ライフサイエンスコーパス: membrane

1 the proteins from the vesicle to the plasma membrane.

2 ing of KATP and Kv2.1 channels to the plasma membrane.

3 y, enabling the complex to traverse the cell membrane.

4 o Akt to facilitate its translocation to the membrane.

5 1-VCP complex and reduces FAF1 at the plasma membrane.

6 attaches to two channels, mobile within the membrane.

7 sicles prior to re-insertion into the plasma membrane.

8 on the intermembrane space side of the inner membrane.

9 localize in specific layers relative to the membrane.

10 of the early and late proteins at the plasma membrane.

11 thus assists its localization into the outer membrane.

12 he ion channel gramicidin embedded in a POPC membrane.

13 mediated trafficking of Nav1.5 to the plasma membrane.

14 reatment of spheroids across a semipermeable membrane.

15 4,5)P2), the main lipid marker of the plasma membrane.

16 angiogenesis in chick embryo chorioallantoic membrane.

17 lypeptides through the endoplasmic reticulum membrane.

18 ueous pore that is largely shielded from the membrane.

19 signaling and angiogenesis in the peritoneal membrane.

20 that mimic both bacterial and mammalian cell membranes.

21 osamine, insulin can efficiently bind to RBC membranes.

22 umbers of bonds at the interface between two membranes.

23 photovoltaic action from photoacid-modified membranes.

24 hase-change devices based on atomically thin membranes.

25 cytoplasmic to the exocytoplasmic leaflet of membranes.

26 le stress (by 31%) when compared to pure PES membranes.

27 hase, which could explain their role in cell membranes.

28 pology and dimensions to interact with lipid membranes.

29 ications were cataract (0.31/EY), epiretinal membrane (0.16/EY), and recurrent macular edema (0.09/EY

30 e regulatory kinase at the outer chloroplast membrane 1 (KOC1).

31 choroid endothelial cells (ECs) and Bruch's membrane, a highly organized basement membrane that lies

32 utocatalysis severs the protein into a large membrane-anchored beta subunit that noncovalently associ

33 Inner membrane-anchored long OPA1 (L-OPA1) undergoes proteolyt

34 e with barriers for membrane exit due to the membrane anchors.

35 e molecular details of the interplay between membrane and CaM binding to Akt may help in the developm

36 Transport of membrane and cytosolic proteins in primary cilia is thou

37 that Rab8a is first recruited to the plasma membrane and dorsal ruffles, but it is retained during c

38 veal 2D dynamics of the mitochondria, plasma membrane and filopodia, and the 2D and 3D dynamics of th

39 on but co-localizes with PD-L1 at the plasma membrane and in recycling endosomes, where it prevents P

40 1,347 CEPs encompassing 90% inner- and outer-membrane and periplasmic proteins of Escherichia coli.

41 th the lateral diffusion of molecules at the membrane and the continuous release of the proteins from

42 IN1 and PIN1b in Arabidopsis illustrates how membrane and tissue-level accumulation, transport activi

43 lipids are a major component of plant plasma membranes and endomembranes, and mediate a diverse range

44 ) for ion-conductance measurement in polymer membranes and epithelial cell monolayers at discrete poi

45 To fully mimic the complexity of cell membranes and optimize the efficiency of delivery vesicl

46 Predictive cysteine cross-linking in E. coli membranes and PELDOR measurements along the transport cy

47 al and chemical stability of block copolymer membranes and their chemical versatility for adaptation

48 First validated with standard synthetic membranes and then demonstrated in living epithelial cel

49 ed by measuring their flux across large pore membranes and using dynamic light scattering, with excel

50 s an ABC transporter expressed on the plasma membrane, and actively exports phospholipid complexes fr

51 erythrocytes, are enclosed within a basement membrane, and can always be traced back to the renal art

52 y are poly-ubiquitinated, extracted from the membrane, and degraded by the proteasome-a pathway terme

53 ion of bioactives in pomegranate peel, inner membrane, and edible aril portion was investigated under

54 ion proteins (F) insert into the target cell membrane, and form a transient intermediate that pulls t

55 ubmembrane compartments, different organelle membranes, and also between cells of different cell stag

56 s the characteristics observed in the native membranes, and is described by a multisquare model with

57 sphatidylinositol (PtdIns) molecules between membranes, and this property is central to PITP-mediated

58 xtracts had significantly more anti-basement membrane antibodies than sera from patients with CRSwNP

59 nd that changes in antibody levels to Apical Membrane Antigen 1 suggested a decrease in transmission

60 he separation of the inner and outer nuclear membrane are responsible for the additional fluctuation

61 only the PG lipids in the outer leaflets of membranes are accessible to daptomycin.

