ライフサイエンスコーパス: melatonin

1 in drug metabolism/degradation (nicotine and melatonin).

2 vincristine, and prednisone, with or without melatonin.

3 structures to the bioactive conformation of melatonin.

4 vitro, in some cases to a higher extent than melatonin.

5 d to reproduce the bioactive conformation of melatonin.

6 average action potential rate in response to melatonin.

7 , the penultimate enzyme in the synthesis of melatonin.

8 emosensing ensemble for the neurotransmitter melatonin.

9 concentrations in the absence or presence of melatonin.

10 acental communication via the pineal hormone melatonin.

11 the range of 1.63-4.68 mg/100g d.w. and for melatonin 0.43-0.64 mg/100g d.w.

12 mproved median survival time in rats (sepsis/melatonin [0.1 mg/kg], 554 min, [1.0 mg/kg] 570 min, [10

13 P-DM-MEL) were treated with a single dose of melatonin (10 mg/body weight) every day for 14 consecuti

14 Melatonin, 3 mg/d, or placebo for 4 weeks followed by a

15 nk) and red wine while the highest amount of melatonin (341.7 +/- 29.3 pg/g) was detected in crumb.

16 vehicle, 303 min) and wild-type mice (sepsis/melatonin, 781 min; sepsis/ramelteon, 701 min; both p <

17 study, we document that chloroplasts produce melatonin, a recently-discovered plant antioxidant molec

18 collection of a 24-hr time series of plasma melatonin, a suprachiasmatic nucleus-driven pineal hormo

19 However, while melatonin abnormalities are associated with delayed slee

20 igands of 34 serotonin, dopamine, histamine, melatonin, acetylcholine, and adrenergic receptors.

21 Strikingly, our results also showed that melatonin acted both as a tumor metabolic inhibitor and

22 Maternal melatonin acts on the fetal PT to control expression of

23 photoperiodic input to this rhythm, wherein melatonin acts on thyrotroph cells of the pituitary pars

24 Evening melatonin administration as a sole treatment appears pro

25 aims to investigate the effects of systemic melatonin administration on alveolar bone resorption in

26 apeutic effects of prolonged dark therapy or melatonin administration on hepatic fibrosis in the mult

27 f this study examines the effect of systemic melatonin administration on proinflammatory cytokine lev

28 cular interest in light of the "synergistic" melatonin agonist/5-HT2C antagonist profile of the novel

29 ies of early morning bright light or evening melatonin agonists have found improved rates of delirium

30 Evidence for benzodiazepine hypnotics, melatonin agonists, and antidepressants, and for most ph

31 Melatonin also has sleep-inducing and anti-inflammatory

32 Melatonin also significantly decreased the increased mye

33 Treatment with melatonin ameliorates disease in an experimental model o

34 constant light, (2) exogenous delivery of a melatonin analog under inhibitory constant light conditi

35 e examined the association between nocturnal melatonin and breast cancer risk in a case-control study

36 against sleep-loss decrements in alertness, melatonin and cortisol profile, skin temperature and wri

37 Subjective sleepiness, melatonin and cortisol were assessed hourly.

38 and sleepiness, master clock markers (plasma melatonin and cortisol), plasma triglycerides, or clock

39 erences in the circadian amplitude of plasma melatonin and electroencephalographic slow-wave activity

40 al programming of brain function by maternal melatonin and establish TSH signal transduction as a key

41 Melatonin and its derivatives also stimulated the expres

42 Thus, melatonin and its derivatives can serve as excellent pro

43 e analytical method for the determination of melatonin and its isomers in various food products.

44 Melatonin and its metabolites enhanced the DNA repair in

45 In conclusion, melatonin and its metabolites protect melanocytes from U

46 RK channels are necessary for the effects of melatonin and ramelteon within the SCN.

47 Our results show that melatonin and ramelteon, a potent and clinically relevan

48 lays the circadian clock, acutely suppresses melatonin, and has important implications for understand

49 Articles relevant to circadian rhythms, melatonin, and light in the critically ill were selected

50 ent, and 24-hour analyses of serum cortisol, melatonin, and peripheral clock gene expression (Bmal1,

51 ntally to produce alerting effects, suppress melatonin, and phase-shift the biological clock.

