ライフサイエンスコーパス: membered

1 yl bromide "half-threads" through 37- and 38-membered 2,2':6',2''-terpyridyl macrocycles generate tri

2 Computational modeling of the six-membered 3',5'-cyclic phosphoester ring derived from deo

3 Functionalization of 16-membered aglycone of spiramycin with the use of intramol

4 bstituted benzo-fused five-, six-, and seven-membered alkenes.

5 netically and thermodynamically disfavored 6-membered alkyl palladacycle intermediates.

6 alpha-benzyl pentenolides, whereas the five-membered alpha-methylene lactone reacts to mixtures of r

7 ults suggested that alpha-triflate and a six-membered alpha-spiroPhen are plausible intermediates of

8 hetic approach was carried out to form seven-membered and eight-membered rings, giving rise to tetran

9 s with ketenes and carbodiimides afford four-membered anionic heterocycles in formal [2+2] cycloaddit

10 Using a 256-membered ANNNN comonomer library comprising 16 sublibrar

11 highlighted in the copolymerization of a 256-membered ANNNN library comprising 16 sub-libraries modif

12 Five-membered aromatic heterocycles are a ubiquitous skeleton

13 bstituting the amide moiety by five- and six-membered aromatic heterocycles.

14 cently discovered that incorporation of four-membered azetidine rings into classic fluorophore struct

15 bstituents in tetramethylrhodamine with four-membered azetidine rings.

16 ing on the substituents attached to the four-membered azetidinone ring.

17 calculations revealed that the unique three-membered (BB)>Ru metalacycle is formed by two bent B-Ru

18 I) catalyst triggered the formation of seven-membered benzoxazepinones.

19 -exo-dig annulations to afford family of six-membered benzoxazinones.

20 zation of ketenes can lead to important four-membered beta-lactones.

21 cloallene D as halogenated C15-acetogenin 12-membered bicyclic and tricyclic ether bromoallene-contai

22 ilzabicycloallene D as a pentahalogenated 12-membered bicyclic ether bromoallene was synthesized by a

23 different inhibitors: cytochalasin B, a nine-membered bicyclic ring fused to a 14-membered macrocycle

24 athesis served for construction of the seven-membered C ring.

25 enylidenecyclopropanes (ACPs) to afford five-membered carbo- and heterocyclic rings with concomitant

26 A one-carbon spacer between the 15-membered carbocycle and the appended polyamine showed im

27 antitumour antibiotics characterized by a 10-membered carbocycle fused to an anthraquinone, both of p

28 phenol is covalently bridged by a 5, 6, or 7 membered carbocycle to the quinoline.

29 ommon methods to chemically synthesize a six-membered carbocycle.

30 the oxidation state of the newly formed six-membered carbocycle.

31 tive ring contraction of monounsaturated six-membered carbocycles and heterocycles.

32 The selected example affords six-membered carbocycles with five stereogenic centers in a

33 ndary metabolites that consist of 7, 8, or 9-membered carbocycles with one or two fused maleic anhydr

34 on before a Mur ligase homolog forms the six-membered carbocyclic ring in the final step of the pathw

35 t common tactic starts with a three- or four-membered carbon-ring system, in which strain release pro

36 plexes, as they facilitate a mononuclear six-membered chelate complex via the displacement of two hyd

37 n and result in formation of observable five-membered chelate intermediates.

38 such as conformers associated with the five membered chelate rings (lambda/delta), alignment modes o

39 e the consequences of the bite angle of five-membered chelates in cubic tetramers and resulting solva

40 and 1,2 insertion pathways to yield 4- and 5-membered chelates, respectively.

41 s with hydroxyl groups forming five- and six-membered chelation complexes with the iodine atom.

42 By the nature of its structure, the 5-membered chiral biaryl heterocyclic scaffold represents

43 opyran and viologen unit assembles with a 24-membered crown ether into a stable host-guest complex di

44 The macrocycle resembles a five-membered cucurbituril in which four glycoluril units are

45 intramolecular hydrogen bonds that form 5-8-membered cycles with moderately acidic N-H's.

46 lar hydroboration for the synthesis of a six-membered cyclic amine-borane.

47 of optically enriched five-, six-, and seven-membered cyclic amines from aminodialkenes and enantiose

48 action with alpha-substituted five- to seven-membered cyclic amines proceeds very efficiently to prov

49 polyhydroxyurethanes (PHUs) derived from six-membered cyclic carbonates and amines.

