical for various phys

130 h in turn opens transient receptor potential melastatin (TRPM)2 channels.

131 studies have demonstrated that expression of melastatin/TRPM1 strongly predicts nonmetastatic propens

132 The transient receptor potential melastatin type 6 (TRPM6) epithelial Mg(2+) channels par

133 Mg(2+) channel transient receptor potential melastatin type 6 that determines the final urinary Mg(2

134 The transient receptor potential melastatin type 8 (TRPM8) is a nonselective cation chann

135 dulation of the transient receptor potential melastatin type 8 (TRPM8) is currently under investigati

136 Melastatin was also found to be differentially expressed

137 Benign nevi express high levels of melastatin, whereas primary melanomas showed variable me

138 We recently described a novel gene, melastatin, whose expression is inversely correlated wit