52 ogical functions of the pineal gland hormone melatonin are mediated via activation of two G-protein-c

53 Its major function is to secrete melatonin as a hormonal night signal in response to noct

54 cal gene expression and confirm the value of melatonin as a means of retarding events associated with

55 asts in the CHX context, thereby implicating melatonin as a promising drug in periodontitis and peri-

56 ted by a circadian rhythm and potentiated by melatonin at multiple timescales.

57 mplitude of the melatonin rhythm and 24-hour melatonin AUC (P = .001).

58 We also found that several of these melatonin-based compounds promoted differentiation of ra

59 Herein we present a new family of melatonin-based compounds, in which the acetamido group

60 o daily treatment with bright light, bedtime melatonin, both or placebos only in a 3.5-year double-bl

61 sible pleiotropic physiological functions of melatonin, but instrumental variable effect estimates we

62 These results provide a mechanism by which melatonin can control pituitary function in a seasonal m

63 not significantly related to measures of the melatonin circadian rhythm.

64 Peak salivary melatonin concentration increased after surgery (P = 0.0

65 Flashes did not change melatonin concentrations or alertness in an ISI-dependen

66 n diurnal birds, the nocturnal production of melatonin, considered the major vertebrate timekeeping h

67 We also studied the effect of ripeness on melatonin content and identified one group of pepper cul

68 Under shade conditions, the melatonin content in most of tomato cultivars tended to

69 d one group of pepper cultivars in which the melatonin content increased as the fruit ripened and ano

70 ffect of cultivar and solar radiation on the melatonin content of Capsicum annuum (pepper) and Solanu

71 influence of environmental conditions on the melatonin content of plants.

72 The melatonin content of red pepper fruits ranged from 31 to

73 rall, the results also demonstrated that the melatonin content of the fruits was not related to carbo

74 The melatonin content of tomato ranged from 7.5 to 250ngg(-1

75 No melatonin could be detected in black and green tea, sour

76 This daily melatonin-driven modulation of rod dark adaptation could

77 Here we use animals lacking melatonin due to mutation of arylalkylamine N-acetyltran

78 Increased melatonin due to the highly-expressed MzASMT9 resulted i

79 Five out of the seven strains formed Melatonin during the fermentation process: three S. cere

80 applications for the genetic enhancement of melatonin-enriched plants for increasing crop production

81 ilms responded linearly to added (exogenous) melatonin, even in the presence of many possible interfe

82 Also, strawberry fruits treated with melatonin exhibited higher gamma-aminobutyric acid trans

83 a daily single dose of 10 mg/kg body weight melatonin for 15 consecutive days.

84 Recovery of melatonin from different matrices were found to be 86.0

85 ter removal of the ligature, the rats in the melatonin groups (EP-MEL, DM-MEL, and EP-DM-MEL) were tr

86 d compounds, in which the acetamido group of melatonin has been bioisosterically replaced by a series

87 Melatonin has been demonstrated to improve survival afte

88 fed to purified chloroplasts, they produced melatonin in a dose-response manner.

89 emiologic data support a protective role for melatonin in breast cancer etiology, yet studies in prem

90 Reduced suppression of melatonin in response to working the night shift among p

91 o elucidate whether the synthetic pathway of Melatonin in Saccharomyces and non-Saccharomyces strains

92 n response to 3 d subcutaneous injections of melatonin in the late day.

93 How melatonin in the PT controls the PD is not understood.

94 elucidated the molecular mechanisms linking melatonin-induced changes in neuronal activity to its th

95 The time-dependent, melatonin-induced differential expression of VEGF-A isof

96 G-protein signaling plays a large role in melatonin-induced phase shifts of locomotor behavior and

97 The melatonin-induced suppression of firing rate corresponde

98 ed Gq/phospholipase C response and triggered melatonin-induced unidirectional transactivation of the

99 Melatonin induces the expression of the repressor transc

100 The present study tested the hypothesis that melatonin influences circadian phase and electrical acti

101 Melatonin is a neurohormone involved in the regulation o

102 Melatonin is an important secondary messenger in plant i

103 These results suggest that melatonin is another example of how environmental-driven

104 Low-quality evidence shows that melatonin is associated with 24 minutes longer daytime s

105 The concentration of melatonin is greatly variable in edible seeds, exhibitin

106 hodopus sungorus), the programming effect of melatonin is mediated by the pars tuberalis (PT) of the

107 N-acetyltransferase 2 (aanat2) to show that melatonin is required for circadian regulation of sleep

108 , the aim of this study is to investigate if melatonin is suitable as an auxiliary agent for protecti

109 ical night, when body temperature is low and melatonin is synthesized.