50 c ring opening polymerization (ROP) of eight-membered cyclic carbonates was explored as a route to ac

51 Aliphatic N-substituted functional eight-membered cyclic carbonates were synthesized from N-subst

52 elective synthesis of five-, six-, and seven-membered cyclic imines from aminodialkynes.

53 zation of alpha-oxoesters with five- and six-membered cyclic imines, respectively, is reported.

54 ffective participation of esters through six-membered cyclic intermediates in this series.

55 undergo ring-opening cyclization to form six-membered cyclic oxyallyl cations.

56 on efficiencies in the decomposition of four-membered cyclic peroxide derivatives: 1,2-dioxetanes, 1,

57 Our six-membered cyclic phosphoester ring-opening polymerization

58 ytic ring-opening polymerization (OROP) of 5-membered cyclic phospholane monomers followed by oligome

59 C-H bond of the imidazole ring of 1 and four-membered cyclic silylene (4) via insertion of a silicon(

60 despite the strain associated with the four-membered cyclic structure.

61 ree, and eco-friendly domino reaction of 5/6-membered cyclic sulfamidate imines with a variety of bet

62 An interesting domino reaction of 5-membered cyclic sulfamidate imines with a variety of Mor

63 Based on DFT calculations, an eight-membered cyclic transition state involving coordination

64 nd provides access to five-, six-, and seven-membered cyclic vinyl fluorides.

65 ective synthesis of quaternary 5-, 6-, and 7-membered cycloalk-1-enecarbonitriles substituted on the

66 Using nomenclature from eight-membered cycloalkanes, the heavy atoms of the low-energy

67 clic conjugated hydrocarbons containing four-membered cyclobutadienoids (CBDs) are of great fundament

68 A self-aggregated 48-membered dansyl library was screened against a series of

69 x allowed the target benzothiophene-fused 11-membered dienediyne to be obtained via RCM; the alkyne c

70 active alkaloids that contain a unique eight-membered endoperoxide.

71 cular hydrogen bond (CH...N) between the six-membered ethene bridge and the azole substituents.

72 ta-acetoxylation and tosyloxylation via five-membered exo-palladacycles.

73 The cassava genome contains a seven membered family of feruloyl CoA 6'-hydroxylase genes, fo

74 ontaining phosphatase 2 (SHP2) and the three-membered family of phosphatases of regenerating liver (P

75 uring metal anions can be added to this rare-membered family.

76 However, the bioderived five-membered gamma-butyrolactone (gamma-BL) is commonly refe

77 rizontal lineC bond and a highly stable five-membered gamma-butyrolactone ring.

78 LM)-domain B-GATAs are a subfamily of the 30-membered GATA transcription factor family from Arabidops

79 preferences, relying on eight-, six- or five-membered H-bonded pseudocycles (C8, C6 or C5), depending

80 obenzene class has been replaced with a five-membered heteroaromatic ring.

81 zo photoswitches containing an indazole five-membered heterocycle shows photochemical isomerization w

82 Instead of the predicted seven-membered heterocycle, a symmetrical serratamolide analog

83 a-lactams without harming the sensitive four-membered heterocycle.

84 ood potential for synthesis of five- and six-membered heterocycles and may serve as potentially usefu

85 The ubiquitous use of pi-rich five-membered heterocycles has driven the development of new

86 of the amide with a variety of five- and six-membered heterocycles led to the identification of 6-(1-

87 of one or two pyrrole rings with other five-membered heterocycles such as furan, thiophene, selenoph

88 orted is a method for the synthesis of seven-membered heterocycles via a Pictet-Spengler condensation

89 r modular and atom-efficient assembly of six-membered heterocycles with multiple chirality centres.

90 cluding beta-substituted vinylarenes and six-membered heterocycles, under relatively mild conditions.

91 nthesis of enantioenriched benzo-fused seven-membered heterocycles.

92 SNO-OCTs are eight-membered heterocyclic alkynes that have fast rates of re

93 vated Smiles rearrangement of five- to eight-membered heterocyclic anthranilamides.

94 The five-membered heterocyclic products are generated in good to

95 ic shift values of the covalently fused five-membered heterocyclic rings are more negative than the f

96 cyclic rings are more negative than the five-membered heterocyclic rings formed by intramolecular coo

97 cation (K(+)) chelated into the malonate six-membered hole as a Z-enolate.

98 rely observed series of intramolecular seven-membered hydrogen bonds.

99 t a cyclic transition state involving a nine-membered hydrogen-bonded ring is preferred.