62 We find that the positively curved membranes are CME hotspots, and that key CME proteins, c

63 this review, we discuss the extent to which membranes are naturally curved at each of the cellular s

64 Ceramide-rich membrane areas promote structural changes within the pla

65 aging of the dynamics of the bacterial outer membrane as cells divide.

66 that this protein is localized at the plasma membrane as well as in endosomes and soluble in the apop

67 by C3 glomerulopathy can develop neovascular membranes as retinal complications of pigment epithelial

68 stigate peptide and protein binding to lipid membranes, as it allows for very low amounts of sample,

69 by results obtained for luminal and nuclear membrane-associated EGFP-tagged proteins.

70 RNase E/enolase distribution changes from membrane-associated patterns under aerobic to diffuse pa

71 r examine the interaction of PorB with outer membrane-associated proteins, including PorA and RmpM.

72 EN controls multicellular assembly through a membrane-associated regulatory protein complex composed

73 Previously, we reported that membrane association of HIV-1 Gag, as well as purified R

74 trate the membrane bilayer, stabilizing ExoU-membrane association.

75 Thus, use of 2D membrane based off surface matrix may present the new pl

76 s that undergoes no residence time on plasma membrane before fusion and, to a lesser extent, also the

77 al four-helix bundle appear to penetrate the membrane bilayer, stabilizing ExoU-membrane association.

78 ow measurements suggest that initial PROPPIN-membrane binding is driven by non-specific PIP interacti

79 n mimicked effects of full-length PTEN but a membrane-binding defective mutant of the C2 domain abrog

80 conditions-answer long-standing questions in membrane biology and illustrate a fundamentally new appr

81 ith retinal pigment epithelium (RPE)-Bruch's membrane (BM) complex thickness as measured by spectral-

82 ate intracellular pathogen that resides in a membrane-bound compartment, the inclusion.

83 IL-15, which was primarily presented in its membrane-bound form by follicular dendritic cells.

84 MFN2 encodes mitofusin 2, a membrane-bound mediator of mitochondrial membrane fusion

85 , two possibly involved in biogenesis of the membrane-bound photosynthetic apparatus and one for phos

86 oding approximately 100 million secreted and membrane-bound single-chain antibodies and identify anti

87 en developed to overcome the cellular plasma membrane, but they all result in reduced cell viability.

88 s requires evagination of its ciliary plasma membrane by an unknown molecular mechanism.

89 e targeted to the inner chloroplast envelope membrane by undescribed translocases.

90 ulative N terminus of the Arabidopsis plasma membrane Ca(2+)-ATPase isoform 8 (ACA8) and that this in

91 L-type Ca(2+) channels (LTCCs) in the plasma membrane can initiate a signaling pathway that ultimatel

92 llular investigations reveal that the plasma membrane cell fate regulator, SCRAMBLED (SCM), is misloc

93 activated receptor 2 activates airway apical membrane chloride permeability and increases ciliary bea

94 e yeast Saccharomyces cerevisiae, this inner membrane complex is composed of 11 protein subunits.

95 resence, not the functionality, of the ESX-1 membrane complex.

96 action analysis and drug screening involving membrane components.

97 We conclude that the mitochondrial outer membrane contains a considerably larger variety of chann

98 ically, combining FRET-based measurements of membrane coverage with multiple, independent measurement

99 Upon binding, the M2AH induces membrane curvature and lipid ordering, constricting and

100 that segregate membrane receptors and affect membrane curvature and vesicle formation, fusion, and tr

101 eometrical cell-membrane properties, such as membrane curvature, volume, and surface area.

102 at CME proteins actively modulate the plasma membrane curvature.

103 n, show a strong preference towards positive membrane curvatures with a radius <200 nm.