110 Inasmuch as the neurohormone melatonin is synthetically derived from serotonin (5-HT)

111 AANAT is also found in the retina, where melatonin is thought to play a paracrine role.

112 this study we report that dopamine, but not melatonin, is responsible for entrainment of the PER2::L

113 marked by the 24-hour rhythm of the hormone melatonin, is responsible for the alternation of high/lo

114 The highest amounts of melatonin isomer were detected in yeast-fermented foods

115 8); 4) ligature (L, n = 6); 5) ligature and melatonin (L+Mel, n = 8); 6) STZ and ligature (STZ+L, n

116 explore the relationship between circulatory melatonin level and the extent of senile cataracts.

117 had no significant effect on the endogenous melatonin level.

118 ically-expressing MzASMT9 possessed improved melatonin level.

119 a substantially longer duration of elevated melatonin levels (41 min) and delayed circadian phase of

120 pport an overall association between urinary melatonin levels and breast cancer risk.

121 suggest a modest inverse association between melatonin levels and breast cancer risk.

122 elatonin, Mdr2(-/-) mice show elevated serum melatonin levels and inhibition of biliary mass, along w

123 blood sampling for the measurement of serum melatonin levels at 30-minute intervals for 24 hours und

124 creased melatonin levels in plant organs and melatonin levels fluctuate over the light:dark cycle; th

125 Agents that induce stress cause increased melatonin levels in plant organs and melatonin levels fl

126 We show the longer melatonin levels remained high after wake time, insulin

127 Melatonin levels were not significantly associated with

128 n rhythm and the 24-hour AUC for circulating melatonin levels were significantly lower in PD patients

129 rcadian misalignment)-a time when endogenous melatonin levels were still high indicating the internal

130 f serum cortisol levels, reduced circulating melatonin levels, and altered Bmal1 expression in patien

131 Melatonin levels, biliary mass, liver fibrosis, angiogen

132 ports have shown that these devices suppress melatonin levels, but little is known about the effects

133 Here, we report that melatonin levels, whose production is modulated by seaso

134 reaction between ferulic (or lipoic acid), a melatonin-like isocyanide, formaldehyde, and tacrine der

135 ipsychotics, iliac fascia block, gabapentin, melatonin, lower levels of intraoperative propofol sedat

136 agonist luzindole, ramelteon + luzindole, or melatonin + luzindole (each 1.0 mg/kg).

137 Additionally, we provide evidence that melatonin may induce sleep in part by promoting adenosin

138 k, or its output signals (e.g., dopamine and melatonin), may contribute to eye disease and pathology.

139 er exposure to darkness or administration of melatonin, Mdr2(-/-) mice show elevated serum melatonin

140 alysis using actigraphy and 24-hour salivary melatonin measurements.

141 ts the involvement of sugars and glycerol in melatonin-mediated innate immunity against bacterial pat

142 However, the metabolic homeostasis in melatonin-mediated innate immunity is unknown.

143 and experimental periodontitis treated with melatonin [Mel-Ped]).

144 hepatic encephalopathy and impaired hepatic melatonin metabolism, but the understanding of their pat

145 n secretion, estimated by measuring the main melatonin metabolite, 6-sulfatoxymelatonin, from the fir

146 he magnitude or direction of phase shifts of melatonin midpoint in response to 2 h of light at either

147 hifts were analysed according to the time of melatonin midpoint on the nights before and after light

148 Dark therapy or targeting melatonin/miR-200b axis may be important in the manageme

149 ss-talk mediated via physical association of melatonin MT2 and 5-HT2C receptors into functional heter

150 receptor for the circadian-regulated hormone melatonin (MTNR1B) is associated with increased fasting

151 amine D2, histamine H1 and H2, melanocortin, melatonin, muscarinic M1 and M3, neurokinin, opioid KOP

152 Melatonin (N-acetyl-5-methoxytrypamine) is the vertebrat

153 Melatonin (N-acetyl-5-methoxytryptamine) is an interesti

154 his multifunctional profile highlights these melatonin-N,N-dibenzyl(N-methyl)amine hybrids as useful

155 Here, we describe a new family of melatonin-N,N-dibenzyl(N-methyl)amine hybrids that show

156 in) and delayed circadian phase of dim-light melatonin offset (1.37 h), partially mediated through de

157 the impact of 0, 1, 10, 100 and 1000mumol/L melatonin on attenuating fungal decay and maintaining nu

158 e in accord with prior data on the effect of melatonin on cortical gene expression and confirm the va

159 on establishes a receptor-mediated action of melatonin on L1 expression.