100 ition states of these reactions involve nine-membered hydrogen-bonded rings in distinct conformations

101 ion of cationic charge density into the five-membered imidazoline ring.

102 mer and the carbonyl compound to form a four-membered intermediate and (ii) a cycloreversion leading

103 sters or ketones to generate heterocyclic 10-membered intermediates that contain pairs of allyl phosp

104 zation of the amide linker resulted in a six-membered lactam analogue, compound 18.

105 t is spiro-fused to a thiazole-containing 18-membered lactam ring.

106 elation revealed that in the case of the six-membered lactone an energetically favorable conformer ad

107 HepG2) approximately 6 muM] properties of 16-membered lactone macrolides based on spiramycin's aglyco

108 r the analogous Pd sigma-complex of the five-membered lactone the smallest Pd/endo-beta-H dihedral an

109 Seven-membered lactones undergo selective SmI2 -H2 O-promoted

110 converted into diastereomerically pure five-membered lactones.

111 The polyhydroxylated 18-membered lichen macrolide (+)-aspicilin was synthesized

112 emonstrates that even challenging 15- and 19-membered ligation transition states are suitable for inf

113 D acts with a partner protein to form the 12-membered macroamidine unique to bottromycins.

114 The 18-membered macrocycle H2 macropa was investigated for (225

115 An analogous 39-membered macrocycle produced no rotaxane products under

116 The optimal 16-membered macrocycle was 60-fold more potent than an acyc

117 a nine-membered bicyclic ring fused to a 14-membered macrocycle, which has been described extensivel

118 k coupling has been chosen to cyclize the 14-membered macrocycle.

119 Furthermore, modifying 12-membered macrocycles by heteroatom substitution and util

120 Therefore, a series of 12- to 18-membered macrocycles incorporating two phosphorus and si

121 are attributable to the folding of the even-membered macrocycles into exciton-vibrational coupled di

122 this study, the two recently synthesized 13-membered macrocyclic competitive IRAP inhibitors HA08 an

123 ither full module catalysis, leading to a 14-membered macrolactone, or direct cyclization to a 12-mem

124 plied to a concise total synthesis of the 14-membered macrolactone, Sch 725674.

125 talyzes a formal [4+2] cycloaddition of a 22-membered macrolactone, which may proceed as a concerted

126 structure of apoptolidin A consists of a 20-membered macrolide with mono- and disaccharide moieties.

127 ssible diastereomers of gliomasolide E, a 14-membered macrolides isolated from the marine sponge Phak

128 Syntheses of two 14-membered macrolides Sch-725674 and Gliomasolide C are de

129 An initial screen of a 1.5 million-membered metagenomic library constructed in Streptomyces

130 emonstrate functional screening of a million-membered metagenomic library in microfluidic picolitre d

131 erates a system containing a five- and a six-membered metallacycle, respectively, sharing a P-N bond

132 bridging interactions, resulting in 5- and 7-membered metallacycles, respectively.

133 A highly reactive seven-membered Mn(I) intermediate is detected and characterize

134 st 5.4 kcal/mol higher than those of the six-membered monocyclic phosphoester, 2-ethoxy-1,3,2-dioxaph

135 yclobutanes, cyclopentanes, indanes, and six-membered N- and O-heterocycles.

136 yclometalation deprotonation provides a five-membered nickelacycle intermediate, which upon the rate-

137 routes for novel thieno-fused five- and six-membered nitrogen and oxygen heterocycles such as thieno

138 ues of dibenzodiazepines, in which the seven-membered nitrogen heterocycle is replaced by a 9-12-memb

139 Due in part to the common occurrence of five-membered nitrogen heterocycles in bioactive molecules, t

140 c feature of these natural products is a six-membered nitrogenous heterocycle that is assembled via a

141 The six-membered oxazinone ring can be opened by reduction with

142 The four-membered oxetane ring has been increasingly exploited fo

143 an olefin followed by oxidation to form a 5-membered oxocarbenium intermediate and subsequent nucleo

144 A four-membered oxygen ring (oxetane) can be readily grafted in

145 yclic scaffold represents a departure from 6-membered P,N-ligands that facilitates tuning and enables

146 Alkynylation of beta-arylethamines via a six-membered palladacycle is favored over gamma-C(sp(2))-H b

147 ence is provided that the formation of a six-membered palladacyclic intermediate leads toward the for

148 and accordingly template the folding of even-membered PBI macrocycles into ropelike folded conformati

149 ted dinuclear hydrido Ni complex with a four-membered planar Ni2Si2 core.