104 whereas Ctn had a lag phase before inducing membrane damage and exhibited more complex cell-killing

105 We present a hypothesis in which the membrane deformation changes upon channel opening.

106 Moreover, PES/AG membranes demonstrated higher antifouling and tensile st

107 lix in SM N100 attaches reversibly to the ER membrane depending on cholesterol levels; with excess, t

108 PS asymmetry on the plasma membrane depends on the activities of P4-ATPases, and di

109 ts showed decreased hypoxia-induced cellular membrane depolarization in Cox4i2(-/-) PASMCs compared w

110 eostasis in excitable cells following plasma membrane depolarization.

111 , made by wrapping polymeric cores with cell membrane derived from macrophages, possess an antigenic

112 ocalization to chromosome reorganization and membrane dilation up to rupture.

113 Formation of membrane discs in photoreceptor cells requires evaginati

114 HAP1-Deltab and HAP1-DeltaOSCP, lacking the membrane domain of subunit b or the OSCP, respectively,

115 and plasma membrane, respectively, to create membrane domains that partition upstream regulators of t

116 d biosynthesis) and StoA (apical sterol-rich membrane domains), and its essentiality in polar deposit

117 rs insertion of GLUT4 into the axonal plasma membrane driven by activation of the metabolic sensor AM

118 pher specific influences on molecular plasma membrane dynamics.

119 of intraocular lenses (IOLs) after Descemet membrane endothelial keratoplasty (DMEK).

120 tes in a detergent-free native or artificial membrane environment.

121 We find that the daily rhythm in membrane excitability in the ventral SCN (vSCN) was enha

122 , yielding a force profile with barriers for membrane exit due to the membrane anchors.

123 ental hemimandibles exhibited lower rates of membrane exposure and a noteworthy, ectopic bone formati

124 the prepilin peptidase, essential for pilin membrane extraction and assembly, is followed by N-methy

125 phase and is encompassed by two free liquid membranes (FLMs) and two extraction solutions.

126 cursor within the lipid bilayer of the inner membrane, followed by cleavage by the inner membrane pep

127 ctive than WQ in blocking HIV-1 Env-mediated membrane fusion and had higher levels of binding affinit

128 , a membrane-bound mediator of mitochondrial membrane fusion and inter-organelle communication.

129 that network maintenance requires continuous membrane fusion and that Yop1p favours the generation of

130 formation during homotypic vacuolar lysosome membrane fusion in Saccharomyces cerevisiae Using cell-f

131 engaging the host receptor and in mediating membrane fusion, respectively.

132 The formation of the ER requires homotypic membrane fusion, which is mediated by a family of Dynami

133 post-F) state at the time of virus-host cell membrane fusion.

134 uling experiments, while that of the control membranes had a greater decline of approximately 21%.

135 Continuum elastic models of the membrane have been widely used to study protein-membrane

136 term premature rupture of membranes (pPROM), membranes heal spontaneously and pregnancy continues unt

137 se ATG4 and conjugated to the autophagosomal membrane; however, its removal is mediated by the same p

138 Ctn(15-34) permeabilized the membrane immediately upon addition to the cells, whereas

139 ranslocation of RodZ to the bacterial plasma membrane in an obligatorily cotranslational mechanism.

140 ty triggers lysosomal fusion with the plasma membrane in dendrites.

141 of KCNQ1 trapped beta-catenin at the plasma membrane, induced a patent lumen in CRC spheroids, and s

142 n essential heteroligomer that catalyzes the membrane insertion of OMPs.

143 Here we found that known membrane insertion pathways fail to effectively engage t

144 Alterations of GCS not only affect membrane integrity, but also closely correlate with stem

145 for understanding and controlling polycation-membrane interactions, yet such information is surprisin

146 brane have been widely used to study protein-membrane interactions.

147 proteins are retro-translocated through the membrane into the cytosol, where they are poly-ubiquitin

148 suggesting that release of the Q toward the membrane is coupled to an energy transduction step that

149 a 15 kDa polyelectrolyte, a 50 kDa dialysis membrane is not sufficient to remove all PAH polymers.