160 osure were assessed using salivary dim-light melatonin onset (DLMO) and wrist-worn photometry, respec

161 actigraphy and a tendency toward an earlier melatonin onset (P = 0.095) were found.

162 showed a significant delay in the timing of melatonin onset in workers with electric light compared

163 d that the timing of food intake relative to melatonin onset was significantly associated with the pe

164 sumed most of their calories 1.1 h closer to melatonin onset, which heralds the beginning of the biol

165 MT2) did not change the activities of either melatonin or its derivatives.

166 ion, which was reduced in cells treated with melatonin or its metabolites: 6-hydroxymelatonin (6-OHM)

167 upplementation of human blood with exogenous melatonin or melatonin receptor antagonist during the in

168 Forty-eight children were randomized 1:1 to melatonin or placebo treatment, and 38 of these (79%) co

169 rog/kg), or high (3 mg/kg) concentrations of melatonin, or control feed through approximately one lay

170 Melatonin phase shift and suppression, along with change

171 ivariate whole-blood mRNA-based predictor of melatonin phase which requires few samples.

172 Seven edible seeds for the levels of melatonin, phenolic compounds and their antioxidant capa

173 Furthermore, melatonin-rich, but not melatonin-poor, human blood collected at different times

174 , keratinocytes, and fibroblasts transformed melatonin primarily into 6(OH)M and AFMK.

175 clear delineation of serotonergic areas and melatonin-producing pineal gland in rat brains.

176 how dLEN-mediated disturbances in nocturnal melatonin production can render tumors insensitive to ta

177 data imply that light-induced suppression of melatonin production in shift workers may increase L1-in

178 been hypothesized that suppressed nocturnal melatonin production is associated with an increased ris

179 re the fetal circadian system and autonomous melatonin production is established.

180 allele may extend the duration of endogenous melatonin production later into the morning and that ear

181 ysregulation of both sleep-wake behavior and melatonin production strongly suggests impaired non-visu

182 Notably, only rods in melatonin-proficient mice were affected by this daily vi

183 rcadian modulation that closely followed the melatonin profile.

184 We find that melatonin promotes sleep downstream of the circadian clo

185 These data reveal that melatonin protects osteoblasts in the CHX context, there

186 Melatonin, ramelteon, or luzindole had no significant ef

187 treated IV with vehicle, different doses of melatonin (rats: 0.01/0.1/1.0/10 mg/kg; mice: 1.0 mg/kg)

188 and depression/anxiety-related behavior in a melatonin receptor 1 (MT1)-dependent manner.

189 We report that melatonin receptor 1 inhibits mobilization of L1 in cult

190 ifferentially methylated CpG site within the melatonin receptor 1A (MTNR1A) gene mediates the effect

191 The T2D risk variant in the melatonin receptor 1B gene (MTNR1B) predicted risk of PO

192 ell as the duration of single calls, and (3) melatonin receptor 1b is highly expressed in evolutionar

193 at this protective capacity may also rely on melatonin receptor activation.

194 ity of our previous 5-HT2C agonists with the melatonin receptor agonist tasimelteon and the putative

195 ramelteon, a potent and clinically relevant melatonin receptor agonist, significantly affect the neu

196 Finally, application of ramelteon, a potent melatonin receptor agonist, significantly decreased firi

197 nce) of once-daily tasimelteon, a novel dual-melatonin receptor agonist.

198 n of human blood with exogenous melatonin or melatonin receptor antagonist during the in situ perfusi

199 The addition of melatonin receptor antagonists abolishes the MT1 effect

200 ctivity, and agonist behavior of these novel melatonin receptor ligands based on superposition models

201 erposition models guided the design of novel melatonin receptor ligands characterized by a 2-acylamin

202 polymicrobial sepsis in rats, wild-type and melatonin receptor MT1/MT2 double knockout mice.