150 these proteins involves the BBSome, an eight-membered protein complex that is recruited to ciliary me

151 Ten antifouling 14-membered resorcylic acid lactones 1-10 were isolated pre

152 moiety can also stabilize unsaturated seven-membered rhodacycle intermediates through extra interact

153 splays a boat conformation for its Ge-Se six-membered ring ("six-ring"), while the previously known a

154 ved with the unbleachable analogue, 11-cis-6-membered ring (11-cis-6mr)-retinal, which has therapeuti

155 The cis-isomers align in the main 12-membered ring (MR) channel of GME.

156 spin trap, leading to the formation of a six-membered ring adduct, occurs through a very favorable pa

157 ck-Matsuda reaction of five-, six- and seven-membered ring alkenes and aryl diazonium salts is presen

158 strates for FPP synthase, giving novel seven-membered ring analogues of GPP and FPP.

159 catalysed fragmentation to install the seven-membered ring and vicinal quaternary stereocentres of th

160 th other electron-rich heteroaromatics and 6-membered ring aromatics provided they had donor groups i

161 Suitable substitution of the five-membered ring backbone exemplarily allowed the Co-cataly

162 s showed that electron donation on the three-membered ring boosted the TOF of ring opening.

163 e conformational equilibria of the heterosix-membered ring by low temperature (13)C NMR spectroscopy

164 tures a type-I beta-turn with a canonical 10-membered ring C=O-H-N hydrogen bond between backbone ami

165 p was tethered to the acetal group by a five-membered ring compared to one where it was tethered by a

166 hey are mainly hexadecamers, with each eight-membered ring composed of one or two (in Archaea) or eig

167 studied, all efforts to synthesize the five-membered ring compound have thus far met with failure.

168 ion of a fused-ring benzazirine into a seven-membered ring cyclic ketenimine.

169 idine-2-caboxylic acid, a more flexible four-membered ring derivative of proline, shows relaxed eIF5A

170 migration processes are observed in the five-membered ring due to the high barrier to 1,3-hydrogen mi

171 hway proceeds via the initial step of a five-membered ring formation upon attack of the hydrazine, fo

172 and the systems with fused benzene and a six-membered ring formed atropisomers separated by a barrier

173 tenolide to produce stereoselectively a five-membered ring fused bicyclic lactone, the core structure

174 f each Gln sidechain participates in a seven-membered ring hydrogen bond with the backbone NH of the

175 mediate to form an energetically stable four-membered ring in the singlet state.

176 A five-membered ring indene skeleton is also prepared via olefi

177 addition with the nitrone, generating a five-membered ring intermediate.

178 ssible cycloadditions, a pair of novel three-membered ring intermediates has been discovered.

179 N-N bond formation, producing unstable five-membered ring intermediates that spontaneously dehydrate

180 l syn-pentane interactions which force a six-membered ring into a twist-boat conformation.

181 blished that the alpha-position of the three-membered ring is the favored deprotonation site.

182 g metathesis reactions, generating 14- to 21-membered ring macrocyclic alkenes in 40-70% yield and 96

183 es has been tailored to bind the small, four-membered ring of oxetanocin-A over larger substrates.

184 ization procedures leading to the core seven-membered ring of the iboga skeleton, a cyclization that

185 this alkynylaldehyde, to construct the eight-membered ring of the target, unexpectedly provided a cyc

186 open-cage fullerene, MMK-9, with an open 12-membered ring on its surface and silver(I) salts have be

187 modeling suggest that 7 was formed via a six-membered ring oxathiaphosphenine intermediate rather tha

188 nine intermediate rather than the usual four-membered ring oxathiaphosphetane of 2-6.

189 ophile attack for 2,3-trans-substituted five-membered ring oxocarbenium ions is strongly influenced b

190 nce of oxygen, leads to formation of a seven-membered ring product, an overall [4+4-1] reaction.

191 ssed by PikAIII-TE and failed to generate 12-membered ring products.

192 early 10(6)-fold between the five- and eight-membered ring series.

193 ross-metathesis reactions, and a strained 14-membered ring stapled peptide by means of macrocyclic ri

194 up abilities already established for the six-membered ring system (NHBn >> OH > NBn2), an N,N-dibenzy

195 The reaction produces substituted five-membered ring systems stereoselectively and on preparati

196 ety of heterocyclic systems spanning small 3-membered ring systems to macroheterocycles.