150 into how polycations disrupt and cross cell membranes is needed for understanding and controlling po

151 combination with all kinds of ion-selective membranes (ISMs) would match the performance characteris

152 For such a complex reaction with membranes, it has been difficult to uncover the molecula

153 our experiments between protons in the near-membrane layers and in the aqueous bulk.

154 epleted membranes, PmB forms clusters on the membranes leading to an indentation of the bilayers and

155 important role in the formation of multiple membrane-less organelles involved in RNA metabolism, inc

156 of AP-2 in the maintenance of proper apical membrane lipid and cell wall composition is further supp

157 Membrane lipid composition varies greatly within submemb

158 ficients, measured by immobilized artificial membrane liquid chromatography (IAM-LC) and by micellar

159 nd the closely related field of nanoparticle membrane-loading of liposomes and polymersomes.

160 itoylated display drastically reduced plasma membrane localization, which effectively prevents TF fro

161 e optical trapping technique for determining membrane mechanics of cultured primary afferent neurons

162 environment and release progeny virions in a membrane-mediated cell-to-cell manner.

163 athways and becomes concentrated in specific membrane microdomains that serve as signaling platforms.

164 The generation of membrane microtears upon ablation is consistent with stu

165 d diffusion modes of many but not all of the membrane molecules and highlight a powerful experimental

166 ordering, constricting and destabilizing the membrane neck, causing scission.

167 P2Y2R provides allosteric resistance to the membrane-normal motion associated with the switchblade m

168 om the cytosol, analogous to the lipid-based membrane of eukaryotic organelles.

169 BC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylc

170 on, mediated by the odorant receptors on the membrane of olfactory sensory neurons, plays a vital rol

171 localized in the cytoplasm and Dock7 on the membrane of or in alpha-granules.

172 X2 to promote translocation across the inner membrane of the COX2 C-tail that contains the apo-CuA si

173 a residual calyx attached to the basolateral membrane of the hair cells.

174 nd detached state) and the internal limiting membrane of the retina is essential to understanding the

175 nute PKA activity microdomains on the plasma membranes of living cells and to uncover the role of clu

176 ssembles beta-barrel proteins into the outer membrane (OM) of Gram-negative bacteria.

177 dria and clusters at the outer mitochondrial membrane (OMM).

178 ted optical coherence tomography (OCT) Bruch membrane opening (BMO) algorithm and stereoscopic optic

179 inal parameters in glaucoma, and (2) Bruch's membrane or anterior sclera should be used as a referenc

180 ontribute to the biogenesis of virus-induced membrane organelles.

181 Comparative studies with extracorporeal membrane oxygenation have not been completed.

182 and dependency on venovenous extracorporeal membrane oxygenation support.

183 CFTR more rapidly lost function in cell-free membrane patches and showed altered channel gating and c

184 tients with clinically typical ocular mucous membrane pemphigoid (MMP).

185 membrane, followed by cleavage by the inner membrane peptidase.

186 s cooperative lipid extraction mechanism for membrane perforation represents another distinct process

187 Once formed, membrane permeability (integrity) was unaffected by mine

188 , probably because of two different modes of membrane permeabilization.

189 A (PKA), phosphodiesterase 3B (PDE3B), and a membrane-permeable cyclic guanosine monophosphate (cGMP)

190 ce for contributions of complement-dependent membrane perturbations to prothrombotic TF activation on

191 ggered by a pH gradient across the thylakoid membrane (pH).

192 vo synthesis of PA, a central metabolite for membrane phospholipid biosynthesis.

193 scission and subsequent endocytosis of these membrane pits.

194 n whose reversible localization to ER-plasma membrane (PM) contacts is governed by phosphorylation an

195 In cholesterol depleted membranes, PmB forms clusters on the membranes leading t

196 rial cytoplasm to the periplasm via an inner-membrane pore complex (TraC and TraG) with homology to t

197 e absence of exogenous substrates upon inner membrane pore formation by alamethicin or Ca(2+)-induced

198 cardiac macrophages have a negative resting membrane potential and depolarize in synchrony with card

199 abolites, as well as decreased mitochondrial membrane potential and deranged mitochondrial ultra-stru

200 lded protein response, loss of mitochondrial membrane potential and sensitivity to mitochondrial remo

201 cardiomyocytes exhibit two levels of resting membrane potential at subphysiological extracellular K(+

202 axons in an all-or-none manner, subthreshold membrane potential fluctuations at the soma affect neuro

203 mPTP opening decreases the mitochondrial membrane potential leading to the activation of Ca(2+)-i

204 the inward tail current (Cl(-) efflux) at a membrane potential of -100 mV due to the lowered outward

205 red outward current (gluconate(-) influx) at membrane potential of 100 mV.