203 the current status in the emerging field of melatonin receptor oligomerization are critically discus

204 as designed to investigate whether selective melatonin receptor-agonist ramelteon may influence survi

205 1/1.0/10 mg/kg; mice: 1.0 mg/kg), ramelteon, melatonin receptor-antagonist luzindole, ramelteon + luz

206 ive effects of melatonin, while the membrane melatonin receptors (MT1 or MT2) did not change the acti

207 New compounds were fully characterized at melatonin receptors (MT1R and MT2R), and results were ra

208 duced phase shifts of locomotor behavior and melatonin receptors activate G-protein-coupled inwardly

209 in the pars distalis (PD) of the pituitary, melatonin receptors are localized in the pars tuberalis

210 Melatonin receptors mediate improvements of survival aft

211 pendent of an effect on the classic membrane melatonin receptors.

212 antity and quality, circadian alignment, and melatonin regulation.

213 and the relevance of neurogenesis induced by melatonin-related structures.

214 In mammals, the pineal hormone melatonin relays photoperiodic information to the hypoth

215 ssessed their body composition and timing of melatonin release during an in-laboratory assessment.Non

216 In contrast, in the BS, melatonin releases antiangiogenic VEGF-Axxxb from the PT

217 subjected to dLEN if they received nocturnal melatonin replacement.

218 ) had a significantly lower amplitude of the melatonin rhythm and 24-hour melatonin AUC (P = .001).

219 compared with controls; the amplitude of the melatonin rhythm and the 24-hour AUC for circulating mel

220 arlier baseline phase and lower amplitude of melatonin rhythm compared to younger subjects, but there

221 t observed in animals in which the circadian melatonin rhythm was not disrupted, or in animals subjec

222 epiness Scale), and circadian markers of the melatonin rhythm, including the amplitude, area under th

223 th cirrhosis, who show delays in the 24-hour melatonin rhythm, most likely in relation to reduced sen

224 significant phase advance of the CBT but not melatonin rhythms, as well as an advance in the diurnal

225 altered rhythmicity in body temperature and melatonin rhythms, high day-to-day variability in activi

226 Furthermore, melatonin-rich, but not melatonin-poor, human blood coll

227 II cohort, we measured the concentration of melatonin's major urinary metabolite, 6-sulfatoxymelaton

228 vocalizers and provide a striking example of melatonin's niche-specific functions.

229 findings, together with those in birds, show melatonin's remarkable versatility as a timing signal in

230 We propose that melatonin's separable effects at different timescales de

231 se in AANAT expression, and subsequent lower melatonin secretion by cholangiocytes, was associated wi

232 nts with PD had blunted circadian rhythms of melatonin secretion compared with controls; the amplitud

233 .e., photoperiod), encoded by the pattern of melatonin secretion from the pineal gland.

234 not the dim lighting condition, the onset of melatonin secretion in the evening (as marker for circad

235 Further research is warranted to assess if melatonin secretion is a modifiable risk factor for diab

236 Lower melatonin secretion was independently associated with a

237 son's disease (PD) and include disruption of melatonin secretion, disturbances of glucose, insulin re

238 the association between endogenous nocturnal melatonin secretion, estimated by measuring the main mel

239 he MTNR1B risk allele influences dynamics of melatonin secretion, generating a novel hypothesis that

240 and had reduced evening sleepiness, reduced melatonin secretion, later timing of their circadian clo

241 contribute to the circadian rhythm of pineal melatonin secretion.

242 n photoentrainment and suppression of pineal melatonin secretion.

243 Twenty-four hour monitoring of serum melatonin secretion.

244 sent SERS measurements of neurotransmitters (melatonin, serotonin, and epinephrine) at various concen

245 suggests an evolutionary connection between melatonin signaling in invertebrates and sleep regulatio

246 Tosches et al. show that melatonin signaling regulates circadian swimming in anne

247 of circadian disruption, including aberrant melatonin signaling.

248 idate genes (FGF5, IRF4, DKK2) and pathways (melatonin signalling, adipogenesis) that are likely to b

249 Therefore, both the circannual and the melatonin signals converge on PT TSHbeta expression to s

250 Systemically administered melatonin significantly decreased ABL in the STZ+L+Mel g

251 ers were the highest in the STZ+L group, and melatonin significantly decreased osteoclast numbers (P

252 with vehicle, administration of ramelteon or melatonin significantly improved median survival time in

253 is revealed in this experimental study that melatonin significantly inhibited hyperglycemia-induced

254 re (STZ+L, n = 8); and 7) STZ, ligature, and melatonin (STZ+L+Mel, n = 8).