197 3,5-triazinanes, leading to the five- or six-membered ring systems under mild conditions in yields up

198 re converted to trans-disubstituted 5- and 6-membered ring systems with perfect diastereoselectivity

199 strained by incorporation into six- or seven-membered ring systems, by addition of a lithiated primar

200 the enamine-iminium complex by forming a six-membered ring that favors one helicity of the electrocyc

201 and three-component domino reaction of four-membered ring thionation reagents such as 2,4-bis(4-meth

202 he diastereoselective formation of the seven-membered ring through a Friedel-Crafts triflation and a

203 ompetition reactions showed that these seven-membered ring trans-alkenes underwent [4+2] cycloadditio

204 es have been elaborated from a panel of five-membered ring trifluoromethylated amino acids (Tfm-AAs)

205 l lineNH and cis-1,3-butadiene to form a six-membered ring was examined by quantum calculations.

206 The influence of four-membered ring was examined using spectroscopy, crystallo

207 red to one where it was tethered by an eight-membered ring was less than 100-fold, suggesting that fu

208 distinct local structures, situated in the 8 membered ring windows of the side pockets.

209 rtion of the catalytic domain, such as a six-membered ring, confer selectivity for HKs.

210 almost planar N-arylamine and a planar four-membered ring, was revealed by both AM1 calculations and

211 d nitrogen heterocycle is replaced by a 9-12-membered ring, were made by an unactivated Smiles rearra

212 ization of 6pi-electrons over the BC2N2 five-membered ring, which thus indicates the aromatic propert

213 ic acid led to jadomycin AVA, a second eight-membered ring-containing jadomycin.

214 ctive exo-Diels-Alder reaction to form the 6-membered ring.

215 nar hexagonal B36 cluster with a central six-membered ring.

216 n mild activation sufficed to close the five membered ring.

217 Cgamma of the ligand giving a boat-like six-membered ring.

218 ient manner followed by cyclization of the 8-membered ring.

219 ing late-stage creation of the central seven-membered ring.

220 hietane is feasible, leaving intact the four-membered ring.

221 macrolactone, or direct cyclization to a 12-membered ring.

222 an imino-to-sulfur substitution in the five-membered ring.

223 assembly, also synthesizes the embedded four-membered ring.

224 two naphthoquinone units connected by a five-membered ring.

225 fully substituted and highly oxygenated five-membered ring.

226 due to smaller hindrance for a five vs a six membered ring.

227 tive nets with a vertex figure as double six-membered-ring (d6R) building unit, namely the (4,12)-coo

228 y enantioselective addition to racemic seven-membered-ring allyl chlorides for the first time.

229 the approach by preparing recifeiolide (a 12-membered-ring antibiotic) and pacritinib (an 18-membered

230 e inorganic framework bearing the largest 18-membered-ring channels in gallium phosphites, denoted as

231 bered-ring antibiotic) and pacritinib (an 18-membered-ring enzyme inhibitor), the Z-isomer of which i

232 s proposed to account for the selective five-membered-ring formation with the rearrangement of the ar

233 ne have shown reliable selectivity with five-membered-ring heterocycles.

234 By low-temperature NMR spectroscopy the six-membered-ring interconversion could be frozen at 103 K a

235 hree-component reaction, giving rise to nine-membered-ring lactones.

236 Notably, the 18-membered-ring moiety of pacritinib-a potent anti-cancer

237 Nucleophilic attack on seven-membered-ring oxocarbenium ions is generally highly ster

238 compared to that of reactions involving six-membered-ring oxocarbenium ions.

239 nicellin natural products from a number of 9-membered-ring precursors.

240 Seven-membered-ring trans-alkenes undergo rapid, uncatalyzed c

241 a transition states involving six- and seven-membered rings (1,5 and 1,6 H-shifts, respectively) of a

242 ine derivative salts with fused five and six-membered rings (X-ray) were obtained via modification of

243 ]tetraphene, which "unexpectedly" forms five-membered rings accompanying highly selective 1,2-shift o

244 formal pentalene subunit at the central five-membered rings and [5]-radialene-like structures at the

245 ediated Yamamoto reaction to close the seven-membered rings and create the borepins 4a-c.