206 cently were bacteria shown to modulate their membrane potential on the timescale of seconds, and litt

207 Kv1.3, regulating the membrane potential, facilitates downstream Ca(2+) -depen

208 complicated by preterm premature rupture of membranes (pPROM), membranes heal spontaneously and preg

209 shown that the major AAV2 binding protein in membrane preparations of human cells corresponds to a gl

210 Hence, the industrial potential of membrane processing to concentrate omega-3 fatty acids i

211 These results illustrate how membrane properties and voltage-gated conductances can e

212 overed laws derive from the geometrical cell-membrane properties, such as membrane curvature, volume,

213 Latent membrane protein 1 (LMP1) is an Epstein-Barr virus (EBV)

214 ed in vitro system that phosphorylation of a membrane protein can trigger a change in topological arr

215 ediated by a highly conserved heterotrimeric membrane protein complex denoted Sec61 in eukaryotes and

216 in-protein contacts and triggering/promoting membrane protein crystallization, and to visualize the d

217 tunities for applications built upon diverse membrane protein functions, or involved with drug target

218 plemented RosettaMP, a general framework for membrane protein modeling.

219 indicate that these agents have potential in membrane protein research.

220 ikingly, we also find that the inner nuclear membrane protein Sun1 antagonizes Sun2 LINC complexes an

221 mutations in Nramp1 (SLC11A1), a phagosomal membrane protein that controls iron export from vacuoles

222 24 is an endoplasmic reticulum (ER)-anchored membrane protein whose reversible localization to ER-pla

223 pression of the oncogenic protein epithelial membrane protein-2 (EMP2) correlates with endometrial ca

224 ogical ligand, podoplanin, being an integral membrane protein.

225 ible for the biogenesis of beta-barrel outer membrane proteins (OMPs) in Gram-negative bacteria.

226 Signals from two different membrane proteins are combined to modulate how strongly

227 Membrane proteins are targets of most available pharmace

228 ing this line, we show here that crystals of membrane proteins display systematically higher diffract

229 t sorting mechanisms target aggregated Golgi membrane proteins for lysosomal degradation.

230 An important subset of membrane proteins have globular, cofactor-containing ext

231 rs to determine the oligomerization state of membrane proteins in a static quenching FRET experiment:

232 Notably, clustered patterning of membrane proteins is a commonly conserved feature across

233 owever, achievement of the overexpression of membrane proteins is not necessarily straightforward, an

234 Expression of membrane proteins often leads to growth inhibition and p

235 ays fail to effectively engage tail-anchored membrane proteins with moderately hydrophobic transmembr

236 the Rosetta biomolecular modeling suite for membrane proteins, we recently implemented RosettaMP, a

237 in studies of the structure and function of membrane proteins.

238 ed for the insertion of mitochondria-encoded membrane proteins.

239 riphery, where distinct types of actin-based membrane protrusions formed.

240 interactions near the Cbeta H3 helix at the membrane-proximal face of the TCR, a region implicated i

241 These residues are located in the membrane-proximal region of the N terminus of chECL1, su

242 phagy machinery of the host cell, and the PV membrane (PVM) becomes decorated with several autophagy

243 esoid X receptor (FXR) and G protein-coupled membrane receptor TGR5 that demonstrated beneficial effe

244 es within the plasma membrane that segregate membrane receptors and affect membrane curvature and ves

245 nteracts with and is regulated at the target membrane remain unclear.

246 tide transport across the additional plastid membranes remains to be clarified.

247 actor (VEGF) is implicated in the peritoneal membrane remodeling that limits ultrafiltration in patie

248 nd Ltc3/4 function at the vacuole and plasma membrane, respectively, to create membrane domains that

249 ered the fusion of lysosomes with the plasma membrane, resulting in the release of Cathepsin B.