255 ; 2) streptozotocin (STZ, n = 8); 3) STZ and melatonin (STZ+Mel, n = 8); 4) ligature (L, n = 6); 5) l

256 Core body temperature (CBT), salivary melatonin, subjective alertness, and polysomnographicall

257 Despite the widespread use of melatonin supplementation for the treatment of sleep dis

258 Melatonin supplementation has been used as a therapeutic

259 Melatonin supplementation is a safe and effective way to

260 entia, namely timed bright light therapy and melatonin supplementation.

261 However, simultaneous melatonin supply supported cell morphogenesis and growth

262 ulate the circadian clock, masking behavior, melatonin suppression, the pupillary light reflex, and s

263 reflex, masking behavior, and light-induced melatonin suppression.

264 own about the underlying mechanisms by which melatonin synchronizes circadian rhythms.

265 sferase (AANAT; the rate-limiting enzyme for melatonin synthesis from serotonin) in cholangiocytes an

266 the purified recombinant MzASMT9 protein for melatonin synthesis were 500 muM and 12 pmol/min.mg prot

267 tyltransferase (AANAT; the enzyme regulating melatonin synthesis) or inhibition of miR-200b in cholan

268 e is consequently thought to be important in Melatonin synthesis, but limited data and reference text

269 ion of chloroplasts, the terminal enzyme for melatonin synthesis, N-acetylserotonin-O-methyltransfera

270 When N-acetylserotonin, a substrate for melatonin synthesis, was fed to purified chloroplasts, t

271 partially mediated through delayed offset of melatonin synthesis.

272 No data exist regarding the role of melatonin synthesized locally by cholangiocytes in the a

273 nts include low-dose clonazepam or high-dose melatonin taken orally at bedtime.

274 (LEN) suppresses the nocturnal production of melatonin that inhibits breast cancer growth.

275 Melatonin therapy or prolonged exposure to complete dark

276 Here we show that melatonin time-dependently acts on its receptors in the

277 EP and melatonin treatment (EP-MEL), DM and melatonin treatment (DMMEL), and EP-DM-MEL groups.

278 nduced periodontitis (EP), DM, EP-DM, EP and melatonin treatment (EP-MEL), DM and melatonin treatment

279 After melatonin treatment among the 48 children included in th

280 glycerol were commonly increased after both melatonin treatment and Pst DC3000 infection in Arabidop

281 Melatonin treatment at 100mumol/L triggered H2O2 accumul

282 nset latency shortened by 21.4 minutes after melatonin treatment compared with after placebo (95% CI,

283 Melatonin treatment decreased serum CTX levels and incre

284 his study, it can be concluded that systemic melatonin treatment may decrease osteoclastic activity a

285 study is to evaluate the effects of systemic melatonin treatment on serum oxidative stress index (OSI

286 pe and Mdr2(-/-) mice exposed to darkness or melatonin treatment or in male patients with PSC and hea

287 d corresponding sham); neither ramelteon nor melatonin treatment significantly affected immune respon

288 This study reveals that melatonin treatment significantly inhibits regional alve

289 Melatonin treatment significantly reduced fasting plasma

290 Mdr2(-/-) mice subjected to dark exposure or melatonin treatment.

291 Melatonin was administered by intraperitoneal injection

292 The evening rise in melatonin was attentuated under both WL and BL only in t

293 hase resetting of the SCN circadian clock by melatonin was blocked by coadministration of a GIRK chan

294 Melatonin was proposed for use in periodontitis and peri

295 Reduced levels of nocturnal melatonin were found to be associated with sleep disturb

296 ch had the highest levels of polyphenols and melatonin were those that showed the most relevant antir

297 tivity was comparable to that of the indole, melatonin, which is an effective hydroxyl radical scaven

298 patterns and decrease nocturnal secretion of melatonin, which may disturb estrogen regulation, leadin

299 g siRNA diminished the protective effects of melatonin, while the membrane melatonin receptors (MT1 o

300 rez et al. report that the circadian hormone melatonin, whose levels vary with seasonal changes in ni