246 rings are cis-fused and the five- and three-membered rings are mutually trans, provides a synthetic

247 acene derivatives with externally fused five-membered rings are prepared by means of a key palladium-

248 ed the ketone and dipolarophile to give five-membered rings but mixtures resulted with four atoms in

249 -bisallylaldehydes rearrange to generate six-membered rings by a mechanism triggered by aldehyde C-H

250 Distribution of produced five- or seven-membered rings depends on the substitution pattern on th

251 ionenes (spiro-ionenes) containing 5- and 6-membered rings fused by central nitrogen cations.

252 ty is strongly ring size dependent, with six-membered rings giving exclusively alpha-benzyl pentenoli

253 of a large diversity of highly functional 7-membered rings in good yields up to 95%.

254 4-disubstituted carbo- and heterocyclic five-membered rings in high yields and with good to excellent

255 e moieties with differently substituted five-membered rings in the backbone of the newly formed heter

256 -substituted benzene units to construct five-membered rings in this work provides a unique entry to n

257 he resulting bistetracene analogue with five-membered rings is comprehensively investigated by single

258 ation of the bistetracene analogue with five-membered rings is kinetically controlled while an "expec

259 trolled while an "expected" product with six-membered rings is thermodynamically more favored.

260 to compare the aromaticity in both the five-membered rings of 33, 34, 36 and 1,6-dioxa-6a-chalcopent

261 ains carried by the beta-lactam and the five-membered rings of the carbapenem core.

262 ded one-dimensional lines of five- and eight-membered rings that are domain boundaries and stacking f

263 es ranging in size from twelve- to seventeen-membered rings were synthesized in moderate to high yiel

264 of natural origin is a 1,2-trans fusion of 5-membered rings within a [3.3.0]-bicycle, a motif present

265 rivatives (containing five-, six-, and seven-membered rings) have been investigated.

266 (2) structures incorporating seven- or eight-membered rings, (3) selective heteroatom doping, and (4)

267 arrangement of substituents on one of its 5-membered rings, a pattern shared by a number of other te

268 The reaction generates 5- to 9-membered rings, and of the 44 examples studied, 10 inclu

269 enes, which contain four linearly fused five-membered rings, are benchtop stable and behave as hole-t

270 is located in the intersection of the two 10 membered rings, Cu-MOR provides two distinct local struc

271 ained amide, amine, and hetero-aromatic five-membered rings, each of which had a hetero-atom and an u

272 carried out to form seven-membered and eight-membered rings, giving rise to tetranitro dipyrazolo-1,3

273 tramolecular hydroacylation has favored five-membered rings, in preference to four membered rings.

274 ctions directed toward the syntheses of five-membered rings, other carbocycles and, finally, heterocy

275 m ions have been imaged sitting inside the 7-membered rings.

276 charged core composed of a series of fused 6-membered rings.

277 hat the final structure consists of only six-membered rings.

278 dialene-like structures at the proximal five-membered rings.

279 oms bridged by carbene groups yielding seven-membered rings.

280 teristics, such as windows that comprise odd-membered rings.

281 o [6 + 4] cycloaddition to form unbridged 10-membered rings.

282 ular cycloaddition reaction producing 5 to 7-membered rings.

283 d five-membered rings, in preference to four membered rings.

284 Si:Al ratios, the volumetric density of six-membered-rings (6MR) containing two Al (2Al sites) is co

285 A general approach for the formation of five-membered saturated heterocycles by intramolecular C(sp(3

286 metry of the Si4R4 system with a square four-membered silicon ring as a reference geometry, and emplo

287 c ions to OTOS trimers suggests that the six-membered siloxane rings are binding locations for single

288 cturally allowed cyclic trimers with the six-membered siloxane rings, which explain well both the X-r

289 aled that 2 contains a cyclic nonplanar four-membered SiPSiP ring.

290 c a-axis that are formed from six- and eight-membered sp(3) silicon rings.

291 ion of sulfur dioxide from the respective 16-membered sulfone precursors.

292 n THF unexpectedly gives both the first five-membered, sulfur-containing, zwitterionic silylene ring

293 the epoxidation reaction in a five- or seven-membered system.

294 The first examples of 4-membered thietane-oximines are prepared.

295 lowed by a Grubbs metathesis to close a five-membered "top" ring to form an alpha,beta-unsaturated la

296 y from Me3SiCl to the metal center via a six-membered transition state (IV) that leads to the interme

297 oselectivity is rationalized via closed, six-membered transition-state arrangements leading to the fo

298 own), which are characterized to contain a 6-membered twist-boat ring.

299 two terminal PKS modules that produce the 16-membered tylosin macrocycle, using them as biocatalysts

300 on results in the formation of five- and six-membered unsaturated carbocycles.