250 cently constructed truncated versions of the membrane scaffold protein, allowing the preparation of a

251 Both flux decline and membrane scale formation decreased after a chemical-free

252 n erythroid-specific, protein 4.1R-dependent membrane skeleton is an important feature not only of de

253 tion of transmembrane helices constituting a membrane-spanning furrow that provides a path for lipids

254 t dilution series with solid supported lipid membranes (SSLMs).

255 or systematic in vivo investigations of cell membrane structure.

256 op1p favours the generation of highly curved membrane structures.

257 The membrane subunits ATP6, ATP8, and subunit c have been el

258 agents that are added to the feed side of a membrane system and seal the defect site because of incr

259 ation on proteins frequently affecting their membrane targeting and trafficking.

260 During protrusion, as membrane tension increases, velocity slows, and the lame

261 nvaginations of plasma membranes that buffer membrane tension through their deformation.

262 st vesiculation against opposing forces like membrane tension.

263 water-filled pore in response to changes in membrane tension.

264 Similar to other membrane-tethered actin structures, we find proteins loc

265 ruch's membrane, a highly organized basement membrane that lies between both cell types.

266 promote structural changes within the plasma membrane that segregate membrane receptors and affect me

267 bundant flask-shaped invaginations of plasma membranes that buffer membrane tension through their def

268 ive-strand RNA [(+)RNA] viruses and cellular membranes that contribute to the biogenesis of virus-ind

269 neered self-patterning bacteria on permeable membranes that serve as a structural scaffold.

270 serve the initial particle attachment to the membrane, then particle wrapping, and in rare cases spon

271 Here, we examine the effects of membrane thickness, the Escherichia coli periplasmic cha

272 ing peptides (CPPs) are able to bind to cell membranes, thus promoting cell internalization by active

273 locons on the outer membrane (TOM) and inner membrane (TIM).

274 The permeability of the mitochondrial inner membrane to HNO2, but not to NO2(-), combined with the l

275 tic DFNA5-N fragment that targets the plasma membrane to induce secondary necrosis/pyroptosis.

276 imerize and move laterally across the plasma membrane to phosphatidylinositol (4,5)-bisphosphate-enri

277 iferate and spread onto the denuded basement membrane to reseal the barrier.

278 t intermediate that pulls the viral and cell membranes together as two heptad-repeat regions refold t

279 to mitochondria use translocons on the outer membrane (TOM) and inner membrane (TIM).

280 It is typically assumed that membrane topologies remain static after this process has

281 unifying pathogenesis in CNMs via defective membrane trafficking and excitation-contraction coupling

282 phospholipid species with important roles in membrane trafficking and reorganization.

283 further illustrate the importance of normal membrane trafficking in the physiology and pathogenicity

284 ing in the brain, where it has a key role in membrane trafficking, vesicle secretion, and endocytosis

285 cognized as the premier plant cell model for membrane transport, signaling, and homeostasis.

286 icle wrapping, and in rare cases spontaneous membrane tubulation.

287 tion of high-content imaging and a mammalian membrane two-hybrid protein-protein interaction method,

288 By direct analysis of water purification membranes using ambient ionization mass spectrometry, an

289 C membrane was coated onto the nanogel via a membrane vesicle templated in situ gelation process, whe

290 e with multiple, independent measurements of membrane vesiculation revealed that fission became spont

291 this issue is in situ healing of compromised membranes via healing agents that are added to the feed

292 RBC membrane was coated onto the nanogel via a membrane vesi

293 The LRV recovered back to 5 when the membrane was critically fouled, and the achieved LRV rem

294 The membranes were robust enough to withstand strong cross-f

295 70-SGTA-Hsp105 complex is tethered to the ER membrane, where Hsp105 and SGTA facilitate the extractio

296 DNER is present on the plasma membrane, while NFIA is confined to the nucleus, consist

297 zation improved biofouling resistance in the membranes, whose flux had a decline of 8% after 24 h of

298 ain of nectin-2 that is most distal from the membrane with an affinity of 6 mum, which was moderately

299 a2 and -gamma3 chains in the limbal basement membrane, with LN-alpha5 representing a signature compon

300 uch persistence selectively attack bacterial membranes without oligomerizing into visible pores.